Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms
Akinc, Akin, Querbes, William, De, Soma, Qin, June, Frank-Kamenetsky, Maria, Jayaprakash, K. Narayanannair, Jayaraman, Muthusamy, Rajeev, Kallanthottathil G +17 more·2010·Molecular Therapy
Cited by (1,002)
Items 701–800 of 1,002
- APOE polymorphism in ATTR amyloidosis patients treated with lipid nanoparticle siRNANiemietz, Christoph, Nadzemova, Oksana, Zibert, Andree, Schmidt, Hartmut H.-J. · 2020 · Amyloid
- Nonviral targeted mRNA delivery: principles, progresses, and challengesXi He, Guohong Li, Letao Huang, Haixing Shi, Sha Zhong, Siyu Zhao, Xiangyu Jiao, Jinxiu Xin, Xiaoling Yin, Shengbin Liu et al. · 2025 · MedComm
- Structural stability and RNase resistance of mRNA Polyplex micelles for systemic deliveryAnjaneyulu Dirisala, Satoshi Uchida, Kazuko Toh, Junjie Li, Xueying Liu, Panyue Wen, Shigeto Fukushima, Kazunori Kataoka · 2025 · Journal of Controlled Release
- Short-interference RNAs: becoming medicinesTamara Martı́nez, Jiménez, Ana Isabel, Covadonga Pañeda · 2015 · EXCLI journal
- Ligand conjugate SAR and enhanced delivery in NHPRichard Holland, Kieu Lam, Xin Ye, Alan D. Martin, Mark Wood, Lorne Palmer, DAVID D. FRASER, Kevin McClintock, Sara Majeski, Agnes Jarosz et al. · 2021 · Molecular Therapy
- The Potential of Nanomedicine to Unlock the Limitless Applications of mRNALaura Taina-González, María de la Fuente · 2022 · Pharmaceutics
- Synthetic RNA-based post-transcriptional expression control methods and genetic circuitsMalvin Leonardo Pardi, Juanqi Wu, Shunsuke Kawasaki, Hirohide Saito · 2022 · Advanced Drug Delivery Reviews
- In Situ Programming of CAR-T Cells: A Pressing Need in Modern ImmunotherapyMarta Śledź, Alicja Wojciechowska, Radosław Zagożdżon, Beata Kaleta · 2023 · Archivum Immunologiae et Therapiae Experimentalis
- RNA nanomedicine in liver diseasesAnita K. Bakrania, Yulin Mo, Gang Zheng, Mamatha Bhat · 2023 · Hepatology
- Modeling on in vivo disposition and cellular transportation of RNA lipid nanoparticles via quantum mechanics/physiologically-based pharmacokinetic approachesWei Wang, Shiwei Deng, Jinzhong Lin, Defang Ouyang · 2024 · Acta Pharmaceutica Sinica B
- Engineered microRNA therapeuticsNW Gibson · 2014 · The Journal of the Royal College of Physicians of Edinburgh
- Galactosylated manganese ferrite nanoparticles for targeted MR imaging of asialoglycoprotein receptorSeung‐Hyun Yang, Dan Heo, Eugene Lee, Eunjung Kim, Eun‐Kyung Lim, Young Han Lee, Seungjoo Haam, Jin‐Suck Suh, Yong‐Min Huh, Jaemoon Yang et al. · 2013 · Nanotechnology
- One-step scalable preparation method for non-cationic liposomes with high siRNA contentMasaharu Somiya, Kotomi Yamaguchi, Qiushi Liu, Tomoaki Niimi, Andrés Daniel Maturana, Masumi Iijima, Nobuo Yoshimoto, Shun’ichi Kuroda · 2015 · International Journal of Pharmaceutics
- Editing Approaches to Treat Alpha-1 Antitrypsin DeficiencyDerek M. Erion, Leah Y. Liu, Christopher R. Brown, Stephen I. Rennard, Humam Farah · 2024 · CHEST Journal
- In vivo genome editing of human haematopoietic stem cells for treatment of blood disorders using mRNA deliverySaijuan Xu, Dan Liang, Qiudao Wang, Yan Cheng, Da Xie, Gui Yang, Haokun Zhang, Changrui Feng, Feiyan Zhao, Wendan Ren et al. · 2025 · Nature Biomedical Engineering
