Off-target Effects in CRISPR/Cas9-mediated Genome Engineering

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339

Genome engineering using the CRISPR-Cas9 system

Ran, F. A., Hsu, P. D., Wright, J., Agarwala, V., Scott, D. A., & Zhang, F. (2013) · Nature Protocols · doi:10.1038/nprot.2013.143 · Cited by 11,133

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210

The new frontier of genome engineering with CRISPR-Cas9

Doudna, J. A., & Charpentier, E. (2014) · Science · doi:10.1126/science.1258096 · Cited by 7,062

Development and Applications of CRISPR-Cas9 for Genome Engineering

Hsu, P. D., Lander, E. S., & Zhang, F. (2014) · Cell · doi:10.1016/j.cell.2014.05.010 · Cited by 5,762

Improved vectors and genome-wide libraries for CRISPR screening

Sanjana, N. E., Shalem, O., & Zhang, F. (2014) · Nature Methods · doi:10.1038/nmeth.3047 · Cited by 5,239

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

Qi, L. S., Larson, M. H., Gilbert, L. A., Doudna, J. A., Weissman, J. S., Arkin, A. P., & Lim, W. A. (2013) · Cell · doi:10.1016/j.cell.2013.02.022 · Cited by 5,016

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

Zetsche, B., Gootenberg, J. S., Abudayyeh, O. O., Slaymaker, I. M., Makarova, K. S., Essletzbichler, P., Volz, S. E., Joung, J., van der Oost, J., Regev, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.09.038 · Cited by 4,761

DNA targeting specificity of RNA-guided Cas9 nucleases

Hsu, P. D., Scott, D. A., Weinstein, J. A., Ran, F. A., Konermann, S., Agarwala, V., Li, Y., Fine, E. J., Wu, X., Shalem, O., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2647 · Cited by 4,741

Crispr-SGRU: Prediction of CRISPR/Cas9 Off-Target Activities with Mismatches and Indels Using Stacked BiGRU

Zhang, G., Luo, Y., Xie, H., & Dai, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010945 · Cited by 20

Universal and Efficient Electroporation Protocol for Genetic Engineering of Gastrointestinal Organoids

Gaebler, A.-M., Hennig, A., Buczolich, K., Weitz, J., Welsch, T., Stange, D. E., & Pape, K. (2020) · Journal of Visualized Experiments · doi:10.3791/60704 · Cited by 20

The Surface Protein Fructose-1, 6 Bisphosphate Aldolase of Klebsiella pneumoniae Serotype K1: Role of Interaction with Neutrophils

Lee, C., Chuah, S., Chang, C., & Chen, F. (2020) · Pathogens · doi:10.3390/pathogens9121009 · Cited by 18

CRISPR-dCas9-Based Artificial Transcription Factors to Improve Efficacy of Cancer Treatment With Drug Repurposing: Proposal for Future Research

Martinez‐Escobar, A., Luna-Callejas, B., & Ramón‐Gallegos, E. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.604948 · Cited by 18

Immunotherapy perspectives in the new era of B-cell editing

Ueda, N., Cahen, M., Danger, Y., Moreaux, J., Sirac, C., & Cogné, M. (2021) · Blood Advances · doi:10.1182/bloodadvances.2020003792 · Cited by 19

Novel therapies in β‐thalassaemia

Grech, L., Borg, K., & Borg, J. (2021) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14918 · Cited by 18

Genotype/Phenotype Interactions and First Steps Toward Targeted Therapy for Sphingosine Phosphate Lyase Insufficiency Syndrome

Saba, J. D., Keller, N. P., Wang, J., Tang, F., Slavin, A., & Shen, Y. (2021) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-021-01013-9 · Cited by 18

Base and Prime Editing in the Retina—From Preclinical Research toward Human Clinical Trials

Yee, T., & Wert, K. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012375 · Cited by 21

Versatile and multifaceted CRISPR/Cas gene editing tool for plant research

Pandey, P. K., Quilichini, T. D., Vaid, N., Gao, P., Xiang, D., & Datla, R. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.04.012 · Cited by 18

Fluorescence-based tracing of transplanted intestinal epithelial cells using confocal laser endomicroscopy

