The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Epigenetic rejuvenation
Abstract
Induced pluripotent stem (iPS) cells have provided a rational means of obtaining histo‐compatible tissues for ‘patient‐specific’ regenerative therapies (Hanna et al. 2010; Yamanaka & Blau 2010). Despite the obvious potential of iPS cell‐based therapies, there are certain problems that must be overcome before these therapies can become safe and routine (Ohi et al. 2011; Pera 2011). As an alternative, we have recently explored the possibility of using ‘epigenetic rejuvenation’, where the specialized functions of an old cell are rejuvenated in the absence of any change in its differentiated state (Singh & Zacouto 2010). The mechanism(s) that underpin ‘epigenetic rejuvenation’ are unknown and here we discuss model systems, using key epigenetic modifiers, which might shed light on the processes involved. Epigenetic rejuvenation has advantages over iPS cell techniques that are currently being pursued. First, the genetic and epigenetic abnormalities that arise through the cycle of dedifferentiation of somatic cells to iPS cells followed by redifferentiation of iPS cells into the desired cell type are avoided (Gore et al. 2011; Hussein et al. 2011; Pera 2011): epigenetic rejuvenation does not require passage through the de‐/redifferentiation cycle. Second, because the aim of epigenetic rejuvenation is to ensure that the differentiated cell type retains its specialized function it makes redundant the question of transcriptional memory that is inimical to iPS cell‐based therapies (Ohi et al. 2011). Third, to produce unrelated cell types using the iPS technology takes a long time, around three weeks, whereas epigenetic rejuvenation of old cells will take only a matter of days. Epigenetic rejuvenation provides the most safe, rapid and cheap route to successful regenerative medicine.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The idea of inducing epigenetic transition to a 'youthful' state without the loss of cell identity, defined as 'epigenetic rejuvenation', was proposed for the first time in 2010.
“The idea of inducing epigenetic transition to a 'youthful' state without the loss of cell identity, defined as 'epigenetic rejuvenation', was proposed for the first time in 2010 (refs.99-101).”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [99]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278 · cited 5×
“SAHF contain within them a variety of markers the most notable being the repressive me3K9H3 determinant of the histone code, heterochromatin protein 1 (HP1) proteins, and the variant histone macro H2A (mH2A) (Narita et al. 2003; Zhang et al. 2005).”
BackgroundInfluentialIGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109
Somatic coding mutations in human induced pluripotent stem cells
Gore, A., Li, Z., Fung, H.-L., Young, J. E., Agarwal, S., Antosiewicz-Bourget, J., Canto, I., Giorgetti, A., Israel, M. A., Kiskinis, E., et al. (2011) · Nature · doi:10.1038/nature09805 · Cited by 1,273
Cellular Senescence in Aging Primates
Herbig, U., Ferreira, M., Condel, L., Carey, D., & Sedivy, J. M. (2006) · Science · doi:10.1126/science.1122446 · Cited by 1,101
Increased cell-to-cell variation in gene expression in ageing mouse heart
Bahar, R., Hartmann, C. H., Rodriguez, K. A., Denny, A. D., Busuttil, R. A., Dollé, M. E. T., Calder, R. B., Chisholm, G. B., Pollock, B. H., Klein, C. A., et al. (2006) · Nature · doi:10.1038/nature04844 · Cited by 603
Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state
Lapasset, L., Milhavet, O., Prieur, A., Besnard, E., Babled, A., Aït-Hamou, N., Leschik, J., Pellestor, F., Ramirez, J.-M., De Vos, J., et al. (2011) · Genes & Development · doi:10.1101/gad.173922.111 · Cited by 570
Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer
Di Micco, R., Sulli, G., Dobreva, M., Liontos, M., Botrugno, O. A., Gargiulo, G., dal Zuffo, R., Matti, V., d'Ario, G., Montani, E., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2170 · Cited by 382
Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence
Adams, P. D. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.021 · Cited by 326
The role of nuclear architecture in genomic instability and ageing.
