Cited by 266Ion channel regulation and functionNerve injury and regenerationIon Channels and Receptors

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Neurotrophin-evoked depolarization requires the sodium channel NaV1.9

Blum, Robert, Kafitz, Karl W., Konnerth, Arthur·2002·Nature

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Abstract

Brain-derived neurotrophic factor (BDNF) and other neurotrophins are essential for normal brain function. Many types of neurons in the central nervous system are excited by BDNF or neurotrophin-4/5, an action that has recently been implicated in synaptic plasticity. The mechanisms involved in this transmitter-like action of neurotrophins remains unclear. Here, by screening candidate genes with an antisense messenger RNA expression approach and by co-expressing the receptor tyrosine kinase TrkB and various sodium channels, we demonstrate that the tetrodotoxin-insensitive sodium channel Na(V)1.9 underlies the neurotrophin-evoked excitation. These results establish the molecular basis of neurotrophin-evoked depolarization and reveal a mechanism of ligand-mediated sodium channel activation.

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Kafitz, K. W., Lepier, A., Thoenen, H. & Konnerth, A. Saxitoxin-sensitivity of neurotrophin-induced rapid excitation and neurite growth. Pfluegers Arch. 441, R125 (2001)

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Authors: Blum, R., Kafitz, K. W., & Konnerth, A.
Affiliations: Physiologisches Institut (DE)
Corresponding author: Konnerth, Arthur
ORCID: Blum, Robert
Konnerth, Arthur
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-10
Volume: 419
Issue: 6908
Pages: 687-693
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature01085
OpenAlex: W2070568755
Cited by: 266
References: 45
Citations by year: 2026: 1 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 9 · 2017: 6 · 2016: 10 · 2015: 9 · 2014: 11 · 2013: 10 · 2012: 15
FWCI: 10.08
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: neurotrophins, brain-derived neurotrophic factor, neurotrophin-4/5, TrkB receptor, synaptic plasticity, neuronal excitation
MeSH terms: Animals, Cell Line, Cells, Cultured, Cloning, Molecular, Electric Conductivity, Hippocampus, Humans, Molecular Sequence Data, Nerve Growth Factors, Neuroblastoma, Neurons, Neuropeptides, RNA, Messenger, Saxitoxin, Sodium, Sodium Channels, RNA, Antisense, Rats, Wistar, Brain-Derived Neurotrophic Factor, Receptor, trkB, Rats, NAV1.9 Voltage-Gated Sodium Channel

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Neurotrophin-evoked depolarization requires the sodium channel NaV1.9

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