Cited by 1,010Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesHypothalamic control of reproductive hormones

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STAT3 signalling is required for leptin regulation of energy balance but not reproduction

Bates, Sarah H., Stearns, Walter H., Dundon, Trevor A., Schubert, Markus, Tso, Annette W. K., Wang, Yongping, Banks, Alexander S., Lavery, Hugh J., Haq, Asma K., Maratos-Flier, Eleftheria, Neel, Benjamin G., Schwartz, Michael W., Myers, Martin G.·2003·Nature

DOI 10.1038/nature01388

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Abstract

Secretion of leptin from adipocytes communicates body energy status to the brain by activating the leptin receptor long form (LRb). LRb regulates energy homeostasis and neuroendocrine function; the absence of LRb in db/db mice results in obesity, impaired growth, infertility and diabetes. Tyr 1138 of LRb mediates activation of the transcription factor STAT3 during leptin action. To investigate the contribution of STAT3 signalling to leptin action in vivo, we replaced the gene encoding the leptin receptor (lepr) in mice with an allele coding for a replacement of Tyr 1138 in LRb with a serine residue (lepr(S1138)) that specifically disrupts the LRb-STAT3 signal. Here we show that, like db/db mice, lepr(S1138) homozygotes (s/s) are hyperphagic and obese. However, whereas db/db mice are infertile, short and diabetic, s/s mice are fertile, long and less hyperglycaemic. Furthermore, hypothalamic expression of neuropeptide Y (NPY) is elevated in db/db mice but not s/s mice, whereas the hypothalamic melanocortin system is suppressed in both db/db and s/s mice. LRb-STAT3 signalling thus mediates the effects of leptin on melanocortin production and body energy homeostasis, whereas distinct LRb signals regulate NPY and the control of fertility, growth and glucose homeostasis.

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Background
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Background
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“leading to the activation of STAT and subsequent physiological actions, including energy balance regulation (5; 6; 7) .”
Background
Evolution of Vertebrate Hormones and Their Receptors: Insights from Non-Osteichthyan Genomes
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“However, little change in glucose homeostasis was observed (3, 39).”
Background
Rats that are predisposed to excessive obesity show reduced (leptin‐induced) thermoregulation even in the preobese state
Git, K. C. G., Outer, J. A., Wolterink‐Donselaar, I. G., Luijendijk, M. C. M., Schéle, E., Dickson, S. L., & Adan, R. A. H. (2019) · Physiological Reports · doi:10.14814/phy2.14102 · Cited by 12
“…to LS rats, LR rats showed a preexisting reduction in the activation of leptin-induced signal transducer and activator of transcript 3 (pSTAT3), a marker for cellular leptin sensitivity (Bates et al. 2003; Gao et al. 2004), in the dorsomedial hypothalamus (DMH) but not the arcuate nucleus (ARC).”
Background
Leptin increases GABAergic synaptogenesis through the Rho guanine exchange factor β-PIX in developing hippocampal neurons
Sahin, G. S., Rodriguez-Llamas, J. L., Dillon, C., Medina, I., Appleyard, S. M., Gaïarsa, J., & Wayman, G. A. (2021) · Science Signaling · doi:10.1126/scisignal.abe4111 · Cited by 12
“We used previously verified leptin receptor constructs LepRY985L and LepRY1138S, which cannot be phosphorylated at Tyr985 and Tyr1138, respectively, and consequently cannot activate the respective downstream signaling pathways (17, 38, 39).”
Method
A novel compound heterozygous leptin receptor mutation causes more severe obesity than in Lepr mice
Berger, C., Heyne, H., Heiland, T., Dommel, S., Höfling, C., Guiu‐Jurado, E., Lorenz, J. E., Roßner, S., Dannemann, M., Kelso, J. F., et al. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100105 · Cited by 15
“Activation of Stat3 signaling pathway has been shown to mediate the effects of leptin on melanocortin production and energy homeostasis (25).”
Background
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“As reported by Bates et al. (2003), STAT3-deficient mice display an obesity phenotype, implicating the essential role of STAT3 in energy balance.”
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“From the third to fourth week, obesity starts [16] and the blood glucose level begins to rise between the fourth and eighth week [17].”
