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Insulin-Like Growth Factors and Insulin: At the Crossroad Between Tumor Development and Longevity

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Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome

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RNAi screens to identify components of gene networks that modulate aging in Caenorhabditis elegans

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The Phytochemical Glaucarubinone Promotes Mitochondrial Metabolism, Reduces Body Fat, and Extends Lifespan ofCaenorhabditis elegans

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Age Specificity of Inbreeding Load inDrosophila melanogasterand Implications For the Evolution of Late-Life Mortality Plateaus

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IGF-1 signaling reduces neuro-inflammatory response and sensitivity of neurons to MPTP

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From heterochromatin islands to the NAD World: A hierarchical view of aging through the functions of mammalian Sirt1 and systemic NAD biosynthesis

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Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1

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Regulated spatial organization and sensitivity of cytosolic protein oxidation in Caenorhabditis elegans

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Probing the Relationship Between Insulin Sensitivity and Longevity Using Genetically Modified Mice

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Exogenous insulin can reverse the effects of caloric restriction on mitochondria

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Longevity Genes: From Primitive Organisms to Humans

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Calorie restriction and NAD+/sirtuin counteract the hallmarks of aging

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Figitumumab (CP-751,871) for cancer therapy

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The Roles of Cellular and Organismal Aging in the Development of Late-Onset Maladies

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Identification of miR‐305, a micro RNA that promotes aging, and its target mRNA s in Drosophila

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Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction

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Regulation of Protein Turnover by Longevity Pathways

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Mitochondrial dysfunction in Caenorhabditis elegans causes metabolic restructuring, but this is not linked to longevity

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Growth hormone treatment in human ageing: benefits and risks

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Integrating Metabolism and Longevity Through Insulin and IGF1 Signaling

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Exploring endocrine GH pattern in mice using rank plot analysis and random blood samples

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Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells

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Management of growth hormone deficiency in adults

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Correlated resistance to glucose deprivation and cytotoxic agents in fibroblast cell lines from long-lived pituitary dwarf mice

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Caloric restriction and growth hormone receptor knockout: Effects on expression of genes involved in insulin action in the heart

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Molecular crosstalk between insulin‐like growth factors and follicle‐stimulating hormone in the regulation of granulosa cell function

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Genetics and Pharmacology of Longevity

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Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes

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Lipid-lowering fibrates extend C. elegans lifespan in a NHR-49/PPARalpha-dependent manner

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Pyrroloquinoline quinone enhances the resistance to oxidative stress and extends lifespan upon DAF-16 and SKN-1 activities in C. elegans

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Drosophila Models to Investigate Insulin Action and Mechanisms Underlying Human Diabetes Mellitus

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G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes

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A Kinetic Aggregation Assay Allowing Selective and Sensitive Amyloid-β Quantification in Cells and Tissues

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Comprehensive mRNA Expression Profiling Distinguishes Tauopathies and Identifies Shared Molecular Pathways

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Involvement of Insulin-Like Growth Factor-1 in the Effect of Caloric Restriction: Regulation of Plasma Adiponectin and Leptin

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Cellular ageing mechanisms in osteoarthritis

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Compounds that extend longevity are protective in neurodegenerative diseases and provide a novel treatment strategy for these devastating disorders

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Autophagy in neuronal cell loss: a road to death

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Dietary restriction: could it be considered as speed bump on tumor progression road?

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MicroRNAs, DNA damage response and ageing

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Genetic differences and longevity‐related phenotypes influence lifespan and lifespan variation in a sex‐specific manner in mice

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Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease

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Insulin-like Growth Factor 1 Signaling in Mammalian Hearing

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Novel roles for JNK1 in metabolism

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Turning anti-ageing genes against cancer

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Fibroblasts from long-lived mutant mice show diminished ERK1/2 phosphorylation but exaggerated induction of immediate early genes

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Sirt1’s Complex Roles in Neuroprotection

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Safety aspects of GH replacement

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Perspectives of Targeting mTORC1–S6K1 in Cardiovascular Aging

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Cells From Long-Lived Mutant Mice Exhibit Enhanced Repair of Ultraviolet Lesions

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Aging and the programmed death phenomena

Skulachev, V. P. (2003) · Topics in current genetics · doi:10.1007/978-3-540-37005-5_8 · Cited by 36

How hormones mediate trade-offs in human health and disease

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Emerging Omics Approaches in Aging Research

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MicroRNA, the putative molecular control for mid-life decline

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Gender and the regulation of longevity: Implications for autoimmunity

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miR-96, miR-145 and miR-9 expression increases, and IGF-1R and FOXO1 expression decreases in peripheral blood mononuclear cells of aging humans

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GH/IGF-I/insulin system in centenarians

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Insulin-like growth factor 1 of wild vertebrates in a life-history context

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An RNAi-based genetic screen for oxidative stress resistance reveals retinol saturase as a mediator of stress resistance

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GENETIC CORRELATION BETWEEN RESISTANCE TO OXIDATIVE STRESS AND REPRODUCTIVE LIFE SPAN IN A BIRD SPECIES

Kim, S., Velando, A., Sorci, G., & Alonso‐Álvarez, C. (2009) · Evolution · doi:10.1111/j.1558-5646.2009.00862.x · Cited by 35

The somatotropic axis and aging: Mechanisms and persistent questions about practical implications

Bartke, A. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.04.001 · Cited by 36

Mouse models of senile osteoporosis

Watanabe, K., & Hishiya, A. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2005.01.006 · Cited by 36

High calorie diet augments age-associats sleep impairment in Drosophila

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D-chiro-Inositol and Pinitol Extend the Life Span of Drosophila melanogaster

Hada, B., Yoo, M.-R., Seong, K. M., Jin, Y. W., Myeong, H.-K., & Min, K. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls156 · Cited by 35

Low Serum Insulin-Like Growth Factor-I Predicts Cognitive Decline in Alzheimer’s Disease

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Manukyan, M., & Singh, P. B. (2012) · Genes to Cells · doi:10.1111/j.1365-2443.2012.01595.x · Cited by 35

The impact of DNA damage, genetic mutation and cellular responses on cancer prevention, longevity and aging: observations in humans and mice

Hasty, P. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.09.036 · Cited by 35

Public and private mechanisms of life extension in Caenorhabditis elegans

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Inference of transcription modification in long-live yeast strains from their expression profiles

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Adipose tissue-specific PPARγ deficiency increases resistance to oxidative stress

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C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age

Mooijaart, S. P., Brandt, B. W., Baldal, E. A., Pijpe, J., Kuningas, M., Beekman, M., Zwaan, B. J., Slagboom, P. E., Westendorp, R. G. J., & van Heemst, D. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.03.006 · Cited by 39

Oxidative Aging and Insulin Receptor Signaling

Dröge, W. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.11.1378 · Cited by 36

Molecular mechanisms of sex determination and differentiation in decapod crustaceans for potential aquaculture applications: An overview

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The IGF System and Aging

Conover, C. A., & Oxvig, C. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae029 · Cited by 35

Systematic gene expression profile of hypothalamus in calorie-restricted mice implicates the involvement of mTOR signaling in neuroprotective activity

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