GSK3 inhibitors enhance retinoic acid receptor activity and induce the differentiation of retinoic acid-sensitive myeloid leukemia cells
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GSK3b inhibition sensitizes AML cells to ATRA and to 1,25 vitamin D-mediated differentiation.
“While GSK3b inhibition was independently shown to sensitize AML cells to ATRA (48) as well 1,25 vitamin D-mediated differentiation (30), the underlying molecular mechanism remained unknown.”
From FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1 (2021) · cites this paper as [48]
ATRA inhibits GSK3b in AML cells in a time- and concentration-dependent manner by phosphorylating its N-terminal serine, as an early step to induce myeloid differentiation.
“However, ATRA itself was also shown to inhibit GSK3b in AML cells in a time-and concentration-dependent manner by phosphorylating its N-terminal serine (48) as an early step to induce myeloid differentiation highlighting the importance of GSK-3b inhibition in myeloid differentiation.”
From FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1 (2021) · cites this paper as [48]
Cites
GSK3 takes centre stage more than 20 years after its discovery
FRAME, S., & COHEN, P. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3590001 · Cited by 1,433 · see citing works
Welcker, M., & Clurman, B. E. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2290 · Cited by 1,084 · see citing works
GSK3 takes centre stage more than 20 years after its discovery
Frame, S., & Cohen, P. (2001) · Biochemical Journal · doi:10.1042/bj3590001 · Cited by 997 · see citing works
Embi, N., Rylatt, D. B., & Cohen, P. (1980) · PubMed · Cited by 911 · see citing works
Glycogen Synthase Kinase‐3 from Rabbit Skeletal Muscle
Noor, E. M. B. I., RYLATT, D. B., & Cohen, P. (1980) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1980.tb06059.x · Cited by 837 · see citing works
GSK3 inhibitors: development and therapeutic potential
Cohen, P., & Goedert, M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1415 · Cited by 788 · see citing works
Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy
Wang, Z., Smith, K. S., Murphy, M., Piloto, O., Somervaille, T. C. P., & Cleary, M. L. (2008) · Nature · doi:10.1038/nature07284 · Cited by 265 · see citing works
One Hundred Years after the Discovery of Alzheimer's Disease. A Turning Point for Therapy?
Giacobini, E., & Becker, R. E. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-12105 · Cited by 92 · see citing works
Ghosh, J. C., & Altieri, D. C. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2624 · Cited by 86 · see citing works
Si, J., Mueller, L., & Collins, S. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30779 · Cited by 45 · see citing works
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GSK3 is a regulator of RAR-mediated differentiation
Gupta, K., Gulen, F., Sun, L., Aguilera, R., Chakrabarti, A., Kiselar, J., Agarwal, M. K., & Wald, D. N. (2012) · Leukemia · doi:10.1038/leu.2012.2 · Cited by 50 · see citing works
GSK-3 inhibition sensitizes acute myeloid leukemia cells to 1,25D-mediated differentiation
Gupta, K., Stefan, T., Ignatz-Hoover, J., Moreton, S., Parizher, G., Saunthararajah, Y., & Wald, D. N. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2290 · Cited by 44 · see citing works
Mishra, M., Thacker, G., Sharma, A., Singh, A. K., Upadhyay, V., Sanyal, S., Verma, S. P., Tripathi, A. K., Bhatt, M. L. B., & Trivedi, A. K. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0268 · Cited by 30 · see citing works
- Authors
- Si, J., Mueller, L., & Collins, S. J.
- Affiliations
- Fred Hutch Cancer Center (US)
- Corresponding author
- Collins, S J
- ORCID
- Collins, S J
- Venue
- Leukemia
- Published
- 2011-07-26
- Volume
- 25
- Issue
- 12
- Pages
- 1914-1918
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- OpenAlex
- W1979915243
- Cited by
- 30
- References
- 10
- Citations by year
- 2022: 1 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 5
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Leukemia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Samuel Waxman Cancer Research Foundation
- National Institutes of Health
- National Cancer Institute (R01CA118971)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Keywords
- GSK-3 inhibitors, retinoic acid receptor, myeloid leukemia, leukemia cell differentiation, Wnt/β-catenin signaling, hematopoiesis, leukemogenesis
- MeSH terms
- Glycogen Synthase Kinase 3 beta, Cell Differentiation, Enzyme Inhibitors, Humans, Leukemia, Myeloid, Phosphorylation, Tretinoin, Tumor Cells, Cultured, Blotting, Western, Receptors, Retinoic Acid, Glycogen Synthase Kinase 3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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