Meta-analysis of the dose-response relationship of SSRI in obsessive–compulsive disorder
Open accessAbstract
We sought to determine differences in efficacy and tolerability between different doses of selective serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder (OCD) using meta-analysis. We identified 9 studies involving 2268 subjects that were randomized, double-blind placebo-controlled clinical trials that compared multiple, fixed-doses of selective serotonin reuptake inhibitors (SSRIs) to each other and to placebo in the treatment of adults with OCD. Change in Y-BOCS score, proportion of treatment responders, and dropouts (all-cause and due to side-effects) were determined for each included study. Weighted mean difference was used to examine mean change in Y-BOCS score. Pooled absolute risk difference was used to examine dichotomous outcomes. Meta-analysis was performed using a fixed effects model in RevMan 4.2.8. We found that compared with either low or medium doses, higher doses of SSRIs were associated with improved treatment efficacy, using either Y-BOCS score or proportion of treatment responders as an outcome. Dose of SSRIs was not associated with the number of all-cause dropouts. Higher doses of SSRIs were associated with significantly higher proportion of dropouts due to side-effects. These results suggests that higher doses of SSRIs are associated with greater efficacy in the treatment of OCD. This SSRI efficacy pattern stands in contrast to other psychiatric disorders like Major Depressive Disorder. This greater treatment efficacy is somewhat counterbalanced by the greater side-effect burden with higher doses of SSRIs. At present, there are insufficient data to generalize these findings to children or adolescents with OCD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SSRIs are generally prescribed in OCD at much higher doses than is the typically recommended dose for SSRI use in depression and anxiety disorders.
“SSRIs are generally prescribed in OCD at much higher doses than is the typically recommended dose for SSRI use in depression and anxiety disorders (Bloch et al., 2010).”
From The role of habit in compulsivity (2016) · cites this paper as Bloch et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110048007 · Cited by 7,712 · see citing works
(1996) · Cited by 6,884 · see citing works
The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication
Ruscio, A. M., Stein, D. J., Chiu, W. T., & Kessler, R. C. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.94 · Cited by 2,771 · see citing works
The Yale-Brown Obsessive-Compulsive Scale: Measures of internal consistency
Kim, S. W., Dysken, M. W., Pheley, A. M., & Hoover, K. M. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90039-6 · Cited by 2,361 · see citing works
A multidimensional model of obsessive-compulsive disorder
Mataix-Cols, D., do Rosario-Campos, M. C., & Leckman, J. F. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.2.228 · Cited by 1,074 · see citing works
Self-citationPractice Guideline for the Treatment of Patients With Obsessive-Compulsive Disorder
(2008) · APA Practice Guidelines for the Treatment of Psychiatric Disorders: Comprehensive Guidelines and Guideline Watches · doi:10.1176/appi.books.9780890423363.149114 · Cited by 1,028 · see citing works
Meta-analysis of the symptom structure of obsessive–compulsive disorder
Bloch, M. H., Landeros-Weisenberger, A., Rosario, M. C., Pittenger, C., & Leckman, J. F. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08020320 · Cited by 681 · see citing works
Self-citationTreatment non-response in OCD: methodological issues and operational definitions
Pallanti, S., Hollander, E., Bienstock, C., Koran, L., Leckman, J., Marazziti, D., Pato, M., Stein, D., Zohar, J., & International Treatment Refractory OCD Consortium (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702002900 · Cited by 416 · see citing works
