IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

Liu, J.-P., Baker, J. C., Perkins, A. S., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80084-4 · Cited by 2,854

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250

The p66shc adaptor protein controls oxidative stress response and life span in mammals

Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

Tatar, M., Kopelman, A. H., Epstein, D., Tu, M., Yin, C. ‐., & Garofalo, R. S. (2001) · Science · doi:10.1126/science.1057987 · Cited by 1,630

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., & Partridge, L. (2001) · Science · doi:10.1126/science.1057991 · Cited by 1,436

Genetic pathways that regulate ageing in model organisms

Guarente, L., & Kenyon, C. J. (2000) · Nature · doi:10.1038/35041700 · Cited by 1,337

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

Kulkarni, R., Brüning, J. C., Winnay, J. N., Postic, C., Magnuson, M. A., & Kahn, C. R. (1999) · Cell · doi:10.1016/s0092-8674(00)80546-2 · Cited by 1,148

Dwarf mice and the ageing process

Brown‐Borg, H. M., Borg, K. E., Meliska, C. J., & Bartke, A. (1996) · Nature · doi:10.1038/384033a0 · Cited by 1,091

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

Flurkey, K., Papaconstantinou, J., Miller, R. A., & Harrison, D. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111158898 · Cited by 826

Nuclear receptor signal transduction in C. elegans

Antebi, A. (2015) · WormBook · doi:10.1895/wormbook.1.64.2 · Cited by 93

Genetics and genomics of human ageing

Wheeler, H. E., & Kim, S. K. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0259 · Cited by 98

Growth hormone and aging: A challenging controversy

Bartke, A. (2008) · Clinical Interventions in Aging · doi:10.2147/cia.s3697 · Cited by 93

IGF binding protein 2 supports the survival and cycling of hematopoietic stem cells

Huynh, H., Zheng, J., Umikawa, M., Zhang, C., Silvany, R. E., Iizuka, S., Holzenberger, M., Zhang, W., & Zhang, C. C. (2011) · Blood · doi:10.1182/blood-2011-01-331876 · Cited by 92

Insulin-like Growth Factor-I Receptor Blockade Improves Outcome in Mouse Model of Lung Injury

Choi, J.-E., Lee, S.-S., Sunde, D. A., Huizar, I., Haugk, K. H., Thannickal, V. J., Vittal, R., Plymate, S. R., & Schnapp, L. M. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200802-228oc · Cited by 92

The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans

Li, J., Tewari, M., Vidal, M., & Lee, S. S. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.10.013 · Cited by 92

Promoting longevity by maintaining metabolic and proliferative homeostasis

Wang, L., Karpac, J., & Jasper, H. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.089920 · Cited by 91

Down-Regulation of a Forkhead Transcription Factor, FOXO3a, Accelerates Cellular Senescence in Human Dermal Fibroblasts

Kim, H.-J., Kim, Y., Song, I., Baek, S.-H., Lee, S., Kim, J.-R., & Kim, J. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.1.4 · Cited by 93

The role of insulin/IGF-like signaling in C. elegans longevity and aging

Kaletsky, R. L., & Murphy, C. T. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.001040 · Cited by 94

p66Shc, oxidative stress and aging: Importing a lifespan determinant into mitochondria

Pinton, P., & Rizzuto, R. (2008) · Cell Cycle · doi:10.4161/cc.7.3.5360 · Cited by 91

Energy Metabolism and Ageing in the Mouse: A Mini-Review

Azzu, V., & Valencak, T. G. (2017) · Gerontology · doi:10.1159/000454924 · Cited by 90

Mitochondrial longevity pathways

Vendelbo, M. H., & Nair, K. S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.029 · Cited by 92

Proteomics and metabolomics in ageing research: from biomarkers to systems biology

Hoffman, J. M., Lyu, Y., Pletcher, S. D., & Promislow, D. (2017) · Essays in Biochemistry · doi:10.1042/ebc20160083 · Cited by 90

Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans

Mouchiroud, L., Molin, L., Kasturi, P., Triba, M. N., Dumas, M., Wilson, M. C., Halestrap, A. P., Roussel, D., Masse, I., Dallière, N., et al. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00640.x · Cited by 92