- Current knowledge on the tissue distribution of mRNA nanocarriers for therapeutic protein expressionMatthias Zadory, Elliot Lopez, Samuel Babity, Simon‐Pierre Gravel, Davide Brambilla · 2022 · Biomaterials Science
- Advances in non-viral mRNA delivery to the spleenEshan A. Narasipura, Owen S. Fenton · 2024 · Biomaterials Science
- Pathways for macrophage uptake of cell-free circular RNAsLaura Amaya, Brian T. Abe, Jie Liu, Feifei Zhao, Wenyan Lucy Zhang, Robert Chen, Rui Li, Steven Wang, Roarke A. Kamber, Miao-Chih Tsai et al. · 2024 · Molecular Cell
- SiRNAs as antiviral drugs – Current status, therapeutic potential and challengesTrairong Chokwassanasakulkit, Victor Baba Oti, Adi Idris, Nigel A.J. McMillan · 2024 · Antiviral Research
- Advanced siRNA delivery in combating hepatitis B virus: mechanistic insights and recent updatesLinh Nguyen, Tiep Tien Nguyen, Juyeon Kim, Jee‐Heon Jeong · 2024 · Journal of Nanobiotechnology
- Covalent conjugation of oligonucleotides with cell-targeting ligandsMd. Rowshon Alam, Xin Ming, Osamu Nakagawa, Jian Jin, Rudy L. Juliano · 2013 · Bioorganic & Medicinal Chemistry
- Asialoglycoprotein Receptor and Targeting StrategiesSaugandha Das, Pawan R. Kudale, Prajakta P. Dandekar, Padma V. Devarajan · 2019 · AAPS advances in the pharmaceutical sciences series
- In vitro transcribed mRNA for expression of designer nucleases: Advantages as a novel therapeutic for the management of chronic HBV infectionAbdullah Ely, Prashika Singh, Tiffany S. Smith, Patrick B. Arbuthnot · 2020 · Advanced Drug Delivery Reviews
- Nanoparticle delivery of a prodrug-activating bacterial enzyme leads to anti-tumor responsesSebastian G. Huayamares, Liming Lian, Regina Rab, Yuning Hou, Afsane Radmand, Hyejin Kim, Ryan Zenhausern, Bhagelu R. Achyut, Melissa Gilbert‐Ross, Melissa P. Lokugamage et al. · 2025 · Nature Communications
- Engineered hybrid cell membrane nanosystems for treating cardiovascular diseasesHe Lu, Yaohui Jiang, Rui Luo, Dexing Zhou, Feihu Zheng, Liran Shi, He Zhang, Yong Wang, Xiao-Dong Xu, Renfang Zou et al. · 2025 · Materials Today Bio
- Computationally Aided Design of Ionizable Cholesteryl Lipids for Lipid Nanoparticles to Modulate Hepatic mRNA AccumulationYilong Teng, Yuxuan Guo, Zhixiang Liu, Maoping Tang, William Stewart, Xiaoyang Xu, Xue‐Qing Zhang · 2025 · Journal of the American Chemical Society
- Effect of phosphatidylcholine on the stability and lipolysis of nanoemulsion drug delivery systemsBo Zhang, Xin Mei Zhou, Yunqiu Miao, Xiaoli Wang, Yuting Yang, Xinxin Zhang, Yong Gan · 2020 · International Journal of Pharmaceutics
- In vivo genome editing using 244-cis LNPs and low-dose AAV achieves therapeutic threshold in hemophilia A miceJeong Pil Han, Yeji Lee, Jeong Hyeon Lee, Hye Yoon Chung, Geon Seong Lee, Yu Ri Nam, Myeongjin Choi, Kyoung‐Sik Moon, Haeshin Lee, Hyukjin Lee et al. · 2023 · Molecular Therapy — Nucleic Acids
- Ionic liquid-coated lipid nanoparticles increase siRNA uptake into CNS targetsPurva Khare, Sara X. Edgecomb, Christine M. Hamadani, James F. Conway, Eden E. L. Tanner, Devika Soundara Manickam · 2023 · Nanoscale Advances
- Nucleic acid delivery by lipid nanoparticles for organ targetingJialin Guo, Mingrui Gu, Yahui Chen, Tao Xiong, Yiyang Zhang, Simin Chen, Mingle Li, Xiaoqiang Chen, Xiaojun Peng · 2025 · Chinese Chemical Letters
