Adiponectin and Skeletal Muscle
Open accessAbstract
Upregulation of muscular adiponectin could act as a local protective mechanism to counteract cellular damage in obesity by weakening inflammation, oxidative stress, and apoptosis. To test this hypothesis, adiponectin-knockout (KO) and wild-type (WT) mice were fed a Western diet (WD). WT mice under WD conditions displayed 63% higher adiponectin expression in myocytes than those under standard laboratory diet (SLD) conditions (P = 0.011). WD-fed KO mice exhibited approximately threefold larger myocyte degeneration than WT mice (P = 0.003). Even under SLD conditions, myotubes of KO mice displayed already moderate immunolabeling for markers of oxidative stress (peroxiredoxin-3/5) and for a lipid peroxidation product (hydroxynonenal). Expression of tumor necrosis factor-α (TNF-α) and caspase-6, a marker of apoptosis, was also present. After WD challenge, immunoreactivity for these markers was strong in muscle of KO mice, although it was detected to a lesser extent in WT mice. Activation of NF-κB and caspase-6 doubled in myocytes of WD-fed KO mice when compared to WT mice (P < 0.001). Furthermore, muscle electrotransfer of the adiponectin gene prevented these abnormalities in WD-fed KO mice. Finally, gene abrogation of the adiponectin receptor 1 (AdipoR1) by siRNA recapitulated a pro-inflammatory state in C2C12 myotubes. Thus, upregulation of muscular adiponectin may be triggered by obesity and be crucial locally to counteract oxidative stress, inflammation, and apoptosis. These effects operate in an autocrine/paracrine manner via AdipoR1 and down-regulation of NF-κB signaling.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Although mainly secreted by adipocytes under normal conditions, ApN may be produced in skeletal muscle of mice submitted to stressful challenges.
“Although it is mainly secreted by adipocytes under normal conditions, ApN may be produced in skeletal muscle of mice submitted to stressful challenges.”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [39]
Acute (LPS injection) or low-grade inflammation (genetic or nutritional induced obesity) enhanced ApN expression in muscle of challenged mice.
“Thus, acute (lipopolysaccharides (LPS) injection) or low-grade inflammation (genetic or nutritional induced obesity) enhanced ApN expression in muscle of challenged mice [36,38,39,40].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [39]
Muscle electro-transfer of the ApN gene corrected local inflammation, oxidative stress and apoptosis in ApN-KO mice submitted to inflammatory challenge.
“muscle electro-transfer of the ApN gene actually corrected local inflammation, oxidative stress and apoptosis [39,40].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [39]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003) · Nature · doi:10.1038/nature01705 · Cited by 3,176 · see citing works
AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity
Hu, E., Liang, P., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10697 · Cited by 2,239 · see citing works
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,074 · see citing works
Yamauchi, T., Nio, Y., Maki, T., Kobayashi, M., Takazawa, T., Iwabu, M., Okada-Iwabu, M., Kawamoto, S., Kubota, N., Kubota, T., et al. (2007) · Nature Medicine · doi:10.1038/nm1557 · Cited by 1,396 · see citing works
Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome
Maury, E., & Brichard, S. M. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.031 · Cited by 1,026 · see citing works
Adiponectin and AdipoR1 Regulate PGC-1α and Mitochondria by Ca2+ and AMPK/SIRT1
Iwabu, M., Yamauchi, T., Okada-Iwabu, M., Sato, K., Nakagawa, T., Funata, M., Yamaguchi, M., Namiki, S., Nakayama, R., Tabata, M., et al. (2010) · Nature · doi:10.1038/nature08991 · Cited by 971 · see citing works
Adiponectin as an anti-inflammatory factor
Ouchi, N., & Walsh, K. X. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.01.026 · Cited by 883 · see citing works
Role of Myokines in Exercise and Metabolism
Pedersen, B. K., Åkerström, T. C. A., Nielsen, A. R., & Fischer, C. P. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00080.2007 · Cited by 841 · see citing works
Adipocytokines and the Metabolic Complications of Obesity
Rasouli, N., & Kern, P. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1613 · Cited by 739 · see citing works