Insulin Is a Stronger Inducer of Insulin Resistance than Hyperglycemia in Mice with Type 1 Diabetes Mellitus (T1DM)

Liu, H.-Y., Cao, S. Y., Hong, T., Han, J., Liu, Z., & Cao, W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.016675 · Cited by 93

Low Circulating Insulin-Like Growth Factor I Bioactivity in Elderly Men Is Associated with Increased Mortality

Brugts, M. P., van den Beld, A. W., Hofland, L. J., van der Wansem, K., van Koetsveld, P. M., Frystyk, J., Lamberts, S. W. J., & Janssen, J. A. M. J. L. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1633 · Cited by 90

Prospects for Life Span Extension

Sierra, F., Hadley, E., Suzman, R., & Hodes, R. J. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.60.061607.220533 · Cited by 92

Growth hormone administration to long-living dwarf mice alters multiple components of the antioxidative defense system

Brown‐Borg, H. M., & Rakoczy, S. G. (2003) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2003.07.001 · Cited by 90

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity

Ma, S., Upneja, A., Galecki, A., Tsai, Y.-M., Burant, C. F., Raskind, S., Zhang, Q., Zhang, Z. D., Seluanov, A., Gorbunova, V., et al. (2016) · eLife · doi:10.7554/elife.19130 · Cited by 89

The Insulin-Like Growth Factor-1 Receptor Is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium

Abbas, A., Imrie, H., Viswambharan, H., Sukumar, P., Rajwani, A., Cubbon, R. M., Gage, M., Smith, J., Galloway, S. L., Yuldasheva, N. Y., et al. (2011) · Diabetes · doi:10.2337/db11-0197 · Cited by 92

Pan-mammalian analysis of molecular constraints underlying extended lifespan

Kowalczyk, A., Partha, R., Clark, N. L., & Chikina, M. (2020) · eLife · doi:10.7554/elife.51089 · Cited by 95

Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging

Bartke, A. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.01.002 · Cited by 91

IGF-1 receptor antagonism inhibits autophagy

Renna, M., Bento, C. F., Fleming, A., Menzies, F. M., Siddiqi, F. H., Ravikumar, B., Puri, C., García-Arencibia, M., Sadiq, O., Corrochano, S., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt300 · Cited by 92

Insulin and aging – a disappointing relationship

Kolb, H., Kempf, K., & Martin, S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1261298 · Cited by 92

Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression

Brandhorst, S., Wei, M., Hwang, S., Morgan, T. E., & Longo, V. D. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.016 · Cited by 89

Quantitative and Molecular Genetic Analyses of Mutations Increasing Drosophila Life Span

Magwire, M. M., Ah, Y., Carbone, M. A., Roshina, N. V., Symonenko, A. V., PASYUKOVA, E. G., Morozova, T. V., & Mackay, T. F. C. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001037 · Cited by 88

Early Postnatal Nutrition Determines Somatotropic Function in Mice

Kappeler, L., Filho, C. D. D. M., Leneuve, P., Xu, J., Brunel, N., Chatziantoniou, C., Bouc, Y. L., & Holzenberger, M. (2008) · Endocrinology · doi:10.1210/en.2008-0981 · Cited by 88

Restriction of Dietary Energy and Protein Induces Molecular Changes in Young Porcine Skeletal Muscles

da Costa, N., McGillivray, C., Bai, Q., Chang, K., Wood, J. D., & Evans, G. (2004) · Journal of Nutrition · doi:10.1093/jn/134.9.2191 · Cited by 91

Disruption of the GH Receptor Gene in Adult Mice Increases Maximal Lifespan in Females

Junnila, R. K., Duran‐Ortiz, S., Suer, O., Sustarsic, E. G., Berryman, D. E., List, E. O., & Kopchick, J. J. (2016) · Endocrinology · doi:10.1210/en.2016-1649 · Cited by 88

Oxidative Stress and the Aging Brain

Vila, J., Gemma, C., Bachstetter, A. D., & Bickford, P. C. (2007) · Frontiers in neuroscience · doi:10.1201/9781420005523.ch15 · Cited by 88

Stress resistance and aging: Influence of genes and nutrition

Harper, J. M., Salmon, A. B., Chang, Y., Bonkowski, M. S., Bartke, A., & Miller, R. A. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.04.002 · Cited by 88

‘Accelerated aging’: a primrose path to insight?

