Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms
Akinc, Akin, Querbes, William, De, Soma, Qin, June, Frank-Kamenetsky, Maria, Jayaprakash, K. Narayanannair, Jayaraman, Muthusamy, Rajeev, Kallanthottathil G +17 more·2010·Molecular Therapy
Cited by (1,002)
Items 501–600 of 1,002
- High-density lipoproteins for the systemic delivery of short interfering RNAKaylin Marie McMahon, Colby Shad Thaxton · 2013 · Expert Opinion on Drug Delivery
- Neutralized Nanoparticle Composed of SS‐Cleavable and pH‐Activated Lipid‐Like Material as a Long‐Lasting and Liver‐Specific Gene Delivery SystemMasami Ukawa, Hidetaka Akita, Yasuhiro Hayashi, Ryohei Ishiba, Kota Tange, Masaya Arai, Kazuhiro Kubo, Yuriko Higuchi, Kazunori Shimizu, Satoshi Konishi et al. · 2014 · Advanced Healthcare Materials
- Rapid Generation of Circulating and Mucosal Decoy Human ACE2 using mRNA Nanotherapeutics for the Potential Treatment of SARS‐CoV‐2Jeonghwan Kim, Antony Jozić, Anindit Mukherjee, Dylan Nelson, Kevin Chiem, Md. Siddiqur Rahman Khan, Jordi Bertran Torrelles, Luis Martínez‐Sobrido, Gaurav Sahay · 2022 · Advanced Science
- The effects of lipoplex formulation variables on the protein corona and comparisons with in vitro transfection efficiencyJamie L. Betker, Joe Gomez, Thomas J. Anchordoquy · 2013 · Journal of Controlled Release
- Harnessing Protein Corona for Biomimetic Nanomedicine DesignZhidong Chen, Xu Chen, Juyang Huang, Junqing Wang, Zhe Wang · 2022 · Biomimetics
- Sex‐Based Differences in the Biodistribution of Nanoparticles and Their Effect on Hormonal, Immune, and Metabolic FunctionMaria Poley, Gal Chen, Noga Sharf‐Pauker, Aviram Avital, Maya Kaduri, Mor Sela, Patricia Mora‐Raimundo, Lilach Koren, Sivan Arber, Egor Egorov et al. · 2022 · Advanced NanoBiomed Research
- Receptor–mediated transcytosis of macromolecules across the blood–brain barrierHabib Baghirov · 2023 · Expert Opinion on Drug Delivery
- Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human SkinJuliana Bolsoni, Danny X. Liu, Fatemeh Mohabatpour, Ronja Ebner, Gaurav Sadhnani, Belal Tafech, Jerry Leung, Selina Rahman Shanta, Kevin An, Tessa Morin et al. · 2023 · ACS Nano
- Organ- and Cell-Selective Delivery of mRNA In Vivo Using Guanidinylated Serinol Charge-Altering Releasable TransportersZhijian Li, Laura Amaya, Aloysius Ee, Sean K. Wang, Alok Ranjan, Robert M. Waymouth, Howard Y. Chang, Paul A. Wender · 2024 · Journal of the American Chemical Society
- Exploring the Challenges of Lipid Nanoparticle Development: The In Vitro–In Vivo Correlation GapSarah Lindsay, Muattaz Hussain, Burcu Binici, Yvonne Perrie · 2025 · Vaccines
- Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancersBrandon M. Lehrich, Evan R. Delgado, Tyler M. Yasaka, Silvia Liu, Catherine Cao, Yuqing Liu, Mohammad Naser Taheri, Xiangnan Guan, Hartmut Koeppen, Sucha Singh et al. · 2025 · Nature Communications
- A magnetic separation method for isolating and characterizing the biomolecular corona of lipid nanoparticlesValentina Francia, Yao Zhang, Miffy H. Y. Cheng, Raymond Michel Schiffelers, Dominik Witzigmann, Pieter R. Cullis · 2024 · Proceedings of the National Academy of Sciences
- Nanotechnology for In vivo Targeted siRNA DeliveryJames E. Dahlman, Kevin J. Kauffman, Róbert Langer, Daniel G. Anderson · 2014 · Advances in genetics
