Preclinical Safety Evaluation of AAV2-sFLT01— A Gene Therapy for Age-related Macular Degeneration

MacLachlan, Timothy K, Lukason, Michael, Collins, Margaret, Munger, Robert, Isenberger, Elisabete, Rogers, Cindy, Malatos, Shana, DuFresne, Elizabeth, Morris, James, Calcedo, Roberto, Veres, Gabor, Scaria, Abraham, Andrews, Laura, Wadsworth, Samuel·2011·Molecular Therapy
DOI 10.1038/mt.2010.258

Cited by (166)

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  10. Antiangiogenic AAV2 gene therapy with a truncated form of soluble VEGFR-2 reduces the growth of choroidal neovascularization in mice after intravitreal injection
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  11. Optimisation of AAV-NDI1 Significantly Enhances Its Therapeutic Value for Correcting Retinal Mitochondrial Dysfunction
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  12. Clinical Characteristics of Neovascular Age‐Related Macular Degeneration without Typical Drusen
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  13. Retinal and Choroidal Neovascularization Antivascular Endothelial Growth Factor Treatments: The Role of Gene Therapy
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  14. Breaking and Sealing Barriers in Retinal Gene Therapy
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  15. X-linked Retinoschisis and Gene Therapy
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  16. Inhibition of pathological brain angiogenesis through systemic delivery of AAV vector expressing soluble FLT1
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  17. Safety and efficacy of CRISPR-mediated genome ablation of VEGFA as a treatment for choroidal neovascularization in nonhuman primate eyes
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  18. Morphological evaluation of retinal ganglion cells expressing the L132C/T159C ChR2 mutant transgene in young adult cynomolgus monkeys
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  19. Today and Future of Age-Related Macular Degeneration
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  20. Gene Therapies for Neovascular Age-Related Macular Degeneration
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  21. Importance of nonhuman primates as a model system for gene therapy development in ophthalmology
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  22. Peripheral cellular immune responses induced by subretinal adeno-associated virus gene transfer can Be restrained by the subretinal-associated immune inhibition mechanism
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  23. Defects and asymmetries in the visual pathway of non-human primates with natural strabismus and amblyopia
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  24. Inhibitors of Angiogenesis
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  25. Gene Delivery of Calreticulin Anti-Angiogenic Domain Attenuates the Development of Choroidal Neovascularization in Rats
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  26. Viral vectors engineered for gene therapy
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  27. Anti-Angiogenic Treatment for Exudative Age-Related Macular Degeneration: New Strategies are Underway
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  28. Preventive, Diagnostic and Therapeutic Applications of Baculovirus Expression Vector System
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  29. Retinal Viral Gene Therapy: Impact of Route of Administration on Serious Adverse Events—A Systematic Review
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  30. Single-dose AAV vector gene immunotherapy to treat food allergy
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  31. Age-related macular degeneration (AMD): Current concepts in pathogenesis and prospects for treatment
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  32. Intracellular virion traffic to the endosome driven by cell type specific sialic acid receptors determines parvovirus tropism
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  33. Gene Therapy for Blinding Pediatric Eye Disorders
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  34. Gene modification: Exploring the potential in treating kidney diseases
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  35. MiRGD peptideticle targeted delivery of hinge-truncated soluble VEGF receptor 1 fusion protein to the retinal pigment epithelium cell line and newborn mice retina
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  36. [Gene therapy for hereditary ophthalmological diseases: Advances and future perspectives].
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  37. Gene Therapy for Retinal Disease
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  38. Chapter 3 - Restoring Vision to the Blind: Gene Therapy for Vision Loss
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  39. Gene Therapy for Vision Disorders
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  40. Gene Therapy for Choroidal Neovascularization
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  41. Administration of Ocular Gene Therapy
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  42. Ocular Gene Therapies
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  43. New innovations for ocular gene therapy
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  44. An optimized gene transfection system in WERI-Rb1 cells
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  45. Inhibitors of Angiogenesis
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  46. Ocular Gene Therapies
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  47. Gene Therapy for Retinal Diseases Is Within Sight
    Charles C. Wykoff · 2014
  48. Extended release anti-VEGF systems: a strategy whose time has come? Or already gone?
    Michael W. Stewart · 2016 · Expert Review of Ophthalmology
  49. Anti-Angiogenic Gene Therapy: Basic Science and Challenges for Translation into the Clinic
    Clemens Lange, James W. Bainbridge · 2016 · Essentials in ophthalmology/Essentials ophthalmology
  50. Antiangiogenic Agents and Photodynamic Therapy
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  51. EXPERIMENTAL AND CLINICAL OCULAR GENE THERAPY
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  52. Genetic testing in translational ophthalmology
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  53. Terapia Génica en Degeneración Macular Relacionada con la Edad
    René Alfredo Cano-Hidalgo, Carlos Quezada-Ruiz · 2013 · Highlights of Vitreoretina
  54. Digital Droplet PCR Method for the Quantification of AAV Transduction Efficiency in Murine Retina
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  55. Gene and Cell Therapy Products
    Peter K. Working · 2014
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  57. Cellular Immune Responses Induced by Subretinal AAV Gene Transfer can be Restrained by the Subretinal Associated Immune Inhibition Mechanism
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  58. Role of stem cell engineering and or gene-editing technologies in eye diseases degeneration, and therapy
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  59. Gene Expression and Editing in Mammalian Retinal Ganglion Cells
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  60. Gene Therapy for Cornea, Conjunctiva, and Lacrimal Gland
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  61. Synthesis and characterization of an injectable telechelic material for the epiretinal delivery of retinal gene therapies
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  63. Evolution dirigée de virus adéno-associés pour un transfert de gène efficace dans le système visuel
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  65. Safety and Efficacy of cceAAV-aflibercept-Fc-YTE (F-CRG-B191): A Gene Therapy for Neovascular Age-Related Macular Degeneration
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