The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
Open accessAbstract
Calorie restriction extends lifespan in a broad range of organisms, from yeasts to mammals. Numerous hypotheses have been proposed to explain this phenomenon, including decreased oxidative damage and altered energy metabolism. In Saccharomyces cerevisiae, lifespan extension by calorie restriction requires the NAD+-dependent histone deacetylase, Sir2 (ref. 1). We have recently shown that Sir2 and its closest human homologue SIRT1, a p53 deacetylase, are strongly inhibited by the vitamin B3 precursor nicotinamide. Here we show that increased expression of PNC1 (pyrazinamidase/nicotinamidase 1), which encodes an enzyme that deaminates nicotinamide, is both necessary and sufficient for lifespan extension by calorie restriction and low-intensity stress. We also identify PNC1 as a longevity gene that is responsive to all stimuli that extend lifespan. We provide evidence that nicotinamide depletion is sufficient to activate Sir2 and that this is the mechanism by which PNC1 regulates longevity. We conclude that yeast lifespan extension by calorie restriction is the consequence of an active cellular response to a low-intensity stress and speculate that nicotinamide might regulate critical cellular processes in higher organisms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Several studies highlight how the external environment and the genetic background of an organism have pivotal roles in the aging process by affecting events that maintain epigenetic information 2,3 .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [3]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“NAM, in contrast, is a well reported and widely used sirtuin inhibitor31 and has been recently shown to inhibit NAD+-consuming activities in vivo24.”
From NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells (2016) · cites this paper as [31]
In the citing paper
“In response to calorie restriction, the yeast NAD biosynthetic gene that catalyses the first and rate-limiting step in NAD+ biosynthesis, PNC1, is induced46.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [46]
In the citing paper
“The resulting availability of NAD+ increases SIR2 activity, which boosts mitochondrial respiration and suppresses recombinant DNA recombination11,46, a known cause of ageing in yeast47.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [46]
In the citing paper
“The upregulation of the NAD salvage pathway, which recycles NAD+ from nicotinamide, was first shown to extend lifespan and mimic caloric restriction in yeast cells46.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [46]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes
Gasch, A. P., Spellman, P. T., Kao, C. M., Carmel-Harel, O., Eisen, M. B., Storz, G., Botstein, D., & Brown, P. O. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4241 · Cited by 4,815
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,690
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · cited 1×
“Cells with an additional copy of SIR2 live 30% longer than the wild type, whereas sir2Δ strains age prematurel”
BackgroundNegative Control of p53 by Sir2α Promotes Cell Survival under Stress
Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081
Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,603
Extrachromosomal rDNA circles—a cause of aging in yeast
Sinclair, D. A., & Guarente, L. (1997) · Cell · doi:10.1016/s0092-8674(00)80493-6 · Cited by 1,500
Self-citationThe Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors
Virág, L., & Szabó, C. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.3.375 · Cited by 1,373
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
Lin, S.-J., Kaeberlein, M., Andalis, A. A., Sturtz, L. A., Defossez, P.-A., Culotta, V. C., Fink, G. R., & Guarente, L. (2002) · Nature · doi:10.1038/nature00829 · Cited by 1,057
Cited by
Sorted by citations
Items 601–700 of 738
