IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

Liu, J.-P., Baker, J. C., Perkins, A. S., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80084-4 · Cited by 2,854

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250

The p66shc adaptor protein controls oxidative stress response and life span in mammals

Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

Tatar, M., Kopelman, A. H., Epstein, D., Tu, M., Yin, C. ‐., & Garofalo, R. S. (2001) · Science · doi:10.1126/science.1057987 · Cited by 1,630

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., & Partridge, L. (2001) · Science · doi:10.1126/science.1057991 · Cited by 1,436

Genetic pathways that regulate ageing in model organisms

Guarente, L., & Kenyon, C. J. (2000) · Nature · doi:10.1038/35041700 · Cited by 1,337

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

Kulkarni, R., Brüning, J. C., Winnay, J. N., Postic, C., Magnuson, M. A., & Kahn, C. R. (1999) · Cell · doi:10.1016/s0092-8674(00)80546-2 · Cited by 1,148

Dwarf mice and the ageing process

Brown‐Borg, H. M., Borg, K. E., Meliska, C. J., & Bartke, A. (1996) · Nature · doi:10.1038/384033a0 · Cited by 1,091

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

Flurkey, K., Papaconstantinou, J., Miller, R. A., & Harrison, D. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111158898 · Cited by 826

Untitled work

(2011) · Europe PMC (PubMed Central)

The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging

Hsieh, C.-C., Kuro‐o, M., Rosenblatt, K. P., Brobey, R. K. B., & Papaconstantinou, J. (2010) · Aging · doi:10.18632/aging.100194 · Cited by 117

Biochemical Genetic Pathways that Modulate Aging in Multiple Species: Figure 1.Preprint

Bitto, A., Wang, A. M., Bennett, C. F., & Kaeberlein, M. R. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025114 · Cited by 122

Systemic DNA damage responses in aging and diseases

Ribezzo, F., Shiloh, Y., & Schumacher, B. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.12.005 · Cited by 116

TOR signaling never gets old: Aging, longevity and TORC1 activity

Evans, D. S., Kapahi, P., Hsueh, W., & Kockel, L. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.001 · Cited by 118

Aspirin Inhibits Oxidant Stress, Reduces Age-Associated Functional Declines, and Extends Lifespan of Caenorhabditis elegans

Ayyadevara, S., Bharill, P., Dandapat, A., Hu, C., Khaidakov, M., Mitra, S., Reis, R. J. S., & Mehta, J. L. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4151 · Cited by 116

The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation

Meng, Z. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki603 · Cited by 121

Integrating evolutionary and molecular genetics of aging

Flatt, T., & SCHMIDT, P. S. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.07.010 · Cited by 116

Do deficiencies in growth hormone and insulin-like growth factor-1 (IGF-1) shorten or prolong longevity?

Laron, Z. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.022 · Cited by 115

Fibroblasts From Naked Mole-Rats Are Resistant to Multiple Forms of Cell Injury, But Sensitive to Peroxide, Ultraviolet Light, and Endoplasmic Reticulum Stress

Salmon, A. B., Akha, A. A. S., Buffenstein, R., & Miller, R. A. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.3.232 · Cited by 115

Genes encoding longevity: from model organisms to humans

Kuningas, M., Mooijaart, S. P., van Heemst, D., Zwaan, B. J., Slagboom, P. E., & Westendorp, R. G. J. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00366.x · Cited by 115

Resveratrol inhibits insulin responses in a SirT1-independent pathway

Zhang, J. (2006) · Biochemical Journal · doi:10.1042/bj20050977 · Cited by 115

Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans

Meyer, J. N., Boyd, W. A., Azzam, G. A., Haugen, A. C., Freedman, J. H., & Houten, B. V. (2007) · Genome biology · doi:10.1186/gb-2007-8-5-r70 · Cited by 114

Aging-Dependent and -Independent Modulation of Associative Learning Behavior by Insulin/Insulin-Like Growth Factor-1 Signal inCaenorhabditis elegans

