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CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression
Open accessAbstract
Cytokine-induced activation of indoleamine 2,3-dioxygenase (IDO) catabolizes L-tryptophan (TRP) into L-kynurenine (KYN), which is metabolized to quinolinic acid (QUIN) and kynurenic acid (KA). QUIN and KA are neuroactive and may contribute to the behavioral changes experienced by some patients during exposure to inflammatory stimuli such as interferon (IFN)-alpha. A relationship between depressive symptoms and peripheral blood TRP, KYN and KA during treatment with IFN-alpha has been described. However, whether peripheral blood changes in these IDO catabolites are manifest in the brain and whether they are related to central nervous system cytokine responses and/or behavior is unknown. Accordingly, TRP, KYN, QUIN and KA were measured in cerebrospinal fluid (CSF) and blood along with CSF concentrations of relevant cytokines, chemokines and soluble cytokine receptors in 27 patients with hepatitis C after approximately 12 weeks of either treatment with IFN-alpha (n=16) or no treatment (n=11). Depressive symptoms were assessed using the Montgomery-Asberg Depression Rating Scale. IFN-alpha significantly increased peripheral blood KYN, which was accompanied by marked increases in CSF KYN. Increased CSF KYN was in turn associated with significant increases in CSF QUIN and KA. Despite significant decreases in peripheral blood TRP, IFN-alpha had no effect on CSF TRP concentrations. Increases in CSF KYN and QUIN were correlated with increased CSF IFN-alpha, soluble tumor necrosis factor-alpha receptor 2 and monocyte chemoattractant protein-1 as well as increased depressive symptoms. In conclusion, peripheral administration of IFN-alpha activated IDO in concert with central cytokine responses, resulting in increased brain KYN and QUIN, which correlated with depressive symptoms.
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“cytokines have been found to reduce levels of serotonin and possibly other related neurotransmitters by decreasing the availability of its serotonin precursor, an essential amino acid called tryptophan”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Raison et al., 2010
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“which may be attributed to the rapid metabolism of KYN once it is produced [47].”
From VEEV TC-83 Triggers Dysregulation of the Tryptophan–Kynurenine Pathway in the Central Nervous System That Correlates with Cognitive Impairment in Tg2576 Mice (2024) · cites this paper as [47]
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“Activation of the enzyme indoleamine 2,3-dioxygenase (IDO) is also believed to be involved in cytokine-induced neurotransmitter alterations, in part by diverting the metabolism of tryptophan (the primary amino acid precursor of serotonin) into kynurenine, a compound that can be converted into the neurotoxic metabolite quinolinic acid by activated microglia and infiltrating monocytes and macrophage”
From The role of inflammation in depression: from evolutionary imperative to modern treatment target (2016) · cites this paper as [76]
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“other studies have suggested that increased kynurenine levels without a decrease in tryptophan levels could also lead to depressive-like behavior in both animal models and human subjects (Raison et al., 2010).”
From A Review of the Relationship between Proinflammatory Cytokines and Major Depressive Disorder (2014) · cites this paper as Raison et al., 2010
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“current results are promising and show altered levels of proinflammatory biomarkers in CSF samples of depressed patients relative to healthy controls (Raison et al., 2010).”
From A Review of the Relationship between Proinflammatory Cytokines and Major Depressive Disorder (2014) · cites this paper as Raison et al., 2010
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Citations
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Statistical Power Analysis for the Behavioral Sciences (2nd ed.).
