Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms

Akinc, Akin, Querbes, William, De, Soma, Qin, June, Frank-Kamenetsky, Maria, Jayaprakash, K. Narayanannair, Jayaraman, Muthusamy, Rajeev, Kallanthottathil G +17 more·2010·Molecular Therapy

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    Kazuki Hashiba, Yusuke Sato, Masamitsu Taguchi, Sachiko Sakamoto, Ayaka Otsu, Yoshiki Maeda, Takuya Shishido, Masao Murakawa, Okazaki Arimichi, Hideyoshi Harashima · 2022 · Small Science
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    Ana M. López-Estévez, Philipp Lapuhs, Laura Pineiro‐Alonso, Marı́a José Alonso · 2023 · Advanced Materials
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  5. A New Era for Rare Genetic Diseases: Messenger RNA Therapy
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    Yoji Yamada · 2021 · Cancers
  7. Chemistry and Art of Developing Lipid Nanoparticles for Biologics Delivery: Focus on Development and Scale-Up
    Rijo John, Jasmin monpara, Shankar Swaminathan, Rahul S. Kalhapure · 2024 · Pharmaceutics
  8. Lactosylated gramicidin-based lipid nanoparticles (Lac-GLN) for targeted delivery of anti-miR-155 to hepatocellular carcinoma
    Mengzi Zhang, Xiaoju Zhou, Bo Wang, Bryant C. Yung, Ly J. Lee, Kalpana Ghoshal, Robert J. Lee · 2013 · Journal of Controlled Release
  9. Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo
    Justin B. Lee, Kaixin Zhang, Yuen Yi C. Tam, Ying K. Tam, Nathan M. Belliveau, Vanessa Y.C. Sung, Paulo J.C. Lin, Eric LeBlanc, Marco A. Ciufolini, Paul S. Rennie et al. · 2011 · International Journal of Cancer
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    Zhou Liu, Wen You Zhou, Qi Cheng, Tiantian Kong · 2020 · Advanced Materials
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    Nigel M. Davies, Daniel Hovdal, Nicholas J. Edmunds, Peter Nordberg, Anders Dahlén, Aleksandra P. Dabkowska, Marianna Yanez Arteta, Aurel Rădulescu, Tomas Kjellman, Andreas Höijer et al. · 2021 · Molecular Therapy — Nucleic Acids
  12. siRNA Functionalized Lipid Nanoparticles (LNPs) in Management of Diseases
    Tutu Kalita, Saba Abbasi Dezfouli, Lalit Mohan Pandey, Hasan Uludağ · 2022 · Pharmaceutics
  13. Gene Therapy for Regenerative Medicine
    Hossein Hosseinkhani, Abraham Jacob Domb, Ghorbanali Sharifzadeh, Victoria Nahum · 2023 · Pharmaceutics
  14. Interaction Kinetics of Individual mRNA-Containing Lipid Nanoparticles with an Endosomal Membrane Mimic: Dependence on pH, Protein Corona Formation, and Lipoprotein Depletion
    Nima Aliakbarinodehi, Audrey Gallud, Mokhtar Mapar, Emelie V. Wesén, Sahar Heydari, Yujia Jing, Gustav Emilsson, Kai Liu, Alan Sabirsh, Vladimir P. Zhdanov et al. · 2022 · ACS Nano
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  16. Relationship Between the Physicochemical Properties of Lipid Nanoparticles and the Quality of siRNA Delivery to Liver Cells
    Yusuke Sato, Hiroto Hatakeyama, Mamoru Hyodo, Hideyoshi Harashima · 2015 · Molecular Therapy
  17. High‐Contrast Fluorescence Detection of Metastatic Breast Cancer Including Bone and Liver Micrometastases via Size‐Controlled pH‐Activatable Water‐Soluble Probes
    Hu Xiong, Hao Zuo, Yunfeng Yan, Gino Occhialini, Kejin Zhou, Yihong Wan, Daniel J. Siegwart · 2017 · Advanced Materials
  18. mRNA lipid nanoparticle phase transition
    Marius F.W. Trollmann, Rainer A. Böckmann · 2022 · Biophysical Journal
  19. Nanoparticles for vaccine and gene therapy: Overcoming the barriers to nucleic acid delivery
    Lara M. Mollé, Cameron H. Smyth, Daniel Yuen, Angus P. R. Johnston · 2022 · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
  20. From Phage Display to Nanoparticle Delivery: Functionalizing Liposomes with Multivalent Peptides Improves Targeting to a Cancer Biomarker
