Scaria, Abraham

CRISPR/Cas9-Mediated Genome Editing as a Therapeutic Approach for Leber Congenital Amaurosis 10

Ruan, G.-X., Barry, E., Yu, D., Lukason, M., Cheng, S. H., & Scaria, A. (2017) · Molecular Therapy

CRISPR and Genetic EngineeringRetinal Development and Disorders

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Intravitreous injection of AAV2-sFLT01 in patients with advanced neovascular age-related macular degeneration: a phase 1, open-label trial

Heier, J. S., Kherani, S., Desai, S., Dugel, P., Kaushal, S., Cheng, S. H., Delacono, C., Purvis, A., Richards, S., Le-Halpere, A., et al. (2017) · The Lancet

Retinal Diseases and TreatmentsRetinal Development and Disorders

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Preclinical safety evaluation of AAV2-sFLT01— a gene therapy for age-related macular degeneration

MacLachlan, T. K., Lukason, M., Collins, M., Munger, R., Isenberger, E., Rogers, C., Malatos, S., DuFresne, E., Morris, J., Calcedo, R., et al. (2011) · Molecular Therapy

Virus-based gene therapy researchRetinal Development and Disorders

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Analytical Ultracentrifugation as an Approach to Characterize Recombinant Adeno-Associated Viral Vectors

Burnham, B., Nass, S., Kong, E., Mattingly, M., Woodcock, D., Song, A., Wadsworth, S., Cheng, S. H., Scaria, A., & O'Riordan, C. R. (2015) · Human Gene Therapy Methods

Virus-based gene therapy researchProtein purification and stability

Cited by 150

Universal Method for the Purification of Recombinant AAV Vectors of Differing Serotypes

Nass, S. A., Mattingly, M. A., Woodcock, D. A., Burnham, B. L., Ardinger, J. A., Osmond, S. E., Frederick, A. M., Scaria, A., Cheng, S. H., & O’Riordan, C. R. (2018) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchProtein purification and stability

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Novel anti-VEGF chimeric molecules delivered by AAV vectors for inhibition of retinal neovascularization

Pechan, P., Rubin, H., Lukason, M., Ardinger, J., DuFresne, E., Hauswirth, W. W., Wadsworth, S. C., & Scaria, A. (2009) · Gene Therapy

Angiogenesis and VEGF in CancerRetinal Development and Disorders

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Rationally designed AAV2 and AAVrh8R capsids provide improved transduction in the retina and brain

Sullivan, J. A., Stanek, L. M., Lukason, M. J., Bu, J., Osmond, S. R., Barry, E. A., O’Riordan, C. R., Shihabuddin, L. S., Cheng, S. H., & Scaria, A. (2018) · Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

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