PLCG2 C2 domain mutations co-occur with BTK and PLCG2 resistance mutations in chronic lymphocytic leukemia undergoing ibrutinib treatment
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Hypermorphic gain-of-function genetic changes in the putative calcium-regulated domain (C2) of PLCG2 are correlated with CLL resistance to Ibrutinib.
“Hypermorphic gain-of-function genetic changes in the putative calcium-regulated domain (C2) of PLCG2 were noted to be correlated with CLL resistance to Ibrutinib (131).”
From The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration (2021) · cites this paper as [131]
Cites
Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib
Woyach, J. A., Furman, R. R., Liu, T.-M., Ozer, H. G., Zapatka, M., Ruppert, A. S., Xue, L., Li, D. H.-H., Steggerda, S. M., Versele, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1400029 · Cited by 1,275 · see citing works
Self-citationLucas, C. L., Kuehn, H. S., Zhao, F. R., Niemela, J. E., Deenick, E. K., Palendira, U., Avery, D. T., Moens, L., Cannons, J. L., Biancalana, M., et al. (2013) · Nature Immunology · doi:10.1038/ni.2771 · Cited by 677 · see citing works
EF-hand calcium-binding proteins
Lewit‐Bentley, A., & Réty, S. (2000) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(00)00142-1 · Cited by 568 · see citing works
<i>BTK</i> <sup>C481S</sup> -Mediated Resistance to Ibrutinib in Chronic Lymphocytic Leukemia
Woyach, J. A., Ruppert, A. S., Guinn, D., Lehman, A., Blachly, J. S., Lozanski, A., Heerema, N. A., Zhao, W., Coleman, J., Jones, D., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.70.2282 · Cited by 484 · see citing works
Self-citationBurger, J. A., Landau, D. A., Taylor-Weiner, A., Bozic, I., Zhang, H., Sarosiek, K., Wang, L., Stewart, C., Fan, J., Hoellenriegel, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms11589 · Cited by 345 · see citing works
Clonal evolution leading to ibrutinib resistance in chronic lymphocytic leukemia
Ahn, I. E., Underbayev, C., Albitar, A., Herman, S. E. M., Tian, X., Maric, I., Arthur, D. C., Wake, L., Pittaluga, S., Yuan, C. M., et al. (2017) · Blood · doi:10.1182/blood-2016-06-719294 · Cited by 341 · see citing works
Ibrutinib Resistance in Chronic Lymphocytic Leukemia
Furman, R. R., Cheng, S., Lu, P., Setty, M., Perez, A. R., Guo, A., Racchumi, J., Xu, G., Wu, H., Ma, J., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmc1402716 · Cited by 300 · see citing works
Kurosaki, T., & Tsukada, S. (2000) · Immunity · doi:10.1016/s1074-7613(00)80153-3 · Cited by 223 · see citing works
Electrostatic Control of the Membrane Targeting of C2 Domains
Murray, D., & Honig, B. H. (2002) · Molecular Cell · doi:10.1016/s1097-2765(01)00426-9 · Cited by 223 · see citing works
Liu, T.-M., Woyach, J. A., Zhong, Y., Lozanski, A., Lozanski, G., Dong, S., Strattan, E., Lehman, A., Zhang, X., Jones, J. A., et al. (2015) · Blood · doi:10.1182/blood-2015-02-626846 · Cited by 178 · see citing works
Self-citationBattling Btk mutants with noncovalent inhibitors that overcome Cys481 and Thr474 mutations
Johnson, A. R., Kohli, P. B., Katewa, A., Gogol, E., Belmont, L. D., Choy, R., Penuel, E., Burton, L., Eigenbrot, C., Yu, C., et al. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b00480 · Cited by 137 · see citing works
Self-citationDysfunction of phospholipase Cγ in immune disorders and cancer
Koss, H., Bunney, T. D., Behjati, S., & Katan, M. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.09.004 · Cited by 115 · see citing works
Bunney, T. D., Esposito, D., Mas-Droux, C., Lamber, E., Baxendale, R. W., Martins, M., Cole, A., Svergun, D., Driscoll, P. C., & Katan, M. (2012) · Structure · doi:10.1016/j.str.2012.09.005 · Cited by 88 · see citing works
García‐Sánz, R., Corchete, L. A., Alcoceba, M., Chillón, C., Jiménez, C., Prieto, I., García‐Álvarez, M., Puig, N., Rapado, I., Barrio, S., et al. (2016) · Hematological Oncology · doi:10.1002/hon.2337 · Cited by 28 · see citing works