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  21. Testing thousands of nanoparticles in vivo using DNA barcodes
    Melissa P. Lokugamage, Cory D. Sago, James E. Dahlman · 2018 · Current Opinion in Biomedical Engineering
  22. RNA delivery biomaterials for the treatment of genetic and rare diseases
    Zhao, Weiyu, Hou, Xucheng, Vick, Olivia G., Dong, Yizhou · 2019 · Biomaterials
  23. Optimizing synthetic nucleic acid and protein nanocarriers: The chemical evolution approach
    Franziska Freitag, Ernst Wagner · 2020 · Advanced Drug Delivery Reviews
  24. Expanding RNAi to Kidneys, Lungs, and Spleen via Selective ORgan Targeting (SORT) siRNA Lipid Nanoparticles
    Amogh Vaidya, Stephen Moore, Sumanta Chatterjee, Erick Damian Guerrero, Minjeong Kim, Lukas Farbiak, Sean A. Dilliard, Daniel J. Siegwart · 2024 · Advanced Materials
  25. Targeted delivery and controlled release of doxorubicin into cancer cells using a multifunctional graphene oxide
    Yao Lv, Lei Tao, S. W. Annie Bligh, Huihui Yang, Qixia Pan, Li‐Min Zhu · 2015 · Materials Science and Engineering C
  26. In Vivo Introduction of mRNA Encapsulated in Lipid Nanoparticles to Brain Neuronal Cells and Astrocytes via Intracerebroventricular Administration
    Tanaka, Hiroki, Nakatani, Taichi, Furihata, Tomomi, Tange, Kota, Nakai, Yuta, Yoshioka, Hiroki, Harashima, Hideyoshi, Akita, Hidetaka · 2018 · Molecular Pharmaceutics
  27. Lipid Nanoparticle (LNP) Chemistry Can Endow Unique In Vivo RNA Delivery Fates within the Liver That Alter Therapeutic Outcomes in a Cancer Model
    Lindsay T. Johnson, Di Zhang, Kejin Zhou, Sang M. Lee, Shuai Liu, Sean A. Dilliard, Lukas Farbiak, Sumanta Chatterjee, Yu-Hsuan Lin, Daniel J. Siegwart · 2022 · Molecular Pharmaceutics
  28. Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery
    Savan K. Patel, Margaret M. Billingsley, Alvin J. Mukalel, Ajay S. Thatte, Alex G. Hamilton, Ningqiang Gong, Rakan D. El-Mayta, Hannah C. Safford, Maria I. Merolle, Michael J. Mitchell · 2023 · Theranostics
  29. Cationic cholesterol-dependent LNP delivery to lung stem cells, the liver, and heart
    Afsane Radmand, Hyejin Kim, Jared P. Beyersdorf, Curtis N. Dobrowolski, Ryan Zenhausern, Kalina Paunovska, Sebastian G. Huayamares, Xuanwen Hua, Keyi Han, David Loughrey et al. · 2024 · Proceedings of the National Academy of Sciences
  30. Microfluidic self-assembly of folate-targeted monomolecular siRNA-lipid nanoparticles
    Rafał Krzysztoń, B. Salem, Dian-Jang Lee, Gerlinde Schwake, Ernst Wagner, Joachim Oskar Rädler · 2017 · Nanoscale
  31. iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer
    Justin Han-Je Lo, Liangliang Hao, Mandar Deepak Muzumdar, Srivatsan Raghavan, Ester J. Kwon, Emilia M. Pulver, Felicia Hsu, Andrew J. Aguirre, Brian Matthew Wolpin, Charles S. Fuchs et al. · 2018 · Molecular Cancer Therapeutics
  32. mRNA in cancer immunotherapy: beyond a source of antigen
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  33. Lipid Nanoparticle Delivery Systems to Enable mRNA-Based Therapeutics
    Sean C. Semple, Robert D. Leone, Christopher Barbosa, Ying K. Tam, Paulo J.C. Lin · 2022 · Pharmaceutics
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  35. Effect of Cholesterol Content of Lipid Composition in mRNA-LNPs on the Protein Expression in the Injected Site and Liver After Local Administration in Mice
    Maho Kawaguchi, Marin Noda, Akari Ono, Mariko Kamiya, Makoto Matsumoto, Masako Tsurumaru, Shusaku Mizukami, Hidefumi Mukai, Shigeru Kawakami · 2022 · Journal of Pharmaceutical Sciences
  36. Mechanistic Studies of an Automated Lipid Nanoparticle Reveal Critical Pharmaceutical Properties Associated with Enhanced mRNA Functional Delivery In Vitro and In Vivo