Miller, R. A. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00081.x · Cited by 87

Regulation of replicative senescence by insulin‐like growth factor‐binding protein 3 in human umbilical vein endothelial cells

Kim, K. S., Kim, M., Seu, Y. B., Chung, H. Y., Kim, J. H., & Kim, J. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00315.x · Cited by 91

The Regulation of Aging and Longevity: A New and Complex Role of p53

Feng, Z., Lin, M., & Wu, R. (2011) · Genes & Cancer · doi:10.1177/1947601911410223 · Cited by 88

Mitochondrial longevity pathways

Raffaello, A., & Rizzuto, R. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.10.007 · Cited by 72

Long-Lived Ames Dwarf Mice Are Resistant to Chemical Stressors

Bokov, A. F., Lindsey, M. L., Khodr, C. E., Sabia, M. R., & Richardson, A. G. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp052 · Cited by 87

Counting the Calories: The Role of Specific Nutrients in Extension of Life Span by Food Restriction

Piper, M. D. W., Mair, W. B., & Partridge, L. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.5.549 · Cited by 87

Human aging and disease: Lessons from age-related macular degeneration

Luu, J. C., & Palczewski, K. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721033115 · Cited by 88

Hormonal control of aging in rodents: The somatotropic axis

Brown‐Borg, H. M. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.07.001 · Cited by 86

Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation

Seo, Y., Jung, H., Shin, H., Kim, Y., Yim, H., Chung, H., Lim, I. K., & Yoon, G. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00436.x · Cited by 90

Depressive symptoms are associated with allostatic load among community-dwelling older adults

Kobrosly, R. W., van Wijngaarden, E., Seplaki, C. L., Cory‐Slechta, D. A., & Moynihan, J. A. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.10.014 · Cited by 94

Modulation of longevity and diapause by redox regulation mechanisms under the insulin-like signaling control in Caenorhabditis elegans

Honda, Y., Tanaka, M., & Honda, S. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.02.009 · Cited by 90

Ageing and metabolism: drug discovery opportunities

Curtis, R., Geesaman, B. J., & DiStefano, P. S. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1777 · Cited by 86

Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice

Quipildor, G. F., Mao, K., Hu, Z., Novaj, A., Cui, M., Gulinello, M. E., Branch, C. A., Gubbi, S., Patel, K., Moellering, D. R., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00065-3 · Cited by 85

The Involvement of Thioredoxin and Thioredoxin Binding Protein‐2 on Cellular Proliferation and Aging Process

Yoshida, T., NAKAMURA, H., Masutani, H., & Yodoi, J. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1323.002 · Cited by 87

Altered longevity‐assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death

Pehar, M., O’Riordan, K. J., Burns‐Cusato, M., Andrzejewski, M. E., del Alcazar, C. R. G., Bürger, C., Scrable, H. J., & Puglielli, L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00547.x · Cited by 89

The Evolution of Programmed Death in a Spatially Structured Population

Travis, J. M. J. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.4.b301 · Cited by 85

Linking sirtuins, IGF-I signaling, and starvation

Longo, V. D. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.06.005 · Cited by 85

Allostatic Load and Frailty in the Women's Health and Aging Studies

Szanton, S. L., Allen, J. K., Seplaki, C. L., Bandeen‐Roche, K., & Fried, L. P. (2008) · Biological Research For Nursing · doi:10.1177/1099800408323452 · Cited by 84

Effect of IGF‐1 on the balance between autophagy of dysfunctional mitochondria and apoptosis

Gu, Y., Wang, C., & Cohen, A. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.10.040 · Cited by 84