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Kim, M.-S., Quan, W., & Lee, M. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9257-5 · Cited by 12
“Indeed, STAT3 activation in hypothalamic neurons is a major signaling pathway for the central metabolic effects of leptin as disruption of leptin receptor-STAT3 signaling phenocopied leptin receptor deficiency [64].”
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Chronic stress aggravates glucose intolerance in leptin receptor-deficient (db/db) mice
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“…et al. 2015a, b, for a review). db/db mice are known to develop obesity due to hyperphagia that is sustained by the defective leptin circuitry (Bates et al. 2003) and compensate for the obesity-associated insulin resistance by pancreatic beta-cell hyperplasia, thereby maintaining only mildly…”
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Cardiotrophin‐1 decreases intestinal sugar uptake in mice and in C aco‐2 cells
Lópeź‐Yoldi, M., Castilla‐Madrigal, R., Lostao, M. P., et al. (2016) · Acta Physiologica · doi:10.1111/apha.12674 · Cited by 11
“In line with these observations, it has also been described that leptin, a potent activator of STAT3 signalling pathway (Bates et al. 2003), also decreases the hypothalamic activity of AMPK (Minokoshi et al.”
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Physiological Mechanisms for the Metabolic Control of Reproduction
Tena‐Sempere, M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00035-1 · Cited by 12
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“This implies that in addition to leptin-induced adiposity signals, leptin receptor/STAT3 independent pathways also contribute to control leptin-mediated glucose homeostasis.(21) Disadvantages of such models include the potential for embryonic lethality and the fact that embryonic KO may result in compensatory changes…”
Background
Targeting Type 2 Diabetes
Schwanstecher, C., & Schwanstecher, M. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-17214-4_1 · Cited by 11
“Downstream signalling seems to include JAK2/STAT3, PI3K, AMPK and mTOR (Dennis et al. 2001; Bates et al. 2003; Andersson et al. 2004; Morton et al. 2005; Buettner et al. 2006; Cota et al. 2006; Plum et al. 2006).”
Background
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“Leptin exerts antifeedant activity by binding to LepR expressed on neurons in the hypothalamus [55].”
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IUPHAR ECR review: Cancer-related anorexia-cachexia in cancer patients: Pathophysiology and treatment
Chowdhury, I. H., Rahman, S., Afroze, Y. J., & Shovah, S. T. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107129 · Cited by 10
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Loss of leptin receptor-expressing cells in the hindbrain decreases forebrain leptin sensitivity
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“[146] Bates SH, Stearns WH, Dundon TA, Schubert M, Tso AW, Wang Y, et al.”
Background
Breast feeding, obesity, and asthma association: clinical and molecular views
Kian, N., Bagheri, A., Salmanpour, F., Soltani, A., Mohajer, Z., Samieefar, N., Barekatain, B., & Kelishadi, R. (2023) · Clinical and Molecular Allergy · doi:10.1186/s12948-023-00189-0 · Cited by 12
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Background
Testosterone interacts with the feedback mechanisms engaged by Tyr985 of the leptin receptor and diet-induced obesity
Johnson, J. A., Calo, S., Nair, L. T., IglayReger, H. B., Greenwald-Yarnell, M. L., Skorupski, J. C., Myers, M. G., & Bodary, P. F. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.06.002 · Cited by 10
Self-citation
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Motta, M., Accornero, P., Taulli, R., Bernabei, P., Desrivières, S., & Baratta, M. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.09.010 · Cited by 10
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Self-citation
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José Luis Santos, M. (2009) · Revista médica de Chile · doi:10.4067/s0034-98872009000900014 · Cited by 14
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Hormonal Regulation of Clonal, Immortalized Hypothalamic Neurons Expressing Neuropeptides Involved in Reproduction and Feeding
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“Leptin has been postulated to signal through the JAK-STAT signal transduction pathway, yet a knockout mouse that leaves the leptin receptor intact, but specifically disrupts the ObR-STAT3 signal (leprS1138) does not affect repression of NPY by leptin [107].”
Background
Leptin inhibits lysophosphatidic acid‐induced intracellular calcium rise by a protein kinase C‐dependent mechanism
Eiras-Penas, S., Camiña, J. P., Díaz-Rodríguez, E., Gualillo, O., & Casanueva, F. F. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20046 · Cited by 10
“This Box 3 sequence is implicated in recruiting the transcription factor STAT3 to the receptor, which has been recently shown to mediate the effects of leptin on melanocortin production and body energy homeostasis (Bates et al., 2003).”
