Cited by 2,779Ion Channels and ReceptorsCalcium signaling and nucleotide metabolismBiochemical Analysis and Sensing Techniques

The DOI matches its Crossref record; 99 of the 100 references it cites were found in a registry or an index.

TRP channels as cellular sensors

Clapham, David E.·2003·Nature

DOI 10.1038/nature02196

Open this paper in CoChat — free account

Abstract

TRP channels are the vanguard of our sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than classical sensory transduction. They are an ancient sensory apparatus for the cell, not just the multicellular organism, and they have been adapted to respond to all manner of stimuli, from both within and outside the cell.

Integrity signals

Registry

Crossref · 10.1038/nature02196

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132
Ion Channels/Excitable Membranes
(2011) · Springer eBooks · doi:10.1007/springerreference_33998 · Cited by 4,066
Impaired nociception and pain sensation in mice lacking the capsaicin receptor
Caterina, M. J., Leffler, A., Malmberg, A. B., Martin, W. J., Trafton, J., Petersen-Zeitz, K. R., Koltzenburg, M., Basbaum, A. I., & Julius, D. (2000) · Science · doi:10.1126/science.288.5464.306 · Cited by 3,544
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
McKemy, D. D., Neuhausser, W., & Julius, D. J. (2002) · Nature · doi:10.1038/nature719 · Cited by 2,716
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00158-2 · Cited by 2,494
A TRP Channel that Senses Cold Stimuli and Menthol
Peier, A. M., Moqrich, A., Hergarden, A. C., Reeve, A. J., Andersson, D. A., Story, G. M., Earley, T. J., Dragoni, I., McIntyre, P., Bevan, S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00652-9 · Cited by 2,361
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057
A capsaicin-receptor homologue with a high threshold for noxious heat
Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J., & Julius, D. J. (1999) · Nature · doi:10.1038/18906 · Cited by 1,599
Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor
Liedtke, W., Choe, Y., Martı́-Renom, M. A., Bell, A. M., Denis, C. S., AndrejŠali, Hudspeth, A. J., Friedman, J. M., & Heller, S. (2000) · Cell · doi:10.1016/s0092-8674(00)00143-4 · Cited by 1,391
Coding of Sweet, Bitter, and Umami Tastes
Zhang, Y., Hoon, M. A., Chandrashekar, J., Mueller, K. L., Cook, B., Wu, D., Zuker, C. S., & Ryba, N. J. P. (2003) · Cell · doi:10.1016/s0092-8674(03)00071-0 · Cited by 1,312

Flagged first, then by citations

Show all 100 references

1 of the 100 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Nilius, B. TRP Channels: facts, fiction, challenges. Cell Calcium 14, 33–34 (2003)

