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Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis
Open accessAbstract
Food-derived exosome-like nanoparticles pass through the intestinal tract throughout our lives, but little is known about their impact or function. Here, as a proof of concept, we show that the cells targeted by grape exosome-like nanoparticles (GELNs) are intestinal stem cells whose responses underlie the GELN-mediated intestinal tissue remodeling and protection against dextran sulfate sodium (DSS)-induced colitis. This finding is further supported by the fact that coculturing of crypt or sorted Lgr5⁺ stem cells with GELNs markedly improved organoid formation. GELN lipids play a role in induction of Lgr5⁺ stem cells, and the liposome-like nanoparticles (LLNs) assembled with lipids from GELNs are required for in vivo targeting of intestinal stem cells. Blocking β-catenin-mediated signaling pathways of GELN recipient cells attenuates the production of Lgr5⁺ stem cells. Thus, GELNs not only modulate intestinal tissue renewal processes, but can participate in the remodeling of it in response to pathological triggers.
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Metadata
- Authors
- Ju, S., Mu, J., Dokland, T., Zhuang, X., Wang, Q., Jiang, H., Xiang, X., Deng, Z.-B., Wang, B., Zhang, L., Roth, M., Welti, R., Mobley, J., Jun, Y., Miller, D., & Zhang, H.-G.
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 21
- Issue
- 7
- Pages
- 1345-1357
- ISSN
- 1525-0016 (ISSN-L)
- OpenAlex
- W2105251923
- Cited by
- 862
- References
- 5
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ju, S., Mu, J., Dokland, T., Zhuang, X., Wang, Q., Jiang, H., Xiang, X., Deng, Z.-B., Wang, B., Zhang, L., Roth, M., Welti, R., Mobley, J., Jun, Y., Miller, D., & Zhang, H.-G. (2013). Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis. Molecular Therapy. https://doi.org/10.1038/mt.2013.64
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