Enhancing Longevity: Novel Caloric Restriction Mimetics
Michalow, A. E. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0685 · Cited by 3
Qualia NAD+® Increases NAD+ Levels In Human Participants: A Double-Blind, Placebo-Controlled StudyPreprint
Blomquist, S. A., Kelly, G., Adães, S., D’Adamo, C. R., Ardagh, A., Ramer, S., & Scuba, W. (2025) · medRxiv · doi:10.1101/2025.03.19.25324259 · Cited by 4
Huo, L., Zhang, H., Tang, C., Cui, G., Xue, T., Guo, H., Yao, F., Zhang, W., & Feng, W. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04503-y · Cited by 2
Molecular underpinnings of induced degenerative heterogeneity in the retinal pigment epithelium
Singh, K. K., Jin, Y. O., Hu, M.-W., Palazzo, I., Cano, M., Hoang, T., Bhutto, I. A., Wang, S., Sinha, D., Blackshaw, S., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2505412123 · Cited by 4
Decoding human longevity: Genetic and molecular insights from accelerated to successful ageing
Cattaneo, M., Carnevali, S., Madeddu, P. R., & Puca, A. A. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103176 · Cited by 2
NAD: Metabolism and Regulatory Functions
Ziegler, M. (2008) · Springer eBooks · doi:10.1007/0-387-36005-0_12 · Cited by 2
Nicotinamide Adenine Dinucleotide in the Development and Treatment of Cardiac Remodeling and Aging
Wang, F., Pei, Z., Wang, K., & Wang, L. (2022) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557522666220304121917 · Cited by 2
Yan, X., Gu, C., Yu, Z., Ding, L., He, M., Xiao, W., Zhao, M., Qing, Y., & He, L. (2022) · Microbial Pathogenesis · doi:10.1016/j.micpath.2022.105785 · Cited by 2
Goorden, S. M. I., van Haaften–Visser, D. Y., Trętowicz, M. M., Bonte, R., Bogaerts, E., Jamal, Y., Vrieswijk, S., Huijser, E., Bökenkamp, R., van der Palen, R. L. F., et al. (2025) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2025.109194 · Cited by 3
Kalita, A. I., Letai, C. T., Enriquez-Hesles, E., Power, L. N., Mishra, S., Saha, S., Dinda, M., Wang, D., Singh, P., & Smith, J. S. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111158 · Cited by 2
Applications to Aging Networks
Wimble, C., & Witten, T. M. (2014) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000364925 · Cited by 2
Update to Medicinal Chemistry of Nicotinamide in the Treatment of Ischemia and Reperfusion
Yang, J., Klaidman, K., & Adams, J. D., Jr. (2004) · Medicinal Chemistry Reviews - Online · doi:10.2174/1567203043480403 · Cited by 2
Identification of sirtuin and its target as the ribosomal protein S4 in Lactobacillus paracasei
Atarashi, H., Kawasaki, S., NIIMURA, Y.-I., Tanaka, N., Okada, S., Shiwa, Y., Endo, A., & Nakagawa, J. (2016) · The Journal of General and Applied Microbiology · doi:10.2323/jgam.62.98 · Cited by 2
Molecular Targets of Resveratrol
O’Brian, C. A., & Chu, F. (2005) · CRC Press eBooks · doi:10.1201/9781420026474-8 · Cited by 4
Heywood, H. K., Thorpe, S. D., Jeropoulos, R. M., Caton, P., & Lee, D. A. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.971932 · Cited by 2
Dong, Y., & Zou, S. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0639-7_5 · Cited by 2
The Controversy Around Sirtuins and Their Functions in Aging
Sun, Y., & Dang, W. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801816-3.00017-0 · Cited by 2
Sirtuins as Metabolic Modulators of Muscle Plasticity
Menzies, K. J., Zaldivar‐Jolissaint, J. F., & Auwerx, J. H. (2016) · Springer eBooks · doi:10.1007/978-94-024-0962-8_9 · Cited by 2
Pharmacological Approaches for Modulating Sirtuins
Kane, A. E., & Sinclair, D. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813499-3.00006-x · Cited by 2
Self-citationRegulation of Sirtuins by Systemic NAD + Biosynthesis
Yoshida, M., & Imai, S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813499-3.00002-2 · Cited by 3
Sirtuin Inhibitors and Activators
Rahnasto‐Rilla, M., Tyni, J., & Lahtela-Kakkonen, M. K. (2019) · Topics in medicinal chemistry · doi:10.1007/7355_2019_70 · Cited by 2
