The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
Open accessAbstract
Calorie restriction extends lifespan in a broad range of organisms, from yeasts to mammals. Numerous hypotheses have been proposed to explain this phenomenon, including decreased oxidative damage and altered energy metabolism. In Saccharomyces cerevisiae, lifespan extension by calorie restriction requires the NAD+-dependent histone deacetylase, Sir2 (ref. 1). We have recently shown that Sir2 and its closest human homologue SIRT1, a p53 deacetylase, are strongly inhibited by the vitamin B3 precursor nicotinamide. Here we show that increased expression of PNC1 (pyrazinamidase/nicotinamidase 1), which encodes an enzyme that deaminates nicotinamide, is both necessary and sufficient for lifespan extension by calorie restriction and low-intensity stress. We also identify PNC1 as a longevity gene that is responsive to all stimuli that extend lifespan. We provide evidence that nicotinamide depletion is sufficient to activate Sir2 and that this is the mechanism by which PNC1 regulates longevity. We conclude that yeast lifespan extension by calorie restriction is the consequence of an active cellular response to a low-intensity stress and speculate that nicotinamide might regulate critical cellular processes in higher organisms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Several studies highlight how the external environment and the genetic background of an organism have pivotal roles in the aging process by affecting events that maintain epigenetic information 2,3 .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [3]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“NAM, in contrast, is a well reported and widely used sirtuin inhibitor31 and has been recently shown to inhibit NAD+-consuming activities in vivo24.”
From NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells (2016) · cites this paper as [31]
In the citing paper
“In response to calorie restriction, the yeast NAD biosynthetic gene that catalyses the first and rate-limiting step in NAD+ biosynthesis, PNC1, is induced46.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [46]
In the citing paper
“The resulting availability of NAD+ increases SIR2 activity, which boosts mitochondrial respiration and suppresses recombinant DNA recombination11,46, a known cause of ageing in yeast47.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [46]
In the citing paper
“The upregulation of the NAD salvage pathway, which recycles NAD+ from nicotinamide, was first shown to extend lifespan and mimic caloric restriction in yeast cells46.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [46]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes
Gasch, A. P., Spellman, P. T., Kao, C. M., Carmel-Harel, O., Eisen, M. B., Storz, G., Botstein, D., & Brown, P. O. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4241 · Cited by 4,815
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,690
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · cited 1×
“Cells with an additional copy of SIR2 live 30% longer than the wild type, whereas sir2Δ strains age prematurel”
BackgroundNegative Control of p53 by Sir2α Promotes Cell Survival under Stress
Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081
Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,603
Extrachromosomal rDNA circles—a cause of aging in yeast
Sinclair, D. A., & Guarente, L. (1997) · Cell · doi:10.1016/s0092-8674(00)80493-6 · Cited by 1,500
Self-citationThe Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors
Virág, L., & Szabó, C. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.3.375 · Cited by 1,373
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
Lin, S.-J., Kaeberlein, M., Andalis, A. A., Sturtz, L. A., Defossez, P.-A., Culotta, V. C., Fink, G. R., & Guarente, L. (2002) · Nature · doi:10.1038/nature00829 · Cited by 1,057
Flagged first, then by citations
Cited by
Sorted by citations
Items 401–500 of 738
Biosynthesis of NAD and Its Manipulation in Plants☆
Noctor, G., Hager, J., & Li, S. (2011) · Advances in botanical research · doi:10.1016/b978-0-12-386479-6.00002-0 · Cited by 38
Mayers, J. R., Iliff, B. W., & Swoap, S. J. (2008) · The FASEB Journal · doi:10.1096/fj.08-115923 · Cited by 39
