Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms

Akinc, Akin, Querbes, William, De, Soma, Qin, June, Frank-Kamenetsky, Maria, Jayaprakash, K. Narayanannair, Jayaraman, Muthusamy, Rajeev, Kallanthottathil G +17 more·2010·Molecular Therapy

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  12. Galactosylated manganese ferrite nanoparticles for targeted MR imaging of asialoglycoprotein receptor
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  23. In vitro transcribed mRNA for expression of designer nucleases: Advantages as a novel therapeutic for the management of chronic HBV infection
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  36. Development of New Genome Editing Tools for the Treatment of Hyperlipidemia
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  40. Polyester nanoparticles delivering chemotherapeutics: Learning from the past and looking to the future to enhance their clinical impact in tumor therapy
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  42. Enhancing the Pharmacokinetic/Pharmacodynamic Properties of Therapeutic Nucleotides Using Lipid Nanoparticle Systems
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  43. Small molecules convey big messages: Boosting non-viral nucleic acid delivery with low molecular weight drugs
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  44. RNA Structure Design Improves Activity and Specificity of trans-Splicing-Triggered Cell Death in a Suicide Gene Therapy Approach
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  45. Better, Faster, Stronger: Accelerating mRNA ‐Based Immunotherapies With Nanocarriers
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  49. Drug Targeting and Nanomedicine: Lessons Learned from Liver Targeting and Opportunities for Drug Innovation
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  53. Optimal delivery strategies for nanoparticle-mediated mRNA delivery
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  54. Quaternization drives spleen-to-lung tropism conversion for mRNA-loaded lipid-like nanoassemblies
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  55. Enhancing precision medicine: Bispecific antibody-mediated targeted delivery of lipid nanoparticles for potential cancer therapy
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  56. Chemical Design Strategy of Ionizable Lipids for In Vivo mRNA Delivery
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  57. Defining ortholog-specific UHRF1 inhibition by STELLA for cancer therapy
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  60. Treatment of Anderson-Fabry Disease
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  61. Viral Mimicry as a Design Template for Nucleic Acid Nanocarriers
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  62. Toward a New Paradigm for Targeted Natriuretic Peptide Enhancement in Heart Failure
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  63. Active transport nanochelators for the reduction of liver iron burden in iron overload
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  67. Lipid nanoparticles: A delicate nucleic acid delivery system to be further explored
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  73. High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering
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  93. Lipid nanoparticles containing labile PEG-lipids transfect primary human skin cells more efficiently in the presence of apoE
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  97. Cellular environment-responsive nanomaterials for use in gene and siRNA delivery: molecular design for biomembrane destabilization and intracellular collapse
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  98. Advances in Development of mRNA-Based Therapeutics
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