The Class III Protein Deacetylases
Schwer, B., North, B. J., Ahuja, N., Marshall, B. L., & Verdin, E. M. (2006) · Humana Press eBooks · doi:10.1385/1-59745-024-3:237 · Cited by 2
Models of oxidative stress in the biology of aging
Lithgow, G. J., & Andersen, J. K. (2005) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2005.11.009 · Cited by 2
A metabolic and mitochondrial angle on aging
Duarte, A. I., Sadowska‐Bartosz, I., Karkucińska‐Więckowska, A., Lebiedzińska, M., Palmeira, C. M., Rolo, A. P., Kabiri, Y., Zavan, B., Pinton, P., Borges, F., et al. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823761-8.00024-0 · Cited by 3
Distinct effect of calorie restriction between congenic mating types of Cryptococcus neoformans
Oliveira, N. K., Yoo, K., Bhattacharya, S., Gambhir, R., Kirgizbaeva, N., García, P. A., Prados, I. P., Fernandes, C. M., Poeta, M. D., & Fries, B. C. (2024) · Scientific Reports · doi:10.1038/s41598-024-69087-y · Cited by 2
Hwang, E. S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-18722-3.00011-6 · Cited by 1
Pearson, A. C., & Yampolsky, L. Y. (2025) · Biogerontology · doi:10.1007/s10522-025-10313-z · Cited by 1
Yi, Z., Juvvadi, N., Zhai, R. G., Moraes, C. T., & Pinto, M. (2026) · Mitochondrial Communications · doi:10.1016/j.mitoco.2026.01.001 · Cited by 2
Regeneration and Aging: Regulation by Sirtuins and the NAD+ Salvage Pathway
Borradaile, N. M., Watson, A., & Pickering, J. G. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-380928-5.10019-3 · Cited by 3
The Electronics of HER2/neu Positive Breast Cancer Cells
Baumann, J., Karch, C. P., Kourtidis, A., & Douglas, S. (2011) · InTech eBooks · doi:10.5772/22820 · Cited by 1
Elixir of immortality? Wine, resveratrol and sirtuins: an overview
Casey, D. (2012) · Journal of Wine Research · doi:10.1080/09571264.2012.690091 · Cited by 1
Toward Productive Aging: SIRT1, Systemic NAD Biosynthesis, and the NAD World
Imai, S. (2010) · Cornea · doi:10.1097/ico.0b013e3181ea4714 · Cited by 1
Smith, J. T., & Schneider, B. L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00029-4 · Cited by 1
Nikhra, V. (2019) · Gerontology & Geriatrics Studies · doi:10.31031/ggs.2019.04.000596 · Cited by 1
Diet-Modifiable Redox Alterations in Ageing and Cancer
Hine, C., Patel, A. K., & Ponti, A. K. (2024) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-66768-8_7 · Cited by 1
Advances in Sirtuin on The Mechanism of Calorie Restriction on Lifespan*
Liu, B., Chen, W., Liu, X., & Zhou, Z. (2012) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/sp.j.1206.2011.00146 · Cited by 1
Moreno, D. F., & Açar, M. (2020) · Current Genetics · doi:10.1007/s00294-020-01124-5 · Cited by 1
Biswas, P., & Dam, S. (2020) · Haya The Saudi Journal of Life Sciences · doi:10.36348/sjls.2020.v05i08.002 · Cited by 1
Miller, G. S. (2010) · Human Biology · Cited by 1
NAD‐Dependent Deacetylases as Therapeutic Targets
Li, H., Simon, J. A., & Bedalov, A. (2009) · Methods and principles in medicinal chemistry · doi:10.1002/9783527627073.ch10 · Cited by 1
Functional analysis of mitochondrial sirtuins in C. elegans and mammalian cells
Wirth, M. (2011) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3229 · Cited by 1
Strauß, E. (2003) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2003.19.nf10 · Cited by 1
Models of acetylation and the regulation of longevity: From yeast to humans
Finkel, M., & Cohen, H. Y. (2005) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2005.11.003 · Cited by 1
Anderson, R. M., Colman, R. J., & Weindruch, R. H. (2009) · Springer eBooks · doi:10.1007/978-90-481-3465-6_4 · Cited by 1
Self-citationSmith, D. L., & Smith, J. S. (2009) · Springer eBooks · doi:10.1007/978-90-481-3465-6_6 · Cited by 1
Entropy Stress Based on Organ and Mitochondrial Metabolic Loading
Nanda, A. (2017) · OakTrust (Texas A&M University Libraries) · Cited by 1
Liu, Y., Luo, C., Li, T., Zhang, W., Zong, Z., Liu, X., & Deng, H. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.03.366427 · Cited by 1
Connell, N. J. (2021) · Research Publications (Maastricht University) · doi:10.26481/dis.20210122nc · Cited by 1
Sorokin, A. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.4568984.4439091 · Cited by 1
Preiss-Handler経路によらないNAD^+合成にnicotinamide ribosideは関与している
梅澤, 智., & 新, 真. (2005) · ビタミン · doi:10.20632/vso.79.5-6_297 · Cited by 1
新, 真., & 梅澤, 智. (2004) · ビタミン · doi:10.20632/vso.78.8_413 · Cited by 1
Cell enlargement drives aging-associated proteome remodeling and shortens replicative lifespanPreprint
Lanz, M. C., Hotz, M., Kroll-Ling, R., Wang, E., Kim, J., Elias, J. E., Gottschling, D. E., & Skotheim, J. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.15.706013 · Cited by 2
NAD^+の新規な前駆体,Nicotinamide ribosideへの期待
新, 真. (2007) · ビタミン · doi:10.20632/vso.81.12_624
Mechanisms Linking Lipid Metabolism and Longevity in Yeast
Bourque, S. D. (2011) · Spectrum Research Repository (Concordia University)
The FoxO Transcription Factors and Sirtuins
Levine, T. B., & Levine, A. B. (2012) · Wiley eBooks · doi:10.1002/9781118480045.ch4
An analysis of Apc5p/Fob1p interactions in yeast : implications for extended lifespan
Chen, J. C. (2006) · University Library - University of Saskatchewan (University of Saskatchewan)
A Potential Tumor Suppressive Role of SIRT1 in Cancer
Kabra, N. (2010) · Digital Commons - University of South Florida (University of South Florida)
The Most Probable Genetic Interaction Networks Inferred from Gene Expression Patterns
Lezon, T. R., Banavar, J. R., Cieplak, M., Fedoroff, N. V., & Maritan, A. (2008) · doi:10.1002/9783527622818.ch14
Silva, G. M. (2010) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.41.2010.tde-25112010-122339
Factors affecting growth, differentiation and apoptosis of osteoblastic and osteosarcoma cells
Li, Y. (2008) · Figshare
Tahara, E. B. (2012) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.46.2012.tde-15052012-085726
Cellular glucose sensing, energy metabolism, and aging in Saccharomyces cerevisiae
Lin, S., Manchester, J. K., & Gordon, J. I. (2003) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(03)14010-2
Sirtuins as Potential Drug Targets for Metabolic Diseases
Tong, Q. (2011) · Wiley eBooks · doi:10.1002/9780470910016.ch15
Levine, T. B., & Levine, A. B. (2012) · Wiley eBooks · doi:10.1002/9781118480045.ch11
Kronberg, I. (2004) · Biologie in unserer Zeit · doi:10.1002/biuz.200490038
Dietary Energy Balance, Calorie Restriction, and Cancer Prevention
Hursting, S. D., Smith, S. M., Nogueira, L., de Angel, R. E., Lashinger, L. M., & Perkins, S. N. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-627-6_7
Li, K. (2010) · eScholarship@UMassChan · doi:10.13028/g001-qk95
Functions and Regulation of eukaryotic NAD kinase - an essential enzyme for NADP biosynthesis
Pollak, N. (2008) · NORA - Norwegian Open Research Archives
Managing Oxidative Stress/Targeting ROS
Bansal, M., & Kaushal, N. (2014) · Springer eBooks · doi:10.1007/978-81-322-2032-9_6
Spontaneous rDNA copy number variation modulates Sir2 levels and epigenetic gene silencingPreprint
Michel, A. H., Kornmann, B., Dubrana, K., & Shore, D. (2005) · Genes & Development · doi:10.1101/gad.340205 · Cited by 84
correlation with life-span-prolonging processes Starvation response in mouse liver shows strong
Schorle, H., Pankratz, M. J., Katzenberger, J. D., Bauer, M. F., Hamm, A. C., Bonaus, M., Jacob, A., & Jaekel, J. (2015)
Calorie Restriction, Exercise, and Colon Cancer Prevention: A Mechanistic Perspective
Rogers, C. J., Colbert, L. H., Perkins, S. N., & Hursting, S. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-7551-5_5
Transgenic biomarkers of aging in drosophila melanogaster
Yang, J. (2015) · University of Southern California Digital Library · doi:10.25549/usctheses-m1977
A Longevity Gene in Saccharomyces
(2003) · Mycological Research · doi:10.1017/s0953756203258342
Cellular Longevity of Budding Yeast During Replicative and Chronological Aging
Choi, K.-M., & Lee, C. (2015) · Springer eBooks · doi:10.1007/978-4-431-55763-0_6
Characterization of Sirt2 using conditional RNAi in mice
Reiss, M. (2011) · Kölner Universitäts PublikationsServer (Universität zu Köln)
Molecular Rejuvenation Through Longevity-Gene Activation
Komaroff, A. L. (2003) · Journal watch · doi:10.1056/jw200305270000004
THE P53-NMNAT2 FEEDBACK REGULATORY LOOP: MECHANISMS UNDERLYING P53 ACTIVATION
Pan, L.-Z. (2012) · Library and Archives Canada (Government of Canada)
Calorie Restriction, Mitochondria and Longevity in Saccharomyces cerevisiae
Skinner, C., & Lin, S.-J. (2012) · Oxidative stress and disease · doi:10.1201/b12308-18
Williams, C. (2013) · QSpace (Queen's University Library)
Identifying Genetic Causes of Specific Phenotypes by Whole-genome Sequencing Analysis
Huang, R. (2015) · TSpace (University of Toronto)
Umbilical Cord Blood Expansion as an Alternate Graft Source for HSC Transplantation
Porada, C. D., Porada, D. A., & Almeida-Porada, G. D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812015-6.00016-9
Yang, Y. J., & Sauve, A. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.14664-5
Sirtuins and life span extension
Lee, S., & Min, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-814118-2.00006-9
Circadian Regulation of Autophagy in the Heart Via the mTOR Pathway
Love, M., Rabinovich-Nikitin, I., & Kirshenbaum, L. A. (2021) · Advances in biochemistry in health and disease · doi:10.1007/978-3-030-78799-8_9
Aumayr, B., & Janigro, D. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-021-8_36
子宮内膜癌細胞株における抗癌剤感受性の検討(子宮体部悪性腫瘍VI, 第57回日本産科婦人科学会学術講演会)
茂木, 真., 新美, 茂., 高倉, 聡., 柳田, 聡., 岡本, 愛., 落合, 和., & 田中, 忠. (2005) · 日本産科婦人科學會雜誌
Rastinejad, F. (2007) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1098716.554837
(2003) · Yeast · doi:10.1002/yea.950
Bernstein, B. (2006) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1031952.371867
Wang, S., Han, J. D. J., Xia, J., Hu, Y., Shi, L., Ren, A., Zhu, J. K., & Zhao, M. (2020) · doi:10.21203/rs.2.20914/v1
An overview of recent advancements in anti-aging medicines
Sajid, M. A. A., Hassan, M. U., & Ayesha, A. (2022) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2022.14.1.0244
Imai, S. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726835440.793584719
Kane, A. E., & Sinclair, D. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.62135-9
Self-citationWang, S., Han, J., Xia, J., Hu, Y., Shi, L., Ren, A., Zhu, J. K., & Zhao, M. (2019) · doi:10.21203/rs.2.18765/v1
Metadata
- Authors
- Anderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O., & Sinclair, D. A.
- Affiliations
- Harvard University (US)
- Corresponding author
- Sinclair, David A.
- Venue
- Nature
- Published
- 2003-05
- Volume
- 423
- Issue
- 6936
- Pages
- 181-185
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4802858
- OpenAlex
- W2006806054
- Cited by
- 736
- References
- 30
- Citations by year
- 2026: 18 · 2025: 17 · 2024: 11 · 2023: 10 · 2022: 26 · 2021: 18 · 2020: 24 · 2019: 23 · 2018: 30 · 2017: 26 · 2016: 29 · 2015: 35 · 2014: 30 · 2013: 24 · 2012: 39
- FWCI
- 13.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute on Aging (R37AG028730, P01AG027916, R01AG028730, R01AG019719, R01AG019972)
- National Institute of General Medical Sciences (R01GM068072)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- caloric restriction, lifespan extension, nicotinamide, Sir2, SIRT1, NAD+-dependent histone deacetylase, longevity genes, Saccharomyces cerevisiae, aging
- MeSH terms
- Cell Nucleus, Cytoplasm, Energy Metabolism, Histone Deacetylases, Longevity, NAD, Niacin, Nicotinamidase, Niacinamide, Saccharomyces cerevisiae, Gene Expression Regulation, Fungal, Heat-Shock Response, Gene Silencing, Saccharomyces cerevisiae Proteins, Caloric Restriction, Sirtuins, Silent Information Regulator Proteins, Saccharomyces cerevisiae, Sirtuin 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