Self-citationSoomro, G. M., Altman, D. G., Rajagopal, S., & Oakley Browne, M. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001765.pub3 · Cited by 342 · see citing works
Tollefson, G. D. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950070051010 · Cited by 314 · see citing works
Bollini, P., Pampaliona, S., Tibaldi, G., Kupelnick, B., & Munizza, C. (1999) · British Journal of Psychiatry · doi:10.1192/bjp.174.4.297 · Cited by 274 · see citing works
High-Dose Sertraline Strategy for Nonresponders to Acute Treatment for Obsessive-Compulsive Disorder
Ninan, P. T., Koran, L. M., Kiev, A., Davidson, J. R. T., Rasmussen, S. A., Zajecka, J., Robinson, D. G., Crits-Christoph, P. F., Mandel, F. S., & Austin, C. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0103 · Cited by 246 · see citing works
Greist, J. H. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160039008 · Cited by 243 · see citing works
Treatment of Obsessive Compulsive Disorder
Franklin, M. E., & Foa, E. B. (2011) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032210-104533 · Cited by 227 · see citing works
Montgomery, S., Kasper, S. F., Stein, D. J., Hedegaard, K. B., & Lemming, O. M. (2001) · International Clinical Psychopharmacology · doi:10.1097/00004850-200103000-00002 · Cited by 184 · see citing works
Montgomery, S. A. (1993) · European Neuropsychopharmacology · doi:10.1016/0924-977x(93)90266-o · Cited by 172 · see citing works
Epidemiology of obsessive-compulsive disorder
Bebbington, P. (1998) · The British Journal of Psychiatry · doi:10.1192/s0007125000297833 · Cited by 162 · see citing works
Hollander, E., Allen, A., Steiner, M., Wheadon, D. E., Oakes, R., Burnham, D. B., & Paroxetine OCD Study Group (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0919 · Cited by 156 · see citing works
Stein, D. J., Andersen, E. W., Tonnoir, B., & Fineberg, N. A. (2007) · Current Medical Research and Opinion · doi:10.1185/030079907x178838 · Cited by 134 · see citing works
Treatment of obsessive compulsive disorder
MAVISSAKALIAN, M. R. (1994) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/0005-7916(94)90044-2 · Cited by 106 · see citing works
A comparison of diagnostic criteria for neuroleptic malignant syndrome.
Gurrera, R. J., Chang, S. S., & Romero, J. A. (1992) · PubMed · Cited by 74 · see citing works
(1997) · PubMed · Cited by 40 · see citing works
Efficacy of fluoxetine in Austrian patients with obsessive-compulsive disorder.
Zitterl, W., Meszaros, K., Hornik, K., Twaroch, T., Dossenbach, M. R. K., Zitterl‐Eglseer, K., & Zapotoczky, H. G. (1999) · PubMed · Cited by 17 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [22]Dominguez RA Serotonergic antidepressants and their efficacy in obsessive compulsive disorder J Clin Psychiatry 1992 53 Suppl 56 59 1429485
Cited by
Sorted by citations
Stein, D. J., Costa, D. L. C., Lochner, C., Miguel, E. C., Reddy, Y. C. J., Shavitt, R. G., van den Heuvel, O. A., & Simpson, H. B. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0102-3 · Cited by 895 · see citing works
Baldwin, D. S., Anderson, I. M., Nutt, D. J., Allgulander, C., Bandelow, B., den Boer, J. A., Christmas, D. M., Davies, S., Fineberg, N., Lidbetter, N., et al. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114525674 · Cited by 676 · see citing works
Obsessive-compulsive disorder: Puzzles and prospects
Robbins, T. W., Vaghi, M. M., & Banca, P. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.046 · Cited by 510 · see citing works
Dean, O., Giorlando, F., & Berk, M. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100057 · Cited by 494 · see citing works
Obsessive-Compulsive Disorder: Advances in Diagnosis and Treatment
Hirschtritt, M. E., Bloch, M. H., & Mathews, C. A. (2017) · JAMA · doi:10.1001/jama.2017.2200 · Cited by 493 · see citing works
Self-citationPittenger, C., Bloch, M. H., & Williams, K. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.09.006 · Cited by 426 · see citing works
Self-citationLeckman, J. F., Denys, D., Simpson, H. B., Mataix-Cols, D., Hollander, E., Saxena, S., Miguel, E. C., Rauch, S. L., Goodman, W. K., Phillips, K. A., et al. (2010) · Depression and Anxiety · doi:10.1002/da.20669 · Cited by 411 · see citing works