- RNA Interference Trigger Variants: Getting the Most Out of RNA for RNA Interference-Based TherapeuticsNicholas M. Snead, John J. Rossi · 2012 · Nucleic Acid Therapeutics
- Loss of α-catenin elicits a cholestatic response and impairs liver regenerationKeira Joann Herr, Ying‐Hung Nicole Tsang, Joanne Ong, Qiushi Li, Lai Lai Yap, Weimiao Yu, Hao Yin, Roman L. Bogorad, James E. Dahlman, Yee Gek Chan et al. · 2014 · Scientific Reports
- Biomaterials in RNAi therapeutics: quo vadis?Ernst Wagner · 2013 · Biomaterials Science
- PEGylation of the GALA Peptide Enhances the Lung-Targeting Activity of Nanocarriers That Contain Encapsulated siRNASarochin Santiwarangkool, Hidetaka Akita, Taichi Nakatani, Kenji Kusumoto, Hiroki Kimura, Masaru Suzuki, Masaharu Nishimura, Yusuke Sato, Hideyoshi Harashima · 2017 · Journal of Pharmaceutical Sciences
- Design of synthetic materials for intracellular delivery of RNAs: From siRNA-mediated gene silencing to CRISPR/Cas gene editingJason B. Miller, Daniel J. Siegwart · 2018 · Nano Research
- Charge-reversible lipid derivative: A novel type of pH-responsive lipid for nanoparticle-mediated siRNA deliveryYusuke Hirai, Saeki Ryoko, Furan Song, Hiroyuki Koide, Fukata Naofumi, Koji Tomita, Noriyuki Maeda, Naoto Oku, Tomohiro Asai · 2020 · International Journal of Pharmaceutics
- Gene Therapy Targeting PCSK9Julius L. Katzmann, Arjen J. Cupido, Ulrich Laufs · 2022 · Metabolites
- Development and Characterization of an In Vitro Cell-Based Assay to Predict Potency of mRNA–LNP-Based VaccinesNisarg Patel, Zach Davis, Carl Hofmann, Josef Vlasak, John W. Loughney, Pete A. DePhillips, Malini Mukherjee · 2023 · Vaccines
- Advances in dendritic cell targeting nano-delivery systems for induction of immune toleranceGuojiao Lin, Jialiang Wang, Yong‐Guang Yang, Yuning Zhang, Tianmeng Sun · 2023 · Frontiers in Bioengineering and Biotechnology
- Time-Resolved Inspection of Ionizable Lipid-Facilitated Lipid Nanoparticle Disintegration and Cargo Release at an Early Endosomal Membrane MimicNima Aliakbarinodehi, Simon Niederkofler, Gustav Emilsson, Petteri Parkkila, Erik Olsén, Yujia Jing, Mattias Sjöberg, Björn Agnarsson, Lennart Lindfors, Fredrik Höök · 2024 · ACS Nano
- A perspective on the apparent pKa of ionizable lipids in mRNA-LNPsJens B. Simonsen, Per Larsson · 2025 · Journal of Controlled Release
- Cationic Nanohydrogel Particles for Therapeutic Oligonucleotide DeliveryNadine Leber, Lutz Nuhn, Rudolf Zentel · 2017 · Macromolecular Bioscience
- Efficient siRNA Delivery by Lipid Nanoparticles Modified with a Nonstandard Macrocyclic Peptide for EpCAM-TargetingYu Sakurai, Wataru Mizumura, Manami Murata, Tomoya Hada, Shoshiro Yamamoto, Kenichiro Ito, Kazuhiro Iwasaki, Takayuki Katoh, Yuki Goto, Asako Takagi et al. · 2017 · Molecular Pharmaceutics
- Correlation of mRNA delivery timing and protein expression in lipid-based transfectionAnita Reiser, Daniel Woschée, Neha Mehrotra, Rafał Krzysztoń, Helmut H. Strey, Joachim Oskar Rädler · 2019 · Integrative Biology
- Boosting ionizable lipid nanoparticle-mediated in vivo mRNA delivery through optimization of lipid amine-head groupsFeng Ding, Hongqian Zhang, Jiwei Cui, Qiang Li, Chuanxu Yang · 2021 · Biomaterials Science