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  38. A neutral lipid envelope-type nanoparticle composed of a pH-activated and vitamin E-scaffold lipid-like material as a platform for a gene carrier targeting renal cell carcinoma
    Hidetaka Akita, Ryohei Ishiba, Ryohei Togashi, Kota Tange, Yuta Nakai, Hiroto Hatakeyama, Hideyoshi Harashima · 2014 · Journal of Controlled Release
  39. The systemic administration of an anti-miRNA oligonucleotide encapsulated pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice
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  40. The liver sieve and atherosclerosis
    R. Fraser, V. Cogger, B. Dobbs, H. Jamieson, A. Warren, S. Hilmer, D. Le Couteur · 2012 · Pathology (Sydney)
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  42. Lipid Nanoparticles for Organ-Specific mRNA Therapeutic Delivery
    Magdalena M. Żak, Lior Zangi · 2021 · Pharmaceutics
  43. Cholesterol-Mediated Seeding of Protein Corona on DNA Nanostructures for Targeted Delivery of Oligonucleotide Therapeutics to Treat Liver Fibrosis
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  44. Nanoparticulate Drug Delivery in Pregnancy: Placental Passage and Fetal Exposure
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  45. Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys
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  46. The Extent to Which Lipid Nanoparticles Require Apolipoprotein E and Low-Density Lipoprotein Receptor for Delivery Changes with Ionizable Lipid Structure
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  47. mRNA therapeutics: New vaccination and beyond
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  48. Comparative analysis of lipid Nanoparticle-Mediated delivery of CRISPR-Cas9 RNP versus mRNA/sgRNA for gene editing in vitro and in vivo
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    Yi Lin, Qiang Cheng, Tuo Wei · 2023 · Biophysics Reports
  50. Delivery Strategy to Enhance the Therapeutic Efficacy of Liver Fibrosis via Nanoparticle Drug Delivery Systems
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  51. Targeting Therapeutics to the Glomerulus With Nanoparticles
    Jonathan E. Zuckerman, Mark E. Davis · 2013 · Advances in Chronic Kidney Disease
  52. Protein Binding Affinity of Polymeric Nanoparticles as a Direct Indicator of Their Pharmacokinetics
    Zhiting Cao, Li-Qin Gan, Wei Jiang, Jilong Wang, Houbing Zhang, Yue Zhang, Yucai Wang, Xianzhu Yang, Menghua Xiong, Jun Wang · 2020 · ACS Nano
  53. Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded lipid nanoparticles for neuronal gene silencing
    Apoorva Sarode, Yuchen Fan, Amy E. Byrnes, Michal Hammel, Greg L. Hura, Yige Fu, Ponien Kou, Chloe Hu, Flora I. Hinz, Jasmine Roberts et al. · 2022 · Nanoscale Advances
  54. Cell‐penetrating peptides: A tool for effective delivery in gene‐targeted therapies
    Inês Rego de Figueiredo, João Miguel Freire, Luis R. Flores, Ana Salomé Veiga, Miguel A. R. B. Castanho · 2014 · IUBMB Life
  55. MicroRNAs and Drug Resistance in Prostate Cancers
    Feng Li, Ram I. Mahato · 2014 · Molecular Pharmaceutics
  56. Preparation of novel curdlan nanoparticles for intracellular siRNA delivery
    Jingfen Han, Jia Cai, Wuyinga Borjihan, Tsogzolmaa Ganbold, Tariq M. Rana, Huricha Baigude · 2014 · Carbohydrate Polymers
  57. Cationic Lipid-Coated Gold Nanoparticles as Efficient and Non-Cytotoxic Intracellular siRNA Delivery Vehicles
    Won Ho Kong, Ki Hyun Bae, Sung Duk Jo, Jee Seon Kim, Tae Gwan Park · 2011 · Pharmaceutical Research
  58. Lipid nanoparticles for hepatic delivery of small interfering RNA
    Bo Yu, Shu‐Hao Hsu, Chenguang Zhou, Xinmei Wang, Megan Cavanaugh Terp, Yun Wu, Lesheng Teng, Yicheng Mao, Feng Wang, Weiming Xue et al. · 2012 · Biomaterials
