Adolescent and young adult patients with cancer: a milieu of unique features

Sender, Leonard; Zabokrtsky, Keri B.

doi:10.1038/nrclinonc.2015.92

Cited by 130Childhood Cancer Survivors' Quality of LifeAcute Lymphoblastic Leukemia researchAdolescent and Pediatric Healthcare

Adolescent and young adult patients with cancer: a milieu of unique features

Sender, Leonard, Zabokrtsky, Keri B.·2015·Nature Reviews Clinical Oncology

DOI 10.1038/nrclinonc.2015.92

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Abstract

Adolescent and young adult (AYA) patients with cancer are a unique category of patients who, depending on age at time of diagnosis, might receive treatment from oncologists specializing either in the treatment of children or adults. In the USA, AYA oncology generally encompasses patients 15-39 years of age. AYA patients with cancer typically present with diseases that span the spectrum from 'paediatric' cancers (such as acute lymphoblastic leukaemia [ALL] and brain tumours) to 'adult' tumours (such as breast cancer and melanoma), as well as cancers that are largely unique to their age group (such as testicular cancer and bone tumours). Research indicates that outcomes of AYA patients with cancer are influenced not only by the treatment provided, but also by factors related to 'host' biology. In addition to the potential biological and cancer-specific differences between AYAs and other patients with cancer, AYA patients also often have disparate access to clinical trials and suffer from a lack of age-appropriate psychosocial support services and health services, which might influence survival as well as overall quality of life. In this Review, these issues are discussed, with a focus on two types of AYA cancer--ALL and melanoma--highlighting findings arising from the use of emerging technologies, such as whole-genome sequencing.

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There is a lack of age-appropriate psychosocial support for adolescents and young adults after cancer treatment.
“Despite this disproportionate need, there remains a lack of age-appropriate psychosocial support for adolescents and young adults after cancer treatment, which is further complicated by the difficulty reaching this geographically dispersed population [9].”
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Use of the Chatbot “Vivibot” to Deliver Positive Psychology Skills and Promote Well-Being Among Young People After Cancer Treatment: Randomized Controlled Feasibility Trial
Greer, S., Ramo, D., Chang, Y.-J., Fu, M., Moskowitz, J., & Haritatos, J. (2019) · JMIR mHealth and uHealth · doi:10.2196/15018 · Cited by 265 · see citing works

Authors: Sender, L., & Zabokrtsky, K. B.
Affiliations: University of California, Irvine (US)
Children's Hospital of Orange County (US)
Corresponding author: Sender, Leonard
ORCID: Sender, Leonard
Venue: Nature Reviews Clinical Oncology
Publisher: Springer Science and Business Media LLC
Published: 2015-05-26
Volume: 12
Issue: 8
Pages: 465-480
ISSN: 1759-4774 (ISSN-L)
1759-4782
DOI: 10.1038/nrclinonc.2015.92
OpenAlex: W427596666
Cited by: 130
References: 196
Citations by year: 2026: 8 · 2025: 14 · 2024: 10 · 2023: 11 · 2022: 18 · 2021: 13 · 2020: 13 · 2019: 7 · 2018: 8 · 2017: 16 · 2016: 10 · 2015: 1
FWCI: 1.77
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Clinical Oncology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
Health Sciences › Health Professions › Speech and Hearing › Adolescent and Pediatric Healthcare
Keywords: adolescent and young adult cancer, acute lymphoblastic leukemia, melanoma, long-term outcomes, host biology, clinical trial access, psychosocial support, quality of life, whole genome sequencing
MeSH terms: Adolescent, Adult, Clinical Trials as Topic, Delivery of Health Care, Health Services Accessibility, Humans, Immunotherapy, Health Knowledge, Attitudes, Practice, Melanoma, Mutation, Neoplasm Metastasis, Patient Advocacy, Risk Factors, Skin Neoplasms, Social Work, Survivors, Patient Selection, Proto-Oncogene Proteins B-raf, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Young Adult, Patient Protection and Affordable Care Act

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