Cited by 2,779Ion Channels and ReceptorsCalcium signaling and nucleotide metabolismBiochemical Analysis and Sensing Techniques

The DOI matches its Crossref record; 99 of the 100 references it cites were found in a registry or an index.

TRP channels as cellular sensors

Clapham, David E.·2003·Nature

DOI 10.1038/nature02196

Open this paper in CoChat — free account

Abstract

TRP channels are the vanguard of our sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than classical sensory transduction. They are an ancient sensory apparatus for the cell, not just the multicellular organism, and they have been adapted to respond to all manner of stimuli, from both within and outside the cell.

Integrity signals

Registry

Crossref · 10.1038/nature02196

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132
Ion Channels/Excitable Membranes
(2011) · Springer eBooks · doi:10.1007/springerreference_33998 · Cited by 4,066
Impaired nociception and pain sensation in mice lacking the capsaicin receptor
Caterina, M. J., Leffler, A., Malmberg, A. B., Martin, W. J., Trafton, J., Petersen-Zeitz, K. R., Koltzenburg, M., Basbaum, A. I., & Julius, D. (2000) · Science · doi:10.1126/science.288.5464.306 · Cited by 3,544
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
McKemy, D. D., Neuhausser, W., & Julius, D. J. (2002) · Nature · doi:10.1038/nature719 · Cited by 2,716
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00158-2 · Cited by 2,494
A TRP Channel that Senses Cold Stimuli and Menthol
Peier, A. M., Moqrich, A., Hergarden, A. C., Reeve, A. J., Andersson, D. A., Story, G. M., Earley, T. J., Dragoni, I., McIntyre, P., Bevan, S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00652-9 · Cited by 2,361
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057
A capsaicin-receptor homologue with a high threshold for noxious heat
Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J., & Julius, D. J. (1999) · Nature · doi:10.1038/18906 · Cited by 1,599
Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor
Liedtke, W., Choe, Y., Martı́-Renom, M. A., Bell, A. M., Denis, C. S., AndrejŠali, Hudspeth, A. J., Friedman, J. M., & Heller, S. (2000) · Cell · doi:10.1016/s0092-8674(00)00143-4 · Cited by 1,391
Coding of Sweet, Bitter, and Umami Tastes
Zhang, Y., Hoon, M. A., Chandrashekar, J., Mueller, K. L., Cook, B., Wu, D., Zuker, C. S., & Ryba, N. J. P. (2003) · Cell · doi:10.1016/s0092-8674(03)00071-0 · Cited by 1,312

Flagged first, then by citations

Show all 100 references

1 of the 100 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Nilius, B. TRP Channels: facts, fiction, challenges. Cell Calcium 14, 33–34 (2003)