Self-citationSkapinakis, P., Caldwell, D. M., Hollingworth, W., Bryden, P., Fineberg, N. A., Salkovskis, P., Welton, N. J., Baxter, H., Kessler, D., Churchill, R., et al. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)30069-4 · Cited by 407 · see citing works
Baldessarini, R. J. (2013) · doi:10.1007/978-1-4614-3710-9 · Cited by 365 · see citing works
Evidence-based pharmacotherapy of obsessive-compulsive disorder
Fineberg, N. A., Brown, A., Reghunandanan, S., & Pampaloni, I. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001829 · Cited by 336 · see citing works
A meta-analysis of behavior therapy for Tourette Syndrome
McGuire, J. F., Piacentini, J., Brennan, E. A., Lewin, A. B., Murphy, T. K., Small, B. J., & Storch, E. A. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.12.009 · Cited by 334 · see citing works
Self-citationNon-adherence and non-response in the treatment of anxiety disorders
Taylor, S., Abramowitz, J. S., & McKay, D. (2012) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2012.02.010 · Cited by 317 · see citing works
The role of habit in compulsivity
Gillan, C. M., Robbins, T. W., Sahakian, B. J., van den Heuvel, O. A., & van Wingen, G. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.12.033 · Cited by 292 · see citing works
Sleep in the anxiety-related disorders: A meta-analysis of subjective and objective research
Cox, R. C., & Olatunji, B. O. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101282 · Cited by 235 · see citing works
Pharmacological Treatment of Obsessive-Compulsive Disorder
Pittenger, C., & Bloch, M. H. (2014) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2014.05.006 · Cited by 222 · see citing works
Self-citationJakubovski, E., Varigonda, A. L., Freemantle, N., Taylor, M. J., & Bloch, M. H. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15030331 · Cited by 197 · see citing works
Self-citationPharmacological treatment of anxiety disorders: Current treatments and future directions
Farach, F. J., Pruitt, L. D., Jun, J. J., Jerud, A. B., Zoellner, L. A., & Roy‐Byrne, P. (2012) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2012.07.009 · Cited by 183 · see citing works
Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive Disorder
Bloch, M. H., Wasylink, S., Landeros-Weisenberger, A., Panza, K. E., Billingslea, E., Leckman, J. F., Krystal, J. H., Bhagwagar, Z., Sanacora, G., & Pittenger, C. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.028 · Cited by 162 · see citing works
Self-citationFineberg, N. A., Hollander, E., Pallanti, S., Walitza, S., Grünblatt, E., Dell’Osso, B. M., Albert, U., Geller, D. A., Brakoulias, V., Janardhan Reddy, Y. C., et al. (2020) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000314 · Cited by 161 · see citing works
Clinical practice guidelines for Obsessive-Compulsive Disorder
Janardhan Reddy, Y., Sundar, A., Narayanaswamy, J., & Math, S. (2017) · Indian Journal of Psychiatry · doi:10.4103/0019-5545.196976 · Cited by 156 · see citing works
Pharmacotherapy of anxiety disorders: A critical review
Koen, N., & Stein, D. J. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.4/nkoen · Cited by 151 · see citing works
Fineberg, N. A., Reghunandanan, S., Simpson, H. B., Phillips, K. A., Richter, M. A., Matthews, K., Stein, D. J., Sareen, J., Brown, A., & Sookman, D. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2014.12.003 · Cited by 150 · see citing works
McGuire, J. F., Ung, D., Selles, R. R., Rahman, O., Lewin, A. B., Murphy, T. K., & Storch, E. A. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.07.015 · Cited by 142 · see citing works
Self-citationSuicide Risk in Obsessive-Compulsive Disorder and Exploration of Risk Factors: A Systematic Review
Albert, U., Ronchi, D. D., Maina, G., & Pompili, M. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180620155941 · Cited by 123 · see citing works
