The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression
Open accessAbstract
Cytokine-induced activation of indoleamine 2,3-dioxygenase (IDO) catabolizes L-tryptophan (TRP) into L-kynurenine (KYN), which is metabolized to quinolinic acid (QUIN) and kynurenic acid (KA). QUIN and KA are neuroactive and may contribute to the behavioral changes experienced by some patients during exposure to inflammatory stimuli such as interferon (IFN)-alpha. A relationship between depressive symptoms and peripheral blood TRP, KYN and KA during treatment with IFN-alpha has been described. However, whether peripheral blood changes in these IDO catabolites are manifest in the brain and whether they are related to central nervous system cytokine responses and/or behavior is unknown. Accordingly, TRP, KYN, QUIN and KA were measured in cerebrospinal fluid (CSF) and blood along with CSF concentrations of relevant cytokines, chemokines and soluble cytokine receptors in 27 patients with hepatitis C after approximately 12 weeks of either treatment with IFN-alpha (n=16) or no treatment (n=11). Depressive symptoms were assessed using the Montgomery-Asberg Depression Rating Scale. IFN-alpha significantly increased peripheral blood KYN, which was accompanied by marked increases in CSF KYN. Increased CSF KYN was in turn associated with significant increases in CSF QUIN and KA. Despite significant decreases in peripheral blood TRP, IFN-alpha had no effect on CSF TRP concentrations. Increases in CSF KYN and QUIN were correlated with increased CSF IFN-alpha, soluble tumor necrosis factor-alpha receptor 2 and monocyte chemoattractant protein-1 as well as increased depressive symptoms. In conclusion, peripheral administration of IFN-alpha activated IDO in concert with central cytokine responses, resulting in increased brain KYN and QUIN, which correlated with depressive symptoms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“cytokines have been found to reduce levels of serotonin and possibly other related neurotransmitters by decreasing the availability of its serotonin precursor, an essential amino acid called tryptophan”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Raison et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“which may be attributed to the rapid metabolism of KYN once it is produced [47].”
From VEEV TC-83 Triggers Dysregulation of the Tryptophan–Kynurenine Pathway in the Central Nervous System That Correlates with Cognitive Impairment in Tg2576 Mice (2024) · cites this paper as [47]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Activation of the enzyme indoleamine 2,3-dioxygenase (IDO) is also believed to be involved in cytokine-induced neurotransmitter alterations, in part by diverting the metabolism of tryptophan (the primary amino acid precursor of serotonin) into kynurenine, a compound that can be converted into the neurotoxic metabolite quinolinic acid by activated microglia and infiltrating monocytes and macrophage”
From The role of inflammation in depression: from evolutionary imperative to modern treatment target (2016) · cites this paper as [76]
In the citing paper
“other studies have suggested that increased kynurenine levels without a decrease in tryptophan levels could also lead to depressive-like behavior in both animal models and human subjects (Raison et al., 2010).”
From A Review of the Relationship between Proinflammatory Cytokines and Major Depressive Disorder (2014) · cites this paper as Raison et al., 2010
In the citing paper
“current results are promising and show altered levels of proinflammatory biomarkers in CSF samples of depressed patients relative to healthy controls (Raison et al., 2010).”
From A Review of the Relationship between Proinflammatory Cytokines and Major Depressive Disorder (2014) · cites this paper as Raison et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Statistical Power Analysis for the Behavioral Sciences (2nd ed.).