Sorted by citations

Items 801–900 of 1,001

The Cold and Menthol Receptor TRPM8 Contains a Functionally Important Double Cysteine Motif
Dragoni, I., Guida, E., & McIntyre, P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607227200 · Cited by 60
Evidence for functional expression of TRPM7 channels in human atrial myocytes
Zhang, Y., Sun, H., Chen, K.-H., Du, X., Liu, B., Cheng, L., Li, X., Jin, M., & Li, G. (2012) · Basic Research in Cardiology · doi:10.1007/s00395-012-0282-4 · Cited by 60
4-Oxo-2-nonenal (4-ONE): Evidence of Transient Receptor Potential Ankyrin 1-Dependent and -Independent Nociceptive and Vasoactive Responses In Vivo
Graepel, R., Fernandes, E. S., Aubdool, A. A., Andersson, D. A., Bevan, S., & Brain, S. D. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.172403 · Cited by 60
Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors
Scholz, N., Monk, K. R., Kittel, R. J., & Langenhan, T. (2016) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-41523-9_10 · Cited by 64
Plasmodium cysteine repeat modular proteins 1?4: complex proteins with roles throughout the malaria parasite life cycle
Thompson, J., Fernández-Reyes, D., Sharling, L., Moore, S. G., Eling, W. M. C., Kyes, S., Newbold, C., Kafatos, F. C., Janse, C. J., & Waters, A. P. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00885.x · Cited by 63
Differential regulation of TRPM channels governs electrolyte homeostasis in the C. elegans intestine
Teramoto, T., Lambie, E. J., & Iwasaki, K. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.04.007 · Cited by 60
Role of Reactive Oxygen Species and Redox in Regulating the Function of Transient Receptor Potential Channels
Song, M., Makino, A., & Yuan, J. X. ‐. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3648 · Cited by 59
Suppression of TRPM 7 Inhibits Proliferation, Migration, and Invasion of Malignant Human Glioma Cells
Leng, T., Li, M., Shen, J., Liu, M., Li, X., Sun, H., Branigan, D., Zeng, Z., Si, H., Li, J., et al. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12354 · Cited by 59
Bradykinin regulates calpain and proinflammatory signaling through TRPM7-sensitive pathways in vascular smooth muscle cells
Yogi, Á., Callera, G. E., Tostes, R. C., & Touyz, R. M. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90602.2008 · Cited by 59
Curcumin inhibits oxidative stress-induced TRPM2 channel activation, calcium ion entry and apoptosis values in SH-SY5Y neuroblastoma cells: Involvement of transfection procedure
Öz, A., & Çelik, Ö. (2016) · Molecular Membrane Biology · doi:10.1080/09687688.2017.1318224 · Cited by 59
Insulin and leptin excite anorexigenic pro‐opiomelanocortin neurones via activation of TRPC 5 channels
Qiu, J., Wagner, E. J., Rønnekleiv, O. K., & Kelly, M. J. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12501 · Cited by 63
Neural evidence supports a dual sensory-motor role for insect wings
Pratt, B. G., Deora, T., Mohren, T. L., & Daniel, T. (2017) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2017.0969 · Cited by 59
TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain
Morales, M. A., González‐Rodríguez, S., & Ferrer-Montiel, A. V. (2018) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2018.00073 · Cited by 59
TRPV Protein Family—From Mechanosensing to Cancer Invasion
Kärki, T., & Tojkander, S. (2021) · Biomolecules · doi:10.3390/biom11071019 · Cited by 59
Methyl p ‐hydroxybenzoate causes pain sensation through activation of TRPA1 channels
Fujita, F., Moriyama, T., Higashi, T., Shima, A., & Tominaga, M. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707219 · Cited by 59
Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2α
Liang, G., Yang, J., Wang, Z., Li, Q., Tang, Y., & Chen, X. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn221 · Cited by 59
Pancreatic Ductal Bicarbonate Secretion: Challenge of the Acinar Acid Load
Hegyi, P. J., Maléth, J., Venglovecz, V., & Rakonczay, Z. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00036 · Cited by 58
Intrathecal AAV Serotype 9-mediated Delivery of shRNA Against TRPV1 Attenuates Thermal Hyperalgesia in a Mouse Model of Peripheral Nerve Injury