Bergenheim, F. H., Seidelin, J. B., Pedersen, M. T., Mead, B. E., Jensen, K. B., Karp, J. M., & Nielsen, O. H. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1246-5 · Cited by 18

Evaluation of the effects of sequence length and microsatellite instability on single-guide RNA activity and specificity

Zhao, C., Wang, Y., Nie, X., Han, X., Liu, H., Li, G., Yang, G., Ruan, J., Ma, Y., Li, X., et al. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.37152 · Cited by 17

Use of Genome Editing Techniques to Produce Transgenic Farm Animals

Hay, A. N., Farrell, K., Leeth, C. M., & Lee, K. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-85686-1_14 · Cited by 17

Biological and genetic therapies for the treatment of Duchenne muscular dystrophy

Wilton-Clark, H., & Yokota, T. (2022) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2022.2150543 · Cited by 17

Chitosan nanoplatforms in agriculture for multi-potential applications - Adsorption/removal, sustained release, sensing of pollutants & delivering their alternatives – A comprehensive review

Kandasamy, G., Manisekaran, R., & Arthikala, M. (2023) · Environmental Research · doi:10.1016/j.envres.2023.117447 · Cited by 17

Application of CRISPR/Cas9 System in the Treatment of Alzheimer’s Disease and Neurodegenerative Diseases

Rahimi, A., Sameei, P., Mousavi, S., Ghaderi, K., Hassani, A., Hassani, S., & Alipour, S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04143-2 · Cited by 18

International Society for Cell & Gene Therapy Stem Cell Engineering Committee report on the current state of hematopoietic stem and progenitor cell–based genomic therapies and the challenges faced

Gupta, A. O., Azul, M., Bhoopalan, S. V., Abraham, A., Bertaina, A., Bidgoli, A., Bonfim, C., Dezern, A. E., Li, J., Louis, C. U., et al. (2024) · Cytotherapy · doi:10.1016/j.jcyt.2024.06.002 · Cited by 17

In vivo evaluation of guide-free Cas9-induced safety risks in a pig model

Ge, W., Gou, S., Zhao, X., Jin, Q., Zhuang, Z., Zhao, Y., Liang, Y., Ouyang, Z., Liu, X., Chen, F., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01905-1 · Cited by 17

Peptide nucleic acids: Recent advancements and future opportunities in biomedical applications

Sannigrahi, A., De, N., Bhunia, D., & Bhadra, J. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108146 · Cited by 18

The long and winding road: stem cells for cystic fibrosis

Conese, M., Beccia, E., Castellani, S., Di Gioia, S., Colombo, C., Angiolillo, A., & Carbone, A. (2018) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2018.1413087 · Cited by 15

Temperature-dependent small RNA expression in Drosophila melanogaster

Fast, I., & Rosenkranz, D. (2018) · RNA Biology · doi:10.1080/15476286.2018.1429881 · Cited by 17

Angels and Devils: Dilemmas in Dual-Use Biotechnology

Getz, L. J., & Dellaire, G. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.07.016 · Cited by 17

Proteomics Reveals Cell‐Surface Urokinase Plasminogen Activator Receptor Expression Impacts Most Hallmarks of Cancer

Ahn, S. B., Mohamedali, A., Pascovici, D., Adhikari, S., Sharma, S., Nice, E. C., & Baker, M. S. (2019) · PROTEOMICS · doi:10.1002/pmic.201900026 · Cited by 18

Application of genome-editing systems to enhance available pig resources for agriculture and biomedicine

Lee, K., Farrell, K., & Uh, K. (2019) · Reproduction Fertility and Development · doi:10.1071/rd19273 · Cited by 18

Applying gene‐editing technology to elucidate the functional consequence of genetic and epigenetic variation in Alzheimer’s disease

Schrauben, M., Dempster, E. L., & Lunnon, K. (2020) · Brain Pathology · doi:10.1111/bpa.12881 · Cited by 17

Regulatory Assessment of Off-Target Changes and Spurious DNA Insertions in Gene-Edited Organisms for Agri-Food Use

Lema, M. A. (2021) · Journal of Regulatory Science · doi:10.21423/jrs-v09i1lema · Cited by 17

Targeted knockout of the gene OsHOL1 removes methyl iodide emissions from rice plants