Lachenbruch, P. A., & Cohen, J. (1989) · Journal of the American Statistical Association · doi:10.2307/2290095 · Cited by 37,421
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Self-citationInflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848
Self-citationThe Mini-Mental State Examination
Folstein, M. F. (1983) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790060110016 · Cited by 2,016
Cytokine-Associated Emotional and Cognitive Disturbances in Humans
Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365
O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278
Self-citationTyring, S., Gottlieb, A., Papp, K., Gordon, K., Leonardi, C., Wang, A., Lalla, D., Woolley, M., Jahreis, A., Zitnik, R., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(05)67763-x · Cited by 1,069
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–400 of 629
Lu, D., Leung, Y., & Su, K. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000338 · Cited by 43
Desipramine decreases expression of human and murine indoleamine-2,3-dioxygenases
Brooks, A. K., Janda, T. M., Lawson, M. A., Rytych, J. L., Smith, R. A. J., Ocampo-Solis, C., & McCusker, R. H. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.02.010 · Cited by 42
Self-citationToxoplasma gondii, Suicidal Behavior, and Intermediate Phenotypes for Suicidal Behavior
Postolache, T. T., Wadhawan, A., Rujescu, D., Hoisington, A. J., Dagdag, A., Baca‐García, E., Lowry, C. A., Okusaga, O. O., & Brenner, L. A. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.665682 · Cited by 47
Discovering the Potential Mechanisms of Medicinal Mushrooms Antidepressant Activity: A Review
Lazur, J., Hnatyk, K., Kała, K., Sułkowska‐Ziaja, K., & Muszyńska, B. (2023) · Antioxidants · doi:10.3390/antiox12030623 · Cited by 44
Ramos-Chávez, L. A., Roldán-Roldán, G., García-Juárez, B., González‐Esquivel, D. F., de la Cruz, G. P., Pineda, B., Ortega, D. R., Muñoz, I. G., Herrera, B. J., Rı́os, C., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8604718 · Cited by 45
Porterfield, V. M., Gabella, K. M., Simmons, M. A., & Johnson, J. D. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.08.001 · Cited by 42
Krause, D., Riedel, M. J., Müller, N., Weidinger, E., Schwarz, M., & Myint, A.-M. (2012) · Inflammopharmacology · doi:10.1007/s10787-011-0112-6 · Cited by 42
Current Neurological Observations and Complications of Dengue Virus Infection
Solbrig, M. V., & Perng, G. (2015) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-015-0550-4 · Cited by 42
The Role of Inflammation in the Pathophysiology of Depression and Suicidal Behavior
Serafini, G., Costanza, A., Aguglia, A., Amerio, A., Trabucco, A., Escelsior, A., Sher, L., & Amore, M. (2022) · Medical Clinics of North America · doi:10.1016/j.mcna.2022.09.001 · Cited by 48
Zhu, X., Hu, J., Deng, S., Tan, Y., Qiu, C., Zhang, M., Ni, X., Lu, H., Wang, Z., Li, L., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.687757 · Cited by 40
Xiao, W., Li, J., Gao, X., Yang, H., Su, J., Weng, R., Gao, Y., Ni, W., & Gu, Y. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114225 · Cited by 41
Hage, Z., Madeira, M. M., Koliatsis, D., & Tsirka, S. E. (2024) · BMC Immunology · doi:10.1186/s12865-024-00653-9 · Cited by 45
Can we vaccinate against depression?
Rook, G. A. W., Raison, C. L., & Lowry, C. A. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.03.018 · Cited by 39
Self-citationBremner, J. D., Gurel, N. Z., Jiao, Y., Wittbrodt, M. T., Levantsevych, O. M., Huang, M., Jung, H., Shandhi, M. H., Beckwith, J., Herring, I., et al. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100138 · Cited by 44
Vichaya, E. G., Laumet, G. O., Christian, D. L., Grossberg, A. J., Estrada, D. J., Heijnen, C. J., Kavelaars, A., & Dantzer, R. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0075-z · Cited by 42
Self-citationBiney, R. P., Benneh, C. K., Ameyaw, E. O., Boakye‐Gyasi, E., & Woode, E. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.02.023 · Cited by 39
Tryptophan Catabolites in Bipolar Disorder: A Meta-Analysis
Hebbrecht, K., Skorobogatov, K., Giltay, E. J., Coppens, V., Picker, L. D., & Morrens, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.667179 · Cited by 39
Duffy, A. C., Horrocks, J., Doucette, S., Keown‐Stoneman, C. D. G., Grof, P., Andreazza, A. C., & Young, L. T. (2014) · International Journal of Bipolar Disorders · doi:10.1186/2194-7511-2-4 · Cited by 38
Neuroimmune crosstalk and evolving pharmacotherapies in neurodegenerative diseases
