A family-based study of common polygenic variation and risk of schizophrenia
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If rare variants contribute, they do so in the context of many other genetic variants in pedigrees, as shown by a recent analysis of schizophrenia genetics.
“If rare variants are contributing then they are doing so in the context of many other genetic variants in the pedigrees, as shown by a recent analysis of schizophrenia genetics54.”
From Rare and common variants: twenty arguments (2012) · cites this paper as [54]
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Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities
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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
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Common SNPs explain a large proportion of the heritability for human height
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
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Self-citationHundreds of variants clustered in genomic loci and biological pathways affect human height
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- Authors
- Ruderfer, D. M., Kirov, G., Chambert, K., Moran, J. L., Owen, M. J., O'Donovan, M. C., Sklar, P., & Purcell, S. M.
- Affiliations
- Broad Institute (US)
- Cardiff University (GB)
- Corresponding author
- Purcell, S M
- Venue
- Molecular Psychiatry
- Published
- 2011-04-12
- Volume
- 16
- Issue
- 9
- Pages
- 887-888
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC4189087
- OpenAlex
- W2138329909
- Cited by
- 28
- References
- 9
- Citations by year
- 2024: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 6 · 2012: 7
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Human Genome Research Institute (R01HG005827)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- schizophrenia, polygenic risk, common genetic variants, family-based association, genetic risk factors
- MeSH terms
- Family, Humans, Schizophrenia, Genetic Predisposition to Disease, Multifactorial Inheritance, Genome-Wide Association Study
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