The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Efficient translation initiation dictates codon usage at gene start
Open accessAbstract
The genetic code is degenerate; thus, protein evolution does not uniquely determine the coding sequence. One of the puzzles in evolutionary genetics is therefore to uncover evolutionary driving forces that result in specific codon choice. In many bacteria, the first 5–10 codons of protein‐coding genes are often codons that are less frequently used in the rest of the genome, an effect that has been argued to arise from selection for slowed early elongation to reduce ribosome traffic jams. However, genome analysis across many species has demonstrated that the region shows reduced mRNA folding consistent with pressure for efficient translation initiation. This raises the possibility that unusual codon usage is a side effect of selection for reduced mRNA structure. Here we discriminate between these two competing hypotheses, and show that in bacteria selection favours codons that reduce mRNA folding around the translation start, regardless of whether these codons are frequent or rare. Experiments confirm that primarily mRNA structure, and not codon usage, at the beginning of genes determines the translation rate.
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Causes and effects of N-terminal codon bias in bacterial genes
Goodman, D. B., Church, G. M., & Kosuri, S. (2013) · Science · doi:10.1126/science.1241934 · Cited by 573
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Widespread Co-translational RNA Decay Reveals Ribosome Dynamics
Pelechano, V., Wei, W., & Steinmetz, L. M. (2015) · Cell · doi:10.1016/j.cell.2015.05.008 · Cited by 324
Jia, B., & Jeon, C. O. (2016) · Open Biology · doi:10.1098/rsob.160196 · Cited by 295
Pervasive Regulatory Functions of mRNA Structure Revealed by High-Resolution SHAPE Probing
Mustoe, A. M., Busan, S., Rice, G. M., Hajdin, C. E., Peterson, B. K., Ruda, V. M., Kubica, N., Nutiu, R., Baryza, J. L., & Weeks, K. M. (2018) · Cell · doi:10.1016/j.cell.2018.02.034 · Cited by 258
Metadata
- Authors
- Bentele, K., Saffert, P., Rauscher, R., Ignatova, Z., & Blüthgen, N.
- Venue
- Molecular Systems Biology
- Published
- 2013-01
- Volume
- 9
- Issue
- 1
- Pages
- 675-675
- ISSN
- 1744-4292 (ISSN-L)
- OpenAlex
- W2157913328
- Cited by
- 309
- References
- 44
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bentele, K., Saffert, P., Rauscher, R., Ignatova, Z., & Blüthgen, N. (2013). Efficient translation initiation dictates codon usage at gene start. Molecular Systems Biology. https://doi.org/10.1038/msb.2013.32
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