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Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Abstract
Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR-alpha. Here we report the cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning. AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. These two adiponectin receptors are predicted to contain seven transmembrane domains, but to be structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1/R2 or suppression of AdipoR1/R2 expression by small-interfering RNA supports our conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR-alpha ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin.
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“This translocation results from stimulating p38 MAPK via either AMPK [10,44] or interaction with APPL1 [55].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [10]
In the citing paper
“Third, ApN induces the translocation of GLUT4 to the plasma membrane, thereby promoting glucose uptake [10,54].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [10]
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Ding, M., Carrao, A. C. R., Wagner, R. J., Xie, Y., Jin, Y., Rzucidlo, E. M., Yu, J., Li, W., Tellides, G., Hwa, J., et al. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.09.008 · Cited by 59
Human adiponectin binds to bacterial lipopolysaccharide
Peake, P. W., Shen, Y., Campbell, L. V., & CHARLESWORTH, J. A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.162 · Cited by 59
Insulin decreases myocardial adiponectin receptor 1 expression via PI3K/Akt and FoxO1 pathway
Cui, X., Wang, C., Li, L., Dong, F., Zhou, Y., Wu, D., Cui, Q., Fu, F.-Y., & Wu, L. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr273 · Cited by 59
Adiponectin Receptor Signaling on Dendritic Cells Blunts Antitumor Immunity
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Adiponectin and colorectal cancer
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“identified two adiponectin receptors, AdipoR1 and AdipoR2, using expression cloning [49].”
BackgroundAdiponectin as a biomarker linking obesity and adiposopathy to hematologic malignancies
Dalamaga, Μ., & Christodoulatos, G. S. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0016 · Cited by 59
Gender Differences in Adipocyte Metabolism and Liver Cancer Progression
Cheung, O. K.-W., & Cheng, A. S. L. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00168 · Cited by 62
“ADIPOR2, as a receptor for adiponectin, mediates to increased PPARα ligand activities and fatty-acid oxidation by regulating adiponectin and ADIPOR2 signaling in adipose tissue (Yamauchi et al., 2003; Bauer et al., 2010).”
BackgroundHuang, D. Y., Yang, C., Wang, Y., Liao, Y., & Huang, K. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn264 · Cited by 59
Sun, X., Han, R., Wang, Z., & Chen, Y. (2006) · Diabetologia · doi:10.1007/s00125-006-0228-1 · Cited by 60
Polak, J., Kováčová, Z., Jaček, M., Klimčáková, E., Kováčiková, M., Šiklová, M., Kuda, O., Šebela, M., Samcová, E., & Štich, V. (2007) · Clinical Science · doi:10.1042/cs20060296 · Cited by 61
Nowak, Ł., Adamczak, M., & Wiecek, A. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.05.026 · Cited by 59
Gu, W., Li, X., Liu, C., Yang, J., Ye, L., Tang, J., Gu, Y., Yang, Y., Hong, J., Zhang, Y., et al. (2006) · Endocrine · doi:10.1385/endo:30:2:217 · Cited by 58
Pulmonary Hypertension and Obesity: Focus on Adiponectin
Perrotta, F., Nigro, E., Mollica, M., Costigliola, A., D’Agnano, V., Daniele, A., Bianco, A., & Guerra, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040912 · Cited by 58
“Adiponectin hexamers and the HMW multimers also act as ligands for T-cadherin (CDH13) [33,34].”
BackgroundInfluentialAdiponectin signaling and its role in bone metabolism
Pal China, S., Sanyal, S., & Chattopadhyay, N. (2018) · Cytokine · doi:10.1016/j.cyto.2018.06.012 · Cited by 53
Adiponectin and Skeletal Muscle
Jortay, J., Senou, M., Abou-Samra, M., Noel, L., Robert, A., Many, M.-C., & Brichard, S. M. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.03.035 · Cited by 52
Metadata
- Authors
- Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., Murakami, K., Ohteki, T., Uchida, S., Takekawa, S., Waki, H., Tsuno, N. H., Shibata, Y., Terauchi, Y., Froguel, P., Tobe, K., Koyasu, S., Taira, K., Kitamura, T., Shimizu, T., Nagai, R., & Kadowaki, T.
- Affiliations
- The University of Tokyo (JP)
- Nissan Chemical Corporation (Japan) (JP)
- Japan Science and Technology Agency (JP)
- National Institute of Advanced Industrial Science and Technology (JP)
- Keio University (JP)
- Centre National de la Recherche Scientifique (FR)
- Institute of Medical Science, The University of Tokyo (JP)
- Corresponding author
- Kadowaki, Takashi
- ORCID
- Venue
- Nature
- Published
- 2003-06-12
- Volume
- 423
- Issue
- 6941
- Pages
- 762-769
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1997978122
- Cited by
- 3,176
- References
- 28
- Citations by year
- 2026: 43 · 2025: 50 · 2024: 77 · 2023: 102 · 2022: 89 · 2021: 136 · 2020: 114 · 2019: 120 · 2018: 114 · 2017: 117 · 2016: 117 · 2015: 154 · 2014: 173 · 2013: 190 · 2012: 170
- FWCI
- 115.85
- Type
- journal article
- Language
- en
- Update notices
- erratum (2004-10-28)
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Novartis Foundation
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- adiponectin, adiponectin receptors, AdipoR1, AdipoR2, insulin resistance, type 2 diabetes, AMP kinase, PPARα, fatty acid oxidation, glucose uptake, skeletal muscle, liver, adipokines, obesity, receptor cloning
- MeSH terms
- Amino Acid Sequence, Animals, Cell Line, Cloning, Molecular, Diabetes Mellitus, Endothelium, Vascular, Fatty Acids, Glucose, Humans, Hypoglycemic Agents, Ligands, Molecular Sequence Data, Oxidation-Reduction, Proteins, Receptors, Cell Surface, Transcription Factors, Receptors, Cytoplasmic and Nuclear, Hepatocytes, Muscle Cells, RNA Interference, RNA, Small Interfering, Intercellular Signaling Peptides and Proteins, Mice, Adiponectin, Receptors, Adiponectin
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