Cited by 266Ion channel regulation and functionNerve injury and regenerationIon Channels and Receptors

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Neurotrophin-evoked depolarization requires the sodium channel NaV1.9

Blum, Robert, Kafitz, Karl W., Konnerth, Arthur·2002·Nature

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Abstract

Brain-derived neurotrophic factor (BDNF) and other neurotrophins are essential for normal brain function. Many types of neurons in the central nervous system are excited by BDNF or neurotrophin-4/5, an action that has recently been implicated in synaptic plasticity. The mechanisms involved in this transmitter-like action of neurotrophins remains unclear. Here, by screening candidate genes with an antisense messenger RNA expression approach and by co-expressing the receptor tyrosine kinase TrkB and various sodium channels, we demonstrate that the tetrodotoxin-insensitive sodium channel Na(V)1.9 underlies the neurotrophin-evoked excitation. These results establish the molecular basis of neurotrophin-evoked depolarization and reveal a mechanism of ligand-mediated sodium channel activation.

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Niwa, H., Yamamura, K., & Miyazaki, J. (1991) · Gene · doi:10.1016/0378-1119(91)90434-d · Cited by 5,149
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394
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Physiology of the Neurotrophins
Lewin, G. R., & Barde, Y. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001445 · Cited by 1,959
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Thoenen, H. (1995) · Science · doi:10.1126/science.270.5236.593 · Cited by 1,927
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The Trk family of neurotrophin receptors
Barbacid, M. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251107 · Cited by 1,281
Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice
Patterson, S. L., Abel, T., Deuel, T. A. S., Martin, K. C., Rose, J. C., & Kandel, E. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80140-3 · Cited by 1,233

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Kafitz, K. W., Lepier, A., Thoenen, H. & Konnerth, A. Saxitoxin-sensitivity of neurotrophin-induced rapid excitation and neurite growth. Pfluegers Arch. 441, R125 (2001)

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Authors: Blum, R., Kafitz, K. W., & Konnerth, A.
Affiliations: Physiologisches Institut (DE)
Corresponding author: Konnerth, Arthur
ORCID: Blum, Robert
Konnerth, Arthur
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-10
Volume: 419
Issue: 6908
Pages: 687-693
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature01085
OpenAlex: W2070568755
Cited by: 266
References: 45
Citations by year: 2026: 1 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 9 · 2017: 6 · 2016: 10 · 2015: 9 · 2014: 11 · 2013: 10 · 2012: 15
FWCI: 10.08
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: neurotrophins, brain-derived neurotrophic factor, neurotrophin-4/5, TrkB receptor, synaptic plasticity, neuronal excitation
MeSH terms: Animals, Cell Line, Cells, Cultured, Cloning, Molecular, Electric Conductivity, Hippocampus, Humans, Molecular Sequence Data, Nerve Growth Factors, Neuroblastoma, Neurons, Neuropeptides, RNA, Messenger, Saxitoxin, Sodium, Sodium Channels, RNA, Antisense, Rats, Wistar, Brain-Derived Neurotrophic Factor, Receptor, trkB, Rats, NAV1.9 Voltage-Gated Sodium Channel

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Neurotrophin-evoked depolarization requires the sodium channel NaV1.9

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