Carlessi, M., Mariotti, L., Giaume, F., Fornara, F., Pierdomenico Perata, A., & Gonzali, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-95198-x · Cited by 17

Preclinical Assessment of a Gene Editing Approach in a Mouse Model of MNGIE

Parés, M., Fornaguera, C., Vila‐Julià, F., Oh, S., Fan, S. H. Y., Tam, Y. K., Comes, N., Vidal, F., Martí, R., Borrós, S., et al. (2021) · Human Gene Therapy · doi:10.1089/hum.2021.152 · Cited by 18

Highly specific chimeric DNA-RNA-guided genome editing with enhanced CRISPR-Cas12a system

Kim, H., Lee, W.-J., Kim, C. H., Oh, Y., Gwon, L. W., Lee, H. K., Song, W., Hur, J. K., Lim, K. S., Jeong, K. J., et al. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.03.021 · Cited by 17

Decrypting the mechanistic basis of CRISPR/Cas9 protein

Panda, G., & Ray, A. (2022) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2022.05.001 · Cited by 17

CRISPR/Cas9-mediated precision integration of fat-1 and fat-2 from Caenorhabditis elegans at long repeated sequence in channel catfish (Ictalurus punctatus) and the impact on n-3 fatty acid level

Xing, D., Shang, M., Li, S., Wang, W., Hasin, T., Hettiarachchi, D. U., Alston, V. N., Bern, L., Qin, Z., Su, B., et al. (2023) · Aquaculture · doi:10.1016/j.aquaculture.2023.739229 · Cited by 17

Maternal Supply of Cas9 to Zygotes Facilitates the Efficient Generation of Site-Specific Mutant Mouse Models

Cebrian-Serrano, A., Zha, S., Hanssen, L., Biggs, D., Preece, C., & Davies, B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169887 · Cited by 17

Avian Pathogenic Escherichia coli: Advances in Pathogenesis, Diagnosis, and Control

Kamal, O. M., Kneuper, H., Cogan, T. A., & Woodward, M. J. (2025) · Veterinary Sciences · doi:10.3390/vetsci13010019 · Cited by 16

When Extinction Is Warranted: Invasive Species, Suppression-Drives and the Worst-Case Scenario

Thresher, A. C. (2020) · Ethics Policy & Environment · doi:10.1080/21550085.2020.1848197 · Cited by 16

Long Noncoding RNA U90926 Is Induced in Activated Macrophages, Is Protective in Endotoxic Shock, and Encodes a Novel Secreted Protein

Sabikunnahar, B., Caldwell, S. K., Varnum, S., Hogan, T. C., Cooper, A., Lahue, K. G., Bivona, J. J., Cousens, P. M., Symeonides, M., Ballif, B. A., et al. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200215 · Cited by 16

CRISPR/Cas9-mediated knock-in of BRCA1/2 mutations restores response to olaparib in pancreatic cancer cell lines

Witz, A., Dardare, J., François, A., Husson, M., Rouyer, M., Demange, J., Merlin, J., Gilson, P., & Harlé, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-45964-w · Cited by 17

Expanding Horizons of CRISPR/Cas Technology: Clinical Advancements, Therapeutic Applications, and Challenges in Gene Therapy

Bairqdar, A., Karitskaya, P. E., & Stepanov, G. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413321 · Cited by 17

Disruption of diphthamide synthesis genes and resulting toxin resistance as a robust technology for quantifying and optimizing CRISPR/Cas9-mediated gene editing

Killian, T., Dickopf, S., Haas, A. K., Kirstenpfad, C., Mayer, K., & Brinkmann, U. (2017) · Scientific Reports · doi:10.1038/s41598-017-15206-x · Cited by 16

Socioeconomic Impact of Genome Editing on Agricultural Value Chains: The Case of Fungal-Resistant and Coeliac-Safe Wheat

Maaß, O., Consmüller, N., & Kehlenbeck, H. (2019) · Sustainability · doi:10.3390/su11226421 · Cited by 19

CRISPR/Cas9-mediated knockout of PIM3 suppresses tumorigenesis and cancer cell stemness in human hepatoblastoma cells