Murakami, H., Bessinger, K., Hellmann, J. L., & Murakami, S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3600-04.2005 · Cited by 114

Mouse Models to Disentangle the Hallmarks of Human Aging

Folgueras, A. R., Freitas-Rodríguez, S., Velasco, G., & López-Otín, C. (2018) · Circulation Research · doi:10.1161/circresaha.118.312204 · Cited by 113

SIRT1 and neuronal diseases

Tang, B. L., & Chua, C. E. L. (2007) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2007.02.001 · Cited by 114

Hepatocyte proliferation during liver regeneration is impaired in mice with liver‐specific IGF‐1R knockout

Desbois‐Mouthon, C., Wendum, D., Cadoret, A., Rey, C., Leneuve, P., Blaise, A., Housset, C., Tronche, F., Bouc, Y. L., & Holzenberger, M. (2006) · The FASEB Journal · doi:10.1096/fj.05-4704fje · Cited by 116

Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease

Gates, A. C., Bernal-Mizrachi, C., Chinault, S. L., Feng, C., Schneider, J. G., Coleman, T., Malone, J. P., Townsend, R. R., Chakravarthy, M. V., & Semenkovich, C. F. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.010 · Cited by 94

Redox Control of Signal Transduction, Gene Expression and Cellular Senescence

Esposito, F., Ammendola, R., Faraonio, R., Russo, T., & Cimino, F. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000014832.78725.1a · Cited by 113

Genetic factors associated with longevity: A review of recent findings

Shadyab, A. H., & LaCroix, A. Z. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.10.005 · Cited by 112

Tissue Depletion of Taurine Accelerates Skeletal Muscle Senescence and Leads to Early Death in Mice

Ito, T., Yoshikawa, N., Inui, T., Miyazaki, N., Schaffer, S. W., & Azuma, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107409 · Cited by 113

Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

Barinda, A. J., Ikeda, K., Nugroho, D. B., Wardhana, D. A., Sasaki, N., Honda, S., Urata, R., Matoba, S., Hirata, K., & Emoto, N. (2020) · Nature Communications · doi:10.1038/s41467-020-14387-w · Cited by 115

Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline

Xiao, Y.-Z., Yang, M., Xiao, Y., Guo, Q., Huang, Y., Li, C., Cai, D., & Luo, X. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.002 · Cited by 112

Metabolic features and regulation in cell senescence

Kwon, S. M., Hong, S. M., Lee, Y.-K., Min, S., & Yoon, G. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.1.291 · Cited by 111

RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans

Paola Sebastiani, B., Montano, M. A., Puca, A. A., Solovieff, N., Kojima, T., Wang, M. C., Melista, E., Meltzer, M., Fischer, S. E. J., Andersen, S. L., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008210 · Cited by 111

MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury

Calvente, C. J., Pilar, H. D., Tameda, M., Johnson, C. D., & Feldstein, A. E. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.09.013 · Cited by 111

Increased basal level of Akt-dependent insulin signaling may be responsible for the development of insulin resistance

Liu, H.-Y., Hong, T., Wen, G.-B., Han, J., Zuo, D., Liu, Z., & Cao, W. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00374.2009 · Cited by 111

Mediation of vertebrate life historiesviainsulin‐like growth factor‐1

Dantzer, B., & Swanson, E. M. (2011) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2011.00204.x · Cited by 110

Aging and the growth hormone/insulin like growth factor-I axis

Sherlock, M., & Toogood, A. A. (2007) · Pituitary · doi:10.1007/s11102-007-0039-5 · Cited by 111

Cells discover fire: Employing reactive oxygen species in developmentand consequences for aging

de Magalhães, J. P., & Church, G. M. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.09.002 · Cited by 109

What Can We Learn About Human Disease from the Nematode C. elegans?