Acharyya, S., Villalta, S. A., Bakkar, N., Bupha‐Intr, T., Janssen, P. M. L., Carathers, M., Li, Z.-W., Beg, A. A., Ghosh, S., Sahenk, Z., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30556 · Cited by 436 · see citing works
Adiponectin in insulin resistance: lessons from translational research
Ziemke, F., & Mantzoros, C. S. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28449c · Cited by 422 · see citing works
Gilson, H., Schakman, O., Kalista, S., Lause, P., Tsuchida, K., & Thissen, J.-P. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00193.2009 · Cited by 248 · see citing works
Delaigle, A. M., Jonas, J.-C., Bauche, I. B., Cornu, O., & Brichard, S. M. (2004) · Endocrinology · doi:10.1210/en.2004-0503 · Cited by 241 · see citing works
Guerre-Millo, M. (2008) · Diabetes & Metabolism · doi:10.1016/j.diabet.2007.08.002 · Cited by 198 · see citing works
Adiponectin is expressed by skeletal muscle fibers and influences muscle phenotype and function
Krause, M. P., Liu, Y., Vu, V., Chan, L., Xu, A., Riddell, M. C., Sweeney, G., & Hawke, T. J. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00030.2008 · Cited by 168 · see citing works
Berendoncks, A. M. V., Garnier, A., Beckers, P. J., Hoymans, V. Y., Possemiers, N. M., Fortin, D., Martinet, W., Hoof, V. O. V., Vrints, C. J., Ventura‐Clapier, R., et al. (2010) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.885525 · Cited by 153 · see citing works
Bauche, I. B., Ait-El-Mkadem, S., Pottier, A.-M., Sènou, M., Many, M., Rezsöhazy, R., Pénicaud, L., Maeda, N., Funahashi, T., & Brichard, S. M. (2007) · Endocrinology · doi:10.1210/en.2006-0838 · Cited by 143 · see citing works
Muoio, D. M., & Koves, T. R. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-083 · Cited by 129 · see citing works
Oxidative Stress in the Thyroid Gland: From Harmlessness to Hazard Depending on the Iodine Content
Poncin, S., Gérard, A.-C., Boucquey, M., Sènou, M., Calderón, P. B., Knoops, B., Lengelé, B., Many, M., & Colin, I. M. (2007) · Endocrinology · doi:10.1210/en.2007-0951 · Cited by 124 · see citing works
Marked Improvement of Glucose Homeostasis in Diabetic ob/ob Mice Given Oral Vanadate
Brichard, S. M., Bailey, C. J., & Henquin, J. (1990) · Diabetes · doi:10.2337/diab.39.11.1326 · Cited by 113 · see citing works
Leyens, G., Donnay, I., & Knoops, B. (2003) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(03)00290-2 · Cited by 98 · see citing works
Liu, Y., Chewchuk, S., Lavigne, C., Brûlé, S., Pilon, G., Houde, V. P., Xu, A., Marette, A., & Sweeney, G. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00186.2009 · Cited by 86 · see citing works
Bauche, I. B., Ait-El-Mkadem, S., Rezsöhazy, R., Funahashi, T., Maeda, N., Miranda, L., & Brichard, S. M. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.033 · Cited by 80 · see citing works
Induction of adiponectin in skeletal muscle of type 2 diabetic mice: In vivo and in vitro studies
Delaigle, A. M., Senou, M., Guiot, Y., Many, M. C., & Brichard, S. M. (2006) · Diabetologia · doi:10.1007/s00125-006-0210-y · Cited by 79 · see citing works
Self-citationChanges in adiponectin, its receptors and AMPK activity in tissues of diet-induced diabetic mice
Bonnard, C., Durand, A., Vidal, H., & Rieusset, J. (2008) · Diabetes & Metabolism · doi:10.1016/j.diabet.2007.09.006 · Cited by 78 · see citing works
Monitoring NF-κB Transactivation Potential Via Real-Time PCR Quantification of IκB-α Gene Expression
Bottero, V., Imbert, V., Freiin, C., Formento, J., & Peyron, J. (2003) · Molecular Diagnosis · doi:10.1007/bf03260037 · Cited by 71 · see citing works
Globular adiponectin induces differentiation and fusion of skeletal muscle cells
Fiaschi, T., Cirelli, D., Comito, G., Gelmini, S., Ramponi, G., Serio, M., & Chiarugi, P. (2009) · Cell Research · doi:10.1038/cr.2009.39 · Cited by 70 · see citing works
Gérard, A.-C., Many, M., Daumerie, C., Costagliola, S., Miot, F. E. L., DEVIJLDER, J., Colin, I. M., & Denef, J. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8278 · Cited by 58 · see citing works
Adiponectin in health and diseases: from metabolic syndrome to tissue regeneration
Chiarugi, P., & Fiaschi, T. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903530712 · Cited by 52 · see citing works
Changes of skeletal muscle adiponectin content in diet-induced insulin resistant rats.
