The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Oral tolerance to food protein
Open accessAbstract
Oral tolerance is the state of local and systemic immune unresponsiveness that is induced by oral administration of innocuous antigen such as food proteins. An analogous but more local process also regulates responses to commensal bacteria in the large intestine and, together, mucosally induced tolerance appears to prevent intestinal disorders such as food allergy, celiac disease, and inflammatory bowel diseases. Here we discuss the anatomical basis of antigen uptake and recognition in oral tolerance and highlight possible mechanisms underlying the immunosuppression. We propose a model of stepwise induction of oral tolerance in which specialized populations of mucosal dendritic cells and the unique microenvironment of draining mesenteric lymph nodes combine to generate regulatory T cells that undergo subsequent expansion in the small intestinal lamina propria. The local and systemic effects of these regulatory T cells prevent potentially dangerous hypersensitivity reactions to harmless antigens derived from the intestine and hence are crucial players in immune homeostasis.
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Citations
Cites
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The vagal innervation of the gut and immune homeostasis
Matteoli, G., & Boeckxstaens, G. E. (2013) · Gut · doi:10.1136/gutjnl-2012-302550 · Cited by 276
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“described more than a hundred years ago as the ability of an orally administered antigen to inhibit subsequent priming of immune responses against that antigen (Pabst and Mowat, 2012).”
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The dark side of Tregs during aging
Palatella, M., Guillaume, S. M., Linterman, M. A., & Huehn, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.940705 · Cited by 58
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Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections
Lin, Z., Zheng, Y., Zhong, Y., & Wang, H. (2026) · Advanced Science · doi:10.1002/advs.202510758 · Cited by 13
Finamore, A., Peluso, I., & Serafini, M. (2016) · Probiotics, Prebiotics, and Synbiotics · doi:10.1016/b978-0-12-802189-7.00041-1 · Cited by 4
Metadata
- Authors
- Pabst, O., & Mowat, A. M.
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 5
- Issue
- 3
- Pages
- 232-239
- ISSN
- 1933-0219 (ISSN-L)
- OpenAlex
- W1991151214
- Cited by
- 656
- References
- 4
- FWCI
- 19.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
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