Hirai, T., Enomoto, M., Kaburagi, H., Sotome, S., Yoshida‐Tanaka, K., Ukegawa, M., Kuwahara, H., Yamamoto, M., Tajiri, M., Miyata, H., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.247 · Cited by 58
The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death
Katano, M., Numata, T., Aguan, K., Hara, Y., Kiyonaka, S., Yamamoto, S., Miki, T., Sawamura, S., Suzuki, T., Yamakawa, K., et al. (2012) · Cell Calcium · doi:10.1016/j.ceca.2011.12.011 · Cited by 58
Regulation of Activity of Transient Receptor Potential Melastatin 8 (TRPM8) Channel by Its Short Isoforms
Bidaux, G., Beck, B., Zholos, A. V., Gordienko, D. V., Lemonnier, L., Flourakis, M., Roudbaraki, M. M., Borowiec, A., Fernández, J. A., Delcourt, P., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.270256 · Cited by 58
Mechanoregulation of cytoskeletal dynamics by TRP channels
Kuipers, A. J., Middelbeek, J., & van Leeuwen, F. N. (2012) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2012.05.006 · Cited by 61
A structural view of ligand-dependent activation in thermoTRP channels
Steinberg, X. P., Lespay‐Rebolledo, C., & Brauchi, S. E. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00171 · Cited by 58
Temperature-sensitive gating of TRPV1 channel as probed by atomistic simulations of its trans- and juxtamembrane domains
Chugunov, A. O., Volynsky, P. E., Krylov, N. A., Nolde, D. E., & Efremov, R. G. (2016) · Scientific Reports · doi:10.1038/srep33112 · Cited by 58
TRPV1 Antagonists as a Potential Treatment for Hyperalgesia
Roberts, L. A., & Connor, M. A. (2006) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488906775245309 · Cited by 58
Kisspeptin Activation of TRPC4 Channels in Female GnRH Neurons Requires PIP2 Depletion and cSrc Kinase Activation
Zhang, C., Bosch, M. A., Rønnekleiv, O. K., & Kelly, M. J. (2013) · Endocrinology · doi:10.1210/en.2013-1180 · Cited by 58
TRPV1 Channels in Immune Cells and Hematological Malignancies
Omari, S. A., Adams, M. J., & GERAGHTY, D. P. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.01.002 · Cited by 59
TRPM2 in the Brain: Role in Health and Disease
Sita, G., Hrelia, P., Graziosi, A., Ravegnini, G., & Morroni, F. (2018) · Cells · doi:10.3390/cells7070082 · Cited by 57
Lysosomal Ion Channels: What Are They Good For and Are They Druggable Targets?
Riederer, E. A., Cang, C., & Ren, D. (2022) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-051921-013755 · Cited by 58
The distinguishing electrical properties of cancer cells
Gregorio, E. D., Israel, S. L., Staelens, M., Tankel, G., Shankar, K., & Tuszyński, J. A. (2022) · Physics of Life Reviews · doi:10.1016/j.plrev.2022.09.003 · Cited by 58
Effect of oxidative stress on TRPM2 and TRPC3 channels in B lymphoblast cells in bipolar disorder
Roedding, A. S., Gao, A. F., Au‐Yeung, W., Scarcelli, T., Li, P. P., & Warsh, J. J. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2012.01003.x · Cited by 57
Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 4: Intercellular bridges, mitochondria, nuclear envelope, apoptosis, ubiquitination, membrane/voltage‐gated channels, methylation/acetylation, and transcription factors
Hermo, L., Pelletier, R. ‐., Cyr, D. G., & Smith, C. E. (2009) · Microscopy Research and Technique · doi:10.1002/jemt.20785 · Cited by 58
Focal and segmental glomerulosclerosis
Daskalakis, N., & Winn, M. P. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6171-y · Cited by 57
TrkA pathway(s) is involved in regulation of TRPM7 expression in hippocampal neurons subjected to ischemic-reperfusion and oxygen–glucose deprivation
Jiang, H., Tian, S.-L., Zeng, Y., Li, L., & Shi, J. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.01.013 · Cited by 57
Subcellular translocation of the eGFP-tagged TRPL channel inDrosophilaphotoreceptors requires activation of the phototransduction cascade
Meyer, N. E., Joel-Almagor, T., Frechter, S., Minke, B., & Huber, A. (2006) · Journal of Cell Science · doi:10.1242/jcs.02986 · Cited by 57
The Transient Receptor Potential Channel TRPM8 Is Inhibited via the α2A Adrenoreceptor Signaling Pathway