Reciprocal Regulation between SIRT6 and miR-122 Controls Liver Metabolism and Predicts Hepatocarcinoma Prognosis

Elhanati, S., Ben‐Hamo, R., Kanfi, Y., Varvak, A., Glazz, R., Lerrer, B., Efroni, S., & Cohen, H. Y. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.12.023 · Cited by 84

Effect of ageing on tactile transduction processes

Decorps, J., Saumet, J. L., Sommer, P., Sigaudo-Roussel, D., & Fromy, B. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2013.12.003 · Cited by 83

Favorable Glucose Tolerance and Lower Prevalence of Metabolic Syndrome in Offspring without Diabetes Mellitus of Nonagenarian Siblings: The Leiden Longevity Study

Rozing, M. P., Westendorp, R. G. J., de Craen, A. J. M., Frölich, M., de Goeij, M. C. M., Heijmans, B. T., Beekman, M., Wijsman, C. A., Mooijaart, S. P., Blauw, G. J., et al. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02725.x · Cited by 83

Kidney aging—inevitable or preventable?

Choudhury, D., & Levi, M. (2011) · Nature Reviews Nephrology · doi:10.1038/nrneph.2011.104 · Cited by 84

Aging and cardiovascular diseases: the role of gene-diet interactions

Corella, D., & Ordovás, J. M. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.08.002 · Cited by 83

Evolutionary ecology of endocrine‐mediated life‐history variation in the garter snake Thamnophis elegans

Sparkman, A. M., Vleck, C. M., & Bronikowski, A. M. (2009) · Ecology · doi:10.1890/08-0850.1 · Cited by 83

Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?

Smith, H. J., Sharma, A., & Mair, W. B. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.011 · Cited by 83

Peroxisome Proliferator-Activated Receptors and Caloric Restriction—Common Pathways Affecting Metabolism, Health, and Longevity

Duszka, K., Gregor, A., Guillou, H., König, J. S., & Wahli, W. (2020) · Cells · doi:10.3390/cells9071708 · Cited by 86

Insulin/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention

Anisimov, V. V. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00169-4 · Cited by 83

Hypothalamic neurogenesis persists in the aging brain and is controlled by energy-sensing IGF-I pathway

Chaker, Z., George, C., Petrovska, M., Caron, J.-B., Lacube, P., Caillé, I., & Holzenberger, M. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.02.008 · Cited by 82

Resilience in Aging Mice

Kirkland, J. L., Stout, M. B., & Sierra, F. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw086 · Cited by 83

The Alzheimer’s disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons

George, C., Gontier, G., Lacube, P., François, J., Holzenberger, M., & Aïd, S. (2017) · Brain · doi:10.1093/brain/awx132 · Cited by 82

The Paradox of Coenzyme Q10 in Aging

Díaz-Casado, M. E., Quiles, J. L., Barriocanal-Casado, E., González-García, P., Battino, M., López, L. C., & Varela-López, A. (2019) · Nutrients · doi:10.3390/nu11092221 · Cited by 81

Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction

Suda, M., Paul, K. H., Tripathi, U., Minamino, T., Tchkonia, T., & Kirkland, J. L. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae010 · Cited by 83

Long-Term IGF-I Exposure Decreases Autophagy and Cell Viability

Bitto, A., Lerner, C. A., Torres, C. A., Roell, M., Malaguti, M., Pérez, V., Lorenzini, A., Hrelia, S., Ikeno, Y., Matzko, M. E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012592 · Cited by 81

Signals of youth: endocrine regulation of aging in Caenorhabditis elegans

Panowski, S. H., & Dillin, A. G. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.03.006 · Cited by 81

Off-label use of hormones as an antiaging strategy: a review

Samaras, N., Papadopoulou, M.-A., Samaras, D., & Ongaro, F. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s48918 · Cited by 83

Breast cancer treatment and its effects on aging

Chang, L., Weiner, L. S., Hartman, S. J., Horvath, S., Jeste, D. V., Mischel, P. S., & Kado, D. M. (2018) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2018.07.010 · Cited by 84