Background
The Vicious Circle of Leptin and Obesity
Díaz, B. B., Pérez, M. D. C. R., & de León, A. C. (2006) · Current Nutrition & Food Science · doi:10.2174/157340106778699421 · Cited by 10
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Functional Analysis of Steroidogenic Factor 1 (sf-1) and 17α-Hydroxylase/Lyase (cyp17α) Promoters in Yellow Catfish Pelteobagrus fulvidraco
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“STAT3 is considered the most important factor that transmits the leptin signal [21,22].”
Background
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Fjukstad, K. K., Athanasiu, L., Bahrami, S., O’Connell, K. S., van der Meer, D., Bettella, F., Dieset, I., Steen, N. E., Djurovic, S., Spigset, O., et al. (2021) · The Pharmacogenomics Journal · doi:10.1038/s41397-021-00234-8 · Cited by 9
“There is some evidence suggesting that PTPRT regulates metabolism and body weight [55, 56].”
Background
Phosphorylation of STAT3 in hypothalamic nuclei is stimulated by lower doses of leptin than are needed to inhibit food intake
Harris, R. B. S. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00143.2021 · Cited by 9
Inhibition of Hypothalamic FTO Activates STAT3 Signal through ERK1/2 Associated with Reductions in Food Intake and Body Weight
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“of thermoregulation and obesity but does not affect sexual maturation and growth [91, 110].”
Background
Functional characterization of STATa/b genes encoding transcription factors from Branchiostoma belcheri.
Cao, Y.-P., Fang, T., Fan, M., Wang, L., Lv, C., Song, X.-J., Jin, P., & Ma, F. (2020) · Developmental and Comparative Immunology · doi:10.1016/j.dci.2020.103838 · Cited by 9
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Leptin Activation of Dorsal Raphe Neurons Inhibits Feeding Behavior
Maxwell, N. D., Smiley, C. E., Sadek, A. T., Loyo-Rosado, F. Z., Giles, D. C., Macht, V. A., Woodruff, J. L., Taylor, D. L., Glass, V. M., Wilson, S. P., et al. (2024) · Diabetes · doi:10.2337/db24-0207 · Cited by 9
Epigenetic Regulation of Adipokines
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“The binding of leptin to its receptor activates several signaling pathways, including phosphatidylinositol 3-kinase (PI3K), Janus kinase-signal transducer and activator of transcription-3 (STAT3), and mitogen-activated protein kinase pathways, among others [53].”
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Szczęsna, M., Kirsz, K., Misztal, T., & Zieba, D. A. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.01.003 · Cited by 8
Neuroendocrine Control of Body Energy Homeostasis
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Self-citation
Recent evidence in support of traditional chinese medicine to restore normal leptin function in simple obesity
Shao, J., Li, C., Bai, L., Ni, X., Ge, S., Zhang, J., & Zhao, H. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09482 · Cited by 8
“As negative regulators of leptin signaling, both SOCS3 in PTP1B induce central leptin resistance by disrupting the phosphorylation of JAK2-STAT3 (de Git and Adan, 2015; Mark, 2013; Wang et al., 2012).”
BackgroundInfluential
Leptin, Obesity, and Leptin Resistance
Münzberg, H., & Heymsfield, S. B. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6_6 · Cited by 11
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“Selective deletion of SOCS3 in proopiomelanocortin-expressing cells results in enhanced leptin sensitivity.”
BackgroundInfluentialSelf-citation
Tissue-Specific 5′ Heterogeneity of PPARα Transcripts and Their Differential Regulation by Leptin
Garratt, E. S., Vickers, M. H., Gluckman, P. D., Hanson, M. A., Burdge, G. C., & Lillycrop, K. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067483 · Cited by 8
“As leptin has been shown to modulate transcription through a STAT3 signalling pathway [33] we used the highly selective STAT3 inhibitor (PpYLKTK-mts) [34] to test the role of STAT3 in the induction of P2 transcription by leptin.”
Method
LEPR c.668A>G polymorphism in a cohort of Sri Lankan women with pre-eclampsia / pregnancy induced hypertension: a case control study
Tennekoon, K. H., Indika, W. L., Sugathadasa, R., et al. (2012) · BMC Research Notes · doi:10.1186/1756-0500-5-308 · Cited by 8
“The full length isoform as well as some isoforms with short cytoplasmic domains are implicated in signal transduction [3-5].”