Yang, B.-C., Chen, L.-H., Qian, Y., Triantafillou, J., McNulty, J. A., Carrick, K., Clifton, L. G., Han, B., Geske, R., Strum, J., et al. (2006) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2005.12.172 · Cited by 49 · see citing works
Local induction of adiponectin reduces lipopolysaccharide-triggered skeletal muscle damage
Jortay, J., Senou, M., Delaigle, A., Noel, L., Funahashi, T., Maeda, N., Many, M. C., & Brichard, S. M. (2010) · Endocrinology · doi:10.1210/en.2009-1462 · Cited by 44 · see citing works
Ge, Q., Rycken, L., Noël, L., Maury, E., & Brichard, S. M. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00153.2011 · Cited by 34 · see citing works
Maerker, E., Stümvoll, M., Lammers, R., Machicao, F., H�ring, H. U., Staiger, H., Kausch, C., Guirguis, A., & Weisser, M. (2003) · Diabetologia · doi:10.1007/s00125-003-1146-0 · Cited by 29 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Nrf2-Keap1 signaling in oxidative and reductive stress
Bellezza, I., Giambanco, I., Minelli, A., & Donato, R. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.02.010 · Cited by 2,096 · see citing works
Adipose tissue lipolysis and remodeling during the transition period of dairy cows
Contreras, G. A., Strieder‐Barboza, C., & Raphael, W. (2017) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-017-0174-4 · Cited by 176 · see citing works
Adiponectin in inflammatory and immune-mediated diseases
Fantuzzi, G. (2013) · Cytokine · doi:10.1016/j.cyto.2013.06.317 · Cited by 171 · see citing works
Skeletal muscle adiponectin induction in obesity and exercise
Martínez-Huenchullán, S., Tam, C. S., Ban, L. A., Ehrenfeld-Slater, P., McLennan, S. V., & Twigg, S. M. (2019) · Metabolism · doi:10.1016/j.metabol.2019.154008 · Cited by 117 · see citing works
Polvani, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i8.2441 · Cited by 87 · see citing works
Estradiol stimulates mitochondrial biogenesis and adiponectin expression in skeletal muscle
Capllonch-Amer, G., Sbert-Roig, M., Galmés-Pascual, B. M., Proenza, A. M., Lladó, I., Gianotti, M., & García-Palmer, F. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0008 · Cited by 81 · see citing works
Abou-Samra, M., Selvais, C. M., Dubuisson, N., & Brichard, S. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072620 · Cited by 72 · see citing works
Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy
Boursereau, R., Abou-Samra, M., Lecompte, S., Noel, L., & Brichard, S. M. (2018) · BMC Biology · doi:10.1186/s12915-018-0501-z · Cited by 72 · see citing works
Self-citationRen, Y., Li, Y., Yan, J., Ma, M., Zhou, D., Xue, Z., Zhang, Z., Liu, H., Yang, H., Jia, L., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03319-2 · Cited by 68 · see citing works
Adipose–Muscle Crosstalk in Age-Related Metabolic Disorders: The Emerging Roles of Adipo-Myokines
Fang, P., She, Y., Yu, M., Min, W., Shang, W., & Zhang, Z. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101829 · Cited by 62 · see citing works
Kabara, E. A., Sordillo, L. M., Holcombe, S., & Contreras, G. A. (2013) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2013.10.007 · Cited by 57 · see citing works
Involvement of adiponectin in the pathogenesis of dystrophinopathy