- Development and clinical applications of siRNA-encapsulated lipid nanoparticles in cancerPaulo J.C. Lin, Ying K. Tam, Pieter R. Cullis · 2014 · Clinical Lipidology
- Folate-Equipped Cationic Liposomes Deliver Anti-MDR1-siRNA to the Tumor and Increase the Efficiency of ChemotherapyDaniil V. Gladkikh, Сенькова Александра Васильевна, Ivan V. Chernikov, Tatyana O. Kabilova, Nelly A. Popova, Valery P. Nikolin, Elena V. Shmendel, Mikhail A. Maslov, Valentin V. Vlassov, Зенкова Марина Аркадьевна et al. · 2021 · Pharmaceutics
- Recent Advances in mRNA-LNP Delivery Systems for Extrahepatic Organs: A ReviewYing Bai, Li Cui, Tianshu Liu, Zhen Wang, Haiyan Cao, Shukun He, Jiani Qiu, Yingxin Li, Yilan Zhou, Jiawei Shi et al. · 2025 · Molecular Pharmaceutics
- Reprogramming CD22 CAR-T cells in vivo using CD8-targeted mRNA-LNPs to treat hematological malignanciesViktor T. Lemgart, Andrew J. Sawyer, William A. Kuhlman, Aaron P. Griset, Mir M. Ali, Allison Caron, Dharini Shah, Tiffany T. Le, Laura Strauss, Jing Jiao et al. · 2026 · Molecular Therapy
- pH-Responsive Lipid Nanoparticles Achieve Efficient mRNA Transfection in Brain Capillary Endothelial CellsYu Sakurai, Himeka Watanabe, Kazuma Nishio, Kohei Hashimoto, Atsuki Harada, Masaki Gomi, Masayoshi Suzuki, Ryotaro Oyama, Takumi Handa, Risa Sato et al. · 2022 · Pharmaceutics
- Development of New Genome Editing Tools for the Treatment of HyperlipidemiaGiulio Preta · 2023 · Cells
- Design Rules for the Nano‐Bio Interface of Nanodiamonds: Implications for siRNA VectorizationMarek Kindermann, Jitka Neburková, Eva Neuhöferová, Jan Majer, Miroslava Stejfova, Veronika Benson, Petr Cígler · 2024 · Advanced Functional Materials
- Enhancing natural killer cells proliferation and cytotoxicity using imidazole-based lipid nanoparticles encapsulating interleukin-2 mRNAChristophe Delehedde, Ivan Ciganek, Pierre-Louis Bernard, Nabila Laroui, Cathy Costa Da Silva, Cristine Gonçalves, Jacques A. Nunès, Annelise Bennaceur Griscelli, Jusuf Imeri, Matthias Huyghe et al. · 2024 · Molecular Therapy — Nucleic Acids
- Ionizable Drugs Enable Intracellular Delivery of Co‐Formulated siRNAKai V. Slaughter, Eric N. Donders, Michael S. Jones, Sami G. Sabbah, Mitchell J. Elliott, Brian K. Shoichet, David W. Cescon, Molly Sandra Shoichet · 2024 · Advanced Materials
- Polyester nanoparticles delivering chemotherapeutics: Learning from the past and looking to the future to enhance their clinical impact in tumor therapyGiuseppe Longobardi, Thomas L. Moore, Claudia Conte, Francesca Ungaro, Ronit Satchi‐Fainaro, Fabiana Quaglia · 2024 · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
- NANOSPRESSO: toward personalized, locally produced nucleic acid nanomedicinesMariona Estapé Sentí, Alexandre Ceccaldi, Marta Luciani, Nadine Saber, Paul J. L. Schürmann, Maurits W. Geerlings, Peter Hölig, Joel de Beer, Michael Hannus, Fred Campbell et al. · 2025 · Frontiers in Science
- Enhancing the Pharmacokinetic/Pharmacodynamic Properties of Therapeutic Nucleotides Using Lipid Nanoparticle SystemsPaulo J.C. Lin, Ying K. Tam · 2015 · Future Medicinal Chemistry
- Small molecules convey big messages: Boosting non-viral nucleic acid delivery with low molecular weight drugsFreya Joris, Stefaan C. De Smedt, Koen Raemdonck · 2017 · Nano Today