Marayati, R., Stafman, L. L., Williams, A. P., Bownes, L. V., Quinn, C. H., Markert, H. R., Easlick, J. L., Stewart, J. E., Crossman, D. K., Mroczek‐Musulman, E., et al. (2021) · Cancer Gene Therapy · doi:10.1038/s41417-021-00334-4 · Cited by 16

Heparan sulfate promotes differentiation of white adipocytes to maintain insulin sensitivity and glucose homeostasis

Matsuzawa, T., Morita, M., Shimane, A., Otsuka, R., Yu, M., Irie, F., Yamaguchi, Y., Yanai, K., & Yoshikawa, T. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101006 · Cited by 17

CRISPR-Based Genetic Switches and Other Complex Circuits: Research and Application

Du, P., Lou, C., Zhao, X., Wang, Q., Ji, X., & Wei, W. (2021) · Life · doi:10.3390/life11111255 · Cited by 16

Antispacer peptide nucleic acids for sequence-specific CRISPR-Cas9 modulation

Economos, N. G., Quijano, E., Carufe, K. E. W., Perera, J. D. R., & Glazer, P. M. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac095 · Cited by 16

AAV-CRISPR/Cas9 Gene Editing Preserves Long-Term Vision in the P23H Rat Model of Autosomal Dominant Retinitis Pigmentosa

Shahin, S., Xu, H., Lü, B., Mercado, A. T., Jones, M. K., Bakondi, B., & Wang, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14040824 · Cited by 16

Application and Prospect of CRISPR/Cas9 Technology in Reversing Drug Resistance of Non-Small Cell Lung Cancer

Huang, L., Liao, Z., Liu, Z., Chen, Y., Huang, T., & Xiao, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.900825 · Cited by 16

Integration of alligator cathelicidin gene via two CRISPR/Cas9-assisted systems enhances bacterial resistance in blue catfish, Ictalurus furcatus

Wang, J., Su, B., Al-Armanazi, J., Wise, A. L., Shang, M., Bern, L., Li, S., Xing, D., Johnson, A., Wang, W., et al. (2023) · Aquaculture · doi:10.1016/j.aquaculture.2023.739860 · Cited by 16

Implications of hematopoietic stem cells heterogeneity for gene therapies

Epah, J., & Schäfer, R. (2021) · Gene Therapy · doi:10.1038/s41434-021-00229-x · Cited by 17

RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9

Zhang, M., Hyle, J. W., Chen, X., Ye, X., Jin, Y., Zhang, J., Yang, X., Chen, X., Wright, S., Liu, Z., et al. (2024) · Genome biology · doi:10.1186/s13059-023-03149-8 · Cited by 15

Ethical and Welfare Implications of Genetically Altered Non-Human Primates for Biomedical Research

Prescott, M. J. (2020) · Journal of Applied Animal Ethics Research · doi:10.1163/25889567-bja10002 · Cited by 16

Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation

Jin, Q., Liu, X., Zhuang, Z., Huang, J., Gou, S., Shi, H., Zhao, Y., Ouyang, Z., Liu, Z., Li, L., et al. (2023) · Genome biology · doi:10.1186/s13059-023-02851-x · Cited by 15

Development of CRISPR Cas9, spin-off technologies and their application in model construction and potential therapeutic methods of Parkinson’s disease

Qu, J., Liu, N., Gao, L., Hu, J. M., Sun, M., & Yu, D. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1223747 · Cited by 17

The Germin-like protein gene OsGER4 is involved in heat stress response in rice root development

Nguyen, T. T., Pham, T. D., Nguyen, N. H. A., Tien, P., & To, H. T. M. (2023) · Functional & Integrative Genomics · doi:10.1007/s10142-023-01201-1 · Cited by 15

The Dawn of In Vivo Gene Editing Era: A Revolution in the Making

Niazi, S. K. (2023) · Biologics · doi:10.3390/biologics3040014 · Cited by 17

CRISPR/Cas9-Mediated Customizing Strategies for Adoptive T-Cell Therapy

Park, H., Kang, Y. K., & Shim, G. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16030346 · Cited by 16