Abou-Samra, M., Lecompte, S., Schakman, O., Noel, L., Many, M. C., Gailly, P., & Brichard, S. M. (2015) · Skeletal Muscle · doi:10.1186/s13395-015-0051-9 · Cited by 55 · see citing works
Martínez-Huenchullán, S., Maharjan, B. R., Williams, P. F., Tam, C. S., McLennan, S. V., & Twigg, S. M. (2018) · Physiological Reports · doi:10.14814/phy2.13599 · Cited by 48 · see citing works
Martínez-Huenchullán, S., Ban, L. A., Luisa Fernanda Olaya, A., Maharjan, B. R., Williams, P. F., Tam, C. S., McLennan, S. V., & Twigg, S. M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00459 · Cited by 47 · see citing works
Geng, T., Yang, B., Li, F., Xia, L., Wang, Q., Zhao, X., & Gong, D. (2016) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2016.01.006 · Cited by 46 · see citing works
<scp>AdipoRon</scp>, a new therapeutic prospect for Duchenne muscular dystrophy
Abou‐Samra, M., Selvais, C. M., Boursereau, R., Lecompte, S., Noel, L., & Brichard, S. M. (2020) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12531 · Cited by 44 · see citing works
Inflammatory and Oxidative Stress Markers in Skeletal Muscle of Obese Subjects
Catalán, V., Frühbeck, G., & Gómez‐Ambrosi, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812504-5.00008-8 · Cited by 43 · see citing works
Lecompte, S., Abou-Samra, M., Boursereau, R., Noel, L., & Brichard, S. M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2465-5 · Cited by 34 · see citing works
Role of Adipokines in Sarcopenia
Lu, W., Feng, W., Lai, J., Yuan, D., Xiao, W., & Li, Y. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002255 · Cited by 34 · see citing works
Adiponectin and Thyroid Cancer: Insight into the Association between Adiponectin and Obesity
Zhou, Y., Yang, Y., Zhou, T., Li, B., & Wang, Z. (2021) · Aging and Disease · doi:10.14336/ad.2020.0919 · Cited by 36 · see citing works
Selvais, C. M., de Carrizosa, M. A. D., Nachit, M., Versele, R., Dubuisson, N., Noël, L., Gillard, J., Leclercq, I. A., Brichard, S. M., & Abou‐Samra, M. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13148 · Cited by 33 · see citing works
Differential Gene Expression Profiling of Dystrophic Dog Muscle after MuStem Cell Transplantation
Robriquet, F., Lardenois, A., Babarit, C., Larcher, T., Dubreil, L., Leroux, I., Zuber, C., Ledevin, M., Deschamps, J., Fromes, Y., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123336 · Cited by 27 · see citing works
Aerobic Exercise Ameliorates Cancer Cachexia-Induced Muscle Wasting through Adiponectin Signaling
Morinaga, M., Sako, N., Isobe, M., Lee-Hotta, S., Sugiura, H., & Kametaka, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063110 · Cited by 23 · see citing works
Marique, L., Sènou, M., Craps, J., Delaigle, A., Regemorter, E. V., Wérion, A., Regemorter, V. V., Mourad, M., Behets, C., Lengelé, B., et al. (2015) · Thyroid · doi:10.1089/thy.2015.0087 · Cited by 25 · see citing works
Kang, K., Kim, O., Chin, J. Y., Kim, W., Park, S., Choi, Y. J., Shin, J. H., Jung, K. T., Lim, D.-S., & Lee, S. (2015) · Endocrinology and Metabolism · doi:10.3803/enm.2015.30.4.557 · Cited by 23 · see citing works
Potential Therapeutic Action of Adiponectin in Duchenne Muscular Dystrophy
Abou-Samra, M., Boursereau, R., Lecompte, S., Noel, L., & Brichard, S. M. (2017) · The American Journal of Pathology · doi:10.1016/j.ajpath.2017.02.018 · Cited by 24 · see citing works