- RNA Structure Design Improves Activity and Specificity of trans-Splicing-Triggered Cell Death in a Suicide Gene Therapy ApproachSushmita Poddar, Pei She Loh, Zi Hao Ooi, Farhana Osman, Joachim Eul, Volker Patzel · 2018 · Molecular Therapy — Nucleic Acids
- Better, Faster, Stronger: Accelerating mRNA ‐Based Immunotherapies With NanocarriersHenrique Carvalho, Tiago A. S. Fidalgo, Rita C. Acúrcio, Ana I. Matos, Ronit Satchi‐Fainaro, Helena F. Florindo · 2024 · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
- Impact of pre-existing anti-polyethylene glycol (PEG) IgM on biodistribution and humoral response of intramuscularly administered PEGylated mRNA loaded lipid nanoparticleShunji Abe, Haruka Takata, Taro Shimizu, Yoshino Kawaguchi, Shoichiro Fukuda, Haruka Yamamoto, Hidenori Ando, Tatsuhiro Ishida · 2025 · Journal of Controlled Release
- Advancing Cellular‐Specific Delivery: Machine Learning Insights into Lipid Nanoparticles Design and Cellular TropismBelal I. Hanafy, Michael J. Munson, Ramesh Soundararajan, Sara G. T. Pereira, Audrey Gallud, Sajib Md Sanaullah, Gianluca Carlesso, Mariarosa Mazza · 2025 · Advanced Healthcare Materials
- Ionizable lipid chemistry in lipid nanoparticles determines delivery efficiency to hepatic stellate cellsHiroki Muto, Kenji Kubara, Seiji Hitaoka, Yoshihide Osada, Yuta Suzuki · 2025 · Journal of Controlled Release
- Drug Targeting and Nanomedicine: Lessons Learned from Liver Targeting and Opportunities for Drug InnovationAnna Laura Salvati, Klaas Poelstra · 2022 · Pharmaceutics
- Nanoparticle personalized biomolecular corona: implications of pre-existing conditions for immunomodulation and cancerJacob R. Shaw, Ryan M. Pearson · 2022 · Biomaterials Science
- PCSK9 Monoclonal Antibodies: New Developments and Their Relevance in a Nucleic Acid–Based Therapy EraIoanna Gouni‐Berthold, Jonas Schwarz, Heiner K. Berthold · 2022 · Current Atherosclerosis Reports
- mRNA therapy for myocardial infarction: A review of targets and delivery vehiclesXinming Wang, Douglas H. Wu, Samuel E. Senyo · 2022 · Frontiers in Bioengineering and Biotechnology
- Optimal delivery strategies for nanoparticle-mediated mRNA deliveryXiaoyan Li, Xiaocui Guo, Mingdi Hu, Rong Cai, Chunying Chen · 2023 · Journal of Materials Chemistry B
- Quaternization drives spleen-to-lung tropism conversion for mRNA-loaded lipid-like nanoassembliesYixuan Huang, Jiacai Wu, Sanpeng Li, Zhen Liu, Zhenghua Li, Boping Zhou, Bin Li · 2024 · Theranostics
- Enhancing precision medicine: Bispecific antibody-mediated targeted delivery of lipid nanoparticles for potential cancer therapyYue Zhang, GU Xiao-yan, Lili Huang, Yani Yang, Jun He · 2024 · International Journal of Pharmaceutics
- Chemical Design Strategy of Ionizable Lipids for In Vivo mRNA DeliveryZepeng He, Zhijia Liu, Yongming Chen · 2024 · ChemMedChem
- Defining ortholog-specific UHRF1 inhibition by STELLA for cancer therapyWenjing Bai, Jinxin Xu, Wenbin Gu, Danyang Wang, Ying Cui, Weidong Rong, Xiaoan Du, Mingqiang Li, Cuicui Xia, Qingqing Gan et al. · 2025 · Nature Communications
- Targeting mutant huntingtin for the development of disease-modifying therapyThomas Appl, Linda S. Kaltenbach, Donald C. Lo, Georg C. Terstappen · 2012 · Drug Discovery Today