Chan, K. L., Blombery, P. A., Jones, K. L., Lade, S., Carney, D. A., Tran, H., Seymour, J. F., & Tam, C. S. L. (2016) · British Journal of Haematology · doi:10.1111/bjh.14062 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Jones, J. A., Mato, A. R., Wierda, W. G., Davids, M. S., Choi, M., Cheson, B. D., Furman, R. R., Lamanna, N., Barr, P. M., Zhou, L., et al. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30909-9 · Cited by 383 · see citing works
Self-citationThe BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation
Reiff, S. D., Mantel, R., Smith, L. L., Greene, J. T., Muhowski, E. M., Fabian, C. A., Goettl, V. M., Tran, M., Harrington, B. K., Rogers, K. A., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1409 · Cited by 165 · see citing works
Self-citationThe role of PLCγ2 in immunological disorders, cancer, and neurodegeneration
Jackson, J. T., Mulazzani, E., Nutt, S. L., & Masters, S. L. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100905 · Cited by 113 · see citing works
“However, after Ibrutinib treatment, it was observed that CLL progression favored the selection of rare subclones bearing PLCγ2 mutations (129, 130).”
BackgroundInfluentialRogers, K. A., Thompson, P. A., Allan, J. N., Coleman, M., Sharman, J. P., Cheson, B. D., Jones, D., Izumi, R. E., Frigault, M. M., Quah, C. S., et al. (2021) · Haematologica · doi:10.3324/haematol.2020.272500 · Cited by 112 · see citing works
Self-citationKanagal‐Shamanna, R., Jain, P., Patel, K. P., Routbort, M., Bueso‐Ramos, C., Alhalouli, T., Khoury, J. D., Luthra, R., Ferrajoli, A., Keating, M., et al. (2019) · Cancer · doi:10.1002/cncr.31831 · Cited by 98 · see citing works
Ibrutinib Resistance Mechanisms and Treatment Strategies for B-Cell Lymphomas
George, B., Chowdhury, S. M., Hart, A., Sircar, A., Singh, S. K., Nath, U. K., Mamgain, M., Singhal, N. K., Sehgal, L., & Jain, N. K. (2020) · Cancers · doi:10.3390/cancers12051328 · Cited by 96 · see citing works
Shadman, M. S., Flinn, I. W., Levy, M. Y., Porter, R. F., Burke, J. M., Zafar, S. F., Misleh, J. G., Kingsley, E. C., Yimer, H. A., Freeman, B., et al. (2022) · The Lancet Haematology · doi:10.1016/s2352-3026(22)00320-9 · Cited by 95 · see citing works
Phospholipase C families: Common themes and versatility in physiology and pathology
Katan, M., & Cockcroft, S. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101065 · Cited by 89 · see citing works
Naeem, A., Utro, F., Wang, Q., Cha, J., Vihinen, M., Martindale, S., Zhou, Y., Ren, Y., Tyekucheva, S., Kim, A. S., et al. (2023) · Blood Advances · doi:10.1182/bloodadvances.2022008447 · Cited by 87 · see citing works
A pan-cancer-bioinformatic-based literature review of TRPM7 in cancers
Liu, H., Dilger, J. P., & Lin, J. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108302 · Cited by 87 · see citing works
Genetic and Non-Genetic Mechanisms of Resistance to BCR Signaling Inhibitors in B Cell Malignancies
Ondrišová, L., & Mráz, M. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.591577 · Cited by 76 · see citing works
Lampson, B. L., & Brown, J. R. (2018) · Expert Review of Hematology · doi:10.1080/17474086.2018.1435268 · Cited by 74 · see citing works
Baysac, K., Sun, G., Nakano, H., Schmitz, E. G., Cruz, A. C., Fisher, C., Bailey, A. C., Abbott, J. K., Aldave Becerra, J. C., Allenspach, E. J., et al. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.08.036 · Cited by 63 · see citing works
Resistance-Associated Mutations in Chronic Lymphocytic Leukemia Patients Treated With Novel Agents
Sedlaříková, L., Petráčková, A., Papajík, T., Turcsányi, P., & Kriegová, E. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00894 · Cited by 63 · see citing works
Overcoming Acquired Epigenetic Resistance to BTK Inhibitors
Shaffer, A. L., Phelan, J. D., Wang, J. Q., Huang, D., Wright, G. W., Kasbekar, M., Choi, J., Young, R. M., Webster, D. E., Yang, Y., et al. (2021) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-21-0063 · Cited by 62 · see citing works
Griggio, V., Vitale, C., Todaro, M., Riganti, C., Kopecka, J., Salvetti, C., Bomben, R., Bo, M. D., Magliulo, D., Rossi, D., et al. (2019) · Haematologica · doi:10.3324/haematol.2019.217430 · Cited by 57 · see citing works
Liu, Y., Kimpara, S., Hoang, N. M., Daenthanasanmak, A., Li, Y., Lü, L., Ngo, V. N., Bates, P. D., Song, L., Gao, X., et al. (2023) · Blood · doi:10.1182/blood.2023020142 · Cited by 56 · see citing works
Gángó, A., Alpár, D., Galik, B., Marosvári, D., Kiss, R., Fésüs, V., Aczél, D., Eyüpoglu, E., Nagy, N., Nagy, Á., et al. (2020) · International Journal of Cancer · doi:10.1002/ijc.32502 · Cited by 54 · see citing works
Woyach, J. A., Stephens, D. M., Flinn, I. W., Bhat, S. A., Savage, R. E., Chai, F., Eathiraj, S., Reiff, S. D., Muhowski, E. M., Granlund, L., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-0670 · Cited by 52 · see citing works
Self-citationWoyach, J. A., Jones, D., Jurczak, W. J., Robak, T., Illés, Á., Kater, A. P., Ghia, P., Byrd, J. C., Seymour, J. F., Long, S., et al. (2024) · Blood · doi:10.1182/blood.2023023659 · Cited by 52 · see citing works
Self-citationLiu, Y., Bunney, T. D., Khosa, S., Macé, K., Beckenbauer, K., Askwith, T., Maslen, S., Stubbs, C., de Oliveira, T. M., Sader, K., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2019.102607 · Cited by 42 · see citing works
Single-cell RNA-seq reveals the immune escape and drug resistance mechanisms of mantle cell lymphoma
Wang, L., Mo, S., Li, X., He, Y., & Yang, H. J. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2020.0073 · Cited by 41 · see citing works
The potential of pirtobrutinib in multiple B-cell malignancies
Jensen, J. L., Mato, A. R., Peña, C., Roeker, L. E., & Coombs, C. C. (2022) · Therapeutic Advances in Hematology · doi:10.1177/20406207221101697 · Cited by 39 · see citing works
Fürstenau, M., & Eichhorst, B. F. (2021) · Cancers · doi:10.3390/cancers13061336 · Cited by 37 · see citing works
Wist, M., Meier, L., Gutman, O., Haas, J., Endres, S., Zhou, Y., Rösler, R., Wiese, S., Stilgenbauer, S., Hobeika, E., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011946 · Cited by 34 · see citing works
Patel, V. M., Flanagan, C. E., Martins, M., Jones, C. L., Butler, R. M., Woollard, W. J., Bakr, F. S., Yoxall, A., Begum, N., Katan, M., et al. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.07.693 · Cited by 31 · see citing works
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Chirino, A., Montoya, S., Safronenka, A., & Taylor, J. (2023) · Genes · doi:10.3390/genes14122182 · Cited by 30 · see citing works
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Jing, H., Reed, A., Ulanovskaya, O. A., Grigoleit, J.-S., Herbst, D. M., Henry, C. L., Li, H., Barbas, S., Germain, J., Masuda, K., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2112971118 · Cited by 24 · see citing works
Li, W., Sano, R., Apatira, M., DeAnda, F., Gururaja, T. L., Yang, M., Lundgaard, G. L., Pan, C., Liu, J., Zhai, Y., et al. (2023) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-22-0642 · Cited by 22 · see citing works
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Kwok, M., & Wu, C. J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.790004 · Cited by 20 · see citing works
Li, K., Ran, B., Wang, Y., Liu, L., & Li, W. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.999061 · Cited by 18 · see citing works
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Mansouri, L., Þorvaldsdóttir, B., Laidou, S., Σταματόπουλος, Κ., & Rosenquist, R. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.10.007 · Cited by 17 · see citing works
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Wiśniewski, K., & Puła, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105246 · Cited by 17 · see citing works
Walliser, C., Wist, M., Hermkes, E., Zhou, Y., Schade, A., Haas, J., Deinzer, J., Désiré, L., Li, S. S. C., Stilgenbauer, S., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.26173 · Cited by 17 · see citing works
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Kittai, A. S., & Woyach, J. A. (2019) · The Cancer Journal · doi:10.1097/ppo.0000000000000406 · Cited by 17 · see citing works
Self-citationBravo-González, A., Alasfour, M., Soong, D., Noy, J., & Pongas, G. N. (2024) · Cancers · doi:10.3390/cancers16203434 · Cited by 14 · see citing works
Pramil, É., Herbi, L., Denèfle, T., Némati, F., Xiao, M., Lardé, E., Maloum, K., Roos‐Weil, D., Chapiro, É., Garff‐Tavernier, M. L., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019000350 · Cited by 13 · see citing works
Zhou, Y., Kang, J., & Lu, X. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00361 · Cited by 12 · see citing works
Thompson, M. C., & Mato, A. R. (2021) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2021.03.008 · Cited by 10 · see citing works
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Lew, T. E., Anderson, M. A., & Seymour, J. F. (2020) · Cancer Drug Resistance · doi:10.20517/cdr.2019.108 · Cited by 9 · see citing works
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Bunney, T. D., Kampyli, C., Gregory, A., & Katan, M. (2024) · Advances in Biological Regulation · doi:10.1016/j.jbior.2024.101053 · Cited by 8 · see citing works
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Sridhar, J., Subramanian, M., Kesavan, P. K., & Jayavel, S. (2025) · Journal of the Egyptian National Cancer Institute · doi:10.1186/s43046-025-00263-5 · Cited by 8 · see citing works
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Britto, L. S., Balasubramani, D., Desai, S., Phillips, P., Trehan, N., Cesarman, E., Koff, J. L., & Singh, A. K. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401192 · Cited by 8 · see citing works
Albi, E., Capasso, A., Schiattone, L., Ghia, P., & Scarfò, L. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.01.009 · Cited by 8 · see citing works
Lin, P., Zhong, X., Wang, X., Li, J., Zhao, R., He, Y., Jiang, Y., Xian-wen, H., Chen, G., He, Y., et al. (2018) · Oncology Reports · doi:10.3892/or.2018.6710 · Cited by 8 · see citing works
Shin, Y.-C., Plummer-Medeiros, A. M., Mungenast, A., Choi, H.-W., TenDyke, K., Zhu, X., Shepard, J., Sanders, K., Zhuang, N., Hu, L., et al. (2024) · Science Advances · doi:10.1126/sciadv.adn6037 · Cited by 7 · see citing works
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Ma, X., Xu, J., Wang, Y., Fleishman, J. S., Bing, H., Yu, B., Li, Y., Bo, L., Zhang, S., Chen, Z., et al. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101195 · Cited by 7 · see citing works
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Giudice, I. D., Starza, I. D., Falco, F. D., Gaïdano, G., & Sportoletti, P. (2024) · Cancers · doi:10.3390/cancers16112049 · Cited by 5 · see citing works
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Thangavadivel, S., & Woyach, J. A. (2021) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2021.03.004 · Cited by 3 · see citing works
Self-citationMu, J., Liu, M., Wang, J., Meng, J., Zhang, R., Jiang, Y., & Deng, Q. (2022) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/145948 · Cited by 3 · see citing works
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Scarfò, L., & Ghia, P. (2019) · Hematologic malignancies · doi:10.1007/978-3-030-11392-6_1 · Cited by 3 · see citing works
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Álvarez-Corrales, E., Moreno-Palomares, R., Gómez‐Escolar, C., Martínez‐Mingo, M., Moral-Pérez, U., Laguna-Herrero, M., Fuertes, T., Estrada, B. S., Mur, S. M., de Bonis, A., et al. (2026) · Leukemia · doi:10.1038/s41375-026-02948-9 · Cited by 2 · see citing works
Dimou, M., Karypidou, M., Bitsani, A., Belia, M., Kopsaftopoulou, A., Zerzi, K., Kiriakopoulos, A., Sachanas, S. P., Pessach, I., Kolotsiou, A., et al. (2025) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2025.2501269 · Cited by 2 · see citing works
Raghunathan, V. M., Fan, G., Kittai, A. S., Okada, C. Y., Danilov, A. V., & Spurgeon, S. E. F. (2020) · European Journal Of Haematology · doi:10.1111/ejh.13538 · Cited by 2 · see citing works
Rogers, K. A., Yan, P. S., Flinn, I. W., Stephens, D. M., Kipps, T. J., Larson, S. M., Martz, L., Chen, X., Wang, H., Hopping, E., et al. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-25-0210 · Cited by 1 · see citing works
Self-citationKhan, A., Sawali, M. A., Shkoor, M., Hasssan, F., Al-Zoubi, R. M., Alshabrmi, F. M., Crovella, S., & Agouni, A. (2026) · Current Research in Structural Biology · doi:10.1016/j.crstbi.2026.100186 · Cited by 1 · see citing works
Mauro, F. R., & Foà, R. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30910-5 · Cited by 1 · see citing works
Likold, E. B., Вениаминовна, Б. Б., Февралева, И. С., Severina, N. A., Dmitrieva, E. A., Petrenko, A. A., Nikitin, E. A., & Sudarikov, A. B. (2023) · Гематология и трансфузиология · doi:10.35754/0234-5730-2023-68-2-182-194 · Cited by 1 · see citing works
Mechanisms of resistance to targeted therapies in chronic lymphocytic leukemia
Sutton, L. (2019) · HemaSphere · doi:10.1097/hs9.0000000000000240 · Cited by 1 · see citing works
BTK Inhibitors: Focus on Ibrutinib and Similar Agents
Mattsson, M., & Scarfò, L. (2018) · Resistance to targeted anti-cancer therapeutics · doi:10.1007/978-3-319-75184-9_1
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Milošević, I. (2022) · Medicinski pregled · doi:10.2298/mpns22s1057m
Mougeot, J.-L., Beckman, M. F., Alexander, A. S., Hovan, A. J., Hasséus, B., Legert, K. G., Johansson, J., Bültzingslöwen, I. V., Brennan, M. T., & Mougeot, F. B. (2024) · Supportive Care in Cancer · doi:10.1007/s00520-024-08408-3
Phua, C. W. W., & Lam, S. (2024) · Canadian Hematology Today · doi:10.58931/cht.2024.3s01-244
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Chen, C., Artymiuk, C. J., Schwab, T. L., Feldman, A. L., Jevremović, D., McPhail, E. D., Rech, K. L., Viswanatha, D. S., Hampel, P. J., Wang, Y., et al. (2025) · Human Pathology · doi:10.1016/j.humpath.2026.106123
Liao, P., Ko, B., Su, Y., Chao, W., & Teng, C. J. (2026) · Cancer Medicine · doi:10.1002/cam4.72022
- Authors
- Jones, D., Woyach, J. A., Zhao, W., Caruthers, S., Tu, H., Coleman, J., Byrd, J. C., Johnson, A. J., & Lozanski, G.
- Affiliations
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Corresponding author
- Jones, D
- Venue
- Leukemia
- Published
- 2017-04-03
- Volume
- 31
- Issue
- 7
- Pages
- 1645-1647
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- OpenAlex
- W2604485134
- Cited by
- 71
- References
- 15
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 11 · 2023: 7 · 2022: 8 · 2021: 10 · 2020: 10 · 2019: 8 · 2018: 7 · 2017: 2
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Leukemia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Keywords
- ibrutinib resistance, chronic lymphocytic leukemia, BTK mutations, Bruton's tyrosine kinase, PLCγ2, B cell receptor signaling, clonal evolution, Richter transformation, BTK inhibitors
- MeSH terms
- C2 Domains, Agammaglobulinaemia Tyrosine Kinase, Adenine, Humans, Mutation, Piperidines, Protein-Tyrosine Kinases, Pyrazoles, Pyrimidines, Leukemia, Lymphocytic, Chronic, B-Cell, Drug Resistance, Neoplasm, Protein Kinase Inhibitors, Phospholipase C gamma
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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