Gene Therapy: A Revolutionary Step in Treating Thalassemia

Salama, R. A. A., Qureshi, G. S. A., Safdar, M., Raafat, A., Janardhan, G., Elshamy, H. A. H., & Jhancy, M. (2024) · Hematology Reports · doi:10.3390/hematolrep16040064 · Cited by 15

Deep Learning Based Models for CRISPR/Cas Off‐Target Prediction

Cao, M., Brennan, A., Lee, C. M., Park, S., & Bao, G. (2025) · Small Methods · doi:10.1002/smtd.202500122 · Cited by 16

Engineering the bacterium Comamonas testosteroni CNB-1: Plasmid curing and genetic manipulation

Tang, Q., Lu, T., & Liu, S. (2018) · Biochemical Engineering Journal · doi:10.1016/j.bej.2018.01.030 · Cited by 15

Role of Modern Technologies in Tissue Engineering

Ali, Q., Malik, S., Malik, A., Hafeez, M. N., & Salman, S. (2020) · Archives of Neuroscience · doi:10.5812/ans.90394 · Cited by 15

CRISPR-Cas9 gene editing causes alternative splicing of the targeting mRNA

Zhang, Q., Fu, Y., Thakur, C., Bi, Z., Wadgaonkar, P., Qiu, Y., Xu, L., Rice, M., Zhang, W., Almutairy, B. S., et al. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.04.145 · Cited by 15

Core circadian clock transcription factor BMAL1 regulates mammary epithelial cell growth, differentiation, and milk component synthesis

Casey, T., Suárez-Trujillo, A., Cummings, S., Huff, K., Crodian, J. S., Bhide, K. P., Aduwari, C., Teeple, K., Shamay, A., Mabjeesh, S. J., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248199 · Cited by 15

Visualizing Live Chromatin Dynamics through CRISPR-Based Imaging Techniques

Chaudhary, N., Im, J., Nho, S.-H., & Kim, H. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.2254 · Cited by 16

Recent Updates on Corticosteroid-Induced Neuropsychiatric Disorders and Theranostic Advancements through Gene Editing Tools

Singh, M., Agarwal, V., Jindal, D., Pancham, P., Agarwal, S., Mani, S., Tiwari, R. K., Das, K., Alghamdi, B. S. A., Abujamel, T. S., et al. (2023) · Diagnostics · doi:10.3390/diagnostics13030337 · Cited by 15

One-step generation of mice carrying a conditional allele together with an HA-tag insertion for the delta opioid receptor

Su, D., Wang, M., Ye, C., Fang, J., Duan, Y., Zhang, Z., Hua, Q., Shi, C., Zhang, L., Zhang, R., et al. (2017) · Scientific Reports · doi:10.1038/srep44476 · Cited by 15

Yeast Still a Beast: Diverse Applications of CRISPR/Cas Editing Technology in S. cerevisiae.

Giersch, R. M., & Finnigan, G. C. (2017) · PubMed Central · Cited by 15

AAV-mediated FOXG1 gene editing in human Rett primary cells

Croci, S., Carriero, M. L., Capitani, K., Daga, S., Donati, F., Papa, F. T., Frullanti, E., Lopergolo, D., Lamacchia, V., Tita, R., et al. (2020) · European Journal of Human Genetics · doi:10.1038/s41431-020-0652-6 · Cited by 15

CRISPR GENOME SURGERY IN THE RETINA IN LIGHT OF OFF-TARGETING

Cho, G. Y., Schaefer, K. A., Bassuk, A. G., Tsang, S. H., & Mahajan, V. B. (2018) · Retina · doi:10.1097/iae.0000000000002197 · Cited by 15

Predictive markers for the efficacy of CAR T-cell therapy: the interplay between CAR T-cell fitness and systemic immunity

Yoo, K. H., Szymura, S. J., Dong, Z., Kandel, A., Cha, S.-C., & Kwak, L. W. (2025) · Blood Advances · doi:10.1182/bloodadvances.2025017873 · Cited by 14

Research Techniques Made Simple: Delivery of the CRISPR/Cas9 Components into Epidermal Cells

Shi, H., Smits, J. P. H., van den Bogaard, E. H. J., & Brewer, M. G. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.01.008 · Cited by 14

A new mouse SNP genotyping assay for speed congenics: combining flexibility, affordability, and power