The function of nicotinamide phosphoribosyltransferase in the heart
Hsu, C.-P., Yamamoto, T., Oka, S., & Sadoshima, J. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.08.005 · Cited by 39
Crystal Structure of a Nicotinate Phosphoribosyltransferase from Thermoplasma acidophilum
Shin, D. H., Oganesyan, N., Jancarik, J., Yokota, H. A., Kim, R., & Kim, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501622200 · Cited by 38
Choudhry, S. K., Singh, R., Williams, C., & van der Klei, I. J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.10.017 · Cited by 39
Kim, W., Lee, J.-W., Quan, C., Youn, H.-J., Kim, H., & Bae, S. (2011) · The Journal of Urology · doi:10.1016/j.juro.2011.02.017 · Cited by 39
Aging, Oxidative Stress and Antioxidants
Poljšak, B., & Milisav, I. (2013) · InTech eBooks · doi:10.5772/51609 · Cited by 40
Li, D., Chen, S., Li, Q., Chen, L., Zhang, H., Li, H., Yu, D., Zhang, R., Niu, Y., Lu, S., et al. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00354-2 · Cited by 36
The first minutes in the life of a peroxisomal matrix protein
Dias, A. F., Francisco, T., Rodrigues, T. A., Grou, C. P. O., & Azevedo, J. E. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.09.025 · Cited by 36
Preferential loss of 5S and 28S rDNA genes in human adipose tissue during ageing
Zafiropoulos, A., Tsentelierou, E., Linardakis, M. K., Kafatos, A., & Spandidos, D. A. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.07.007 · Cited by 36
PARP is involved in replicative aging in Neurospora crassa
Kothe, G. O., Kitamura, M., Masutani, M., Selker, E. U., & Inoue, H. (2010) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2009.12.012 · Cited by 38
Impact of ROS on ageing of two fungal model systems: Saccharomyces cerevisiae and Podospora anserina
Osiewacz, H. D., & Scheckhuber, C. Q. (2006) · Free Radical Research · doi:10.1080/10715760600921153 · Cited by 38
Sirt1’s Complex Roles in Neuroprotection
Tang, B. L. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9414-2 · Cited by 37
Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA
Jewett, M. W., Jain, S., Linowski, A. K., Sarkar, A., & Rosa, P. A. (2011) · Microbiology · doi:10.1099/mic.0.051706-0 · Cited by 36
Sinclair, D. A., Lin, S.-J., & Guarente, L. (2006) · Science · doi:10.1126/science.312.5771.195d · Cited by 36
Self-citationSampaio‐Marques, B., Burhans, W. C., & Ludovico, P. (2014) · Microbial Cell · doi:10.15698/mic2014.04.136 · Cited by 37
Biological synthesis of nicotinamide mononucleotide
Shen, Q., Zhang, S., Xue, Y.-Z., Peng, F., Cheng, D., Xue, Y., & Zheng, Y. (2021) · Biotechnology Letters · doi:10.1007/s10529-021-03191-1 · Cited by 35
SIRT1: A novel target to prevent atherosclerosis
Yu, W., Fu, Y., Chen, C., Wang, X., & Wang, W. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22240 · Cited by 36
Rockenfeller, P., & Madeo, F. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.01.001 · Cited by 36
Hu, Q., Tang, H., & Wang, Y. (2020) · Journal of Analysis and Testing · doi:10.1007/s41664-020-00126-z · Cited by 35
Transcriptional Response According to Strength of Calorie Restriction in Saccharomyces cerevisiae
Lee, Y.-L., & Lee, C. (2008) · Molecules and Cells · doi:10.1016/s1016-8478(23)13999-9 · Cited by 34
The Role of Molecular and Cellular Aging Pathways on Age-Related Hearing Loss
Ege, T., Tao, L., & North, B. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179705 · Cited by 39
Characterization of CobB kinetics and inhibition by nicotinamide
Gallego‐Jara, J., Conesa, A. É., Puente, T. D. D., Terol, G. L., & Cánovas, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189689 · Cited by 34
Li, H. B., Yi, X., Gao, J. M., Ying, X. X., Guan, H. Q., & Li, J. C. (2008) · Pharmacology · doi:10.1159/000139146 · Cited by 33
Sirtuin Deacetylases as Therapeutic Targets in the Nervous System
Langley, B. C., & Sauve, A. A. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0214-5 · Cited by 33
Zhou, J., Zhong, Q., Li, G., & Greenberg, M. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.003236 · Cited by 31
Morton, C. O., Hayes, A., Wilson, M. H., Rash, B. M., Oliver, S. G., & Coote, P. J. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01007-07 · Cited by 33
