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Cited by 483

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology

Open access
Fonken, L K, Xu, X, Weil, Z M, Chen, G, Sun, Q, Rajagopalan, S, Nelson, R J·2011·Molecular Psychiatry
DOI 10.1038/mp.2011.76
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Abstract

Particulate matter air pollution is a pervasive global risk factor implicated in the genesis of pulmonary and cardiovascular disease. Although the effects of prolonged exposure to air pollution are well characterized with respect to pulmonary and cardiovascular function, comparatively little is known about the impact of particulate matter on affective and cognitive processes. The central nervous system may be adversely affected by activation of reactive oxygen species and pro-inflammatory pathways that accompany particulate matter pollution. Thus, we investigated whether long-term exposure to ambient fine airborne particulate matter (<2.5 μm (PM2.5)) affects cognition, affective responses, hippocampal inflammatory cytokines and neuronal morphology. Male mice were exposed to either PM2.5 or filtered air (FA) for 10 months. PM2.5 mice displayed more depressive-like responses and impairments in spatial learning and memory as compared with mice exposed to FA. Hippocampal pro-inflammatory cytokine expression was elevated among PM2.5 mice. Apical dendritic spine density and dendritic branching were decreased in the hippocampal CA1 and CA3 regions, respectively, of PM2.5 mice. Taken together, these data suggest that long-term exposure to particulate air pollution levels typical of exposure in major cities around the globe can alter affective responses and impair cognition.

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Metadata

Authors
Fonken, L. K., Xu, X., Weil, Z. M., Chen, G., Sun, Q., Rajagopalan, S., & Nelson, R. J.
Venue
Molecular Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2011-07-05
Volume
16
Issue
10
Pages
987-995
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
DOI
10.1038/mp.2011.76
OpenAlex
W1997147328
Cited by
483
References
12
FWCI
7.72
Type
journal article
Language
en
Open access
green

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