Pharmacotherapy of obsessive–compulsive disorder: evidence-based treatment and beyond
Fineberg, N. A., Reghunandanan, S., Brown, A., & Pampaloni, I. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412461958 · Cited by 122 · see citing works
High-frequency neuromodulation improves obsessive–compulsive behavior
Grover, S., Nguyen, J. A., Viswanathan, V., & Reinhart, R. M. G. (2021) · Nature Medicine · doi:10.1038/s41591-020-01173-w · Cited by 113 · see citing works
Assessment and Management of Treatment-Refractory Obsessive-Compulsive Disorder in Children
Bloch, M. H., & Storch, E. A. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2015.01.011 · Cited by 105 · see citing works
Self-citationDijk, H. M. H., van de Schoot, R., Rijkeboer, M. M., Mathews, C. A., & Cath, D. C. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.01.051 · Cited by 101 · see citing works
Strawn, J. R., Mills, J. A., Sauley, B. A., & Welge, J. A. (2018) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2018.01.015 · Cited by 98 · see citing works
Sabé, M., Hyde, J., Cramer, C., Eberhard, A., Crippa, A., Brunoni, A. R., Aleman, A., Kaiser, S., Baldwin, D. S., Garner, M. J., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.12616 · Cited by 105 · see citing works
Oliver, G., Dean, O., Camfield, D., Blair-West, S., Ng, C., Berk, M., & Sarris, J. (2015) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2015.13.1.12 · Cited by 96 · see citing works
Varigonda, A. L., Jakubovski, E., & Bloch, M. H. (2016) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2016.07.768 · Cited by 92 · see citing works
Self-citationAlbert, U., Marazziti, D., Di Salvo, G., Solia, F., Rosso, G., & Maina, G. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867325666171222163645 · Cited by 90 · see citing works
Isomura, K., Brander, G., Chang, Z., Kuja‐Halkola, R., Rück, C., Hellner, C., Lichtenstein, P., Larsson, H., Mataix‐Cols, D., & de la Cruz, L. F. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.12.003 · Cited by 86 · see citing works
Duration of untreated illness and response to SRI treatment in Obsessive-Compulsive Disorder
Albert, U., Barbaro, F., Bramante, S., Rosso, G., Ronchi, D. D., & Maina, G. (2019) · European Psychiatry · doi:10.1016/j.eurpsy.2019.01.017 · Cited by 88 · see citing works
Treatment-resistant OCD: Pharmacotherapies in adults
van Roessel, P., Grassi, G., Aboujaoude, E. N., Menchón, J. M., Ameringen, M. V., & Rodríguez, C. I. (2022) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2022.152352 · Cited by 91 · see citing works
Carrasco, M., Volkmar, F. R., & Bloch, M. H. (2012) · PEDIATRICS · doi:10.1542/peds.2011-3285 · Cited by 87 · see citing works
Self-citationObsessive compulsive disorder: diagnosis and management.
Fenske, J., & Schwenk, T. L. (2009) · PubMed · Cited by 87 · see citing works
Bidabadi, S. S., & Mehryar, A. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.04.011 · Cited by 81 · see citing works
Bandelow, B., Allgulander, C., Baldwin, D. S., Costa, D. L. D. C., Denys, D., Dilbaz, N., Domschke, K., Hollander, E., Kasper, S., Möller, H.-J., et al. (2023) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2022.2086296 · Cited by 84 · see citing works
Bokor, G., & Anderson, P. D. (2014) · Journal of Pharmacy Practice · doi:10.1177/0897190014521996 · Cited by 79 · see citing works
Vigod, S. N., Frey, B. N., Clark, C. T., Grigoriadis, S., Barker, L. C., Brown, H. K., Charlebois, J., Dennis, C., Fairbrother, N., Green, S. M., et al. (2025) · The Canadian Journal of Psychiatry · doi:10.1177/07067437241303031 · Cited by 88 · see citing works
Antidepressants for Pediatric Patients.
Dwyer, J. B., & Bloch, M. H. (2019) · PubMed · Cited by 76 · see citing works
Self-citationNassan, M. M., Nicholson, W. T., Elliott, M. A., Vitek, C. R. R., Black, J. L., & Frye, M. A. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.02.023 · Cited by 77 · see citing works
Diniz, J. B., Shavitt, R. G., Fossaluza, V., Koran, L. M., Pereira, C. A. D. B., & Miguel, E. C. (2011) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3182367aee · Cited by 72 · see citing works