Background
Leptin and Obesity
Zhang, Y., & Ren, J. T. (2015) · Springer eBooks · doi:10.1007/978-3-319-19821-7_4 · Cited by 8
The Role of the Choroid Plexus in the Transport and Production of Polypeptides
Silverberg, G. D., Szmydynger‐Chodobska, J., & Chodobski, A. (2005) · CRC Press eBooks · doi:10.1201/9781420023404.ch10 · Cited by 8
Principles of Hormone Action
Lazar, M. A., & Birnbaum, M. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00003-4 · Cited by 8
DNA-binding activity of STAT3 increased in hypothalamus of DIO mice; the reduction of STAT3 phosphorylation may facilitate leptin signaling
Xu, L., Li, H., Zhou, G., Lu, W., Yang, R., Liu, H., & Yang, G. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.09.053 · Cited by 9
Predicting of disease genes for gestational diabetes mellitus based on network and functional consistency
Zhang, Q., He, M., Wang, J., Liu, S., Cheng, H., & Cheng, Y. (2015) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2014.12.016 · Cited by 8
Molecular Connectomics Reveals a Glucagon-Like Peptide 1 Sensitive Neural Circuit for Satiety
Webster, A. N., Becker, J. J., Li, C., Schwalbe, D. C., Kerspern, D., Karolczak, E. O., Bundon, C., Onoharigho, R. A., Crook, M., Jalil, M., et al. (2023) · doi:10.1101/2023.10.31.564990 · Cited by 56
“Of note, our results do not rule out a delayed effect of leptin on these neurons; while leptin can directly alter the activity of some Arc neurons 48,49 , it controls appetite largely through transcriptional changes 50 , which likely occur on a longer timescale than our ex vivo imaging experiments.”
Result
DNA methylation reshapes the expression of adipokines and adipose factors in white adipose tissues
Fang, M.-Y., Liu, S., Kolatkar, P. R., Qi, P., Liu, Y.-C., Sun, F., & Wang, C.-Y. (2025) · Epigenetics & Chromatin · doi:10.1186/s13072-025-00640-3 · Cited by 9
“It acts centrally by binding to its receptor in the central nervous system (CNS), thereby reducing food intake and modulating glucose and fat metabolism by the signal transducer and activator of transcription 3 (STAT3) pathway [41].”
Leptin and Alzheimer’s Disease
Harvey, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407824-6.00041-0 · Cited by 6
Trafic et signalisation du récepteur de la leptine
Dam, J. (2018) · Biologie Aujourd hui · doi:10.1051/jbio/2018020 · Cited by 7
Up-regulation of bone morphogenetic protein and its signaling molecules following castration of bulls and their association with intramuscular fat content in Korean cattle
Jung, D. J. S., & Baik, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-56439-2 · Cited by 7
Regulation of feeding and therapeutic application of bioactive peptides
Ueno, H., Zhang, W., & Nakazato, M. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108187 · Cited by 7
The Influence of New SARS-CoV-2 Variant Omicron (B.1.1.529) on Vaccine Efficacy, its Correlation to Delta Variants: A Computational Approach
Ranjan, P., Neha, N., Devi, C., Devar, K. A., & Das, P. K. (2022) · Microbial Pathogenesis · doi:10.1016/j.micpath.2022.105619 · Cited by 6
Leptin effects: focusing on the relationship between obesity and male infertility
Padula, D. L., Zavaglia, L., Hamad, T., Nocito, M. C., Aquila, S., Avena, P., & Rago, V. (2022) · Minerva Endocrinology · doi:10.23736/s2724-6507.22.03901-x · Cited by 7
Adipokines in pregnancy
Dawid, M., Pich, K., Mlyczyńska, E., Respekta, N., Wachowska, D., Greggio, A., Szkraba, O., Kurowska, P., & Rak, A. (2024) · Advances in clinical chemistry · doi:10.1016/bs.acc.2024.04.006 · Cited by 7
Central leptin action on euglycemia restoration in type 1 diabetes: Restraining responses normally induced by fasting?