Lachenbruch, P. A., & Cohen, J. (1989) · Journal of the American Statistical Association · doi:10.2307/2290095 · Cited by 37,421
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Self-citationInflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848
Self-citationThe Mini-Mental State Examination
Folstein, M. F. (1983) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790060110016 · Cited by 2,016
Cytokine-Associated Emotional and Cognitive Disturbances in Humans
Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365
O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278
Self-citationTyring, S., Gottlieb, A., Papp, K., Gordon, K., Leonardi, C., Wang, A., Lalla, D., Woolley, M., Jahreis, A., Zitnik, R., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(05)67763-x · Cited by 1,069
The Relationship of Depression and Stressors to Immunological Assays: A Meta-Analytic Review
Zorrilla, E. P., Luborsky, L., McKay, J. R., Rosenthal, R., Houldin, A., Tax, A., McCorkle, R., Seligman, D. A., & Schmidt, K. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2000.0597 · Cited by 995
Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter
Owens, M. J., & Nemeroff, C. B. (1994) · Clinical Chemistry · doi:10.1093/clinchem/40.2.288 · Cited by 932
Capuron, L. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00407-9 · Cited by 797
Müller, N., Schwarz, M. J., Dehning, S., Douhe, A., Cerovecki, A., Goldstein-Müller, B., Spellmann, I., Hetzel, G., Maino, K., Kleindienst, N., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001805 · Cited by 794
Blood–Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism
Fukui, S., Schwarcz, R. M., Rapoport, S. I., Takada, Y., & Smith, Q. R. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb03460.x · Cited by 765
Structured Clinical Interview for DSM-IV
(2007) · Sage eBooks · doi:10.4135/9781412952644.n443 · Cited by 725
Heyes, M. P., Saito, K., Crowley, J. S., DAVIS, L. E., Demitrack, M. A., Der, M. G., Dilling, L. A., Elia, J., Kruesi, M. J. P., Lackner, A. A., et al. (1992) · Brain · doi:10.1093/brain/115.5.1249 · Cited by 684
Self-citationD'Mello, C., Le, T., & Swain, M. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3567-08.2009 · Cited by 675
The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression
Müller, N., & Schwarz, M. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002006 · Cited by 670
Brain-immune communication pathways
Quan, N., & Banks, W. A. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.05.005 · Cited by 626
Endotoxin produces a depressive-like episode in rats
Yirmiya, R. (1996) · Brain Research · doi:10.1016/0006-8993(95)01415-2 · Cited by 604
Textbook of psychopharmacology
Edwards, G. (1975) · Nature · doi:10.1038/258648b0 · Cited by 583
Cytokines and psychopathology: Lessons from interferon-α
Capuron, L., & Miller, A. H. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.009 · Cited by 562
Self-citationManipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities
Schwarcz, R. M., & Pellicciari, R. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.034439 · Cited by 556
Kynurenine pathway in major depression: Evidence of impaired neuroprotection
Myint, A.-M., Kim, Y. K., Verkerk, R., Scharpé, S., Steinbusch, H., & Leonard, B. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.07.013 · Cited by 527
Guillemin, G. J., Smythe, G., Takikawa, O., & Brew, B. J. (2005) · Glia · doi:10.1002/glia.20090 · Cited by 497
Interferon-alpha–induced changes in tryptophan metabolism
Capuron, L., Neurauter, G., Musselman, D. L., Lawson, D. H., Nemeroff, C. B., Fuchs, D., & Miller, A. H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00173-2 · Cited by 493
Self-citationCapuron, L., Ravaud, A., Neveu, P. J., Miller, A. H., Maes, M., & Dantzer, R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000995 · Cited by 473
Self-citationWichers, M. C., Koek, G. H., Robaeys, G., Verkerk, R., Scharpé, S., & Maes, M. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001600 · Cited by 445
Bonaccorso, S., Marino, V., Puzella, A., Pasquini, M., Biondi, M., Artini, M., Almerighi, C., Verkerk, R., Meltzer, H., & Maes, M. (2002) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200202000-00014 · Cited by 437
Brydon, L., Harrison, N. A., Walker, C., Steptoe, A., & Critchley, H. D. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.12.007 · Cited by 381
Raison, C. L., Borisov, A. S., Majer, M., Drake, D. F., Pagnoni, G., Woolwine, B. J., Vogt, G. J., Massung, B., & Miller, A. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.010 · Cited by 367
Self-citationAnisman, H., Merali, Z., & Hayley, S. P. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.01.004 · Cited by 341
Indoleamine 2,3 dioxygenase and quinolinic acid Immunoreactivity in Alzheimer's disease hippocampus
Guillemin, G. J., Brew, B. J., Noonan, C. E., Takikawa, O., & Cullen, K. M. (2005) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2005.00655.x · Cited by 338
Capuron, L., Raison, C. L., Musselman, D. L., Lawson, D. H., Nemeroff, C. B., & Miller, A. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.7.1342 · Cited by 308
Self-citationO’Connor, J. C., Lawson, M. A., André, C., Briley, E. M., Szegedi, S. S., Lestage, J., Castanon, N., Herkenham, M. A., Dantzer, R., & Kelley, K. W. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802722 · Cited by 305
Self-citationDepression During Pegylated Interferon-Alpha Plus Ribavirin Therapy
Raison, C. L., Borisov, A. S., Broadwell, S. D., Capuron, L., Woolwine, B. J., Jacobson, I. M., Nemeroff, C. B., & Miller, A. H. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0106 · Cited by 300
Self-citationInflammation, Glutamate, and Glia in Depression:A Literature Review
McNally, L., Bhagwagar, Z., & Hannestad, J. (2008) · CNS Spectrums · doi:10.1017/s1092852900016734 · Cited by 289
Quinolinic acid is a potent lipid peroxidant in rat brain homogenates
Rı́os, C., & Santamarı́a, A. (1991) · Neurochemical Research · doi:10.1007/bf00966592 · Cited by 272
Neopterin production, tryptophan degradation, and mental depression—What is the link?