Brandl, E. J., Tiwari, A. K., Zhou, X., Deluce, J. E., Kennedy, J. L., Müller, D., & Richter, M. A. (2013) · The Pharmacogenomics Journal · doi:10.1038/tpj.2013.12 · Cited by 70 · see citing works
Treatment of anxiety disorders in epilepsy: An evidence‐based approach
Mula, M. (2013) · Epilepsia · doi:10.1111/epi.12101 · Cited by 70 · see citing works
Venlafaxine extended-release treatment of hoarding disorder
Saxena, S., & Sumner, J. (2014) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000036 · Cited by 69 · see citing works
A 2012 evidence-based algorithm for the pharmacotherapy for obsessive-compulsive disorder
Stein, D. J., Koen, N., Fineberg, N., Fontenelle, L. F., Matsunaga, H., Osser, D., & Simpson, H. B. (2012) · Current Psychiatry Reports · doi:10.1007/s11920-012-0268-9 · Cited by 65 · see citing works
Van Ameringen, M., Simpson, W., Patterson, B., Dell’Osso, B., Fineberg, N., Hollander, E., Hranov, L., Hranov, G., Lochner, C., Karamustafalioglu, O., et al. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881113517955 · Cited by 65 · see citing works
Current trends in drug treatment of obsessive–compulsive disorder
Decloedt, E. H., & Stein, D. J. (2010) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s3149 · Cited by 65 · see citing works
Sjöstedt, P., Enander, J., & Isung, J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.682868 · Cited by 62 · see citing works
Swierkosz-Lenart, K., Santos, J. F. A. D., Elowe, J., Clair, A.-H., Bally, J. F., Riquier, F., Bloch, J., Draganski, B., Clerc, M.-T., Moyano, B. P., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1065812 · Cited by 67 · see citing works
Lissemore, J. I., Sookman, D., Gravel, P., Berney, A., Barsoum, A., Dikšić, M., NORDAHL, T. E., Pinard, G., Sibon, I., Cottraux, J. A., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0128-4 · Cited by 62 · see citing works
Handbook on Obsessive-Compulsive and Related Disorders
(2015) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378524 · Cited by 59 · see citing works
Pharmacotherapy of compulsive hoarding
Saxena, S. (2011) · Journal of Clinical Psychology · doi:10.1002/jclp.20792 · Cited by 57 · see citing works
The neuropsychiatry of neuroacanthocytosis syndromes
Walterfang, M., Evans, A. H., Looi, J. C., Jung, H. H., Danek, A., Walker, R. H., & Velakoulis, D. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.01.001 · Cited by 57 · see citing works
Six-Nine Year Follow-Up of Deep Brain Stimulation for Obsessive-Compulsive Disorder
Fayad, S. M., Guzick, A. G., Reid, A. M., Mason, D. M., Bertone, A., Foote, K. D., Okun, M. S., Goodman, W. K., & Ward, H. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167875 · Cited by 55 · see citing works
Richter, P. M. A., & Ramos, R. T. (2018) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000603 · Cited by 51 · see citing works
Pharmacotherapeutic Strategies and New Targets in OCD
Pittenger, C. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_204 · Cited by 51 · see citing works
Self-citationPharmacological Treatments for Disordered Gambling: A Meta-analysis
Goslar, M., Leibetseder, M. M., Münch, H. M., Hofmann, S. G., & Laireiter, A. (2018) · Journal of Gambling Studies · doi:10.1007/s10899-018-09815-y · Cited by 49 · see citing works
Hamoda, H. M., & Osser, D. N. (2008) · Harvard Review of Psychiatry · doi:10.1080/10673220802277904 · Cited by 46 · see citing works
McGregor, N. W., Hemmings, S. M. J., Erdman, L., Calmarza-Font, I., Stein, D. J., & Löchner, C. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.10.044 · Cited by 42 · see citing works
Tini, E., Smigielski, L., Romanos, M., Wewetzer, C., Karwautz, A. F. K., Reitzle, K., Correll, C. U., Plener, P. L., Malzahn, U., Heuschmann, P. U., et al. (2022) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2022.152301 · Cited by 43 · see citing works
Psychocutaneous disease: Pharmacotherapy and psychotherapy.