Bavencoffe, A. G., Gkika, D., Kondratskyi, A., Beck, B., Borowiec, A., Bidaux, G., Busserolles, J., Eschalier, A., Шуба, Я. М., Skryma, R. N., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.069377 · Cited by 57
SNO-ing at the Nociceptive Synapse?
Tegeder, I., Scheving, R., Wittig, I., & Geißlinger, G. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.004200 · Cited by 57
Gadolinium activates and sensitizes the vanilloid receptor TRPV1 through the external protonation sites
Tousova, K., Vyklický, L., Sušánková, K., Benedikt, J., & Vlachová, V. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.07.004 · Cited by 57
New natural agonists of the transient receptor potential Ankyrin 1 (TRPA1) channel
Legrand, C., Merlini, J. M., de Senarclens-Bezençon, C., & Michlig, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-68013-2 · Cited by 56
Beyond Hot and Spicy: TRPV Channels and their Pharmacological Modulation
Seebohm, G., & Schreiber, J. A. (2021) · Cellular Physiology and Biochemistry · doi:10.33594/000000358 · Cited by 56
Neurological susceptibility to environmental exposures: pathophysiological mechanisms in neurodegeneration and multiple chemical sensitivity
Molot, J., Sears, M., Marshall, L. M., & Bray, R. I. (2021) · Reviews on Environmental Health · doi:10.1515/reveh-2021-0043 · Cited by 60
Kisspeptin Excitation of GnRH Neurons
Rønnekleiv, O. K., & Kelly, M. J. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6199-9_6 · Cited by 57
Functional expression of transient receptor potential channels in human endometrial stromal cells during the luteal phase of the menstrual cycle
Clercq, K. D., Held, K., Bree, R. V., Meuleman, C., Peeraer, K., Tomassetti, C., Voets, T., D’Hooghe, T. M., & Vriens, J. (2015) · Human Reproduction · doi:10.1093/humrep/dev068 · Cited by 56
Interplay between TRP channels and the cytoskeleton in health and disease
Clark, K., Middelbeek, J., & van Leeuwen, F. N. (2008) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2008.01.009 · Cited by 58
TRPC 6 inhibited NMDA receptor activities and protected neurons from ischemic excitotoxicity
Li, H., Huang, J., Du, W., Jia, C., Yao, H., & Wang, Y. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12045 · Cited by 56
TRPM7 is required for ovarian cancer cell growth, migration and invasion
Wang, J., Liao, Q., Zhang, Y., Zhou, H., Luo, C., Tang, J., Wang, Y., Tang, Y., Zhao, M., Zhao, X., et al. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.10.118 · Cited by 58
Fused Piperidines as a Novel Class of Potent and Orally Available Transient Receptor Potential Melastatin Type 8 (TRPM8) Antagonists
Tamayo, N. A., Bo, Y. Y., Gore, V., Ma, V., Nishimura, N., Tang, P., Deng, H. X., Klionsky, L., Lehto, S. G., Wang, W., et al. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm2013634 · Cited by 56
Corneal Nerve Fiber Structure, Its Role in Corneal Function, and Its Changes in Corneal Diseases
Eguchi, H., Hiura, A., Nakagawa, H., Kusaka, S., & Shimomura, Y. (2017) · BioMed Research International · doi:10.1155/2017/3242649 · Cited by 56
The Bioelectric Code: Reprogramming Cancer and Aging From the Interface of Mechanical and Chemical Microenvironments
Silver, B. B., & Nelson, C. M. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00021 · Cited by 56
Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes
Clemmensen, C., Jall, S., Kleinert, M., Quarta, C., Gruber, T., Reber, J., Sachs, S., Fischer, K., Feuchtinger, A., Karlas, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06769-y · Cited by 56
Lipid metabolism and Calcium signaling in epithelial ovarian cancer
Kouba, S., Ouldamer, L., Garcia, C., Fontaine, D., Chantôme, A., Vandier, C., Goupille, C., & Potier‐Cartereau, M. (2019) · Cell Calcium · doi:10.1016/j.ceca.2019.06.002 · Cited by 56
TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling
Kasitinon, S. Y., Eskiocak, U., Martin, M., Bezwada, D., Khivansara, V., Tasdogan, A., Zhao, Z., Mathews, T. P., Aurora, A. B., & Morrison, S. J. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.086 · Cited by 58
State-dependent Inhibition of TRPM2 Channel by Acidic pH