Xu, Y., & Tong, Q. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.09.027 · Cited by 7
Low-dose infusions of leptin into the nucleus of the solitary tract increase sensitivity to third ventricle leptin
Harris, R. B. S. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00562.2018 · Cited by 7
“pSTAT3 is accepted as a marker of leptin receptor activation (30) and has also been shown to be essential for the effects of leptin on body weight (1).”
Background
Gut Microbiota and Health: Understanding the Role of Diet
Alasmar, R. M., Kavitha, V., Shanmugakonar, M., & Al‐Naemi, H. A. (2019) · Food and Nutrition Sciences · doi:10.4236/fns.2019.1011097 · Cited by 7
Expression of a hypomorphic Pomc allele alters leptin dynamics during late pregnancy
Yu, H. M., Thompson, Z., Kiran, S., Jones, G. L., Mundada, L. V., Surbhi, Rubinstein, M., & Low, M. J. (2020) · Journal of Endocrinology · doi:10.1530/joe-19-0576 · Cited by 7
Fasting reduces the number of TRH immunoreactive neurons in the hypothalamic paraventricular nucleus of male rats, but not in mice
Campos, A. M. P., Wasinski, F., Klein, M., Bittencourt, J. C., Metzger, M., & Donato, J. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135832 · Cited by 7
Expression of leptin receptor and suppressor of cytokine signaling-3 genes in adenohypophysis of normal-fed and fasted cows.
Amstalden, M., Spencer, T. E., Harms, P. G., et al. (2005) · PubMed · Cited by 7
Insulin Resistance in Obesity
Qi, Y., Guo, X., & Guo, S. (2016) · Springer eBooks · doi:10.1007/978-3-319-11251-0_28 · Cited by 7
Effects of Curcumin on Neuroinflammation in Animal Models and in Patients with Alzheimer Disease
Farooqui, A. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-15889-1_7 · Cited by 6
Maternal exercise and high-fat diet affect hypothalamic neural projections in rat offspring in a sex-specific manner
Song, L., Cui, J., Wang, R., Wang, N., Yan, J., & Sun, B. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.108958 · Cited by 6
Expression of leptin receptor mRNA in cumulus cells is correlated with expression of PTX3
van Tol, H. T. A., Vernooij, J. C. M., Colenbrander, B., Gutknecht, D., Macklon, N. S., & Roelen, B. A. J. (2010) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2010.03.003 · Cited by 6
“However, leptin signalling through the STAT3 pathway appears not to be essential for reproduction since mice with disrupted ObR-Long STAT3 signalling are obese yet fertile (Bates et al., 2003).”
Background
Recombinant human leptin induces growth inhibition and apoptosis in human gastric cancer MGC-803 cells
Wu, N., Wang, Y., Wang, S., Chen, Y., & Yan, J. (2012) · Clinical and Experimental Medicine · doi:10.1007/s10238-012-0211-8 · Cited by 6
“Leptin-induced STAT3 signaling participates in energy homoeostasis, while such as the control of NPY expression, linear growth and reproduction are attained via STAT3-independent pathways [34, 37].”
BackgroundSelf-citation
Novel mutations in the signal transducer and activator of transcription 3 gene are associated with sheep body weight and fatness traits
Chong, Y., Liu, G., Girmay, S., et al. (2021) · Mammalian Genome · doi:10.1007/s00335-020-09850-4 · Cited by 6
Leptin as a Potential Modifier of Neuroinflammation: Contrasting Roles in Alzheimer’s Disease and Multiple Sclerosis
Kasbi, N. A., Stopschinski, B. E., Polyak, A. G., Malladi, A. R., Manouchehri, N., Scherer, P. E., & Stüve, O. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010168 · Cited by 8
Mitochondrial regulation of obesity by POMC neurons
Luo, X.-D., Tang, S., Luo, X., Quzhen, L., Xia, R.-H., & Wang, X.-W. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167682 · Cited by 5
Consuming sucrose solution promotes leptin resistance and site specifically modifies hypothalamic leptin signaling in rats
Harris, R. B. S. (2020) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00238.2020 · Cited by 5
ON THE BIOLOGICAL ROLE OF LEPTIN
Chaulin, A. M., & Grigoryeva, J. (2021) · Научное обозрение Биологические науки (Scientific Review Biological Sciences) · doi:10.17513/srbs.1222 · Cited by 5
Running on Empty: Leptin Signaling in VTA Regulates Reward from Physical Activity
Chen, Z., & Kenny, P. J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.021 · Cited by 5
“Leptin acts in neurons primarily through STAT3 (signal transducer and activator of transcription 3) (Bates et al., 2003).”