Kuhn, H., Mennella, C., Magid, M., Stamu‐O'Brien, C., & Kroumpouzos, G. (2017) · Journal of American Academy of Dermatology · doi:10.1016/j.jaad.2016.11.021 · Cited by 27 · see citing works
Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior
Piantadosi, S. C., Manning, E. E., Chamberlain, B. L., Hyde, J., LaPalombara, Z., Bannon, N. M., Pierson, J. L., Namboodiri, V. M. K., & Ahmari, S. E. (2024) · Nature Communications · doi:10.1038/s41467-024-48331-z · Cited by 39 · see citing works
Pharmacogenetics of Obsessive–Compulsive Disorders
Brandl, E. J., Müller, D. J., & Richter, M. A. (2011) · Pharmacogenomics · doi:10.2217/pgs.11.133 · Cited by 40 · see citing works
Treatment-refractory obsessive compulsive disorder
Atmaca, M. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.12.004 · Cited by 40 · see citing works
Reid, A. M., McNamara, J. P. H., Murphy, T. K., Guzick, A. G., Storch, E. A., Geffken, G. R., & Bussing, R. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.10.006 · Cited by 38 · see citing works
Obsessive–compulsive Disorder: Diagnostic and Treatment Issues
Stein, D. J., Denys, D. A. J. P., Gloster, A. T., Hollander, E., Leckman, J. F., Rauch, S. L., & Phillips, K. A. (2009) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2009.05.007 · Cited by 37 · see citing works
Self-citationKhosravani, V., Ardestani, S. M. S., Bastan, F. S., & Malayeri, S. (2018) · Current Psychology · doi:10.1007/s12144-018-9859-x · Cited by 36 · see citing works
Couto, J. P., & Moreira, R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.06.005 · Cited by 34 · see citing works
Deng, J., Rayner, D. G., Ramaraju, H. B., Abbas, U., Garcia, C., Heybati, K., Zhou, F., Huang, E., Park, Y., & Moskalyk, M. (2023) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2023.01.010 · Cited by 33 · see citing works
Trichotillomania is more related to Tourette disorder than to obsessive-compulsive disorder
Lamothe, H., Baleyte, J., Mallet, L., & Pélissolo, A. (2019) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2019-0471 · Cited by 31 · see citing works
Management and treatment of obsessive–compulsive disorder
Fineberg, N. A., Drummond, L. M., Reid, J. E., Cinosi, E., Carmi, L., & Mpavaenda, D. (2020) · doi:10.1093/med/9780198713005.003.0098 · Cited by 32 · see citing works
How resistant is ‘treatment‐resistant’ obsessive‐compulsive disorder in youth?
Krebs, G., Isomura, K., Lang, K., Jassi, A. D., Heyman, I., Diamond, H., Advani, J., Turner, C. M., & Mataix‐Cols, D. (2014) · British Journal of Clinical Psychology · doi:10.1111/bjc.12061 · Cited by 30 · see citing works
Sexuality and obsessive-compulsive disorder: the hidden affair
Real, E., Montejo, A. L., Alonso, P., & Menchón, J. M. (2013) · Neuropsychiatry · doi:10.2217/npy.12.72 · Cited by 29 · see citing works
The Nature, Assessment, and Treatment of Obsessive–Compulsive Disorder
Mcguire, J. F., Lewin, A. B., Horng, B., Murphy, T. K., & Storch, E. A. (2012) · Postgraduate Medicine · doi:10.3810/pgm.2012.01.2528 · Cited by 28 · see citing works
Self-citationSnorrason, Í., Beard, C., Peckham, A., & Björgvinsson, Þ. (2020) · Psychological Medicine · doi:10.1017/s0033291720000380 · Cited by 29 · see citing works
Troubles anxieux résistants : revue des stratégies de traitements médicamenteux
Ammar, G., Naja, W., & Pélissolo, A. (2014) · L Encéphale · doi:10.1016/j.encep.2013.11.002 · Cited by 27 · see citing works
Management of Treatment-Resistant Obsessive-Compulsive Disorder
Gershkovich, M., Wheaton, M. G., & Simpson, H. B. (2017) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-017-0127-8 · Cited by 28 · see citing works
Giakoumatos, C. I., & Osser, D. N. (2019) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000197 · Cited by 27 · see citing works
Impact of serotonin transporter gene on rTMS augmentation of SSRIs for obsessive compulsive disorder
Zhang, K., Fan, X., Yuan, J., Yin, J., Su, H., Hashimoto, K., & Wang, G. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s209319 · Cited by 26 · see citing works
The Pharmacological Treatment of Obsessive-Compulsive Disorder
Pittenger, C. (2023) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2022.11.005 · Cited by 26 · see citing works
Self-citationClinical Pharmacology of Comorbid Obsessive–Compulsive Disorder in Tourette Syndrome
