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Long-term follow-up of imatinib in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia: Children's Oncology Group Study AALL0031
Open accessAbstract
We previously reported preliminary findings that post induction imatinib mesylate (340 mg/m2/day), in combination with intensive chemotherapy, resulted in outcomes similar to blood and marrow transplant (BMT) for pediatric patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). We now report 5-year outcomes of imatinib plus intensive chemotherapy in 91 children (1–21 years) with and without allogeneic BMT (N=91). We explore the impacts of additional chromosomal abnormalities and minimal residual disease (MRD) by flow cytometry on outcomes. The 5-year disease-free survival was similar for Cohort 5 patients, treated with chemotherapy plus imatinib (70%±12%, n=28), sibling donor BMT patients (65%±11%, n=21) and unrelated donor BMT patients (59±15%; P=0.60, n=13). Patients with additional cytogenetic abnormalities had worse outcomes (P=0.05). End induction (pre-imatinib) MRD was not prognostic for Cohort 5 or allogeneic BMT patients, although limited by small numbers. The re-induction rate following relapse was similar to other higher-risk ALL groups. Longer-term follow-up confirms our initial observation of substantially good outcomes for children and adolescents with Ph+ ALL treated with imatinib plus intensive chemotherapy with no advantage for allogeneic BMT.
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Metadata
- Authors
- Schultz, K. R., Carroll, A., Heerema, N. A., Bowman, W. P., Aledo, A., Slayton, W. B., Sather, H., Devidas, M., Zheng, H. W., Davies, S. M., Gaynon, P. S., Trigg, M., Rutledge, R., Jorstad, D., Winick, N., Borowitz, M. J., Hunger, S. P., Carroll, W. L., Camitta, B., & from the Children’s Oncology Group
- Venue
- Leukemia
- Published
- 2014-01-20
- Volume
- 28
- Issue
- 7
- Pages
- 1467-1471
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- OpenAlex
- W2047597898
- Cited by
- 447
- References
- 18
- FWCI
- 43.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Schultz, K. R., Carroll, A., Heerema, N. A., Bowman, W. P., Aledo, A., Slayton, W. B., Sather, H., Devidas, M., Zheng, H. W., Davies, S. M., Gaynon, P. S., Trigg, M., Rutledge, R., Jorstad, D., Winick, N., Borowitz, M. J., Hunger, S. P., Carroll, W. L., Camitta, B., & from the Children’s Oncology Group. (2014). Long-term follow-up of imatinib in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia: Children's Oncology Group Study AALL0031. Leukemia. https://doi.org/10.1038/leu.2014.30
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