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The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update
Abstract
An updated review of 34 human observational studies indicates that the length polymorphism of the serotonin transporter gene moderates the effect of environmental adversity in the development of depression. This finding depends on the use of contextual or objective methods to assess environmental adversity and is attenuated when self-report instruments are used. Inconsistent findings in male adolescents suggest a developmental stage and sex-specific protective mechanism. These systematic relationships between method and results should be followed up to specify causal mechanisms leading to depression.
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“individuals with one or two copies of the short allele at 5-HTTLPR are at greater risk for MDD than their long-allele homozygous counterparts”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Uher & McGuffin, 2010
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“It is important that the study sample contains adequate numbers of subjects exposed and unexposed to the stressful environment to ensure adequate power”
From Gene–environment interactions: early life stress and risk for depressive and anxiety disorders (2011) · cites this paper as Uher and McGuffin 2010
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“In a subsequent systematic review, the 14 studies (out of 34 possible studies) included in the Risch report were found to show a statistically significant bias toward negative findings (Uher and McGuffin 2010).”
From Gene–environment interactions: early life stress and risk for depressive and anxiety disorders (2011) · cites this paper as Uher and McGuffin 2010
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“Meta-analyses have supported 111,112 and not supported 113,114 this finding.”
From Genetic architectures of psychiatric disorders: the emerging picture and its implications (2012) · cites this paper as [113]
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Metadata
- Authors
- Uher, R., & McGuffin, P.
- Affiliations
- King's College London (GB)
- Corresponding author
- Uher, R
- ORCID
- Uher, R
- Venue
- Molecular Psychiatry
- Published
- 2009-12-22
- Volume
- 15
- Issue
- 1
- Pages
- 18-22
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W1989784453
- Cited by
- 424
- References
- 26
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 31 · 2019: 21 · 2018: 9 · 2017: 25 · 2016: 26 · 2015: 33 · 2014: 40 · 2013: 53 · 2012: 49
- FWCI
- 22.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- serotonin transporter gene, serotonin transporter, environmental adversity, etiology of depression, gene-environment interaction, length polymorphism, self-report measures, contextual assessment, adolescent boys, sex differences, developmental stages, protective mechanisms
- MeSH terms
- Depression, Environment, Humans, Polymorphism, Genetic, Meta-Analysis as Topic, Serotonin Plasma Membrane Transport Proteins
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