Neri, V., & Cardona, F. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-411546-0.00013-5 · Cited by 25 · see citing works
Liang, S.-C., Sun, C., Fan, H.-Y., Chung, W., Tzang, R., Hung, K., Chiu, H., Cheng, Y., & Yeh, P. (2022) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.210191 · Cited by 24 · see citing works
Emerging drugs to treat obsessive–compulsive disorder
Pallanti, S., Grassi, G., & Cantisani, A. (2013) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2014.875157 · Cited by 23 · see citing works
Treating OCD: what to do when first-line therapies fail
Castle, D. J., Bosanac, P., & Rossell, S. L. (2015) · Australasian Psychiatry · doi:10.1177/1039856215590027 · Cited by 23 · see citing works
Pittenger, C., Brennan, B. P., Koran, L. M., Mathews, C. A., Nestadt, G., Pato, M. T., Phillips, K. A., Rodríguez, C. I., Simpson, H. B., Skapinakis, P., et al. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113853 · Cited by 22 · see citing works
Self-citationAndrade, C. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13f08883 · Cited by 22 · see citing works
Arrojo, M., Alonso, M. T., & de León, J. (2013) · Case Reports in Psychiatry · doi:10.1155/2013/612459 · Cited by 22 · see citing works
Error-related brain activity and internalizing disorder symptom dimensions in depression and anxiety
Gorka, S. M., Burkhouse, K. L., Afshar, K., & Phan, K. L. (2017) · Depression and Anxiety · doi:10.1002/da.22648 · Cited by 22 · see citing works
Johnson, C. F. A., Maxwell, M., Williams, B., Dougall, N. J., & MacGillivray, S. A. (2022) · BMJ Medicine · doi:10.1136/bmjmed-2021-000017 · Cited by 26 · see citing works
Yan, H., Shan, X., Li, H., Liu, F., & Guo, W. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.906534 · Cited by 21 · see citing works
Obsessive-Compulsive Disorder: Diagnosis, Epidemiology, Etiology, and Treatment
Sassano-Higgins, S. A., & Pato, M. T. (2015) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.130211 · Cited by 19 · see citing works
Pharmacoepidemiology of obsessive–compulsive disorder: A Swedish nationwide cohort study
Isomura, K., Nordsletten, A. E., Rück, C., Ljung, R., Ivarsson, T., Larsson, H., & Mataix‐Cols, D. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.02.004 · Cited by 20 · see citing works
Pharmacotherapy of obsessive-compulsive disorder during pregnancy: a clinical approach
Uğuz, F. (2015) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2015-1673 · Cited by 20 · see citing works
Challenges in the diagnosis and treatment of pediatric obsessive–compulsive disorder
Stewart, S. E., & Westwell-Roper, C. Y. (2019) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_524_18 · Cited by 21 · see citing works
Assessment and Medication Management of Paediatric Obsessive-Compulsive Disorder
Stewart, S. E., Hezel, D. M., & Stachon, A. C. (2012) · Drugs · doi:10.2165/11632860-000000000-00000 · Cited by 20 · see citing works
Sarris, J., Byrne, G., Castle, D., Bousman, C., Oliver, G., Cribb, L., Blair-West, S., Brakoulias, V., Camfield, D., Ee, C., et al. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110550 · Cited by 19 · see citing works
- Authors
- Bloch, M. H., McGuire, J., Landeros-Weisenberger, A., Leckman, J. F., & Pittenger, C.
- Affiliations
- Yale University (US)
- Corresponding author
- Bloch, M H
- Venue
- Molecular Psychiatry
- Published
- 2009-05-26
- Volume
- 15
- Issue
- 8
- Pages
- 850-855
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC2888928
- OpenAlex
- W2101582587
- Cited by
- 317
- References
- 23
- Citations by year
- 2026: 24 · 2025: 23 · 2024: 24 · 2023: 20 · 2022: 22 · 2021: 15 · 2020: 14 · 2019: 23 · 2018: 17 · 2017: 15 · 2016: 17 · 2015: 34 · 2014: 22 · 2013: 12 · 2012: 17
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R34MH083115, K08MH081190, K05MH076273, K23MH091240, T32MH018268)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- obsessive-compulsive disorder, selective serotonin reuptake inhibitors, dose-response relationship, treatment efficacy, tolerability, adverse effects, treatment discontinuation, Yale-Brown Obsessive Compulsive Scale, antidepressant dosing
- MeSH terms
- Analysis of Variance, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Obsessive-Compulsive Disorder, Randomized Controlled Trials as Topic, Outcome Assessment, Health Care, Selective Serotonin Reuptake Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