The GH-IGF1 axis and longevity: the paradigm of IGF1 deficiency

Laron, Z. (2008) · HORMONES · doi:10.14310/horm.2002.1111034 · Cited by 80

Suppression of IGF ‐I signals in neural stem cells enhances neurogenesis and olfactory function during aging

Chaker, Z., Aïd, S., Berry, H., & Holzenberger, M. (2015) · Aging Cell · doi:10.1111/acel.12365 · Cited by 80

The paradox of neuronal insulin action and resistance in the development of aging‐associated diseases

Steculorum, S. M., Solas, M., & Brüning, J. C. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.12.008 · Cited by 82

Aging of the brain, neurotrophin signaling, and Alzheimer's disease: Is IGF1-R the common culprit?

Puglielli, L. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.01.010 · Cited by 61

Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging

Swindell, W. R. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-353 · Cited by 80

Antagonistic pleiotropy and p53

Ungewitter, E. K., & Scrable, H. J. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.06.002 · Cited by 88

IRS2 integrates insulin/ IGF1 signalling with metabolism, neurodegeneration and longevity

White, M. F. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12347 · Cited by 82

Role of the Insulin-like Growth Factor System in Adrenocortical Growth Control and Carcinogenesis

Fottner, C., Hoeflich, A., Wolf, E., & Weber, M. (2004) · Hormone and Metabolic Research · doi:10.1055/s-2004-814563 · Cited by 78

Lipidome determinants of maximal lifespan in mammals

Bożek, K., Khrameeva, E. E., Reznick, J., Omerbašić, D., Bennett, N. C., Lewin, G. R., Azpurua, J., Gorbunova, V. A., Seluanov, A., Régnard, P., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00037-7 · Cited by 77

Extended longevity and insulin signaling in adipose tissue

Klöting, N., & Blüher, M. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.07.004 · Cited by 78

Protective Mechanisms of the Mitochondrial‐Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells

Minasyan, L., Sreekumar, P. G., Hinton, D. R., & Kannan, R. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1675230 · Cited by 77

Genes, ageing and longevity in humans: Problems, advantages and perspectives

Salvioli, S., Olivieri, F., Marchegiani, F., Cardelli, M., Santoro, A., Bellavista, E., Mishto, M., Invidia, L., Capri, M., Valensin, S., et al. (2006) · Free Radical Research · doi:10.1080/10715760600917136 · Cited by 77

Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity

Hasty, P., & Vijg, J. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00082.x · Cited by 80

The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer

Podlutsky, A. J., Valcarcel‐Ares, M. N., Yancey, K., Podlutskaya, V., Nagykaldi, E., Gautam, T., Miller, R. A., Sonntag, W. E., Csiszár, A., & Ungvari, Z. I. (2017) · GeroScience · doi:10.1007/s11357-017-9966-x · Cited by 76

Causes and Mechanisms of Hematopoietic Stem Cell Aging

Lee, J., Yoon, S. R., Choi, I., & Jung, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061272 · Cited by 82

IFTA-2 is a conserved cilia protein involved in pathways regulating longevity and dauer formation inCaenorhabditis elegans

Schafer, J. C., Winkelbauer, M. E., Williams, C. L., Haycraft, C. J., Desmond, R. A., & Yoder, B. K. (2006) · Journal of Cell Science · doi:10.1242/jcs.03187 · Cited by 78

Oxidative Stress Contributes to Aging by Enhancing Pancreatic Angiogenesis and Insulin Signaling

Laurent, G., Solari, F., Mateescu, B., Karaca, M., Castel, J., Bourachot, B., Magnan, C., Billaud, M., & Mechta‐Grigoriou, F. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.12.010 · Cited by 76

The role of mTOR in the adaptation and failure of β‐cells in type 2 diabetes

Leibowitz, G., Cerasi, E., & Ketzinel‐Gilad, M. (2008) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00952.x · Cited by 76

Haploinsufficiency of Akt1 Prolongs the Lifespan of Mice

Nojima, A., Yamashita, M., Yoshida, Y., Shimizu, I., Ichimiya, H., Kamimura, N., Kobayashi, Y., Ohta, S., Ishii, N., & Minamino, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069178 · Cited by 78

