The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update
Abstract
An updated review of 34 human observational studies indicates that the length polymorphism of the serotonin transporter gene moderates the effect of environmental adversity in the development of depression. This finding depends on the use of contextual or objective methods to assess environmental adversity and is attenuated when self-report instruments are used. Inconsistent findings in male adolescents suggest a developmental stage and sex-specific protective mechanism. These systematic relationships between method and results should be followed up to specify causal mechanisms leading to depression.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“individuals with one or two copies of the short allele at 5-HTTLPR are at greater risk for MDD than their long-allele homozygous counterparts”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Uher & McGuffin, 2010
In the citing paper
“It is important that the study sample contains adequate numbers of subjects exposed and unexposed to the stressful environment to ensure adequate power”
From Gene–environment interactions: early life stress and risk for depressive and anxiety disorders (2011) · cites this paper as Uher and McGuffin 2010
In the citing paper
“In a subsequent systematic review, the 14 studies (out of 34 possible studies) included in the Risch report were found to show a statistically significant bias toward negative findings (Uher and McGuffin 2010).”
From Gene–environment interactions: early life stress and risk for depressive and anxiety disorders (2011) · cites this paper as Uher and McGuffin 2010
In the citing paper
“Meta-analyses have supported 111,112 and not supported 113,114 this finding.”
From Genetic architectures of psychiatric disorders: the emerging picture and its implications (2012) · cites this paper as [113]
Citations
Cites
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J., & Merikangas, K. R. (2009) · JAMA · doi:10.1001/jama.2009.878 · Cited by 1,655
Strategy for Investigating Interactions Between Measured Genes and Measured Environments
Moffitt, T. E., Caspi, A., & Rutter, M. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.5.473 · Cited by 784
Modern Approaches to Conceptualizing and Measuring Human Life Stress
Monroe, S. M. (2008) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.4.022007.141207 · Cited by 618
Dohrenwend, B. P. (2006) · Psychological Bulletin · doi:10.1037/0033-2909.132.3.477 · Cited by 601
Gene×environment interactions at the serotonin transporter locus
Munafò, M. R., Durrant, C., Lewis, G., & Flint, J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.009 · Cited by 576
HPA Axis Reactivity: A Mechanism Underlying the Associations Among 5-HTTLPR, Stress, and Depression
Gotlib, I. H., Joormann, J., Minor, K. L., & Hallmayer, J. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.008 · Cited by 558
Uher, R., & McGuffin, P. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002067 · Cited by 508
Self-citationKilpatrick, D. G., Koenen, K. C., Ruggiero, K. J., Acierno, R. E., Galea, S., Resnick, H. S., Roitzsch, J. C., Boyle, J. M., & Gelernter, J. E. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06122007 · Cited by 405
Polanczyk, G., Caspi, A., Williams, B., Price, T. S., Danese, A., Sugden, K., Uher, R., Poulton, R., & Moffitt, T. E. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.114 · Cited by 285
Self-citationMemories of Childhood Neglect and Abuse: Corroboration in a Series of Sisters
Bifulco, A. T., Brown, G. W., Lillie, A., & Jarvis, J. (1997) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1997.tb01520.x · Cited by 252
Brown, G. W., & Harris, T. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.04.009 · Cited by 200
Battaglia, M., Ogliari, A. L., Zanoni, A., Citterio, A., Pozzoli, U., Giorda, R., Maffei, C., & Marino, C. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.1.85 · Cited by 188
Gene-Environment Interactions in Depression Research
Monroe, S. M., & Reid, M. W. (2008) · Psychological Science · doi:10.1111/j.1467-9280.2008.02181.x · Cited by 170
The implications of gene–environment interactions in depression: will cause inform cure?
Uher, R. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.92 · Cited by 147
Self-citationOtte, C., McCaffery, J. M., Ali, S., & Whooley, M. A. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06101617 · Cited by 146
Variation in the serotonin transporter gene modulates selective attention to threat.