- Recent Advancements in the Design of Nanodelivery Systems of siRNA for Cancer TherapyDokkari Nagalaxmi Yadav, Mohammad Sadik Ali, Ajinkya Madhukar Thanekar, Sunil Venkanna Pogu, Aravind Kumar Rengan · 2022 · Molecular Pharmaceutics
- Versatile cationic lipids for siRNA deliveryJeff Sparks, Gregory Slobodkin, Majed M. Matar, Richard Congo, David Ulkoski, Angela Rea-Ramsey, Casey Pence, Jennifer S. Rice, Diane McClure, Kevin J. Polach et al. · 2011 · Journal of Controlled Release
- The biomolecular corona of nanomedicines: effects on nanomedicine outcomes and emerging opportunitiesAnna Laura Salvati · 2024 · Current Opinion in Biotechnology
- Rational design of lipid nanoparticles for enabling gene therapiesCedric A. Brimacombe, Jayesh A. Kulkarni, Miffy H. Y. Cheng, Kevin An, Dominik Witzigmann, Pieter R. Cullis · 2025 · Molecular Therapy — Methods & Clinical Development
- Next Generation Delivery System for Proteins and Genes of Therapeutic Purpose: Why and How?Ashish Ranjan Sharma, Shyamal Kumar Kundu, Ju‐Suk Nam, Garima Sharma, C. George Priya Doss, Sang‐Soo Lee, Chiranjib Chakraborty · 2014 · BioMed Research International
- Evolution of drug delivery system from viewpoint of controlled intracellular trafficking and selective tissue targeting toward future nanomedicineYuma Yamada, Yusuke Sato, Takashi Nakamura, Hideyoshi Harashima · 2020 · Journal of Controlled Release
- Silencing Apoe with divalent‐siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's diseaseChantal M. Ferguson, Samuel R. Hildebrand, Bruno M.D.C. Godinho, Julianna E. Buchwald, Dimas Echeverria, Andrew H. Coles, Anastasia P. Grigorenko, Lorenc Vangjeli, Jacquelyn Sousa, Nicholas McHugh et al. · 2024 · Alzheimer s & Dementia
- Reducing off-target expression of mRNA therapeutics and vaccines in the liver with microRNA binding sitesBrian J. Parrett, Satoko Yamaoka, Michael A. Barry · 2024 · Molecular Therapy — Methods & Clinical Development
- Lysine-functionalized nanodiamonds as gene carriers: development of stable colloidal dispersion for in vitro cellular uptake studies and siRNA delivery applicationIldikó Badea, Saniya Alwani, Randeep Kaur, Deborah L. Michel, Jackson Mulenga Chitanda, Ronald Ernest Verrall, Chithra Karunakaran · 2016 · International Journal of Nanomedicine
- Drug delivery across length scalesDerfogail Delcassian, Asha Kumari Patel, Abel B. Cortinas, Róbert Langer · 2018 · Journal of drug targeting
- Non-viral siRNA delivery to T cells: Challenges and opportunities in cancer immunotherapyJelter Van Hoeck, Kevin Braeckmans, Stefaan C. De Smedt, Koen Raemdonck · 2022 · Biomaterials
- pH-Responsive polymer boosts cytosolic siRNA release for retinal neovascularization therapyGuo, Shuai, Li, Chunhui, Wang, Changrong, Cao, Xiaowen, Liu, Xinyue, Liang, Xing-Jie, Huang, Yuanyu, Weng, Yuhua · 2024 · Acta Pharmaceutica Sinica B
- siRNA delivery to lymphatic endothelial cells via ApoE-mediated uptake by lipid nanoparticlesYu Sakurai, Keito Yoshikawa, Kenta Arai, Akira Kazaoka, Shigeki Aoki, Kousei Ito, Yuta Nakai, Kota Tange, Tomomi Furihata, Hiroki Tanaka et al. · 2022 · Journal of Controlled Release
- Targeted delivery strategies: The interactions and applications of nanoparticles in liver diseasesXiandi Meng, Ge Zhu, Yong‐Guang Yang, Tianmeng Sun · 2024 · Biomedicine & Pharmacotherapy