Sorted by citations

Items 501–600 of 1,001

The enigmatic TRPCs: multifunctional cation channels
Putney, J. W. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.04.002 · Cited by 99
Transient receptor potential channels and vascular function
Earley, S., & Brayden, J. E. (2010) · Clinical Science · doi:10.1042/cs20090641 · Cited by 98
Non‐neuronal Cells in ALS: Role of Glial, Immune cells and Blood‐CNS Barriers
Puentes, F., Malaspina, A., van Noort, J. M., & Amor, S. (2016) · Brain Pathology · doi:10.1111/bpa.12352 · Cited by 100
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
King, J. V. L., Emrick, J. J., Kelly, M. J. S., Herzig, V., King, G. F., Medzihradszky, K. F., & Julius, D. J. (2019) · Cell · doi:10.1016/j.cell.2019.07.014 · Cited by 98
New Insights on the Role of TRP Channels in Calcium Signalling and Immunomodulation: Review of Pathways and Implications for Clinical Practice
Froghi, S., Grant, C. R., Tandon, R., Quaglia, A., Davidson, B. R., & Fuller, B. J. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08824-3 · Cited by 98
Mechanisms of umami taste perception: From molecular level to brain imaging
Wu, B., Eldeghaidy, S., Ayed, C., Fisk, I. D., Hewson, L., & Liu, Y. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1909532 · Cited by 98
Sensory Nutrition and Bitterness and Astringency of Polyphenols
Osakabe, N., Shimizu, T., Fujii, Y., Fushimi, T., & Calabrese, V. (2024) · Biomolecules · doi:10.3390/biom14020234 · Cited by 102
Role of TRP Channels in Pain Sensation
Chung, M., Jung, S. J., & Oh, S. B. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-0265-3_33 · Cited by 98
Calcium entry mediated by SOCs and TRP channels: variations and enigma
Spassova, M. A., Soboloff, J., He, L., Hewavitharana, T., Xu, W., Venkatachalam, K., van Rossum, D. B., Patterson, R. L., & Gill, D. L. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.09.001 · Cited by 98
Walking nanothermometers: spatiotemporal temperature measurement of transported acidic organelles in single living cells
Oyama, K., Takabayashi, M., Takei, Y., Arai, S., Takeoka, S., Ishiwata, S., & Suzuki, M. (2012) · Lab on a Chip · doi:10.1039/c2lc00014h · Cited by 98
TRP channels as novel players in the pathogenesis and therapy of itch
Bı́ró, T., Tóth, B. I., Marincsák, R., Dobrosi, N., Géczy, T., & Paus, R. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.03.002 · Cited by 98
TRP channel–associated factors are a novel protein family that regulates TRPM8 trafficking and activity
Gkika, D., Lemonnier, L., Shapovalov, G., Gordienko, D. V., Poux, C., Bernardini, M., Bokhobza, A., Bidaux, G., Degerny, C., Verreman, K., et al. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201402076 · Cited by 98
Regulation of TRPV5 and TRPV6 by associated proteins
van de Graaf, S. F. J., Hoenderop, J. G. J., & Bindels, R. J. M. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00443.2005 · Cited by 98
TrpC3/C7 and Slo2.1 Are Molecular Targets for Metabotropic Glutamate Receptor Signaling in Rat Striatal Cholinergic Interneurons
Berg, A. P., Sen, N., & Bayliss, D. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0551-07.2007 · Cited by 97
Capsaicin and TRPV1 Channels in the Cardiovascular System: The Role of Inflammation
Munjuluri, S., Wilkerson, D. A., Sooch, G., Chen, X., White, F. A., & Obukhov, A. G. (2021) · Cells · doi:10.3390/cells11010018 · Cited by 97
TRPM5 and Taste Transduction
Liman, E. R. (2007) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-34891-7_17 · Cited by 97
Characterization Of Selective TRPM8 Ligands And Their Structure Activity Response (S.A.R) Relationship
Sherkheli, M. A., Vogt-Eisele, A. K., Bura, D., Beltrán, L. R., Gisselmann, G., & Hatt, H. H. (2010) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3n88n · Cited by 97
Differential gene expression and lipid metabolism in fatty liver induced by acute ethanol treatment in mice
Yin, H.-Q., Kim, M., Kim, J. H., Kong, G., Kang, K., Kim, H., Yoon, B.-I., Lee, M., & Lee, B. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.06.018 · Cited by 97
EMERGING FUNCTIONS OF 10 TYPES OF TRP CATIONIC CHANNEL IN VASCULAR SMOOTH MUSCLE
Beech, D. J. (2005) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2005.04251.x · Cited by 97
Role of TRPM in melanocytes and melanoma
Guo, H., Carlson, J. A., & Slominski, A. T. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01565.x · Cited by 97
TRPV1 antagonist capsazepine suppresses 4-AP-induced epileptiform activity in vitro and electrographic seizures in vivo
Gonzalez‐Reyes, L. E., Ladas, T. P., Chiang, C., & Durand, D. M. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.10.010 · Cited by 96
The Role of Ca2+-NFATc1 Signaling and Its Modulation on Osteoclastogenesis