Yang, W., Zou, J., Xia, R. M., Vaal, M. L., Seymour, V. A. L., Luo, J., Beech, D. J., & Jiang, L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.139774 · Cited by 56
TRPV Channels’ Role in Osmotransduction and Mechanotransduction
Liedtke, W. (2007) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-34891-7_28 · Cited by 56
Force From Filaments: The Role of the Cytoskeleton and Extracellular Matrix in the Gating of Mechanosensitive Channels
Chuang, Y.-C., & Chen, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.886048 · Cited by 59
Varicose Veins: Role of Mechanotransduction of Venous Hypertension
Atta, H. M. (2012) · International Journal of Vascular Medicine · doi:10.1155/2012/538627 · Cited by 58
Cardioprotection by ischemic postconditioning is lost in isolated perfused heart from diabetic rats: Involvement of transient receptor potential vanilloid 1, calcitonin gene-related peptide and substance P
Ren, J., Song, J.-X., Lu, M., & Chen, H. (2011) · Regulatory Peptides · doi:10.1016/j.regpep.2011.04.004 · Cited by 55
Sarcolipin retention in the endoplasmic reticulum depends on its C-terminal RSYQY sequence and its interaction with sarco(endo)plasmic Ca 2 +-ATPases
Gramolini, A. O., Kislinger, T., Asahi, M., Li, W., Emili, A., & MacLennan, D. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407815101 · Cited by 55
The Reverse Roles of Transient Receptor Potential Canonical Channel-3 and -6 in Neuronal Death Following Pilocarpine-Induced Status Epilepticus
Kim, D., Ryu, H. J., Kim, J., & Kang, T. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9875-6 · Cited by 55
Taste-guided identification of high potency TRPA1 agonists from Perilla frutescens
Bassoli, A., Borgonovo, G., Caimi, S., Scaglioni, L., Morini, G., Moriello, A. S., Marzo, V. D., & PETROCELLIS, L. D. (2008) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.12.057 · Cited by 55
Post-Translational Modifications of TRP Channels
Voolstra, O., & Huber, A. (2014) · Cells · doi:10.3390/cells3020258 · Cited by 55
CFTR and Ca2+ signaling in cystic fibrosis
Antigny, F. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00067 · Cited by 55
Glucose enhances expression of TRPC1 and calcium entry in endothelial cells
Bishara, N. B., & Ding, H. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00699.2009 · Cited by 55
Calcium, TRPC channels, and regulation of the actin cytoskeleton in podocytes: towards a future of targeted therapies
Wieder, N. W., & Greka, A. (2015) · Pediatric Nephrology · doi:10.1007/s00467-015-3224-1 · Cited by 55
Comparative sequence analysis suggests a conserved gating mechanism for TRP channels
Palovcak, E. J., Delemotte, L., Klein, M. L., & Carnevale, V. (2015) · The Journal of General Physiology · doi:10.1085/jgp.201411329 · Cited by 55
Treasure troves of pharmacological tools to study transient receptor potential canonical 1/4/5 channels
Rubaiy, H. N. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14578 · Cited by 55
Silencing of spinal Trpv1 attenuates neuropathic pain in rats by inhibiting CAMKII expression and ERK2 phosphorylation
Guo, S.-H., Lin, J.-P., Huang, L., Yang, Y., Chen, C., Li, N., Su, M.-Y., Zhao, X., Zhu, S., & Yao, Y.-X. (2019) · Scientific Reports · doi:10.1038/s41598-019-39184-4 · Cited by 55
TRPC7 Is a Receptor-Operated DAG-Activated Channel in Human Keratinocytes
Beck, B., Zholos, A. V., Sydorenko, V., Roudbaraki, M. M., Lehen’kyi, V., Bordat, P., Prevarskaya, N. B., & Skryma, R. N. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700352 · Cited by 55
A TRPC-like non-selective cation current activated by α1-adrenoceptors in rat mesenteric artery smooth muscle cells
Hill, A. J., Hinton, J. M., Cheng, H., Gao, Z., Bates, D. O., Hancox, J. C., Langton, P. D., & James, A. F. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.03.007 · Cited by 55
G-protein–gated TRP-like Cationic Channel Activated by Muscarinic Receptors
Zholos, A. V., Zholos, A. A., & Bolton, T. B. (2004) · The Journal of General Physiology · doi:10.1085/jgp.200309002 · Cited by 55