- Messenger RNA as a Novel Therapeutic ApproachMatthew G. Stanton, Kerry E. Murphy-Benenato · 2017 · Topics in medicinal chemistry
- Treatment of Anderson-Fabry DiseaseIrene Simonetta, Antonino Tuttolomondo, Mario Daidone, Salvatore Miceli, Antonio Ventura Pinto · 2020 · Current Pharmaceutical Design
- Viral Mimicry as a Design Template for Nucleic Acid NanocarriersIna F. de la Fuente, Shraddha S. Sawant, Mark Q. Tolentino, Patrick M. Corrigan, Jessica L. Rouge · 2021 · Frontiers in Chemistry
- Toward a New Paradigm for Targeted Natriuretic Peptide Enhancement in Heart FailureOlof Gidlöf · 2021 · Frontiers in Physiology
- Active transport nanochelators for the reduction of liver iron burden in iron overloadSrinivas Abbina, Usama Abbasi, Arshdeep Gill, Heather A. Leitch, Jayachandran N. Kizhakkedathu · 2022 · Journal of Controlled Release
- Spermidine/Spermine N1-Acetyltransferase 1 (SAT1)—A Potential Gene Target for Selective Sensitization of Glioblastoma Cells Using an Ionizable Lipid Nanoparticle to Deliver siRNAVinith Yathindranath, Nur A. Safa, Babu V. Sajesh, Kelly Schwinghamer, Magimairajan Vanan, Rashid Ahmed Bux, DANIEL S. SITAR, Marshall W. Pitz, Teruna J. Siahaan, Donald W. Miller · 2022 · Cancers
- The Application of M 12L 24 Nanocages as Cell-Specific siRNA Delivery Agents in vitroEduard O. Bobylev, Ye Zeng, Kevin Weijgertse, Emma Koelman, Eline M. Meijer, Bas de Bruin, Alexander Kros, Joost N. H. Reek · 2022 · Chem
- Emerging Perspectives on Prime Editor Delivery to the BrainEli BenDavid, Sina Ramezanian, Yaoyao Lu, Joël Rousseau, Avi Schroeder, Marc Lavertu, Jacques P. Tremblay · 2024 · Pharmaceuticals
- Lipid nanoparticles: A delicate nucleic acid delivery system to be further exploredRunpu Ma, Yuting Li, Yang Su, Peng Chen, Sitao Xie, Weihong Tan, Xiangsheng Liu · 2024 · Nano Today
- Frit-inlet asymmetric flow field-flow fractionation for the analysis of lipid nanoparticle-protein interactionsRand Abdulrahman, Panida Punnabhum, Robin Bruno Capomaccio, Kevin Edward Treacher, Yvonne Perrie, Zahra Rattray · 2025 · Journal of Chromatography A
- Intracellular trafficking of lipid nanoparticles is hindered by cholesterolChengzhi Luo, Yunfei Li, Haidong Liu, Jing He, Xiaojuan Yang, E. Zhao, Guanghui Zi, L.-Z. Liu, Yujia Hong, Hui Wang et al. · 2025 · International Journal of Pharmaceutics
- Serum factors create species-specific barriers to hepatic gene transfer by lipid nanoparticles in liver-humanized miceDaniel Stone, Ryo Takeuchi, Harrison Dulin, Michelle A. Loprieno, Daniel E. Strongin, Saraswathi Sathees, Thomas James Cradick, Martine Aubert, Pavitra Roychoudhury, Jennifer Gordon et al. · 2025 · Molecular Therapy — Methods & Clinical Development
- Glycolipid nanoparticles target the spleen and detarget the liver without chargeKara Gentry, Liming Lian, Hyejin Kim, Ozgenur Celik, Camille Jones, Ananda R. Podilapu, Avraham Shakked, David Loughrey, Ryan Zenhausern, Bora Jang et al. · 2025 · Proceedings of the National Academy of Sciences
- mRNA delivery systems 2.0: Engineering extrahepatic delivery for non-vaccine therapeuticsManoj Dalabehera, Arnab Ghosh, Satyajit Mohanty, Dinesh Kumar Chellappan, Shubham Chaudhari, Yogita Ale, Neelam Poonia, Rudra Narayan Subudhi, Madhu Khanna, Hae Gyun Lim · 2025 · Materials Today Bio