- Reductively Responsive Hydrogel Nanoparticles with Uniform Size, Shape, and Tunable Composition for Systemic siRNA Delivery in VivoDa Ma, Shaomin Tian, Jeremy L. Baryza, J. Christopher Luft, Joseph M. DeSimone · 2015 · Molecular Pharmaceutics
- Micro RNA s in neutrophils: potential next generation therapeutics for inflammatory ailmentsTheodore Gurol, Wenqing Zhou, Qing Deng · 2016 · Immunological Reviews
- Morphology, Structure and Function Characterization of PEI Modified Magnetic Nanoparticles Gene Delivery SystemXiang Zhao, Haixin Cui, Wenjie Chen, Yan Wang, Bo Cui, Changjiao Sun, Zhigang Meng, Guoqiang Liu · 2014 · PLoS ONE
- Assessing the Heterogeneity Level in Lipid Nanoparticles for siRNA Delivery: Size-Based Separation, Compositional Heterogeneity, and Impact on BioperformanceJingtao Zhang, Yi Pei, Hangchun Zhang, Lei Wang, Leticia Arrington, Ye Zhang, Angela Glass, Anthony M. Leone · 2012 · Molecular Pharmaceutics
- Gold Nanorods Coated with Apolipoprotein E Protein Corona for Drug DeliveryEugenia L.L. Yeo, Joshua U-Jin Cheah, Patricia S. P. Thong, Khee Chee Soo, James Chen Yong Kah · 2019 · ACS Applied Nano Materials
- Impact of non-ionizable lipids and phase mixing methods on structural properties of lipid nanoparticle formulationsAnna Pratsinis, Yuchen Fan, Michaela Portmann, Michal Hammel, Ponien Kou, Apoorva Sarode, Philippe Ringler, Ľubomír Kováčik, Matthias E. Lauer, Jens Lamerz et al. · 2023 · International Journal of Pharmaceutics
- RNA-based modulation of macrophage-mediated efferocytosis potentiates antitumor immunity in colorectal cancerXuefei Zhou, Dezhi Li, Shenglong Xia, Xixi Ma, Rong Li, Yongli Mu, Zimo Liu, Lu Zhang, Quan Zhou, Wei Zhuo et al. · 2023 · Journal of Controlled Release
- Advancing cancer gene therapy: the emerging role of nanoparticle delivery systemsMao‐Ze Wang, Huina Liu, Jinling Huang, Ting Cai, Zhi Ping Xu, Lingxiao Louis Zhang · 2025 · Journal of Nanobiotechnology
- Active radar guides missile to its target: receptor-based targeted treatment of hepatocellular carcinoma by nanoparticulate systemsJingjun Yan, Jiazhi Liao, Ju‐Sheng Lin, Xingxing He · 2014 · Tumor Biology
- Optimized In Vivo Transfer of Small Interfering RNA Targeting Dermal Tissue Using In Vivo Surface ElectroporationKate E. Broderick, Amy Chan, Feng Wu Lin, Xuefei Shen, Gleb Kichaev, Amir Sada Khan, Justin Aubin, Tracy S. Zimmermann, Niranjan Y. Sardesai · 2012 · Molecular Therapy — Nucleic Acids
- Polymeric nanomedicines for the treatment of hepatic diseasesFeixiang Luo, Ying Fang Yu, Mingqian Li, Yuguo Chen, Peng Zhang, Chunsheng Xiao, Guoyue Lv · 2022 · Journal of Nanobiotechnology
- Single-domain antibody delivery using an mRNA platform protects against lethal doses of botulinum neurotoxin AEugenia A. Panova, Denis A. Kleymenov, Dmitry V. Shcheblyakov, Evgeniia N. Bykonia, Elena P. Mazunina, Alina Sh. Dzharullaeva, Anastasia N. Zolotar, Artem A. Derkaev, Ilias B. Esmagambetov, Ivan I. Sorokin et al. · 2023 · Frontiers in Immunology
- Development of nucleic acid medicines based on chemical technologyYusuke Kawamoto, You Wu, Yuki Takahashi, Yoshinobu Takakura · 2023 · Advanced Drug Delivery Reviews
- State-of-the-Art Review on Inhalable Lipid and Polymer Nanocarriers: Design and Development PerspectivesGabriella Costabile, Gemma Conte, Susy Brusco, Pouria Savadi, Agnese Miro, Fabiana Quaglia, Ivana d’Angelo, Francesca Ungaro · 2024 · Pharmaceutics