Andrews, K. R., Hunter, S. S., Torrevillas, B. K., Céspedes, N., Garrison, S. M., Strickland, J., Wagers, D., Hansten, G., New, D. D., Fagnan, M. W., et al. (2021) · BMC Genomics · doi:10.1186/s12864-021-07698-9 · Cited by 14

IQSEC3 Deletion Impairs Fear Memory Through Upregulation of Ribosomal S6K1 Signaling in the Hippocampus

Kim, D., Jung, H., Shirai, Y., Kim, H., Kim, J., Lim, D., Mori, T., Lee, H., Park, D., Kim, H. Y., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.12.016 · Cited by 14

An overview of structural approaches to study therapeutic RNAs

Mollica, L., Cupaioli, F. A., Rossetti, G., & Chiappori, F. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1044126 · Cited by 15

DNA-free genome editing in tomato protoplasts using CRISPR/Cas9 ribonucleoprotein delivery

Kang, G. H., Kang, B., Han, J.-S., & Lee, J. M. (2023) · Horticulture Environment and Biotechnology · doi:10.1007/s13580-023-00549-4 · Cited by 14

Predicting CRISPR-Cas12a guide efficiency for targeting using machine learning

O’Brien, A. R., Bauer, D. C., & Burgio, G. (2023) · PLoS ONE · doi:10.1371/journal.pone.0292924 · Cited by 15

Preclinical Anticipation of On- and Off-Target Resistance Mechanisms to Anti-Cancer Drugs: A Systematic Review

Dziubańska-Kusibab, P. J., Nevedomskaya, E., & Haendler, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020705 · Cited by 14

CRISPR-Cas9 in basic and translational aspects of cancer therapy

Salavatipour, M. S., Poursalehi, Z., Rouzbahani, N. H., Mohammadyar, S., & Vasei, M. (2024) · Bioimpacts · doi:10.34172/bi.2024.30087 · Cited by 14

Treatment of neurological pathology and inflammation in Machado–Joseph disease through in vivo self-assembled siRNA

Li, Z., Du, X., Yang, Y., Li, Z., Chen, P., Kan, Y., Pan, J., Lin, L., Liu, D. X., Jiang, X., et al. (2024) · Brain · doi:10.1093/brain/awae304 · Cited by 14

Recent advances in spatiotemporal control of the CRISPR/Cas9 system

Zhang, J., Zhou, Y., Qiao, J., & Liu, Y. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.114474 · Cited by 14

CRISPR-Cas9 in the Tailoring of Genetically Engineered Animals

Urban, W., Kropacz, M., Łach, M., & Jankowska, A. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47050330 · Cited by 17

CRISPR-Mediated Ophthalmic Genome Surgery

Cho, G. Y., Abdulla, Y. L., Sengillo, J. D., Justus, S., Schaefer, K. A., Bassuk, A. G., Tsang, S. H., & Mahajan, V. B. (2017) · Current Ophthalmology Reports · doi:10.1007/s40135-017-0144-1 · Cited by 14

Restoration of dystrophin expression and correction of Duchenne muscular dystrophy by genome editing

Aslesh, T., Erkut, E. J. N., & Yokota, T. (2021) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2021.1872539 · Cited by 15

Cleaning the Cellular Factory–Deletion of McrA in Aspergillus oryzae NSAR1 and the Generation of a Novel Kojic Acid Deficient Strain for Cleaner Heterologous Production of Secondary Metabolites

Đào, T. T., de Mattos-Shipley, K. M. J., Prosser, I. M., Williams, K., Zacharova, M. K., Lazarus, C. M., Willis, C. L., & Bailey, A. M. (2021) · Frontiers in Fungal Biology · doi:10.3389/ffunb.2021.632542 · Cited by 14

CRISPR/Cas9-mediated β-globin gene knockout in rabbits recapitulates human β-thalassemia

Yang, Y., Kang, X., Hu, S., Chen, B., Xie, Y., Song, B., Zhang, Q., Wu, H., Ou, Z., Xian, Y., et al. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100464 · Cited by 14

Genome-editing approaches and applications: a brief review on CRISPR technology and its role in cancer

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CRISPR Gene-Editing Models Geared Toward Therapy for Hereditary and Developmental Neurological Disorders

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