- High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ ImmunoengineeringAlex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat-Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph et al. · 2026 · Advanced Materials
- Internalisation and Biological Activity of Nucleic Acids Delivering Cell-Penetrating Peptide Nanoparticles Is Controlled by the Biomolecular CoronaAnnely Lorents, Maria Maloverjan, Kärt Padari, Margus Pooga · 2021 · Pharmaceuticals
- Current state of RNA delivery using lipid nanoparticles to extrahepatic tissues: A review towards clinical translationLinh B. Truong, David Medina-Cruz, Ebrahim Mostafavi · 2023 · International Journal of Biological Macromolecules
- Unravelling the role of lipid composition on liposome-protein interactionsValeria Nele, Federica D’Aria, Virginia Campani, Teresa Silvestri, Marco Biondi, Concetta Giancola, Giuseppe De Rosa · 2023 · Journal of Liposome Research
- Cationic LNP-formulated mRNA expressing Tie2-agonist in the lung endothelium prevents pulmonary vascular leakageKatrin Radloff, Birgitt Gutbier, Charlotte Maeve Dunne, Hanieh Moradian, Marko Schwestka, Manfred Gossen, Katharina Ahrens, Laura Kneller, Yadong Wang, Akanksha Moga et al. · 2023 · Molecular Therapy — Nucleic Acids
- Liver-Specific Ionizable Lipid Nanoparticles Mediated Efficient RNA Interference to Clear “Bad Cholesterol”Chuangjia Huang, Yu Zhang, Jianfen Su, Xiaoling Guan, Sheng Chen, Xiaowei Xu, Xiaohua Deng, Lingmin Zhang, Jionghua Huang · 2023 · International Journal of Nanomedicine
- Lipid nanoparticle mediated small interfering RNA delivery as a potential therapy for Alzheimer's diseaseTanvir Ahmed · 2024 · European Journal of Neuroscience
- A new era of targeting cystic fibrosis with non-viral delivery of genomic medicinesNamratha Turuvekere Vittala Murthy, Kseniya Yu. Vlasova, Jonas Renner, Antony Jozić, Gaurav Sahay · 2024 · Advanced Drug Delivery Reviews
- The mRNA vaccine platform for veterinary speciesFatemeh Fazel, Janan Shoja Doost, Sugandha Raj, Nitish Boodhoo, Khalil Karimi, Shayan Sharif · 2024 · Veterinary Immunology and Immunopathology
- Recent Advances in Oligonucleotide-Based Therapy for Transthyretin Amyloidosis: Clinical Impact and Future ProspectsYuya Hayashi, Hirofumi Jono · 2018 · Biological and Pharmaceutical Bulletin
- Treating brain diseases using systemic parenterally-administered protein therapeutics: Dysfunction of the brain barriers and potential strategiesAhlem Zaghmi, Janelle Drouin‐Ouellet, Davide Brambilla, Marc Andre Gauthier · 2020 · Biomaterials
- Synthetic molecule libraries for nucleic acid delivery: Design parameters in cationic/ionizable lipids and polymersHyun Jin Kim, Ahram Kim, Kanjiro Miyata · 2021 · Drug Metabolism and Pharmacokinetics
- Discovery of a new method for potent drug development using power function of stoichiometry of homomeric biocomplexes or biological nanomotorsFengmei Pi, Mario Vieweger, ZhengYi John Zhao, Shaoying Wang, Peixuan Guo · 2015 · Expert Opinion on Drug Delivery
- Comparison of Modular PEG Incorporation Strategies for Stabilization of Peptide–siRNA NanocomplexesJustin Han-Je Lo, Ester J. Kwon, Angela Q. Zhang, Preeti Singhal, Sangeeta N. Bhatia · 2016 · Bioconjugate Chemistry