Apfeld, J., & Alper, S. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7471-9_4 · Cited by 116

Biology of Aging and Cancer

Anisimov, V. N. (2007) · Cancer Control · doi:10.1177/107327480701400104 · Cited by 114

A Transcription Elongation Factor That Links Signals from the Reproductive System to Lifespan Extension in Caenorhabditis elegans

Ghazi, A., Henis‐Korenblit, S., & Kenyon, C. J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000639 · Cited by 116

Exogenous insulin-like growth factor 1 enhances thymopoiesis predominantly through thymic epithelial cell expansion

Chu, Y.-W., Schmitz, S., Choudhury, B., Telford, W., Kapoor, V., Garfield, S., Howe, D., & Gress, R. E. (2008) · Blood · doi:10.1182/blood-2008-04-149435 · Cited by 107

Single-gene mutations and healthy ageing in mammals

Bartke, A. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0281 · Cited by 110

Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans

Brys, K., Vanfleteren, J. R., & Braeckman, B. P. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.02.004 · Cited by 112

Dynamics of the action of dFOXO on adult mortality in Drosophila

Giannakou, M. E., Goss, M. W., Jacobson, J., Vinti, G., Leevers, S. J., & Partridge, L. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00290.x · Cited by 107

Peroxisome Proliferator-Activated Receptor Coactivator 1 in Caloric Restriction and Other Models of Longevity

Corton, J. C., & Brown-Borg, H. M. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.12.1494 · Cited by 106

hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling

Wang, X., Chrysovergis, K., Kosak, J., Kissling, G., Streicker, M., Moser, G., Li, R., & Eling, T. E. (2014) · Aging · doi:10.18632/aging.100687 · Cited by 106

Antioxidant Defenses Predict Long-Term Survival in a Passerine Bird

Saino, N., Caprioli, M., Romano, M., Boncoraglio, G. P., Rubolini, D., Ambrosini, R., Bonisoli‐Alquati, A., & Romanò, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019593 · Cited by 106

Amelioration of oxidant stress by the defensin lysozyme

Liu, H., Zheng, F., Cao, Q., Ren, B., Zhu, L., Striker, G. E., & Vlassara, H. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00349.2005 · Cited by 106

The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice

Mitchell, S. E., Delville, C., Konstantopedos, P., Hurst, J. L., Derous, D., Green, C. L., Chen, L., Han, J., Wang, Y., Promislow, D., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4003 · Cited by 105

DNA damage and mitochondria in cancer and aging

Patel, J., Baptiste, B. A., Kim, E., Hussain, M., Croteau, D. L., & Bohr, V. A. (2020) · Carcinogenesis · doi:10.1093/carcin/bgaa114 · Cited by 109

The signaling landscape of insulin-like growth factor 1

Khan, M. Z., Zugaza, J. L., & Torres‐Alemán, I. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.108047 · Cited by 115

Sirt1 protects the heart from aging and stress

Hsu, C., Odewale, I., Alcendor, R. R., & Sadoshima, J. (2008) · Biological Chemistry · doi:10.1515/bc.2008.032 · Cited by 108

Maternal Protein Restriction Affects Postnatal Growth and the Expression of Key Proteins Involved in Lifespan Regulation in Mice

Chen, J., Martin‐Gronert, M. S., Tarry‐Adkins, J. L., & Ozanne, S. E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004950 · Cited by 109

Stress resistance in long-lived mouse models

Murakami, S. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.061 · Cited by 104

Compounds that confer thermal stress resistance and extended lifespan

Benedetti, M. G., Foster, A. L., Vantipalli, M. C., White, M. P., Sampayo, J. N., Gill, M. S., Olsen, A., & Lithgow, G. J. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.08.049 · Cited by 108

Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways

Kojima, T., Kamei, H., Aizu, T., Arai, Y., Takayama, M., Nakazawa, S., Ebihara, Y., Inagaki, H., Masui, Y., Gondo, Y., et al. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.05.007 · Cited by 108

The Influence of Genes on the Aging Process of Mice

de Magalhães, J. P., Cabral, J. A. S., & Magalhães, D. (2004) · Genetics · doi:10.1534/genetics.104.032292 · Cited by 106

PTEN: tumour suppressor, multifunctional growth regulator and more

Goberdhan, D. C. I., & WILSON, C. G. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg288 · Cited by 104