Baidya, F., Bohra, M., Datta, A., Sarmah, D., Shah, B., Jagtap, P., Raut, S., Sarkar, A., Singh, U., Kalia, K., et al. (2020) · Immunology · doi:10.1111/imm.13264 · Cited by 39
Chronic mild restraint stress rats decreased CMKLR1 expression in distinct brain region
Guo, X., Fu, Y., Xu, Y., Weng, S.-M., Liu, D., Cui, D., Yu, S., Liu, X., Jiang, K., & Dong, Y. W. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.06.075 · Cited by 37
Improvements in brain and behavior following eradication of hepatitis C
Kuhn, T. P., Sayegh, P., Jones, J. D., Smith, J., Sarma, M. K., Ragin, A. B., Singer, E. J., Thomas, M. A., Thames, A. D., Castellon, S. A., et al. (2017) · Journal of NeuroVirology · doi:10.1007/s13365-017-0533-0 · Cited by 37
Barreto, F. S., Filho, A. J. M. C., Araújo, M. C., de Moraes, M. O., de Moraes, M. E. A., Maes, M. H. J., de Lucena, D. F., & Macêdo, D. S. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000384 · Cited by 37
Morgese, M. G., Schiavone, S., Maffione, A. B., Tucci, P., & Trabace, L. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.01.015 · Cited by 38
Prospective study of the effects of sport-related concussion on serum kynurenine pathway metabolites
Meier, T. B., Nitta, M. E., Teague, T. K., Nelson, L. D., McCrea, M., & Savitz, J. B. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.03.002 · Cited by 37
Indoleamine 2,3-Dioxygenase Activation and Depressive Symptoms
Elovainio, M. J., Hurme, M., Jokela, M. M., Pulkki-Råbäck, L., Mika Kivimaki, B., Hintsanen, M., Hintsa, T., Lehtimäki, T. J., Viikari, J. S. A., Raitakari, O. T., et al. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318266d0f5 · Cited by 40
Korte-Bouws, G. A. H., Albers, E., Voskamp, M. J., Hendriksen, H., de Leeuw, L. R., Güntürkün, O., de Roock, S., Vastert, S. J., & Korte, S. M. (2019) · Pharmaceuticals · doi:10.3390/ph12010009 · Cited by 37
Cytomegalovirus Antibody Elevation in Bipolar Disorder: Relation to Elevated Mood States
Prossin, A. R., Yolken, R. H., Kamali, M., Heitzeg, M. M., Kaplow, J. B., Coryell, W. H., & McInnis, M. G. (2015) · Neural Plasticity · doi:10.1155/2015/939780 · Cited by 36
Neurobiological mechanisms in the kynurenine pathway and major depressive disorder
Bertollo, A. G., Mingoti, M. E. D., & Ignácio, Z. M. (2024) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0065 · Cited by 37
Risk factors for the development of depression in patients with hepatitis C taking interferon-α
Smith, K. J. (2011) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s13917 · Cited by 35
Su, K. (2015) · Biomedicine · doi:10.7603/s40681-015-0021-x · Cited by 38
Blood-based kynurenine pathway alterations in schizophrenia spectrum disorders: A meta-analysis
Morrens, M., Picker, L. D., Kampen, J. K., & Coppens, V. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.09.007 · Cited by 35
Scotton, E., Antqueviezc, B., Vasconcelos, M., Dalpiaz, G., Géa, L. P., Goularte, J. F., Colombo, R., & Rosa, A. R. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114963 · Cited by 37
Hüfner, K., Oberguggenberger, A., Kohl, C. A., Geisler, S. B., Gamper, E., Meraner, V., Egeter, J., Hubalek, M., Beer, B., Fuchs, D., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.06.001 · Cited by 34
Circulating cytokine signatures in healthy medical students exposed to academic examination stress
Kamezaki, Y., Katsuura, S., Kuwano, Y., Tanahashi, T., & Rokutan, K. (2012) · Psychophysiology · doi:10.1111/j.1469-8986.2012.01371.x · Cited by 39
Eggertsen, P. P., Hansen, J., Andersen, M. L., Nielsen, J. F., Olsen, R. K. J., & Palmfeldt, J. (2023) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2023.115304 · Cited by 34
Bakker, L., Köhler, S., Eussen, S. J. P. M., Choe, K., van den Hove, D. L. A., Kenis, G., Rutten, B. P. F., Ulvik, A., Ueland, P. M., Verhey, F. R. J., et al. (2023) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2023.04.015 · Cited by 37
Eskelund, A., Budac, D. P., Sánchez, C., Elfving, B., & Wegener, G. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.024 · Cited by 35
Tashiro, T., Murakami, Y., Mouri, A., Imamura, Y., Nabeshima, T., Yamamoto, Y., & Saito, K. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.09.050 · Cited by 37
Self-citationBarone, P. R. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000477 · Cited by 37
Obara‐Michlewska, M. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105363 · Cited by 33
SCI and depression: Does inflammation commandeer the brain?