  59. siRNA-lipid nanoparticles with long-term storage stability facilitate potent gene-silencing in vivo
    Suzuki, Y., Hyodo, K., Tanaka, Y., Ishihara, H. · 2015 · Journal of Controlled Release
  60. The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo
    Afsane Radmand, Melissa P. Lokugamage, Hyejin Kim, Curtis N. Dobrowolski, Ryan Zenhausern, David Loughrey, Sebastian G. Huayamares, Marine Z. C. Hatit, Huanzhen Ni, Ada Del Cid et al. · 2023 · Nano Letters
  61. Lipid shape and packing are key for optimal design of pH-sensitive mRNA lipid nanoparticles
    Giulio Tesei, Ya‐Wen Hsiao, Aleksandra P. Dabkowska, Gunnar Grönberg, Marianna Yanez Arteta, David Ulkoski, David J. Bray, Martin Trulsson, Johan Ulander, Mikael Lund et al. · 2024 · Proceedings of the National Academy of Sciences
  62. mRNA-based therapeutics–Advances and perspectives
    Olga V. Sergeeva, Victor Koteliansky, Timofei S. Zatsepin · 2016 · Biochemistry (Moscow)
  63. mRNA Therapy Improves Metabolic and Behavioral Abnormalities in a Murine Model of Citrin Deficiency
    Cao, Jingsong, An, Ding, Galduroz, Mikel, Zhuo, Jenny, Liang, Shi, Eybye, Marianne, Frassetto, Andrea, Kuroda, Eishi, Funahashi, Aki, Santana, Jordan et al. · 2019 · Molecular Therapy
  64. Translation of angiotensin-converting enzyme 2 upon liver-and lung-targeted delivery of optimized chemically modified mRNA
    Schrom, Eva, Huber, Maja, Aneja, Manish, Dohmen, Christian, Emrich, Daniela, Geiger, Johannes, Hasenpusch, Günther, Herrmann-Janson, Annika, Kretzschmann, Verena, Mykhailyk, Olga et al. · 2017 · Molecular Therapy — Nucleic Acids
  65. Leveraging Biological Buffers for Efficient Messenger RNA Delivery via Lipid Nanoparticles
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  66. Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery
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  67. Systematic development of ionizable lipid nanoparticles for placental mRNA delivery using a design of experiments approach
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  68. Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy
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  69. Development of a high-throughput platform for screening lipid nanoparticles for mRNA delivery
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  70. Ionizable Lipid Nanoparticles for mRNA Delivery
    Xuefeng Tang, Ying Zhang, Xiaojun Han · 2023 · Advanced NanoBiomed Research
  71. Identification of siRNA delivery enhancers by a chemical library screen
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  72. Mechanism of Macromolecular Structure Evolution in Self-Assembled Lipid Nanoparticles for siRNA Delivery
    Marian E. Gindy, Katherine DiFelice, Varun Kumar, Robert K. Prud’homme, Robert Celano, R. Matthew Haas, Jeffrey S. Smith, David Boardman · 2014 · Langmuir
  73. Using Large Datasets to Understand Nanotechnology
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  74. Gene editing and its applications in biomedicine
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  75. Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors
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  76. mRNA: A promising platform for cancer immunotherapy
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  77. Stimuli-responsive hybrid nanocarriers developed by controllable integration of hyperbranched PEI with mesoporous silica nanoparticles for sustained intracellular siRNA delivery
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  78. Targeting aging and age-related diseases with vaccines
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  100. siRNA as a tool to improve the treatment of brain diseases: Mechanism, targets and delivery
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