- Viral and nonviral nanocarriers for in vivo CRISPR-based gene editingZhongyuan Guo, Audrey T. Zhu, Ronnie H. Fang, Liangfang Zhang · 2024 · Nano Research
- Mechanistic and Strategic Insights into How Lipid Nanoparticles Interact with Membrane-Based Biological BarriersYun Zhao, Chong Liu, Xun Zhang, Tianrui Gu, Yaling Wang, Taisen Zuo, Shuai Liu, Xiao Xu, Huan Meng · 2026 · ACS Nano
- Novel efficacious microRNA-30c analogs reduce apolipoprotein B secretion in human hepatoma and primary hepatocyte cellsPradeep Kumar Yadav, Phensinee Haruehanroengra, Sara Irani, Ting Wang, Abulaish Ansari, Jia Sheng, M. Mahmood Hussain · 2022 · Journal of Biological Chemistry
- Pharmaceutical Strategies to Improve Druggability of Potential Drug Candidates in Nonalcoholic Fatty Liver Disease TherapyReeju Amatya, Dong-Hee Lee, Kyoung Ah Min, Meong Cheol Shin · 2023 · Pharmaceutics
- Exploration of mRNA nanoparticles based on DOTAP through optimization of the helper lipidsXueni Ma, Fanqi Wu, Caihong Peng, Huiling Chen, Dekui Zhang, Tiyun Han · 2023 · Biotechnology Journal
- A combinatorial approach for achieving CNS-selective RNAiChantal M. Ferguson, Bruno M.D.C. Godinho, Dimas Echeverria, Matthew R. Hassler, Lorenc Vangjeli, Jacquelyn Sousa, Nicholas McHugh, Julia F. Alterman, Vignesh Narayan Hariharan, Pranathi Meda Krishnamurthy et al. · 2024 · Nucleic Acids Research
- Lipid nanoparticles containing labile PEG-lipids transfect primary human skin cells more efficiently in the presence of apoECamilla Hald Gregersen, Razan Mearraoui, Pia Pernille Søgaard, Gael Clergeaud, Karsten Petersson, Andrew James Urquhart, Jens B. Simonsen · 2024 · European Journal of Pharmaceutics and Biopharmaceutics
- Broad-spectrum Delta-BA.2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplexPei Du, Lei Huang, Yi Fang, Fanfan Zhao, Qianyun Li, Xuehui Ma, Ruiqi Li, Qian Chen, Haifa Shen, Qihui Wang et al. · 2024 · PLoS Pathogens
- A quantitative systems pharmacology (QSP) platform for preclinical to clinical translation of in-vivo CRISPR-Cas therapyDevam A Desai, Stephan Schmidt, Rodrigo Cristofoletti · 2024 · Frontiers in Pharmacology
- A journey into siRNA therapeutics development: A focus on Pharmacokinetics and PharmacodynamicsGo-Wun Choi, Ju Hee Kim, Dong Wook Kang, Hea‐Young Cho · 2024 · European Journal of Pharmaceutical Sciences
- Cellular environment-responsive nanomaterials for use in gene and siRNA delivery: molecular design for biomembrane destabilization and intracellular collapseHiroki Tanaka, Yusuke Sato, Hideyoshi Harashima, Hidetaka Akita · 2016 · Expert Opinion on Drug Delivery
- Advances in Development of mRNA-Based TherapeuticsLei Huang, Luyao Zhang, Weiwei Li, Shiqiang Li, Jianguo Wen, Hangwen Li, Zhongmin Liu · 2020 · Current topics in microbiology and immunology
- Lipid nanoparticle formulations for targeting leukocytes with therapeutic RNA in liver fibrosisMatthias Bartneck · 2021 · Advanced Drug Delivery Reviews
- Transient yet Robust Expression of Proteins in the Mouse Liver via Intravenous Injection of Lipid Nanoparticle-encapsulated Nucleoside-modified mRNAElissa Everton, Fatima Rizvi, Anna R. Smith, Mitchell B. Beattie, Ying K. Tam, Norbert Pardi, Drew Weissman, Valerie Gouon–Evans · 2021 · BIO-PROTOCOL