Brakel, K., & Hook, M. A. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.112977 · Cited by 35
Kynurenic acid and 3-hydroxykynurenine production from d-kynurenine in mice
Wang, X., Notarangelo, F. M., Wang, J.-Z., & Schwarcz, R. M. (2012) · Brain Research · doi:10.1016/j.brainres.2012.03.026 · Cited by 33
Association between increased tryptophan degradation and depression in cancer patients
Kurz, K., Schroecksnadel, S., Weiss, G., & Fuchs, D. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328340d849 · Cited by 33
Mental Health Disorders Associated with Foodborne Pathogens
Bolton, D., & Robertson, L. J. (2016) · Journal of Food Protection · doi:10.4315/0362-028x.jfp-15-587 · Cited by 36
Microelectrode Biosensors for in vivo Analysis of Brain Interstitial Fluid
Chatard, C., Meiller, A., & Marinesco, S. (2018) · Electroanalysis · doi:10.1002/elan.201700836 · Cited by 34
Alam, M. M., Zameer, S., Najmi, A. K., Ahmad, F. J., Imam, S. S., & Akhtar, M. (2020) · Drug Research · doi:10.1055/a-1131-7793 · Cited by 32
Pawłowski, T., Pawlak, D., Inglot, M., Zalewska, M., Marciniak, D., Bugajska, J., Janocha-Litwin, J., & Małyszczak, K. (2020) · Journal of Psychiatry & Neuroscience · doi:10.1503/jpn.190139 · Cited by 31
Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk
Somoza-Moncada, M. M., Turrubiates‐Hernández, F. J., Muñóz-Valle, J. F., Gutiérrez-Brito, J. A., Díaz-Pérez, S. A., Arelis, A. A., & Hernández‐Bello, J. (2023) · Nutrients · doi:10.3390/nu15071765 · Cited by 37
Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids
Lotrich, F. E., Sears, B., & McNamara, R. K. (2013) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2013.07.012 · Cited by 32
Quist‐Paulsen, E., Aukrust, P., Kran, A. B., Dunlop, O., Ormaasen, V., Stiksrud, B., Midttun, Ø., Ueland, T., Ueland, P. M., Mollnes, T. E., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1366-3 · Cited by 31
Duda, W., Curzytek, K., Kubera, M., Connor, T. J., Fagan, E. M., Basta‐Kaim, A., Trojan, E., Papp, M., Gruca, P., Budziszewska, B., et al. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.05.039 · Cited by 32
Kynurenine and depressive symptoms in a poststroke population
Lanctôt, K. L., Bensimon, K., Herrmann, N., Swardfager, W., Black, S. E., Gao, F., Snaiderman, A., & Yi, H. (2014) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s65740 · Cited by 31
Doney, E., Dion‐Albert, L., Coulombe-Rozon, F., Osborne, N., Bernatchez, R., Paton, S. E. J., Kaufmann, F. N., Agomma, R. O., Solano, J. L., Gaumond, R., et al. (2023) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2023.04.007 · Cited by 32
Kang, Y., Shin, D., Kim, A., You, S., Kim, B., Han, K., & Ham, B. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.12.071 · Cited by 30
Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice
Wang, H., Zhou, J., Liu, Q. Z., Wang, L. L., & Shang, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-02576-5 · Cited by 30
Neuroimmune Mechanisms and Sex/Gender-Dependent Effects in the Pathophysiology of Mental Disorders
Kokkosis, A. G., & Tsirka, S. E. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.266163 · Cited by 29
Positive association between serum quinolinic acid and functional connectivity following concussion
Meier, T. B., España, L. Y., Nitta, M. E., Teague, T. K., Brett, B. L., Nelson, L. D., McCrea, M., & Savitz, J. B. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.11.011 · Cited by 29