- In Vivo Endothelial Cell Gene Silencing by siRNA‐LNPs Tuned with Lipoamino Bundle Chemical and Ligand TargetingMina Yazdi, Jana Pöhmerer, Morteza Hasanzadeh Kafshgari, Johanna Seidl, Melina Grau, Miriam Höhn, Victoria Vetter, Cosima C. Hoch, Barbara Wollenberg, Gabriele Multhoff et al. · 2024 · Small
- Quantitative Visualization of Lipid Nanoparticle Fusion as a Function of Formulation and Process ParametersAlbert Kamanzi, Yao Zhang, Yifei Gu, Faith Liu, Romain Berti, Benjamin L. Wang, Fariba Saadati, Marco A. Ciufolini, Jayesh A. Kulkarni, Pieter R. Cullis et al. · 2024 · ACS Nano
- Engineering Lipid Nanoparticles for mRNA ImmunotherapyRobby C. Zwolsman, Youssef Bahaaeldin Darwish, Ewelina Kluza, Roy van der Meel · 2025 · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
- Replacing cholesterol and PEGylated lipids with zwitterionic ionizable lipids in LNPs for spleen-specific mRNA translationYu Zhao, Zhen Tian, Jialiang Wang, Meng Cui, Zeyu Cao, Pingchuan Liu, Ruoxin Li, Simian Cai, Yuping Hu, Yufei Ma et al. · 2025 · Science Advances
- Small Delivery Vehicles of siRNA for Enhanced Cancer TargetingHyun Jin Kim, Yu Yi, Ahram Kim, Kanjiro Miyata · 2018 · Biomacromolecules
- Delivery of RNAi therapeutics: work in progressAndrew David Miller · 2013 · Expert Review of Medical Devices
- Spleen-targeted nanosystems for immunomodulationFazhan Wang, Jia Lou, Xiaoke Gao, Lijing Zhang, Feifei Sun, Zhaoqing Wang, Tianjiao Ji, Zhihai Qin · 2023 · Nano Today
- Emerging strategies for nanomedicine in autoimmunityAjay S. Thatte, Margaret M. Billingsley, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell · 2024 · Advanced Drug Delivery Reviews
- Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environmentsAdiran Garaizar, Christian David Díaz‐Oviedo, Nina Zablowsky, Sami Rissanen, Johannes Köbberling, Jiawei Sun, Christoph Steiger, Patrick Steigemann, Florian A. Mann, Katharina Meier · 2024 · Proceedings of the National Academy of Sciences
- Novel pharmacotherapies for cardiac amyloidosisKevin Michael Alexander, Avinainder Singh, Rodney H. Falk · 2017 · Pharmacology & Therapeutics
- Engineering lymphocytes with RNAi.S. Ramishetti, D. Peer · 2019 · Advanced Drug Delivery Reviews
- Using CRISPR/Cas9 to model human liver diseaseMichele Alves‐Bezerra, Nika Furey, Collin G. Johnson, Karl‐Dimiter Bissig · 2019 · JHEP Reports
- Isolation methods commonly used to study the liposomal protein corona suffer from contamination issuesKasper Kristensen, Rasmus Münter, Paul Joseph Kempen, Mikkel Eggert Thomsen, Allan Stensballe, Thomas Lars Andresen · 2021 · Acta Biomaterialia
- siRNA-nanoparticle conjugate in gene silencing: A future cure to deadly diseases?Rituparna Acharya, Suman Saha, Sayantan Ray, Sugata Hazra, Manoj Kumar Mitra, Jui Chakraborty · 2017 · Materials Science and Engineering C
- Time evolution of PEG-shedding and serum protein coronation determines the cell uptake kinetics and delivery of lipid nanoparticle formulated mRNAAudrey Gallud, M. J. Munson, Kai Liu, Alexander Idström, Hanna M. G. Barriga, Seyed R. Tabaei, Nima Aliakbarinodehi, Miina Ojansivu, Quentin Lubart, James Doutch et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Increased Bone Marrow Uptake and Accumulation of Very-Late Antigen-4 Targeted Lipid NanoparticlesLaura E. Swart, Marcel H.A.M. Fens, Anita T. van Oort, Piotr Waranecki, L. Daniel Mata Casimiro, D Tuk, Martijn Hendriksen, Luca M. van den Brink, Elizabeth K. Schweighart, Cor W. Seinen et al. · 2023 · Pharmaceutics