Oberdoerffer, P., & Sinclair, D. A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2238 · Cited by 305
Kosar, M., Bartkova, J., Hubackova, S., Hodny, Z., Lukas, J., & Bartek, J. (2011) · Cell Cycle · doi:10.4161/cc.10.3.14707 · Cited by 283
Age‐associated increase in heterochromatic marks in murine and primate tissues
Kreiling, J. A., Tamamori‐Adachi, M., Sexton, A. N., Jeyapalan, J. C., Munoz‐Najar, U., Peterson, A. L., Manivannan, J., Rogers, E. S., Pchelintsev, N. A., Adams, P. D., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2010.00666.x · Cited by 152
Flagged first, then by citations
Research works printed but not linked: 35
- 10.1016/j.tibs.2009.09.003 · DOI
- 10.1073/pnas.38.5.455 · DOI
- 10.1038/nrm2233 · DOI · Paper page
- 10.1128/MCB.02258-05 · DOI
- 10.1007/s00018-003-3121-9 · DOI
- 10.1126/science.1158799 · DOI
- 10.1038/ncb2164 · DOI
- Elsdale T.R., 1960, A description of the technique for nuclear transplantation in Xenopus laevis, J. Embryol. Exp. Morphol., 8, 437
- 10.1016/j.ymeth.2010.01.035 · DOI
- 10.1016/j.cell.2010.10.008 · DOI
- 10.1016/0014-4827(61)90192-6 · DOI · Paper page
- 10.1038/nature09871 · DOI
- 10.1016/j.mad.2006.11.008 · DOI · Paper page
- 10.1038/nrm3140 · DOI
- 10.1038/cr.2010.164 · DOI
- 10.1038/sj.onc.1205077 · DOI
- 10.1038/270301a0 · DOI
- Medawar P.B., 1952, An Unsolved Problem of Biology
- 10.1002/dvg.20420 · DOI
- 10.1074/jbc.M111.244871 · DOI
- 10.1038/nmeth.f.292 · DOI
- 10.1038/nature10397 · DOI
- 10.1038/ncb2239 · DOI
- 10.1038/emboj.2011.144 · DOI
- 10.1038/471046a · DOI
- 10.1007/978-1-59745-154-3_19 · DOI
- 10.1038/ncb1095 · DOI · Paper page
- 10.1007/s12038-010-0034-2 · DOI · Paper page
- 10.1038/443284a · DOI
- 10.1016/S0076-6879(10)76009-2 · DOI
- 10.1111/j.1474-9726.2009.00481.x · DOI · Paper page
- 10.1111/j.1558-5646.1957.tb02911.x · DOI · Paper page
- 10.1038/385810a0 · DOI
- 10.1038/nature09229 · DOI
- 10.1016/j.devcel.2004.10.019 · DOI · Paper page
Cited by
Sorted by citations
Global reorganization of the nuclear landscape in senescent cells
Chandra, T., Ewels, P. A., Schoenfelder, S., Furlan-Magaril, M., Wingett, S. W., Kirschner, K., Thuret, J.-Y., Andrews, S., Fraser, P., & Reik, W. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.055 · Cited by 348
Multi-omic rejuvenation of human cells by maturation phase transient reprogramming
Gill, D., Parry, A., Santos, F., Okkenhaug, H., Todd, C. D., Hernando-Herraez, I., Stubbs, T. M., Milagre, I., & Reik, W. (2022) · eLife · doi:10.7554/elife.71624 · Cited by 185
Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming
Cipriano, A., Moqri, M., Maybury-Lewis, S. Y., Rogers-Hammond, R., de Jong, T. A., Parker, A., Rasouli, S., Schöler, H. R., Sinclair, D. A., & Sebastiano, V. (2023) · Nature Aging · doi:10.1038/s43587-023-00539-2 · Cited by 66
Promises of reprogramming-induced rejuvenation
Simpson, D. J., Arif, N., Suwanlikit, Y., Kirschner, K., & Chandra, T. (2026) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2026.102484 · Cited by 2
Metadata
- Authors
- Manukyan, M., & Singh, P. B.
- Venue
- Genes to Cells
- Publisher
- Wiley
- Published
- 2012-04-04
- Volume
- 17
- Issue
- 5
- Pages
- 337-343
- ISSN
- 1356-9597
- 1365-2443
- PMC
- PMC3444684
- Cited by
- 35
- References
- 11
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