From “Leaky Gut” to Impaired Glia-Neuron Communication in Depression
Rudzki, L., & Maes, M. H. J. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-33-6044-0_9 · Cited by 31
Chen, X., Beltran, D. J., Tsygankova, V., Woolwine, B. J., Patel, T., Baer, W. M., Felger, J. C., Miller, A. H., & Haroon, E. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01587-1 · Cited by 31
Self-citationCoccaro, E. F., Lee, R., Fanning, J. R., Fuchs, D., Goiny, M., Erhardt, S., Christensen, K. R., Brundin, L., & Coussons‐Read, M. E. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.04.024 · Cited by 29
Recent advances in psychoneuroimmunology: Inflammation in psychiatric disorders
Debnath, M., Doyle, K., Langan, C., McDonald, C., Leonard, B., & Cannon, D. (2011) · Translational Neuroscience · doi:10.2478/s13380-011-0019-0 · Cited by 28
Somatic Drugs for Psychiatric Diseases: Aspirin or Simvastatin for Depression?
Rahola, J. G. (2012) · Current Neuropharmacology · doi:10.2174/157015912800604533 · Cited by 28
Neuropathology of Kynurenine Pathway of Tryptophan Metabolism
Tutakhail, A., Boulet, L., Khabil, S., Nazari, Q. A., Hamid, H., & Coudoré, F. (2020) · Current Pharmacology Reports · doi:10.1007/s40495-019-00208-2 · Cited by 28
Zhou, Y., Wu, F., Wang, C., Zheng, W., Lan, X., Deng, X., & Ning, Y. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.06.068 · Cited by 28
Cellular Localization of Kynurenine 3-Monooxygenase in the Brain: Challenging the Dogma
Sathyasaikumar, K. V., de la Cruz, V. P., Pineda, B., Cervantes, G. I. V., Ortega, D. R., Donley, D. W., Severson, P. L., West, B. L., Giorgini, F., Fox, J. H., et al. (2022) · Antioxidants · doi:10.3390/antiox11020315 · Cited by 30
Soichot, M., Hennart, B., Saabi, A. A., Leloire, A., Froguel, P., Lévy‐Marchal, C., Poulain‐Godefroy, O., & Allorge, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025470 · Cited by 28
Luo, G.-Q., Liu, L., Gao, Q., Wu, X., Xiang, W., & Deng, W. (2017) · Neurological Research · doi:10.1080/01616412.2017.1310705 · Cited by 31
Souza, L. C., Jessé, C. R., de Gomes, M. G., Fabbro, L. D., Goes, A. T. R., Donato, F., & Boeira, S. P. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2329-2 · Cited by 28
Astrocytes as Pharmacological Targets in the Treatment of Schizophrenia
Pocivavsek, A., Notarangelo, F. M., Wu, H., Bruno, J. P., & Schwarcz, R. M. (2015) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-800981-9.00025-0 · Cited by 30
Hazrati, E., Eftekhar, S. P., Mosaed, R., Dini, S. S., & Namazi, M. (2024) · Molecular Pain · doi:10.1177/17448069241275097 · Cited by 34
Meinitzer, A., Tomaschitz, A., Pilz, S., Truber, M., Zechner, G., Gaksch, M., Prietl, B., Treiber, G. M., Schwarz, M., & Baranyi, A. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.06.010 · Cited by 27
Dawood, S., Bano, S., & Badawy, A. A. ‐. (2022) · Bioscience Reports · doi:10.1042/bsr20220426 · Cited by 27
Kofler, M., Schiefecker, A. J., Gaasch, M., Sperner‐Unterweger, B., Fuchs, D., Beer, R., Ferger, B., Rass, V., Hackl, W. O., Rhomberg, P., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-39569-5 · Cited by 28
Heterogeneity in major depressive disorder: The need for biomarker-based personalized treatments
Suseelan, S., & Pinna, G. (2022) · Advances in clinical chemistry · doi:10.1016/bs.acc.2022.09.001 · Cited by 28
Taylor, M. J., Godlewska, B. R., Near, J., Christmas, D. M., Potokar, J. P., Collier, J. D., Klenerman, P., Barnes, E. J., & Cowen, P. J. (2013) · Psychological Medicine · doi:10.1017/s0033291713001062 · Cited by 26