Optical neuromodulation at all scales: from nanomaterials to wireless optoelectronics and integrated systems
Karatum, O., Gwak, M.-J., Hyun, J., Önal, A., Koirala, G. R., Kim, T., & Nizamoğlu, S. (2023) · Chemical Society Reviews · doi:10.1039/d2cs01020h · Cited by 54
A microbial TRP-like polycystic-kidney-disease-related ion channel gene
PALMER, C. P., Aydar, E., & Djamgoz, M. B. A. (2005) · Biochemical Journal · doi:10.1042/bj20041710 · Cited by 56
Opportunistic activation of TRP receptors by endogenous lipids: Exploiting lipidomics to understand TRP receptor cellular communication
Bradshaw, H. B., Raboune, S., & Hollis, J. L. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.11.008 · Cited by 54
Modulation of Canonical Transient Receptor Potential Channel 1 in the Proliferation of Oligodendrocyte Precursor Cells by the Golli Products of the Myelin Basic Protein Gene
Paez, P. M., Fulton, D. J., Spreuer, V., Handley, V., & Campagnoni, A. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4424-10.2011 · Cited by 58
Cryo-EM structure of the cytoplasmic domain of murine transient receptor potential cation channel subfamily C member 6 (TRPC6)
Azumaya, C. M., Sierra-Valdez, F. J., Cordero-Morales, J. F., & Nakagawa, T. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003183 · Cited by 54
TRPV2-induced Ca2+-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma
Bai, H., Zhu, H., Yan, Q., Shen, X., Lu, X., Wang, J., Li, J., & Chen, L. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0280-8 · Cited by 54
Transient Receptor Potential Channel Expression Signatures in Tumor-Derived Endothelial Cells: Functional Roles in Prostate Cancer Angiogenesis
Bernardini, M., Brossa, A., Chinigò, G., Grolez, G. P., Trimaglio, G., Allart, L., Hulot, A., Marot, G., Genova, T., Joshi, A. A., et al. (2019) · Cancers · doi:10.3390/cancers11070956 · Cited by 54
TRPs as mechanosensitive channels
Barritt, G. J., & Rychkov, G. Y. (2005) · Nature Cell Biology · doi:10.1038/ncb0205-105 · Cited by 54
TRPV5, the Gateway to Ca2+ Homeostasis
Mensenkamp, A. R., Hoenderop, J. G. J., & Bindels, R. J. M. (2007) · Springer eBooks · doi:10.1007/978-3-540-34891-7_12 · Cited by 54
Drosophila melanogaster--the model organism of choice for the complex biology of multi-cellular organisms.
Beckingham, K., Armstrong, J. D., Texada, M. J., Munjaal, R. P., & Baker, D. A. (2005) · PubMed · Cited by 54
Porous Capsules Allow Pore Opening and Closing That Results in Cation Uptake
Müller, A., Toma, L., Bögge, H., Schäffer, C., & Stammler, A. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200502202 · Cited by 54
Correction: Citral Sensing by Transient Receptor Potential Channels in Dorsal Root Ganglion Neurons
Stotz, S. C., Vriens, J., Martyn, D. C., Clardy, J., & Clapham, D. E. (2008) · PLoS ONE · doi:10.1371/annotation/6ba8e9d9-0035-405e-a7c7-45ee22b2e381 · Cited by 54
Self-citation
Finely-Tuned Calcium Oscillations in Osteoclast Differentiation and Bone Resorption
Okada, H., Okabe, K., & Tanaka, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010180 · Cited by 55
Transient Receptor Potential (TRP) and Thermoregulation in Animals: Structural Biology and Neurophysiological Aspects
Lezama-García, K., Mota‐Rojas, D., Pereira, A. M. F., Martı́nez-Burnes, J., Ghezzi, M. D., Domínguez-Oliva, A., Gómez-Prado, J., Geraldo, A. C. A. P. D. M., Lendez, P. A., Hernández-Ávalos, I., et al. (2022) · Animals · doi:10.3390/ani12010106 · Cited by 53
Ligand-Binding Sites in Vanilloid-Subtype TRP Channels
Yelshanskaya, M. V., & Sobolevsky, A. I. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.900623 · Cited by 53
GPCR ‐mediated EGF receptor transactivation regulates TRPV 4 action in the vasculature
Saifeddine, M., El‐Daly, M., Mihara, K., Bunnett, N. W., McIntyre, P., Altier, C., Hollenberg, M. D., & Ramachandran, R. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13072 · Cited by 53
Gadolinium blocks membrane permeabilization induced by nanosecond electric pulses and reduces cell death
André, F. M., Rassokhin, M. A., Bowman, A. M., & Pakhomov, A. G. (2009) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2009.12.007 · Cited by 53
