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Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells
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“Consistent with these observations, loss of Dnmt3a in mice results in reduced overall survival as well as hepatosplenomegaly, which is associated with myeloid cell infiltration in various tissues, myeloproliferation, and liver-specific expansion of hematopoietic stem and progenitor cells (HSC/Ps) (13).”
From Loss of Dnmt3a impairs hematopoietic homeostasis and myeloid cell skewing via the PI3Kinase pathway (2023) · cites this paper as [13]
In the citing paper
“In mice, loss of Dnmt3a results in enhanced hematopoietic stem cell self-renewal, proliferation, and myeloid cell bias (13).”
From Loss of Dnmt3a impairs hematopoietic homeostasis and myeloid cell skewing via the PI3Kinase pathway (2023) · cites this paper as [13]
In the citing paper
“Although patients with DNMT3A mutations show hepatosplenomegaly and lymphadenopathy due to extramedullary chronic myelomonocytic leukemia (CMML) (13) compared with patients with WT DNMT3A; the signaling pathways that induce such profound hematopoietic”
From Loss of Dnmt3a impairs hematopoietic homeostasis and myeloid cell skewing via the PI3Kinase pathway (2023) · cites this paper as [13]
In the citing paper
“Guryanova et al. reported that Dnmt3a–/– mice show liver specific HSC expansion (13).”
From Loss of Dnmt3a impairs hematopoietic homeostasis and myeloid cell skewing via the PI3Kinase pathway (2023) · cites this paper as [13]
In the citing paper
“Previous studies have shown that diseased Dnmt3a–/– mice present with anemia, reduced mature erythroblasts, and an accumulation of immature CD71+Ter119+ proerythroblasts in the spleen and in the BM (13).”
From Loss of Dnmt3a impairs hematopoietic homeostasis and myeloid cell skewing via the PI3Kinase pathway (2023) · cites this paper as [13]
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Citations
Cites
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
The Cancer Genome Atlas Research Network (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301689 · Cited by 5,078
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The purification and characterization of fetal liver hematopoietic stem cells
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“These mutations occur as monoallelic or biallelic nonsense/frameshift alterations, or a dominant-negative R882 substitution 9, 10 .”
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Cited by
Glass, J. L., Hassane, D., Wouters, B. J., Kunimoto, H., Avellino, R., Garrett-Bakelman, F. E., Guryanova, O. A., Bowman, R., Redlich, S., Intlekofer, A. M., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-1032 · Cited by 142
Self-citationLoss of Dnmt3a impairs hematopoietic homeostasis and myeloid cell skewing via the PI3Kinase pathway
Palam, L. R., Ramdas, B., Pickerell, K., Pasupuleti, S. K., Kanumuri, R., Cesarano, A., Szymanski, M., Selman, B., Dave, U. P., Sandusky, G., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.163864 · Cited by 13
Metadata
- Authors
- Guryanova, O. A., Lieu, Y. K., Garrett-Bakelman, F. E., Spitzer, B., Glass, J. L., Shank, K., Martinez, A. B. V., Rivera, S. A., Durham, B. H., Rapaport, F., Keller, M. D., Pandey, S., Bastian, L., Tovbin, D., Weinstein, A. R., Teruya-Feldstein, J., Abdel-Wahab, O., Santini, V, Mason, C. E., Melnick, A. M., Mukherjee, S., & Levine, R. L.
- Venue
- Leukemia
- Published
- 2015-12-29
- Volume
- 30
- Issue
- 5
- Pages
- 1133-1142
- ISSN
- 0887-6924
- 1476-5551
- PMC
- PMC4856586
- Cited by
- 66
- References
- 9
- Language
- en
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