Meg1/Grb10 overexpression causes postnatal growth retardation and insulin resistance via negative modulation of the IGF1R and IR cascades

Shiura, H., Miyoshi, N., Konishi, A., Wakisaka‐Saito, N., Suzuki, R., Muguruma, K., Kohda, T., Wakana, S., Yokoyama, M., Ishino, F., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.047 · Cited by 76

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: Cross sectional and longitudinal studies

Soerensen, M., Dato, S., Tan, Q., Thinggaard, M., Kleindorp, R., Beekman, M., Lindahl‐Jacobsen, R., Suchiman, H. E. D., de Craen, A. J. M., Westendorp, R. G. J., et al. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.02.010 · Cited by 76

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Sonntag, W. E., Csiszár, A., de Cabo, R., Ferrucci, L., & Ungvari, Z. I. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls115 · Cited by 77

A Heterozygous Mutation of the Insulin-Like Growth Factor-I Receptor Causes Retention of the Nascent Protein in the Endoplasmic Reticulum and Results in Intrauterine and Postnatal Growth Retardation

Wallborn, T., Wüller, S., Klammt, J., Kruis, T., Kratzsch, J., Schmidt, G., Schlicke, M., Müller, E. C., van de Leur, H. S., Kieß, W., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2404 · Cited by 76

Metformin treatment ameliorates diabetes‐associated decline in hippocampal neurogenesis and memory via phosphorylation of insulin receptor substrate 1

Tanokashira, D., Kurata, E., Fukuokaya, W., Kawabe, K., Mana, K., Takeuchi, H., Nakazato, M., & Taguchi, A. (2018) · FEBS Open Bio · doi:10.1002/2211-5463.12436 · Cited by 78

Estrogen, Insulin, and Dietary Signals Cooperatively Regulate Longevity Signals to Enhance Resistance to Oxidative Stress in Mice

Baba, T., Shimizu, T., Suzuki, Y., OGAWARA, M., Isono, K., Koseki, H., Kurosawa, H., & Shirasawa, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500924200 · Cited by 78

Calorie restriction and the nutrient sensing signaling pathways

Dilova, I., Easlon, E. J., & Lin, S.-J. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6381-y · Cited by 77

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Navakkode, S., & Kennedy, B. K. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1428244 · Cited by 75

Insulin/insulin-like growth factor-1 signalling (IIS) based regulation of lifespan across species

Mathew, R., Bhadra, M. P., & Bhadra, U. (2017) · Biogerontology · doi:10.1007/s10522-016-9670-8 · Cited by 79

Temporal requirements of insulin/IGF‐1 signaling for proteotoxicity protection

Cohen, E., Du, D., Joyce, D., Kapernick, E. A., Volovik, Y., Kelly, J. W., & Dillin, A. G. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00541.x · Cited by 78

IGF-I is a matter of heart

Opgaard, O. S., & Wang, P. H. (2005) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2005.02.002 · Cited by 75

Biological processes modulating longevity across primates: a phylogenetic genome-phenome analysis

Muntané, G., Farré, X., Rodríguez, J. A., Pegueroles, C., Hughes, D. A., de Magalhães, J. P., Gabaldón, T., & Navarro, A. (2018) · Molecular Biology and Evolution · doi:10.1093/molbev/msy105 · Cited by 73

Growth hormone in fertility and infertility: Mechanisms of action and clinical applications

Chang, C., Sung, Y.-W., Hsueh, Y., Chen, Y., Ho, M., Hsu, H.-C., Yang, T., Lin, W.-C., & Chang, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1040503 · Cited by 74

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Holzenberger, M. (2004) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-662-07019-2_3

Absence makes the mouse live longer

Bussell, K. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1023

The Role of Insulin-Like Signalling in the Regulation of Ageing

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Does Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?

Bokov, A. F., Garg, N., Ikeno, Y., Thakur, S., Musi, N., DeFronzo, R. A., Zhang, N., Erickson, R. C., Gelfond, J., Hubbard, G. B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026891 · Cited by 152

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