Kellner, E. S., Lee, P. Y., Li, Y., Switanek, J., Zhuang, H., Segal, M. S., Sobel, E. S., Satoh, M., & Reeves, W. H. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.03.018 · Cited by 26
A pro-convulsive carbamazepine metabolite: Quinolinic acid in drug resistant epileptic human brain
Ghosh, C., Marchi, N., Hossain, M. K., Rasmussen, P. A., Alexopoulos, A. V., Gonzalez-Martinez, J. A., Yang, H., & Janigro, D. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.010 · Cited by 26
Kynurenines, Neuropsychiatric Symptoms, and Cognitive Prognosis in Patients with Mild Dementia
Solvang, S.-E. H., Nordrehaug, J. E., Aarsland, D., Lange, J., Ueland, P. M., McCann, A., Midttun, Ø., Tell, G. S., & Giil, L. M. (2019) · International Journal of Tryptophan Research · doi:10.1177/1178646919877883 · Cited by 25
Dantas, R. L., Freff, J., Ambrée, O., Beins, E. C., Forstner, A. J., Dannlowski, U., Baune, B. T., Scheu, S., & Alferink, J. (2021) · Cells · doi:10.3390/cells10040941 · Cited by 29
Rengasamy, M. L., Marsland, A. L., Spada, M. L., Hsiung, K. S., Kovats, T., & Price, R. B. (2021) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2021.100177 · Cited by 29
Khan, H., Nazir, S., Farooq, R. K., Khan, I. N., & Javed, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.806713 · Cited by 29
Pathophysiology of Depression: Stingless Bee Honey Promising as an Antidepressant
Zakaria, F. H., Ismail, S., Mustafa, M. Z., & Shafin, N. (2022) · Molecules · doi:10.3390/molecules27165091 · Cited by 28
VanderZwaag, J., Halvorson, T., Dolhan, K., Šimončičová, E., Ben‐Azu, B., & Tremblay, M. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03772-0 · Cited by 28
Atlas, A., Franzen-Röhl, E., Söderlund, J., Jönsson, E. G., Samuelsson, M., Schwieler, L., Sköldenberg, B., & Engberg, G. (2013) · International Journal of Tryptophan Research · doi:10.4137/ijtr.s13256 · Cited by 25
Souza, L. C., Jessé, C. R., de Gomes, M. G., Viana, C. E., Mattos, E., Silva, N. C., & Boeira, S. P. (2017) · Neurotoxicity Research · doi:10.1007/s12640-016-9691-8 · Cited by 27
Veit, C., Janczak, A. M., Ranheim, B., Vas, J., Valros, A., Sandercock, D. A., Piepponen, P. T., Dulgheriu, D., & Nordgreen, J. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.617634 · Cited by 28
Astroglial Mechanisms of Ketamine Action Include Reduced Mobility of Kir4.1-Carrying Vesicles
Stenovec, M., Božić, M., Pirnat, S., & Zorec, R. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02744-1 · Cited by 25
Zhu, X., Tao, Q., Sun‐Waterhouse, D., Li, W., Liu, S., & Cui, C. (2019) · Food & Function · doi:10.1039/c9fo01467e · Cited by 24
Zhu, X., Sun‐Waterhouse, D., Tao, Q., Li, W., Shu, D., & Cui, C. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103859 · Cited by 27
The Metabolomic Underpinnings of Symptom Burden in Patients With Multiple Chronic Conditions
Corwin, E. J., Brewster, G. S., Dunbar, S. B., Wells, J., Hertzberg, V., Holstad, M. M., Song, M., & Jones, D. P. (2020) · Biological Research For Nursing · doi:10.1177/1099800420958196 · Cited by 25
Brain derived neurotrophic factor deficiency exacerbates inflammation-induced anhedonia in mice
Parrott, J. M., Porter, G. A., Redus, L., & O’Connor, J. C. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105404 · Cited by 28
Anderson, E., Jin, Y., Shih, A., Arazi, A., Goodwin, S., Roeser, J., Furie, R. A., Aranow, C. B., Volpe, B. T., Diamond, B., et al. (2022) · Lupus Science & Medicine · doi:10.1136/lupus-2022-000808 · Cited by 24
