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Phase I Study of a Systemically Delivered p53 Nanoparticle in Advanced Solid Tumors
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“SGT-53, a nanoparticle that has WT TP53 cDNA packed in a plasmid, was shown to inhibit tumor growth, increase the induction of apoptosis, and significantly improve median survival in patients treated in combination with temozolomide.405”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [405]
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Cites
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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
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Restoration of p53 function leads to tumour regression in vivo
Ventura, A., Kirsch, D. G., McLaughlin, M. E., Tuveson, D. A., Grimm, J., Lintault, L., Newman, J., Reczek, E. E., Weissleder, R., & Jacks, T. (2007) · Nature · doi:10.1038/nature05541 · Cited by 1,820
The RB and p53 pathways in cancer
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Modeling the Therapeutic Efficacy of p53 Restoration in Tumors
Martins, C. P., Brown-Swigart, L., & Evan, G. I. (2006) · Cell · doi:10.1016/j.cell.2006.12.007 · Cited by 600
Translating p53 into the clinic
Cheok, C. F., Verma, C. S., Baselga, J., & Lane, D. P. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.174 · Cited by 381
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Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date
Bobo, D., Robinson, K. J., Islam, J., Thurecht, K. J., & Corrie, S. R. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-1958-5 · Cited by 2,586
Anselmo, A. C., & Mitragotri, S. (2016) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10003 · Cited by 1,321
Cancer nanomedicine: A review of recent success in drug delivery
Tran, S., DeGiovanni, P., Piel, B., & Rai, P. (2017) · Clinical and Translational Medicine · doi:10.1186/s40169-017-0175-0 · Cited by 879
Torti, S. V., Manz, D. H., Paul, B. T., Blanchette-Farra, N., & Torti, F. M. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051732 · Cited by 426
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Metadata
- Authors
- Senzer, N., Nemunaitis, J., Nemunaitis, D., Bedell, C., Edelman, G., Barve, M., Nunan, R., Pirollo, K. F., Rait, A., & Chang, E. H.
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 21
- Issue
- 5
- Pages
- 1096-1103
- ISSN
- 1525-0016
- Cited by
- 236
- References
- 8
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 1255 d)
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- Senzer, N., Nemunaitis, J., Nemunaitis, D., Bedell, C., Edelman, G., Barve, M., Nunan, R., Pirollo, K. F., Rait, A., & Chang, E. H. (2013). Phase I Study of a Systemically Delivered p53 Nanoparticle in Advanced Solid Tumors. Molecular Therapy. https://doi.org/10.1038/mt.2013.32
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