- GalNac-siRNA conjugate delivery technology promotes the treatment of typical chronic liver diseasesQin, Zhen-Xin, Zuo, Ling, Zeng, Ziran, Ma, Rongguan, Xie, Wenyan, Zhu, Xiao, Zhou, Xiaorong · 2025 · Expert Opinion on Drug Delivery
- The development of an in vitro assay to screen lipid based nanoparticles for siRNA deliveryYe Zhang, Leticia Arrington, David Boardman, Jared Davis, Yan Xu, Katie DiFelice, Steven M. Stirdivant, Weimin Wang, Brian Budzik, Jack Bawiec et al. · 2013 · Journal of Controlled Release
- Recommendations of the Oligonucleotide Safety Working Group's Formulated Oligonucleotide Subcommittee for the Safety Assessment of Formulated Oligonucleotide-Based TherapeuticsJennifer L. Marlowe, Violetta Akopian, Priya Prakash Karmali, Douglas J. Kornbrust, Jennifer A. Lockridge, Sean C. Semple · 2017 · Nucleic Acid Therapeutics
- Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptideDominik Witzigmann, Philipp Uhl, Sandro Sieber, Christina Kaufman, Tomaž Einfalt, Katrin Schöneweis, Philip Grossen, Jonas Buck, Yi Ni, Susanne Schenk et al. · 2019 · eLife
- Repairing the heart: State-of the art delivery strategies for biological therapeuticsQiangbing Yang, Juntao Fang, Zhiyong Lei, Joost P. G. Sluijter, Raymond Michel Schiffelers · 2020 · Advanced Drug Delivery Reviews
- Strategies and materials of "SMART" non-viral vectors: Overcoming the barriers for brain gene therapyYan Li, Linying Liu, Weihong Ji, Huang Peng, Ruichen Zhao, Xin Zhang · 2020 · Nano Today
- Expanding the Reach of Monoclonal Antibodies: A Review of Synthetic Nucleic Acid Delivery in ImmunotherapyChristopher W. Chung, Sagar B. Kudchodkar, Curtis N. Chung, Young K. Park, Ziyang Xu, Norbert Pardi, Mohamed Abdel‐Mohsen, Kar Muthumani · 2023 · Antibodies
- Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNAJenna L. McCann, Carmen Daniela Sosa‐Miranda, Hui‐Shan Guo, Ryan Reshke, Alexandre Savard, Adriana Zardini Buzatto, James A. Taylor, Liang Li, Derrick Gibbings · 2022 · Journal of Extracellular Vesicles
- Toward low-cost gene therapy: mRNA-based therapeutics for treatment of inherited retinal diseasesPedro Antas, Cláudia Carvalho, Joaquim Cabral-Teixeira, Luísa de Lemos, Miguel C. Seabra · 2023 · Trends in Molecular Medicine
- PEGylated nanoparticles interact with macrophages independently of immune response factors and trigger a non-phagocytic, low-inflammatory responseMonireh Asoudeh, Nicole A Nguyen, Mitch Raith, Desirée S. Denman, Uche C. Anozie, Mahshid Mokhtarnejad, Bamin Khomami, Kaitlyn M. Skotty, Sami Isaac, Taylor Gebhart et al. · 2024 · Journal of Controlled Release
- Oligonucleotide therapies for nonalcoholic steatohepatitisSixu Li, Feng Xiong, Songbo Zhang, Jinghua Liu, Guangping Gao, Jun Hua Xie, Yi Wang · 2024 · Molecular Therapy — Nucleic Acids
- Gene therapy then and now: A look back at changes in the field over the past 25 yearsDan Wang, Gregg Stevens, Terence R. Flotte · 2025 · Molecular Therapy
- Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugatesStephanie E. Barrett, Rob S. Burke, Marc T. Abrams, Carol Bason, Marina Busuek, Edward J. Carlini, Brian Carr, Louis S. Crocker, Haihong Fan, R. M. Garbaccio et al. · 2014 · Journal of Controlled Release
- MicroRNAs in Liver Health and DiseaseShu-Hao Hsu, K. Ghoshal · 2013 · Current Pathobiology Reports
- GalNAc bio-functionalization of nanoparticles assembled by electrostatic interactions improves siRNA targeting to the liverEfrat Korin, Tzlil Bejerano, Smadar Cohen · 2017 · Journal of Controlled Release
- RNA Interference-Based Cancer Drugs: The Roadblocks, and the “Delivery” of the PromiseManisit Das, Sara Musetti, Leaf Huang · 2018 · Nucleic Acid Therapeutics
- Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNSTomoki Hirunagi, Kentaro Sahashi, Kiyoshi Tachikawa, Angel I. Leu, Michelle Nguyen, Rajesh Mukthavaram, Priya Prakash Karmali, Padmanabh Chivukula, Genki Tohnai, Madoka Iida et al. · 2021 · Molecular Therapy — Nucleic Acids
- Screening of the binding affinity of serum proteins to lipid nanoparticles in a cell free environmentFederica Sebastiani, Marianna Yanez Arteta, Lennart Lindfors, Marité Cárdenas · 2021 · Journal of Colloid and Interface Science
- Use of a lipid nanoparticle system as a Trojan horse in delivery of gold nanoparticles to human breast cancer cells for improved outcomes in radiation therapyKyle Bromma, Kristy Rieck, Jayesh A. Kulkarni, Connor O’Sullivan, Wonmo Sung, Pieter R. Cullis, Jan Schuemann, Devika Basnagge Chithrani · 2019 · Cancer Nanotechnology
- Kinetics of RNA-LNP delivery and protein expressionJudith Müller, Nathalie Gabriele Schäffler, Thomas Kellerer, Gerlinde Schwake, Thomas Sumner Ligon, Joachim Oskar Rädler · 2024 · European Journal of Pharmaceutics and Biopharmaceutics
- LNP-mRNA vaccine prevents type 1 diabetes in non-obese diabetes miceJiayin Chen, Yiqi Hu, Yan Chen, Ziqi Zhou, Yiming Shen, Yan Wang, Zichuan Liu, Xianglong Li, Zhigui Su, Jie Wu · 2024 · Journal of Controlled Release
- Synergistic integration of mRNA-LNP with CAR-engineered immune cells: Pioneering progress in immunotherapyZhaozhao Chen, Jinhui Shu, Yu Hu, Heng Mei · 2024 · Molecular Therapy
- Formulated Minimal-Length Synthetic Small Hairpin RNAs Are Potent Inhibitors of Hepatitis C Virus in Mice With Humanized LiversHan Ma, Anne Dallas, Heini Ilves, Joshua Shorenstein, Ian MacLachlan, Klaus Klumpp, Brian H. Johnston · 2013 · Gastroenterology
- Delivery of RNAi-Based Therapeutics for Bone RegenerationDominic W. Malcolm, Yuchen Wang, Clyde T. Overby, Maureen R. Newman, Danielle S. W. Benoit · 2020 · Current Osteoporosis Reports
- Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiencyAmy W. Strilchuk, Scott C. Meixner, Jerry Leung, Nooshin Safikhan, Jayesh A. Kulkarni, Hannah Russell, Roy van der Meel, Michael R. Sutherland, Albert Phillip Owens, Joseph S. Palumbo et al. · 2020 · Blood
- Gene therapy for inherited metabolic diseasesBerna Şeker Yılmaz, Sonam Gurung, Dany P.B. Perocheau, John Robert Counsell, Julien Baruteau · 2020 · PubMed Central
- COVID‐19: Clinical status of vaccine development to dateSunny Kumar, Malini Basu, Pratyasha Ghosh, Aafreen Ansari, Mrinal K. Ghosh · 2022 · British Journal of Clinical Pharmacology
- miRNA Targeting Drugs: The Next Blockbusters?Marco F. Schmidt · 2016 · Methods in molecular biology