Osinsky, R., Reuter, M., Küpper, Y., Schmitz, A., Kozyra, E., Alexander, N., & Hennig, J. (2008) · Emotion · doi:10.1037/a0012826 · Cited by 128
Laucht, M., Treutlein, J., Blomeyer, D., Buchmann, A. F., Schmid, B., Becker, K., Zimmermann, U. S., Schmidt, M. H., Esser, G., Rietschel, M., et al. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009875 · Cited by 127
Association of Serotonin Transporter Gene Polymorphisms With Poststroke Depression
Kohen, R., Cain, K. C., Mitchell, P. H., Becker, K. J., Buzaitis, A., Millard, S. P., Navaja, G. P., Teri, L. L., Tirschwell, D., & Veith, R. C. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.11.1296 · Cited by 123
Life events, anxious depression and personality: a prospective and genetic study
Middeldorp, C. M., Cath, D. C., Beem, A. L., Willemsen, G. A. H. M., & Boomsma, D. I. (2008) · Psychological Medicine · doi:10.1017/s0033291708002985 · Cited by 114
Assessment of Life Stress in Adolescents: Self-Report Versus Interview Methods
Duggal, S., Malkoff-Schwartz, S., Birmaher, B. B., Anderson, B. P., MATTY, M. K., Houck, P. R., BAILEY-ORR, M., Williamson, D. E., & Frank, E. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200004000-00013 · Cited by 111
Middeldorp, C. M., de Geus, E. J. C., Beem, A. L., Lakenberg, N., Hottenga, J., Slagboom, P. E., & Boomsma, D. I. (2007) · Behavior Genetics · doi:10.1007/s10519-006-9139-7 · Cited by 89
McQuaid, J. R., Monroe, S. M., Roberts, J. E., Kupfer, D. J., & Frank, E. (2000) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.109.4.787 · Cited by 89
The role of the serotonin transporter polymorphism for the endocrine stress response in newborns
Mueller‐Alcazar, A., Brocke, B., Fries, E., Lesch, K., & Kirschbaum, C. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.07.002 · Cited by 84
Chipman, P., Jorm, A. F., Prior, M., Sanson, A., Smart, D., Tan, X., & Easteal, S. (2007) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30480 · Cited by 81
Gorman, D. M. (1993) · Behavioral Medicine · doi:10.1080/08964289.1993.9937567 · Cited by 54
Cited by
Sorted by citations
Thapar, A., Collishaw, S., Pine, D. S., & Thapar, A. K. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60871-4 · Cited by 2,365
Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206
“…at 5-HTTLPR are at greater risk for MDD than their long-allele homozygous counterparts (Caspi et al., 2003; Karg, Burmeister, Shedden, & Sen, 2011; Uher & McGuffin, 2010), Bull and colleagues (2009) found that short-allele carriers developed more depressive symptoms during the course of…”
BackgroundResilience as a dynamic concept
Rutter, M. (2012) · Development and Psychopathology · doi:10.1017/s0954579412000028 · Cited by 1,853
Why is depression more common among women than among men?
Kuehner, C. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)30263-2 · Cited by 1,752
Differential susceptibility to the environment: an evolutionary--neurodevelopmental theory
Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & van Ijzendoorn, M. H. (2011) · Development and Psychopathology · doi:10.1017/s0954579410000611 · Cited by 1,564
Metadata
- Authors
- Uher, R., & McGuffin, P.
- Affiliations
- King's College London (GB)
- Corresponding author
- Uher, R
- ORCID
- Uher, R
- Venue
- Molecular Psychiatry
- Published
- 2009-12-22
- Volume
- 15
- Issue
- 1
- Pages
- 18-22
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W1989784453
- Cited by
- 424
- References
- 26
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 31 · 2019: 21 · 2018: 9 · 2017: 25 · 2016: 26 · 2015: 33 · 2014: 40 · 2013: 53 · 2012: 49
- FWCI
- 22.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- serotonin transporter gene, serotonin transporter, environmental adversity, etiology of depression, gene-environment interaction, length polymorphism, self-report measures, contextual assessment, adolescent boys, sex differences, developmental stages, protective mechanisms
- MeSH terms
- Depression, Environment, Humans, Polymorphism, Genetic, Meta-Analysis as Topic, Serotonin Plasma Membrane Transport Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