Ohki, K., Wakui, H., Kishio, N., Azushima, K., Uneda, K., Haku, S., Kobayashi, R., Haruhara, K., Kinguchi, S., Yamaji, T., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-21270-8 · Cited by 22 · see citing works
New targets to alleviate skeletal muscle inflammation: Role of microRNAs regulated by adiponectin
Boursereau, R., Abou-Samra, M., Lecompte, S., Noel, L., & Brichard, S. M. (2017) · Scientific Reports · doi:10.1038/srep43437 · Cited by 18 · see citing works
Costa, L. R., de Castro, C. A., Marine, D. A., Fabrizzi, F., Furino, V. D. O., Malavazi, I., Aníbal, F. D. F., & Duarte, A. C. G. D. O. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.564862 · Cited by 17 · see citing works
Martínez-Huenchullán, S., Maharjan, B. R., Williams, P. F., Tam, C. S., McLennan, S. V., & Twigg, S. M. (2018) · Physiological Reports · doi:10.14814/phy2.13848 · Cited by 17 · see citing works
Muscle–bone and fat–bone interactions in regulating bone mass: do PTH and PTHrP play any role?
Datta, N. S. (2014) · Endocrine · doi:10.1007/s12020-014-0273-3 · Cited by 16 · see citing works
Aouida, M., Kim, K.-C., Shaikh, A. R., Pardo, J. M., Eppinger, J., Yun, D., Bressan, R. A., & Narasimhan, M. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065454 · Cited by 15 · see citing works
Adiponectin overexpression in C2C12 myocytes increases lipid oxidation and myofiber transition
Lopez‐Yus, M., Lopez-Perez, R., García-Sobreviela, M. P., del Moral, R., Lorente‐Cebrián, S., & Arbonés-Mainar, J. M. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00836-7 · Cited by 13 · see citing works
Wang, N., Zhu, S., Chen, S., Zou, J., Zeng, P., & Tan, S. (2025) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0147 · Cited by 12 · see citing works
Jiménez‐Maldonado, A., Virgen‐Ortiz, A., Lemus, M., Castro-Rodríguez, E., Cortés, J. C., Muñı́z, J., Montero, S., & Roces, E. (2019) · Medicina · doi:10.3390/medicina55060291 · Cited by 10 · see citing works
Mimic microgravity effect on muscle transcriptome under ionizing radiation
Tran, K. N., & Choi, J. (2021) · Life Sciences in Space Research · doi:10.1016/j.lssr.2021.12.002 · Cited by 9 · see citing works
Schilling, B. K., Baker, J. S., Komatsu, C., Turer, D. M., Bengür, F. B., Nerone, W. V., Qin, F., Cottrill, A. R., Kokai, L. E., Rubin, J. P., et al. (2022) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000010115 · Cited by 8 · see citing works
MicroRNA-668-3p inhibits myoblast proliferation and differentiation by targeting Appl1
Cao, H., Du, T., Li, C., Wu, L., Liu, J., Guo, Y., Li, X., Yang, G., Jin, J., & Shi, X. (2023) · BMC Genomics · doi:10.1186/s12864-023-09431-0 · Cited by 8 · see citing works
Hornsby, W. G., Haff, G. G., Suarez, D. G., Ramsey, M. W., Triplett, N. T., Hardee, J. P., Stone, M. E., & Stone, M. H. (2020) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk5020044 · Cited by 8 · see citing works
CD4+ T lymphocytes produce adiponectin in response to transplants
Danturti, S., Keslar, K. S., Steinhoff, L. R., Fan, R., Dvorina, N., Valujskikh, A., Fairchild, R. L., & Baldwin, W. M. (2017) · JCI Insight · doi:10.1172/jci.insight.89641 · Cited by 7 · see citing works
Challenging Sarcopenia: Exploring AdipoRon in Aging Skeletal Muscle as a Healthspan-Extending Shield