Dynamic expression of the osmosensory channel trpv4 in multiple developing organs in zebrafish
Mangos, S., Liu, Y., & Drummond, I. A. S. (2006) · Gene Expression Patterns · doi:10.1016/j.modgep.2006.10.011 · Cited by 53
G1 cell cycle arrest by amlodipine, a dihydropyridine Ca2+ channel blocker, in human epidermoid carcinoma A431 cells
Yoshida, J., Ishibashi, T., & Nishio, M. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.12.011 · Cited by 53
Quercetin induces apoptosis by inhibiting MAPKs and TRPM7 channels in AGS cells
KIM, M. C., Lee, H. J., Lim, B., Ha, K., Kim, S. Y., So, I., & Kim, B. J. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1704 · Cited by 53
Mutation of the Melastatin-Related Cation Channel, TRPM3, Underlies Inherited Cataract and Glaucoma
Bennett, T. M., Mackay, D. S., Siegfried, C. J., & Shiels, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104000 · Cited by 53
TRP Channels in Respiratory Pathophysiology: the Role of Oxidative, Chemical Irritant and Temperature Stimuli
Zholos, A. V. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150331223118 · Cited by 53
The TRPM2 channel nexus from oxidative damage to Alzheimer’s pathologies: An emerging novel intervention target for age-related dementia
Jiang, L., Li, X., Mortadza, S. A. S., Lovatt, M., & Yang, W. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.002 · Cited by 53
An overview on transient receptor potential channels superfamily
Tsagareli, M. G., & Nozadze, I. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000524 · Cited by 53
Neophobia, sensory and cognitive functions, and hedonic responses in vitamin D receptor mutant mice
Minasyan, A., Keisala, T., Lou, Y., Kalueff, A. V., & Tuohimaa, P. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.03.032 · Cited by 53
Regulation of TRPV1 by a novel renally expressed rat TRPV1 splice variant
Tian, W., Fu, Y., Wang, D. H., & Cohen, D. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00143.2005 · Cited by 53
TRPV6 exhibits unusual patterns of polymorphism and divergence in worldwide populations
Akey, J. M. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl134 · Cited by 53
Neuroendocrinology of the lung revealed by single-cell RNA sequencing
Kuo, C. S., Darmanis, S., de Arce, A. D., Liu, Y., Almanzar, N., Wu, T.-H., Quake, S. R., & Krasnow, M. A. (2022) · eLife · doi:10.7554/elife.78216 · Cited by 56
Ins(1,4,5)P3 interacts with PIP2 to regulate activation of TRPC6/C7 channels by diacylglycerol in native vascular myocytes
Ju, M. J., Shi, J. R., Saleh, S. N., Albert, A. P., & Large, W. A. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.185256 · Cited by 52
[6]-Gingerol: A Novel AT1 Antagonist for the Treatment of Cardiovascular Disease
Liu, Q., Liu, J., Guo, H., Sun, S., Wang, S., Zhang, Y., Li, S., & Qiao, Y. (2013) · Planta Medica · doi:10.1055/s-0032-1328262 · Cited by 52
Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception
Mancuso, G., Borgonovo, G., Scaglioni, L., & Bassoli, A. (2015) · Molecules · doi:10.3390/molecules201018907 · Cited by 52

Authors: Clapham, D. E.
Affiliations: Boston Children's Hospital (US)
Corresponding author: Clapham, David E.
ORCID: Clapham, David E.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2003-12
Volume: 426
Issue: 6966
Pages: 517-524
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature02196
OpenAlex: W2040664792
Cited by: 2,779
References: 100
Citations by year: 2026: 82 · 2025: 85 · 2024: 113 · 2023: 84 · 2022: 129 · 2021: 115 · 2020: 128 · 2019: 120 · 2018: 96 · 2017: 94 · 2016: 120 · 2015: 112 · 2014: 124 · 2013: 117 · 2012: 137
FWCI: 12.80
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords: TRP channels, sensory transduction, temperature sensing, mechanosensing, pain, osmolarity, pheromones, taste, intracellular signaling, ion channels
MeSH terms: Animals, Calcium, Cells, Humans, Models, Biological, Calcium Channels, Signal Transduction, Ion Channel Gating, TRPC Cation Channels

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

TRP channels as cellular sensors

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks