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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

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Autoimmunity and Inflammation Due to a Gain-of-Function Mutation in Phospholipase Cγ2 that Specifically Increases External Ca2+ Entry

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Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

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The macromolecular crystallography beamline of SSRF

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Four Tyrosine Residues in Phospholipase C-γ2, Identified as Btk-dependent Phosphorylation Sites, Are Required for B Cell Antigen Receptor-coupled Calcium Signaling

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Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b

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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

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The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration

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ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans

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Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations

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Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

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The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions

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Novel PLCG2 Mutation in a Patient With APLAID and Cutis Laxa

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Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer’s disease

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PLCG2 C2 domain mutations co-occur with BTK and PLCG2 resistance mutations in chronic lymphocytic leukemia undergoing ibrutinib treatment

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Centenarian controls increase variant effect sizes by an average twofold in an extreme case–extreme control analysis of Alzheimer’s disease

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Resistance-Associated Mutations in Chronic Lymphocytic Leukemia Patients Treated With Novel Agents

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PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment

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Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ

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Severe Autoinflammatory Manifestations and Antibody Deficiency Due to Novel Hypermorphic PLCG2 Mutations

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Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer’s disease

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A novel <i>N</i>‐ethyl‐<i>N</i>‐nitrosourea–induced mutation in <i>phospholipase Cγ2</i> causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model

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A Germline Mutation in the C2 Domain of PLCγ2 Associated with Gain-of-Function Expands the Phenotype for PLCG2-Related Diseases

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Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes

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PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease‐protective variant PLCγ2 R522

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Phospholipase Cγ2 regulates endocannabinoid and eicosanoid networks in innate immune cells

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Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice

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Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

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PLCγ2 impacts microglia-related effectors revealing variants and pathways important in Alzheimer’s disease

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A High-Throughput Assay to Identify Allosteric Inhibitors of the PLC-γ Isozymes Operating at Membranes

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Fluorogenic XY-69 in Lipid Vesicles for Measuring Activity of Phospholipase C Isozymes

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Untitled work

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Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

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Characterisation of molecular mechanisms for PLCγ2 disease-linked variants

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Bruton protein-tyrosine kinase (BTK) FDA-approved small molecule inhibitors used for the management of neoplastic and inflammatory disorders

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Phosphoinositide-specific phospholipase C enzymes: Recent advances in a long journey

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A high-throughput assay platform to discover small molecule activators of the phospholipase PLC-γ2 to treat Alzheimer's disease

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gapTrick—structural characterization of protein–protein interactions using AlphaFold

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PLCG2 signaling and genetic resilience in Alzheimer’s disease

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Single-Cell RNA Sequencing Reveals Immune Dysregulation and Candidate Drug Targets in Endometriosis

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Genetic and non-genetic drivers of immune dysregulation: Beyond autoinflammation and autoimmunity

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Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation

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Structural and Functional Integration of the PLC gamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation

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Solution structure properties and (dys)function of phospholipase Cγ

Koss, H. (2016) · UCL Discovery (University College London)

Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-γ Isozymes

Hajicek, N., Charpentier, T. H., Rush, J. R., Harden, T. K., & Sondek, J. (2013) · Biochemistry · doi:10.1021/bi400433b · Cited by 41 · see citing works

A kinetic model of phospholipase C-γ1 linking structure-based insights to dynamics of enzyme autoinhibition and activation

Nosbisch, J. L., Bear, J. E., & Haugh, J. M. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101886 · Cited by 7 · see citing works