Selvais, C. M., de Carrizosa, M. A. D., Versele, R., Dubuisson, N., Noël, L., Brichard, S. M., & Abou‐Samra, M. (2024) · Antioxidants · doi:10.3390/antiox13091073 · Cited by 6 · see citing works
Adipokines: Leptin and Adiponectin in the Regulation of Inflammatory and Immune Responses
Fantuzzi, G. (2014) · Humana Press eBooks · doi:10.1007/978-1-62703-770-9_6 · Cited by 6 · see citing works
Jakus, T., Jurdana, M., Žiberna, L., & Pražnikar, Z. J. (2021) · European Journal of Inflammation · doi:10.1177/2058739221998890 · Cited by 6 · see citing works
Bruzina, A. S., Raymond‐Pope, C. J., Murray, K. J., Lillquist, T. J., Castelli, K. M., Bijwadia, S. R., Call, J. A., & Greising, S. M. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00006-5 · Cited by 6 · see citing works
Adiponectin and aging: Mechanistic insights, clinical paradox, and therapeutic horizons
McGregor, E. R., Osterbauer, K. J., Gustafson, G. E., Clark, J. P., Rhoads, T. W., & Anderson, R. M. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103059 · Cited by 6 · see citing works
Wang, Z., Zhao, J., Tan, H., Jiao, Y., Chen, X., & Shen, J. (2024) · JOR Spine · doi:10.1002/jsp2.1318 · Cited by 3 · see citing works
The Immunological Importance of the Mesentery
Weidinger, C., & Siegmund, B. (2023) · Progress in inflammation research · doi:10.1007/978-3-031-17774-3_5 · Cited by 3 · see citing works
Zhang, W., Wu, Q., Chen, Q., Qin, W., Zhang, D., Xu, Q., Han, P., & Sun, J. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1805067 · Cited by 2 · see citing works
Evaluation of molecular mechanisms impacting beef quality and carcass characteristics
Blatter, S. A. (2018) · Montana State University ScholarWorks (Montana State University)
Puspita, D. I., Rejeki, P. S., Sari, G. M., Munir, M., Izzatunnisa, N., Muhammad, Halim, S., & Pranoto, A. (2024) · Revista de Investigación e Innovación en Ciencias de la Salud · doi:10.46634/riics.314
Gopalakrishnan, S., Sobha, S. P., & Lakshmanan, K. (2025) · Diabetology International · doi:10.1007/s13340-025-00837-7
Cao, H., Du, T., Li, C., Wu, L., Liu, J., Guo, Y., Li, X., Yang, G. S., Jin, J., & Shi, X. (2023) · Figshare · doi:10.6084/m9.figshare.23740748
- Authors
- Jortay, J., Senou, M., Abou-Samra, M., Noel, L., Robert, A., Many, M.-C., & Brichard, S. M.
- Affiliations
- UCLouvain (BE)
- Corresponding author
- Brichard, Sonia M.
- ORCID
- Robert, Annie
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 181
- Issue
- 1
- Pages
- 245-256
- ISSN
- 0002-9440 (ISSN-L)
- OpenAlex
- W1813443405
- Cited by
- 52
- References
- 33
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 6 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 3
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal Of Pathology (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- adiponectin, skeletal muscle, obesity, AdipoR1, NF-κB signaling, oxidative stress, inflammation, apoptosis, Western diet, TNF-α, caspase-6, peroxiredoxin, 4-hydroxynonenal, autocrine and paracrine signaling, adiponectin knockout mice
- MeSH terms
- Animals, Body Composition, Body Weight, Diet, Obesity, Stress, Physiological, Tumor Necrosis Factor-alpha, NF-kappa B, Apoptosis, Gene Transfer Techniques, Mice, Knockout, Oxidative Stress, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Cells, Mice, Adiponectin, Caspase 6
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