Widner, B., Laich, A., Sperner‐Unterweger, B., Ledochowski, M., & Fuchs, D. (2002) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00006-5 · Cited by 235
Expression of The Kynurenine Pathway Enzymes in Human Microglia and Macrophages
Guillemin, G. J., Smith, D. G., Smythe, G. A., Armati, P. J., & Brew, G. J. (2003) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4615-0135-0_12 · Cited by 229
Fujigaki, H., Saito, K., Fujigaki, S., Takemura, M., Sudo, K., Ishiguro, H., & Seishima, M. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj072 · Cited by 222
Self-citationFelger, J. C., Alagbe, O., Hu, F., Mook, D., Freeman, A. A., Sanchez, M. M., Kalin, N. H., Ratti, E., Nemeroff, C. B., & Miller, A. H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.026 · Cited by 214
Self-citationFuchs, D., Möller, A. A., Reibnegger, G. J., Stöckle, E., Werner, E. R., & WACHTER, H. (1990) · PubMed · Cited by 203
Maes, M. H. J., Verkerk, R. M., Bonaccorso, S., Ombelet, W. U. A. M., Bosmans, E., & Scharpé, S. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01853-2 · Cited by 203
Miller, G. E., Rohleder, N., & Cole, S. W. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318190d7de · Cited by 197
A mechanism for increased quinolinic acid formation following acute systemic immune stimulation
Saito, K., Crowley, J. S., Markey, S. P., & Heyes, M. P. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82284-0 · Cited by 186
Self-citationWeiss, J. M., Downie, S. A., Lyman, W. D., & Berman, J. W. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.12.6896 · Cited by 186
Raison, C. L., Borisov, A. S., Woolwine, B. J., Massung, B., Vogt, G., & Miller, A. H. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.58 · Cited by 183
Self-citationQuinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytes
Guillemin, G. J., Croitoru‐Lamoury, J., Dormont, D., Armati, P. J., & Brew, B. J. (2003) · Glia · doi:10.1002/glia.10175 · Cited by 176
Heyes, M. P., Saito, K., Major, E. O., Milstien, S., Markey, S. P., & Vickers, J. H. (1993) · Brain · doi:10.1093/brain/116.6.1425 · Cited by 171
Self-citationCapuron, L., Fornwalt, F. B., Knight, B. T., Harvey, P. D., Ninan, P. T., & Miller, A. H. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.02.017 · Cited by 164
Self-citationRobinson, C. M., Shirey, K. A., & Carlin, J. M. (2003) · Journal of Interferon & Cytokine Research · doi:10.1089/107999003322277829 · Cited by 152
Repeated interferon-α administration inhibits dopaminergic neural activity in the mouse brain
Shuto, H., Kataoka, Y., Horikawa, T., Fujihara, N., & Oishi, R. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01371-6 · Cited by 151
Kynurenic acid leads, dopamine follows: A new case of volume transmission in the brain?