Goodkin, K., Evering, T. H., Anderson, A. M. L., Ragin, A. B., Monaco, C. L., Gavegnano, C., Avery, R. J., Rourke, S. B., Cysique, L. A., & Brew, B. J. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1130938 · Cited by 26
Neupane, S. P., Lien, L., Martínez, P., Hestad, K. A., & Bramness, J. G. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12651 · Cited by 25
Zhou, Y., Liu, W., Zheng, W., Wang, C., Zhan, Y., Lan, X., Zhang, B., Zhang, C., & Ning, Y. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.001 · Cited by 23
The neurodegenerative hypothesis of depression and the influence of antidepressant medications
Hall, S., Parr, B.-A., Hussey, S., Anoopkumar‐Dukie, S., Arora, D. S., & Grant, G. D. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176967 · Cited by 26
Li, P., Zheng, J., Bai, Y., Wang, D., Cui, Z., Li, Y., Zhang, J., & Wang, Y. (2020) · European Journal of Histochemistry · doi:10.4081/ejh.2020.3132 · Cited by 23
Arteaga-Henríquez, G., Burger, B., Weidinger, E., Grosse, L., Moll, N., Schütze, G. A., Schwarz, M., Wijkhuijs, A. J. M., de Beeck, G. O., Berghmans, R., et al. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110226 · Cited by 23
Graves’ disease as a driver of depression: a mechanistic insight
Song, Y., Wang, X., Ma, W., Yang, Y., Yan, S., Sun, J., Zhu, X., & Tang, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1162445 · Cited by 26
Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders
Kondo, T., Okada, Y., Saika, S., Yamaguchi, N., Hatakeyama, S., & Maruyama, K. (2024) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2024.151418 · Cited by 24
Metadata
- Authors
- Raison, C. L., Dantzer, R., Kelley, K. W., Lawson, M. A., Woolwine, B. J., Vogt, G., Spivey, J. R., Saito, K., & Miller, A. H.
- Affiliations
- Emory University (US)
- University of Illinois Urbana-Champaign (US)
- Kyoto University (JP)
- Corresponding author
- Miller, A H
- Venue
- Molecular Psychiatry
- Published
- 2009-11-17
- Volume
- 15
- Issue
- 4
- Pages
- 393-403
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC2844942
- OpenAlex
- W1973172818
- Cited by
- 630
- References
- 73
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 35 · 2023: 30 · 2022: 36 · 2021: 45 · 2020: 50 · 2019: 36 · 2018: 48 · 2017: 36 · 2016: 40 · 2015: 57 · 2014: 37 · 2013: 38 · 2012: 49
- FWCI
- 11.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000454)
- National Institute on Aging (R01AG029573)
- National Heart, Lung, and Blood Institute (R01HL073921)
- National Institute of Mental Health (R01MH079829, R01MH083746, R01MH071349, K23MH064619, T32MH020018, R01MH070553, K05MH069124)
- National Center for Research Resources (UL1RR025008, M01RR000039)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- interferon-alpha, kynurenine, quinolinic acid, kynurenic acid, tryptophan metabolism, indoleamine 2,3-dioxygenase, cerebrospinal fluid, depressive symptoms, hepatitis C, MCP-1, neuroinflammation
- MeSH terms
- Adult, Antiviral Agents, Chromatography, High Pressure Liquid, Depression, Enzyme-Linked Immunosorbent Assay, Female, Hepatitis C, Humans, Kynurenine, Longitudinal Studies, Male, Middle Aged, Ribavirin, Statistics as Topic, Tryptophan, Cytokines, Interferon-alpha, Quinolinic Acid, Chemokine CCL2, Receptors, Tumor Necrosis Factor, Type II
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
