Cited by 71Chronic Lymphocytic Leukemia ResearchLymphoma Diagnosis and TreatmentAcute Lymphoblastic Leukemia research

PLCG2 C2 domain mutations co-occur with BTK and PLCG2 resistance mutations in chronic lymphocytic leukemia undergoing ibrutinib treatment

Jones, D, Woyach, J A, Zhao, W, Caruthers, S, Tu, H, Coleman, J, Byrd, J C, Johnson, A J +1 more·2017·Leukemia

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Crossref · 10.1038/leu.2017.110

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15 of 15 references verified0 citation errors · 0 not checkable

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  • Hypermorphic gain-of-function genetic changes in the putative calcium-regulated domain (C2) of PLCG2 are correlated with CLL resistance to Ibrutinib.

    “Hypermorphic gain-of-function genetic changes in the putative calcium-regulated domain (C2) of PLCG2 were noted to be correlated with CLL resistance to Ibrutinib (131).”

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Authors
Jones, D., Woyach, J. A., Zhao, W., Caruthers, S., Tu, H., Coleman, J., Byrd, J. C., Johnson, A. J., & Lozanski, G.
Affiliations
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
Corresponding author
Jones, D
Venue
Leukemia
Published
2017-04-03
Volume
31
Issue
7
Pages
1645-1647
ISSN
  • 0887-6924 (ISSN-L)
  • 1476-5551
OpenAlex
W2604485134
Cited by
71
References
15
Citations by year
2026: 3 · 2025: 5 · 2024: 11 · 2023: 7 · 2022: 8 · 2021: 10 · 2020: 10 · 2019: 8 · 2018: 7 · 2017: 2
FWCI
4.24
Type
journal article
Language
en
Open access
closed
Locations
  • Leukemia (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
Keywords
ibrutinib resistance, chronic lymphocytic leukemia, BTK mutations, Bruton's tyrosine kinase, PLCγ2, B cell receptor signaling, clonal evolution, Richter transformation, BTK inhibitors
MeSH terms
C2 Domains, Agammaglobulinaemia Tyrosine Kinase, Adenine, Humans, Mutation, Piperidines, Protein-Tyrosine Kinases, Pyrazoles, Pyrimidines, Leukemia, Lymphocytic, Chronic, B-Cell, Drug Resistance, Neoplasm, Protein Kinase Inhibitors, Phospholipase C gamma

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