The Aging Mitochondria

Theurey, P., & Pizzo, P. (2018) · Genes · doi:10.3390/genes9010022 · Cited by 108

Genetic variation in insulin/IGF-1 signaling pathways and longevity

Ziv, E., & Hu, D. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.09.002 · Cited by 102

Lifespan extension in genetically modified mice

Ladiges, W., Van Remmen, H., Strong, R., Ikeno, Y., Treuting, P., Rabinovitch, P., & Richardson, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00491.x · Cited by 101

A Familial Insulin-Like Growth Factor-I Receptor Mutant Leads to Short Stature: Clinical and Biochemical Characterization

Inagaki, K., Tiulpakov, A. N., Рубцов, П. М., Sverdlova, P. S., Peterkova, V. A., Yakar, S., Terekhov, S., & LeRoith, D. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2354 · Cited by 101

The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice

Chen, T.-H., Kuro‐o, M., Chen, C., Sue, Y., Chen, Y.-C., Wu, H.-H., & Cheng, C. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.09.032 · Cited by 101

Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice

Ock, S., Lee, W. S., Ahn, J., Kim, H. M., Kang, H., Kim, H.-S., Jo, D., Abel, E. D., Lee, T. J., & Kim, J. (2015) · Endocrinology · doi:10.1210/en.2015-1709 · Cited by 102

Understanding aging: revealing order out of chaos

Dufour, É., & Larsson, N. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2004.04.020 · Cited by 103

Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans

Château, M., Araiz, C., Descamps, S., & Galas, S. (2010) · Aging · doi:10.18632/aging.100195 · Cited by 104

Genome-Wide Association for Sensitivity to Chronic Oxidative Stress in Drosophila melanogaster

Jordan, K. W., Craver, K. L., Magwire, M. M., Cubilla, C. E., Mackay, T. F. C., & Anholt, R. R. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038722 · Cited by 100

Methylation by Set9 modulates FoxO3 stability and transcriptional activity

Calnan, D. R., Webb, A. E., White, J. L., Stowe, T. R., Goswami, T., Shi, X., Espejo, A. B., Bedford, M. T., Gozani, O., Gygi, S. P., et al. (2012) · Aging · doi:10.18632/aging.100471 · Cited by 101

Tissue‐specific insulin signaling in the regulation of metabolism and aging

Zhang, J., & Liu, F. (2014) · IUBMB Life · doi:10.1002/iub.1293 · Cited by 105

Transcriptional response to aging and caloric restriction in heart and adipose tissue

Linford, N. J., Beyer, R. P., Gollahon, K. A., Krajcik, R. A., Malloy, V. L., Demas, V., Burmer, G. C., & Rabinovitch, P. S. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00319.x · Cited by 101

Dynamics of liver GH/IGF axis and selected stress markers in juvenile gilthead sea bream (Sparus aurata) exposed to acute confinement

Saera-Vila, A., Calduch-Giner, J. À., Prunet, P., & Pérez‐Sánchez, J. (2009) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2009.06.004 · Cited by 100

MicroRNAs and the Genetic Network in Aging

Inukai, S., & Slack, F. J. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.01.023 · Cited by 100

Reversal of aging by NFκB blockade

Adler, A. S., Kawahara, T. L. A., Segal, E., & Chang, H. Y. (2008) · Cell Cycle · doi:10.4161/cc.7.5.5490 · Cited by 103

Longevity and Age-Related Pathology of Mice Deficient in Pregnancy-Associated Plasma Protein-A

Conover, C. A., Bale, L. K., Mader, J. R., Mason, M. A., Keenan, K. P., & Marler, R. J. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq032 · Cited by 99

Signaling networks in aging

Greer, E. L., & Brunet, A. (2008) · Journal of Cell Science · doi:10.1242/jcs.021519 · Cited by 102

Delaying aging is neuroprotective in Parkinson’s disease: a genetic analysis in C. elegans models