Ageing and longevity genes in cardiovascular diseases
Liberale, L., Kraler, S. C., Camici, G. G., & Lüscher, T. F. (2020) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13426 · Cited by 34
Kang, W. K., Kim, Y. H., Kang, H. A., Kwon, K., & Kim, J. (2015) · eLife · doi:10.7554/elife.09709 · Cited by 35
Peroxisome Biogenesis: Something Old, Something New, Something Borrowed
Mast, F. D., Fagarasanu, A. D., Knoblach, B., & Rachubinski, R. A. (2010) · Physiology · doi:10.1152/physiol.00025.2010 · Cited by 32
Increased metal tolerance in Salix by nicotinamide and nicotinic acid
Ohlsson, A. B., Landberg, T., Berglund, T., & Greger, M. (2008) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2008.04.004 · Cited by 31
Mahajan, S. S., Leko, V., Simon, J. A., & Bedalov, A. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-21631-2_11 · Cited by 32
Temporal profiling of redox-dependent heterogeneity in single cells
Radzinski, M., Fassler, R., Yogev, O., Breuer, W. V., Shai, N., Gutin, J., Ilyas, S., Geffen, Y., Tsytkin-Kirschenzweig, S., Nahmias, Y., et al. (2018) · eLife · doi:10.7554/elife.37623 · Cited by 30
Cheng, J., Qiao, B., & Yuan, Y. (2008) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-008-1733-6 · Cited by 31
Wu, R., Zhang, F., Liu, L., Li, W., Pichersky, E., & Wang, G. (2018) · Molecular Plant · doi:10.1016/j.molp.2018.07.003 · Cited by 30
Espinoza, S. E., Khosla, S., Baur, J. A., de Cabo, R., & Musi, N. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad034 · Cited by 31
CYB5R3: a key player in aerobic metabolism and aging?
de Cabo, R., Siendones, E., Minor, R. K., & Navas, P. (2009) · Aging · doi:10.18632/aging.100112 · Cited by 30
French, J. B., Cen, Y., Sauve, A. A., & Ealick, S. E. (2010) · Biochemistry · doi:10.1021/bi1012436 · Cited by 30
McClure, J. M., Wierman, M. B., Maqani, N., & Smith, J. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.367524 · Cited by 30
Short-term calorie restriction activates SIRT1–4 and -7 in cardiomyocytes in vivo and in vitro
Yu, W., ZHOU, H.-F., Lin, R., Fu, Y., & Wang, W. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.1944 · Cited by 30
Crystal structure of the yeast nicotinamidase Pnc1p
Hu, G., Taylor, A. B., McAlister-Henn, L., & Hart, P. J. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.01.037 · Cited by 32
Nicotinamide: a Class III HDACi Delays In Vitro Aging of Mouse Oocytes
Lee, A. R., Kishigami, S., Amano, T., Matsumoto, K., Wakayama, T., & Hosoi, Y. (2013) · Journal of Reproduction and Development · doi:10.1262/jrd.2012-171 · Cited by 30
Role of sirtuin proteins in life extension by caloric restriction
Masoro, E. J. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.011 · Cited by 30
Shi, Y., Wang, H., Yan, Y.-X., Cao, H., Liu, X., Lin, F., & Lu, J. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.00687 · Cited by 29
Mitochondrial Metabolism and Aging in Yeast
Baccolo, G., Stamerra, G., Pellegrino-Coppola, D., Orlandi, I., & Vai, M. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.001 · Cited by 33
Odoh, C. K., Guo, X., Arnone, J. T., Wang, X., & Zhao, Z. K. (2022) · Biogerontology · doi:10.1007/s10522-022-09958-x · Cited by 29
Finkel, T. (2003) · Nature · doi:10.1038/425132a · Cited by 29
Sirtuin biology and relevance to diabetes treatment
Dong, X. C. (2012) · Diabetes Management · doi:10.2217/dmt.12.16 · Cited by 29
Xu, J., & Hershman, J. M. (2006) · Thyroid · doi:10.1089/thy.2006.16.151 · Cited by 29
Endothelial dysfunction in the aging kidney
Borri, M., Jacobs, M. E., Carmeliet, P., Rabelink, T. J., & Dumas, S. J. (2025) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00287.2024 · Cited by 31
Braidy, N., Grant, R., & Sachdev, P. S. (2017) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000394 · Cited by 27
Wu, F., Zhang, L., Lai, C., Peng, X., Yu, S., Zhou, C., Zhang, B., & Zhang, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169271 · Cited by 28
NAD metabolism in aging and cancer
Kincaid, J. W. R., & Berger, N. A. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220929287 · Cited by 29
Schleit, J., Wasko, B. M., & Kaeberlein, M. R. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.07.038 · Cited by 27
How do K-RAS-activated cells evade cellular defense mechanisms?
Lee, Y.-S., & Bae, S.-C. (2015) · Oncogene · doi:10.1038/onc.2015.153 · Cited by 27
Yeast as a model for ageing and apoptosis research
Breitenbach, M., Madeo, F., Laun, P., Heeren, G., Jarolim, S., Fröhlich, K., Wissing, S., & Pichová, A. (2003) · Topics in current genetics · doi:10.1007/978-3-540-37005-5_4 · Cited by 27
Is the use of resveratrol in the treatment and prevention of obesity premature?
van der Spuy, W. J., & Pretorius, E. (2009) · Nutrition Research Reviews · doi:10.1017/s0954422409990084 · Cited by 26
Cellular effects of NAT-mediated histone N-terminal acetylation
Constantinou, M., Klavaris, A., Koufaris, C., & Kirmizis, A. (2023) · Journal of Cell Science · doi:10.1242/jcs.260801 · Cited by 26
Yeast at the Forefront of Research on Ageing and Age-Related Diseases
Sampaio‐Marques, B., Burhans, W. C., & Ludovico, P. (2019) · Progress in molecular and subcellular biology · doi:10.1007/978-3-030-13035-0_9 · Cited by 28
Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast
Kaya, A., Phua, C. Z. J., Lee, M. B., Wang, L., Tyshkovskiy, A., Ma, S., Barré, B. P., Liu, W., Harrison, B. R., Zhao, X., et al. (2021) · eLife · doi:10.7554/elife.64860 · Cited by 23
Sirtuins, a key regulator of ageing and age-related neurodegenerative diseases
Bhatt, V., & Tiwari, A. K. (2023) · International Journal of Neuroscience · doi:10.1080/00207454.2022.2057849 · Cited by 28
NAD+ Metabolism and Interventions in Premature Renal Aging and Chronic Kidney Disease
Chanvillard, L., Tammaro, A., & Sorrentino, V. (2022) · Cells · doi:10.3390/cells12010021 · Cited by 28
Metabolic modulation of chromatin: implications for DNA repair and genomic integrity
Liu, J. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00182 · Cited by 26
HSF-1: Guardian of the Proteome Through Integration of Longevity Signals to the Proteostatic Network
Lázaro‐Peña, M. I., Ward, Z. C., Yang, S., Strohm, A. O., Merrill, A. K., Soto, C. A., & Samuelson, A. V. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.861686 · Cited by 27
Proteomic study on gender differences in aging kidney of mice
Amelina, H., & Cristóbal, S. (2009) · Proteome Science · doi:10.1186/1477-5956-7-16 · Cited by 25
Unraveling of the Structure and Function of Peroxisomal Protein Import Machineries
Kalel, V. C., & Erdmann, R. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-2233-4_13 · Cited by 25
Herbert, A. P., Riesen, M., Bloxam, L., Kosmidou, E., Wareing, B. M., Johnson, J. R., Phelan, M. M., Pennington, S. R., Lian, L., & Morgan, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041975 · Cited by 26
Sirtuins as Modifiers of Huntington's Disease (HD) Pathology
Neo, S. H., & Tang, B. L. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.11.013 · Cited by 25
Maślanka, R., & Zadrąg‐Tęcza, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197313 · Cited by 24
Jiang, Y., Wang, D., Zhang, C., Jiao, Y., Pu, Y., Cheng, R., Li, C., & Chen, Y. (2023) · Cell Proliferation · doi:10.1111/cpr.13419 · Cited by 24
Gurd, B. J., & Williams, C. (2012) · The Application of Clinical Genetics · doi:10.2147/tacg.s31276 · Cited by 24
Nicotinamide N -Methyltransferase in Health and Cancer
Ramsden, D. B., Waring, R. H., Barlow, D. J., & Parsons, R. B. (2017) · International Journal of Tryptophan Research · doi:10.1177/1178646917691739 · Cited by 28
Glas, C., Dietschreit, J. C. B., Wössner, N., Urban, L., Ghazy, E., Sippl, W., Jung, M., Ochsenfeld, C., & Bracher, F. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112676 · Cited by 23
Jenwitheesuk, A., Park, S., Wongchitrat, P., Tocharus, J., Mukda, S., Shimokawa, I., & Govitrapong, P. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2369-7 · Cited by 25
Monteiro, J. P., & Cano, M. I. N. (2011) · Protein and Peptide Letters · doi:10.2174/092986611794475039 · Cited by 24
New Insights into the Genetics and Epigenetics of Aging Plasticity
Zhang, J., Wang, S., & Liu, B. (2023) · Genes · doi:10.3390/genes14020329 · Cited by 25
Kataya, A. R. A., Schei, E., & Lillo, C. (2015) · Journal of Plant Physiology · doi:10.1016/j.jplph.2015.03.002 · Cited by 23
An acetylation rheostat for the control of muscle energy homeostasis
Menzies, K. J., & Auwerx, J. H. (2013) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0140 · Cited by 23
Orlandi, I., Pellegrino-Coppola, D., Strippoli, M., Ronzulli, R., & Vai, M. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.06.006 · Cited by 23
Croft, T., Raj, C. J. T., Salemi, M., Phinney, B. S., & Lin, S.-J. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.807214 · Cited by 25
Iskandar, M., Barbero, M. X., Jaber, M. T., Chen, R., Gomez-Guevara, R., Cruz, E., & Westerheide, S. D. (2025) · Cancers · doi:10.3390/cancers17020257 · Cited by 30
Bhattacharya, B., Dey, R., Maity, D. K., & Ghoshal, D. (2013) · CrystEngComm · doi:10.1039/c3ce40754c · Cited by 22
McClure, J. M., Gallo, C. M., Smith, D. L., Matecic, M., Hontz, R. D., Buck, S. W., Racette, F. G., & Smith, J. S. (2008) · Genetics · doi:10.1534/genetics.108.091090 · Cited by 22
Calorie Restriction-Mediated Replicative Lifespan Extension in Yeast Is Non-Cell Autonomous
Mei, S.-C., & Brenner, C. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002048 · Cited by 24
Khan, A. N., & Lewis, P. N. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511482200 · Cited by 22
A Regulatory Role of NAD Redox Status on Flavin Cofactor Homeostasis inS. cerevisiaeMitochondria
Giancaspero, T. A., Locato, V., & Barile, M. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/612784 · Cited by 22
Multiple Pathways Regulating the Calorie Restriction Response in Yeast
Rahat, O., Maoz, N., & Cohen, H. Y. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq165 · Cited by 21
Non-Coding RNA Molecules Connect Calorie Restriction and Lifespan
Abraham, K. J., Ostrowski, L., & Mekhail, K. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.08.020 · Cited by 21
Lü, P., Hogan-Cann, A. D., Kamboj, A. K., Chowdhury, S. R., Aghanoori, M., Fernyhough, P., & Anderson, C. M. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107755 · Cited by 21
Mitochondria: A Potential Rejuvenation Tool against Aging
Phua, Q. H., Ng, S., & Soh, B.-S. (2023) · Aging and Disease · doi:10.14336/ad.2023.0712 · Cited by 21
Genome-Wide Analysis of Yeast Aging
Sutphin, G. L., Olsen, B., Kennedy, B. K., & Kaeberlein, M. R. (2011) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-2561-4_12 · Cited by 21
Tsang, F. A., & Lin, S.-J. (2015) · Frontiers in Biology · doi:10.1007/s11515-015-1367-x · Cited by 21
The Yeast PNC1 Longevity Gene Is Up-Regulated by mRNA Mistranslation
Silva, R. M., Duarte, I. C. N., Paredes, J. A., Lima-Costa, T., Perrot, M., Boucherie, H., Goodfellow, B. J., Gomes, A. C., Mateus, D. D., Moura, G. R., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005212 · Cited by 20
Pnc1 piggy-back import into peroxisomes relies on Gpd1 homodimerisation
Al-Saryi, N. A., Hutchinson, J. D., Al-Hejjaj, M. Y., Sedelnikova, S. E., Baker, P. J., & Hettema, E. H. (2017) · Scientific Reports · doi:10.1038/srep42579 · Cited by 20
Fan, Y., Zhao, H., Lu, L., & Wu, W. (2025) · Nutrients · doi:10.3390/nu17111855 · Cited by 21
Sirtuins in Epigenetic Silencing and Control of Gene Expression in Model and Pathogenic Fungi
Zhao, G., & Rusché, L. N. (2022) · Annual Review of Microbiology · doi:10.1146/annurev-micro-041020-100926 · Cited by 20
Biochemical and Mutational Analysis of a Novel Nicotinamidase from Oceanobacillus iheyensis HTE831
Sánchez-Carrón, G., García-García, M. I., Perez, R. Z., Takami, H., García‐Carmona, F., & Sánchez‐Ferrer, Á. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056727 · Cited by 19
Synthesis of cyclic analogues of hexamethylenebis(3-pyridine)amide (HMBPA) in a one-pot process
Zamudio‐Medina, A., García‐González, M. C., Gutierrez‐Carrillo, A., & González‐Zamora, E. (2014) · Tetrahedron Letters · doi:10.1016/j.tetlet.2014.12.018 · Cited by 19
Perspectives on the mitochondrial etiology of replicative aging in yeast
Ugidos, A., Nyström, T., & Caballero, A. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.02.002 · Cited by 18
Metadata
- Authors
- Anderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O., & Sinclair, D. A.
- Affiliations
- Harvard University (US)
- Corresponding author
- Sinclair, David A.
- Venue
- Nature
- Published
- 2003-05
- Volume
- 423
- Issue
- 6936
- Pages
- 181-185
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4802858
- OpenAlex
- W2006806054
- Cited by
- 736
- References
- 30
- Citations by year
- 2026: 18 · 2025: 17 · 2024: 11 · 2023: 10 · 2022: 26 · 2021: 18 · 2020: 24 · 2019: 23 · 2018: 30 · 2017: 26 · 2016: 29 · 2015: 35 · 2014: 30 · 2013: 24 · 2012: 39
- FWCI
- 13.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute on Aging (R37AG028730, P01AG027916, R01AG028730, R01AG019719, R01AG019972)
- National Institute of General Medical Sciences (R01GM068072)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- caloric restriction, lifespan extension, nicotinamide, Sir2, SIRT1, NAD+-dependent histone deacetylase, longevity genes, Saccharomyces cerevisiae, aging
- MeSH terms
- Cell Nucleus, Cytoplasm, Energy Metabolism, Histone Deacetylases, Longevity, NAD, Niacin, Nicotinamidase, Niacinamide, Saccharomyces cerevisiae, Gene Expression Regulation, Fungal, Heat-Shock Response, Gene Silencing, Saccharomyces cerevisiae Proteins, Caloric Restriction, Sirtuins, Silent Information Regulator Proteins, Saccharomyces cerevisiae, Sirtuin 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