Background
Possible involvement of 4-hydroxy-2-nonenal in the pathogenesis of leptin resistance in obesity
Hosoi, T., Kuwamura, A., Thon, M., Tsuchio, K., El‐Hafeez, A. A. A., & Ozawa, K. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00080.2018 · Cited by 6
“Leptin-induced STAT3 activation was suggested to play an important role in the antiobesity action of leptin (1, 48).”
Background
The effect of human wharton's jelly-derived mesenchymal stem cells on MC4R, NPY, and LEPR gene expression levels in rats with streptozotocin-induced diabetes.
Sarvestani, F. S., Zare, M. A., Saki, F., Koohpeyma, F., Al-Abdullah, I. H., & Azarpira, N. (2020) · PubMed Central · doi:10.22038/ijbms.2019.39582.9387 · Cited by 5
“The inhibitory effects of LEP and insulin in NPY/AgRP neurons have been directly associated with that of PI3K (82-87).”
Background
Leptin Upregulates the Expression of β3-Integrin, MMP9, HB-EGF, and IL-1β in Primary Porcine Endometrium Epithelial Cells In Vitro
Wang, H., Fu, J., & Wang, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186508 · Cited by 5
Understanding the impact of missense mutations on the structure and function of the EDA gene in X‐linked hypohidrotic ectodermal dysplasia: A bioinformatics approach
Ranjan, P., & Das, P. K. (2021) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30186 · Cited by 5
“Protein dysfunction has also been shown to play a key part in biology and diseases caused by protein misfolding and aggregation.(81,82) The wild type and all five EDA mutants have substantial structural differences, according to our findings.”
Background
Does β-Hydroxy-β-Methylbutyrate Have Any Potential to Support the Treatment of Duchenne Muscular Dystrophy in Humans and Animals?
Gorji, A. E., Ostaszewski, P., Urbańska, K., & Sadkowski, T. (2023) · Biomedicines · doi:10.3390/biomedicines11082329 · Cited by 6

Authors: Bates, S. H., Stearns, W. H., Dundon, T. A., Schubert, M., Tso, A. W. K., Wang, Y., Banks, A. S., Lavery, H. J., Haq, A. K., Maratos-Flier, E., Neel, B. G., Schwartz, M. W., & Myers, M. G.
Affiliations: Joslin Diabetes Center (US)
Beth Israel Deaconess Medical Center (US)
University of Washington (US)
Corresponding author: Myers, Martin G.
ORCID: Schubert, Markus
Wang, Yongping
Banks, Alexander S.
Lavery, Hugh J.
Neel, Benjamin G.
Schwartz, Michael W.
Myers, Martin G.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2003-02
Volume: 421
Issue: 6925
Pages: 856-859
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature01388
OpenAlex: W2103270369
Semantic Scholar: 25ab9d73ec0d0c8fc3c6ec167cccbfe002d52c52
Cited by: 1,010
References: 25
Citations by year: 2026: 12 · 2025: 14 · 2024: 19 · 2023: 21 · 2022: 34 · 2021: 35 · 2020: 50 · 2019: 32 · 2018: 46 · 2017: 35 · 2016: 48 · 2015: 52 · 2014: 66 · 2013: 67 · 2012: 54
FWCI: 20.53
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: STAT3 signaling, leptin, leptin receptor, energy homeostasis, obesity, fertility, neuropeptide Y, melanocortin system, hypothalamus, glucose homeostasis, db/db mice, hyperphagia, insulin resistance
MeSH terms: Alleles, alpha-MSH, Animals, Blood Glucose, Body Weight, Cell Line, Diabetes Mellitus, DNA-Binding Proteins, Energy Metabolism, Female, Homeostasis, Humans, Infertility, Male, Neuropeptide Y, Obesity, Phenotype, Receptors, Cell Surface, Reproduction, RNA, Messenger, Signal Transduction, Trans-Activators, Leptin, Estrous Cycle, STAT3 Transcription Factor, Mice, Receptors, Leptin

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STAT3 signalling is required for leptin regulation of energy balance but not reproduction

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