Cooper, J. F., Dues, D. J., Spielbauer, K. K., Machiela, E., Senchuk, M. M., & Raamsdonk, J. M. V. (2015) · npj Parkinson s Disease · doi:10.1038/npjparkd.2015.22 · Cited by 101

A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer

Morris, B. J. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000173509.45363.dd · Cited by 98

SH2B Regulation of Growth, Metabolism, and Longevity in Both Insects and Mammals

Song, W., Ren, D., Li, W., Jiang, L., Cho, K. W., Huang, P., Fan, C., Song, Y., Liu, Y., & Rui, L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.002 · Cited by 99

Pro-Aging Effects of Glucose Signaling through a G Protein-Coupled Glucose Receptor in Fission Yeast

Roux, A. E., Leroux, A., Alaamery, M. A., Hoffman, C. S., Chartrand, P., Ferbeyre, G., & Rokeach, L. A. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000408 · Cited by 99

Heat shock proteins and aging in Drosophila melanogaster

Morrow, G., & Tanguay, R. M. (2003) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2003.09.023 · Cited by 101

Cell non-autonomous regulation of health and longevity

Miller, H. A., Dean, E. S., Pletcher, S. D., & Leiser, S. F. (2020) · eLife · doi:10.7554/elife.62659 · Cited by 102

Evolution of the Insulin Receptor Family and Receptor Isoform Expression in Vertebrates

Hernández‐Sánchez, C., Mansilla, A., de Pablo, F., & Zardoya, R. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn036 · Cited by 99

Insulin and longevity: antidiabetic biguanides as geroprotectors

Anisimov, V. N., Semenchenko, A. V., & Yashin, A. I. (2003) · Biogerontology · doi:10.1023/a:1026299318315 · Cited by 100

IGF signaling defects as causes of growth failure and IUGR

Klammt, J., Pfäffle, R. W., Werner, H., & Kieß, W. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.03.003 · Cited by 98

Expression profiling of aging in the human skin

Lener, T., Moll, P. R., Rinnerthaler, M., Bauer, J. W., Aberger, F., & Richter, K. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.01.012 · Cited by 98

Insulin-like Growth Factor I Plasmid Therapy Promotes in Vivo Angiogenesis

Rabinovsky, E. D., & Draghia, R. (2003) · Molecular Therapy · doi:10.1016/j.ymthe.2003.10.003 · Cited by 96

Hormonal regulation of longevity in mammals

Brown‐Borg, H. M. (2007) · Ageing Research Reviews · doi:10.1016/j.arr.2007.02.005 · Cited by 106

Clustering of Genetically Defined Allele Classes in the Caenorhabditis elegans DAF-2 Insulin/IGF-1 Receptor

Patel, D. S., Garza-Garcı́a, A., Nanji, M. S., McElwee, J. J., Ackerman, D., Driscoll, P. C., & Gems, D. (2008) · Genetics · doi:10.1534/genetics.107.070813 · Cited by 100

Modulating human aging and age-associated diseases

Fontana, L. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.02.002 · Cited by 99

mTOR signalling: the molecular interface connecting metabolic stress, aging and cardiovascular diseases

Yang, Z., & Ming, X. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01038.x · Cited by 97

Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging

Janssens, G. E., Lin, X.-X., Millán-Ariño, L., Kavšek, A., Sen, I., Seinstra, R. I., Stroustrup, N., Nollen, E. A. A., & Riedel, C. G. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.044 · Cited by 96

Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost

Zhang, Y., Zhang, W.-H., Zhang, P., Li, Q., Sun, Y., Wang, J., Zhang, S. O., Cai, T., Zhan, C., & Dong, M. (2022) · Nature Communications · doi:10.1038/s41467-022-33850-4 · Cited by 99

The Role of Thioredoxin in the Aging Process: Involvement of Oxidative Stress

Yoshida, T., Oka, S., Masutani, H., Nakamura, H., & Yodoi, J. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603770310211 · Cited by 97

Forkhead transcription factors and ageing

Partridge, L., & Brüning, J. C. (2008) · Oncogene · doi:10.1038/onc.2008.28 · Cited by 97

