Nutritional Keys for Intestinal Barrier Modulation
Open accessAbstract
The intestinal tract represents the largest interface between the external environment and the human body. Nutrient uptake mostly happens in the intestinal tract, where the epithelial surface is constantly exposed to dietary antigens. Since inflammatory response toward these antigens may be deleterious for the host, a plethora of protective mechanisms take place to avoid or attenuate local damage. For instance, the intestinal barrier is able to elicit a dynamic response that either promotes or impairs luminal antigens adhesion and crossing. Regulation of intestinal barrier is crucial to control intestinal permeability whose increase is associated with chronic inflammatory conditions. The cross talk among bacteria, immune, and dietary factors is able to modulate the mucosal barrier function, as well as the intestinal permeability. Several nutritional products have recently been proposed as regulators of the epithelial barrier, even if their effects are in part contradictory. At the same time, the metabolic function of the microbiota generates new products with different effects based on the dietary content. Besides conventional treatments, novel therapies based on complementary nutrients are now growing. Fecal therapy has been recently used for the clinical treatment of refractory Clostridium difficile infection instead of the classical antibiotic therapy. In the present review, we will outline the epithelial response to nutritional components derived from dietary intake and microbial fermentation focusing on the consequent effects on the integrity of the epithelial barrier.
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Malnutrition increases intestinal permeability and facilitates bacterial translocation.
“Of note, malnutrition increases intestinal permeability and facilitates bacterial translocation159.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [159]
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- Authors
- De Santis, S., Cavalcanti, E., Mastronardi, M., Jirillo, E., & Chieppa, M.
- Affiliations
- Gastroenterology Hospital "Saverio de Bellis" (IT)
- University of Bari Aldo Moro (IT)
- Corresponding author
- Chieppa, Marcello
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2015-12-07
- Volume
- 6
- Pages
- 612-612
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC4670985
- OpenAlex
- W2195104529
- Cited by
- 232
- References
- 182
- Citations by year
- 2026: 16 · 2025: 19 · 2024: 15 · 2023: 31 · 2022: 28 · 2021: 26 · 2020: 33 · 2019: 24 · 2018: 19 · 2017: 17 · 2016: 4
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- AIRUS (submittedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, other-oa)
- Funders
- Ministero della Salute (GR-2011-02347991)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- intestinal barrier, intestinal permeability, epithelial barrier integrity, dietary nutrients, gut microbiota, microbial fermentation, mucosal immunity, dietary antigens, Clostridium difficile infection, fecal microbiota transplantation, chronic inflammation, epithelial response
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