Wu, H., Rassoulpour, A., & Schwarcz, R. M. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0562-y · Cited by 151
Quinolinic Acid Production by Macrophages Stimulated with IFN-γ, TNF-α, and IFN-α
PEMBERTON, L. A., KERR, S. J., SMYTHE, G., & BREW, B. J. (1997) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1997.17.589 · Cited by 149
Guillemin, G. J., Wang, L. H.-C., & Brew, B. J. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-16 · Cited by 135
Majer, M., Welberg, L. A. M., Capuron, L., Pagnoni, G., Raison, C. L., & Miller, A. H. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.12.009 · Cited by 124
Self-citationVoltammetric study of the control of striatal dopamine release by glutamate
Borland, L. M., & Michael, A. C. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02708.x · Cited by 115
Owe‐Young, R., Webster, N. L., Mukhtār, M., Pomerantz, R. J., Smythe, G. A., Walker, D. W., Armati, P. J., Crowe, S. M., & Brew, B. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05241.x · Cited by 112
Maes, M. H. J., Bonaccorso, S., Marino, V., Puzella, A., Pasquini, M., Biondi, M., Artini, M., Almerighi, C., & Meltzer, H. Y. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000872 · Cited by 108
Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis
Guillemin, G. J., Meininger, V., & Brew, B. J. (2005) · Neurodegenerative Diseases · doi:10.1159/000089622 · Cited by 105
Tryptophan Catabolism and T Cell Responses
Mellor, A. L., Munn, D. H., Chandler, P., Keskin, D. B., Johnson, T. S., Marshall, B., Jhaver, K. G., & Baban, B. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0135-0_3 · Cited by 99
Measurement of tryptophan, kynurenine and neopterin in women with and without postpartum blues
Kohl, C. A., Walch, T., Huber, R., Kemmler, G., Neurauter, G., Fuchs, D., Sölder, E., Schröcksnadel, H., & Sperner‐Unterweger, B. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2004.12.013 · Cited by 78
Robinson, C. M., Hale, P. T., & Carlin, J. M. (2006) · Cytokine · doi:10.1016/j.cyto.2006.07.007 · Cited by 73
Kynurenine in blood plasma and DST in patients with endogenous anxiety and endogenous depression
Orlikov, A. B., Prakh'e, I. B., & Ryzhov, I. V. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)91189-4 · Cited by 60
3-Hydroxykynurenine and Quinolinate: Pathogenic Synergism in Early Grade Huntington’s Disease?
Guidetti, P., & Schwarcz, R. M. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0135-0_16 · Cited by 58
Diminished quality of life in patients with cancer correlates with tryptophan degradation
Schroecksnadel, K., Fiegl, M., Prassl, K., Winkler, C., Denz, H. A., & Fuchs, D. (2007) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-007-0191-3 · Cited by 54
Weidenfeld, J., & Yirmiya, R. (1997) · Neuroimmunomodulation · doi:10.1159/000097295 · Cited by 43
Scrandis, D. A., LANGENBERG, P. W., Tonelli, L. H., Sheikh, T. M., Manogura, A. C., Alberico, L. A., Hermanstyne, T. O., Fuchs, D., Mighty, H. E., Hasday, J. D., et al. (2008) · PubMed · Cited by 42
Vécsei, L., & Beal, M. F. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90043-h · Cited by 38
Tryptophan tolerance and metabolism in endogenous depression
M�ller, S. E., Kirk, L. N., & Honor�, P. (1982) · Psychopharmacology · doi:10.1007/bf00430761 · Cited by 27
The effect of antidepressant drugs on plasma kynurenine in depressed patients
WOOD, K. M., Harwood, J., & Coppen, A. J. (1978) · Psychopharmacology · doi:10.1007/bf00426632 · Cited by 27
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Metadata
- Authors
- Raison, C. L., Dantzer, R., Kelley, K. W., Lawson, M. A., Woolwine, B. J., Vogt, G., Spivey, J. R., Saito, K., & Miller, A. H.
- Affiliations
- Emory University (US)
- University of Illinois Urbana-Champaign (US)
- Kyoto University (JP)
- Corresponding author
- Miller, A H
- Venue
- Molecular Psychiatry
- Published
- 2009-11-17
- Volume
- 15
- Issue
- 4
- Pages
- 393-403
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC2844942
- OpenAlex
- W1973172818
- Cited by
- 630
- References
- 73
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 35 · 2023: 30 · 2022: 36 · 2021: 45 · 2020: 50 · 2019: 36 · 2018: 48 · 2017: 36 · 2016: 40 · 2015: 57 · 2014: 37 · 2013: 38 · 2012: 49
- FWCI
- 11.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000454)
- National Institute on Aging (R01AG029573)
- National Heart, Lung, and Blood Institute (R01HL073921)
- National Institute of Mental Health (R01MH079829, R01MH083746, R01MH071349, K23MH064619, T32MH020018, R01MH070553, K05MH069124)
- National Center for Research Resources (UL1RR025008, M01RR000039)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- interferon-alpha, kynurenine, quinolinic acid, kynurenic acid, tryptophan metabolism, indoleamine 2,3-dioxygenase, cerebrospinal fluid, depressive symptoms, hepatitis C, MCP-1, neuroinflammation
- MeSH terms
- Adult, Antiviral Agents, Chromatography, High Pressure Liquid, Depression, Enzyme-Linked Immunosorbent Assay, Female, Hepatitis C, Humans, Kynurenine, Longitudinal Studies, Male, Middle Aged, Ribavirin, Statistics as Topic, Tryptophan, Cytokines, Interferon-alpha, Quinolinic Acid, Chemokine CCL2, Receptors, Tumor Necrosis Factor, Type II
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