Sex differences in lifespan extension with acarbose and 17‐α estradiol: gonadal hormones underlie male‐specific improvements in glucose tolerance and mTORC 2 signaling

Garratt, M., Bower, B., Garcia, G. G., & Miller, R. A. (2017) · Aging Cell · doi:10.1111/acel.12656 · Cited by 106

Aging bone and cartilage: cross-cutting issues

Carrington, J. L. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.041 · Cited by 96

Tau Is Hyperphosphorylated in the Insulin-Like Growth Factor-I Null Brain

Cheng, C. M., Tseng, V., Wang, J., Wang, D., Matyakhina, L., & Bondy, C. A. (2005) · Endocrinology · doi:10.1210/en.2005-0063 · Cited by 94

Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension

Yu, D., Tomasiewicz, J. L., Yang, S. E., Miller, B. R., Wakai, M. H., Sherman, D. S., Cummings, N. E., Baar, E. L., Brinkman, J. A., Syed, F. A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.084 · Cited by 98

A Muscle-Specific p38 MAPK/Mef2/MnSOD Pathway Regulates Stress, Motor Function, and Life Span in Drosophila

Vrailas‐Mortimer, A. D., del Rivero, T., Mukherjee, S., Nag, S., Gaitanidis, A., Kadas, D., Consoulas, C., Duttaroy, A., & Sanyal, S. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.09.002 · Cited by 95

NFκB Promotes Inflammation, Coagulation, and Fibrosis in the Aging Glomerulus

Wiggins, J. E., Patel, S. R., Shedden, K., Goyal, M., Wharram, B. L., Martini, S., Kretzler, M., & Wiggins, R. C. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009060663 · Cited by 94

IGF-I and the aging mammalian brain

Piriz, J., Muller, A. P., Trejo, J. L., & Torres‐Alemán, I. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.08.022 · Cited by 93

Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases

Wang, Z., Li, W., Guo, Q., Wang, Y., Ma, L., & Xiao-ju, Z. (2018) · BioMed Research International · doi:10.1155/2018/6057589 · Cited by 93

Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span

Sun, J., Molitor, J., & Tower, J. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.01.009 · Cited by 93

Longevity effect of IGF ‐1 R +/− mutation depends on genetic background‐specific receptor activation

Xu, J., Gontier, G., Chaker, Z., Lacube, P., Dupont, J., & Holzenberger, M. (2013) · Aging Cell · doi:10.1111/acel.12145 · Cited by 96

Aging as a Mitochondria‐Mediated Atavistic Program: Can Aging Be Switched Off?

Skulachev, V. P., & Longo, V. D. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1356.009 · Cited by 94

Age-Related Phasic Patterns of Mitochondrial Maintenance in Adult Caenorhabditis elegans Neurons

Morsci, N. S., Hall, D. H., Driscoll, M., & Sheng, Z.-H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2799-15.2016 · Cited by 92

Body size, inbreeding, and lifespan in domestic dogs

Yordy, J., Kraus, C., Hayward, J. J., White, M. E., Shannon, L. M., Creevy, K. E., Promislow, D. E. L., & Boyko, A. R. (2020) · Conservation Genetics · doi:10.1007/s10592-019-01240-x · Cited by 92

IGF-1 Receptors in Mammalian Longevity: Less is More

Holzenberger, M. (2004) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-662-07019-2_3

Absence makes the mouse live longer

Bussell, K. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1023

The Role of Insulin-Like Signalling in the Regulation of Ageing

Holzenberger, M. (2004) · Hormone Research in Paediatrics · doi:10.1159/000080765 · Cited by 21

Does Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?

Bokov, A. F., Garg, N., Ikeno, Y., Thakur, S., Musi, N., DeFronzo, R. A., Zhang, N., Erickson, R. C., Gelfond, J., Hubbard, G. B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026891 · Cited by 152

Hormonal regulation of aging and life span

Brown‐Borg, H. M. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(03)00051-1 · Cited by 28