Kang, J. Y., Kang, N., Yang, Y., Hong, J. H., & Shin, D. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103646 · Cited by 96
Pathophysiology of chikungunya virus infection associated with fatal outcomes
de Souza, W. M., Fumagalli, M. J., de Lima, S. T. S., Parise, P. L., Carvalho, D. C. M., Hernandez, C., de Jesus, R., Delafiori, J., Cândido, D. D. S., Carregari, V. C., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.02.011 · Cited by 96
Mechanosensitive channels: what can we learn from ?simple? model systems?
Sukharev, S. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.04.006 · Cited by 99
Polycystins and renovascular mechanosensory transduction
Patel, A. J., & Honoré, É. (2010) · Nature Reviews Nephrology · doi:10.1038/nrneph.2010.97 · Cited by 100
Central Role of TRPM4 Channels in Cerebral Blood Flow Regulation
Reading, S. A., & Brayden, J. E. (2007) · Stroke · doi:10.1161/strokeaha.107.483404 · Cited by 96
What is the hair cell transduction channel?
Corey, D. P. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.116582 · Cited by 96
SOCE in neurons: Signaling or just refilling?
Majewski, Ł., & Kuźnicki, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.01.019 · Cited by 101
Learning from Nature: Binary Cooperative Complementary Nanomaterials
Su, B., Guo, W. H., & Jiang, L. (2014) · Small · doi:10.1002/smll.201401307 · Cited by 95
Calcium homeostasis in human melanocytes: role of transient receptor potential melastatin 1 (TRPM1) and its regulation by ultraviolet light
Devi, S., Kedlaya, R., Maddodi, N., Bhat, K. M. R., Weber, C. S., Valdivia, H. H., & Setaluri, V. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00092.2009 · Cited by 95
Activation of M1 Muscarinic Acetylcholine Receptors Stimulates the Formation of a Multiprotein Complex Centered on TRPC6 Channels
Kim, J. Y., & Saffen, D. W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500429200 · Cited by 95
Ionizing radiation induces migration of glioblastoma cells by activating BK K+ channels
Steinle, M., Palme, D., Misovic, M., Rudner, J., Dittmann, K., Łukowski, R., Ruth, P., & Huber, S. M. (2011) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2011.05.069 · Cited by 95
CIF and other mysteries of the store-operated Ca2+-entry pathway
Bolotina, V. M., & Csutora, P. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.05.009 · Cited by 95
CaV1.1: The atypical prototypical voltage-gated Ca2+ channel
Bannister, R. A., & Beam, K. G. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.09.007 · Cited by 94
Phosphatidylinositol 4,5‐bisphosphate regulates inspiratory burst activity in the neonatal mouse preBötzinger complex
Crowder, E. A., Saha, M. S., Pace, R. W., Zhang, H., Prestwich, G. D., & Negro, C. A. D. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.134577 · Cited by 94
Neurotoxicity in Marine Invertebrates: An Update
Deidda, I., Russo, R., Bonaventura, R., Costa, C., Zito, F., & Lampiasi, N. (2021) · Biology · doi:10.3390/biology10020161 · Cited by 94
Structural basis for human TRPC5 channel inhibition by two distinct inhibitors
Song, K., Wei, M., Guo, W., Li, Q., Kang, Y., Wu, J.-X., & Chen, L. (2021) · eLife · doi:10.7554/elife.63429 · Cited by 94
Liposome reconstitution and modulation of recombinant N -methyl- d -aspartate receptor channels by membrane stretch
Kloda, A., Lua, L. H. L., Hall, R., Adams, D. J., & Martinac, B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609649104 · Cited by 94
WNK kinases influence TRPV4 channel function and localization
Fu, Y., Subramanya, A. R., Rozansky, D. J., & Cohen, D. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00391.2005 · Cited by 94
Direct Role of Streptozotocin in Inducing Thermal Hyperalgesia by Enhanced Expression of Transient Receptor Potential Vanilloid 1 in Sensory Neurons
Pabbidi, R. M., Cao, D.-S., Parihar, A., Pauza, M. E., & Premkumar, L. S. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.041707 · Cited by 94
Caspase-11 Controls Interleukin-1β Release through Degradation of TRPC1
Py, B. F., Jin, M., Desai, B. N., Penumaka, A., Zhu, H., Kober, M., Dietrich, A., Lipinski, M. M., Henry, T., Clapham, D. E., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.015 · Cited by 93
Self-citation
Capsaicin: Physicochemical properties, cutaneous reactions and potential applications in painful and inflammatory conditions (Review)
Ilie, M. A., Căruntu, C., Tampa, M. Ş., Georgescu, S. R., Matei, C., Negrei, C., Ion, R., Constantin, C., Neagu, M. T., & Boda, D. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7513 · Cited by 93
TRPV1: Receptor structure, activation, modulation and role in neuro-immune interactions and pain
Maximiano, T. K. E., Carneiro, J. A., Fattori, V., & Verri, W. A., Jr. (2024) · Cell Calcium · doi:10.1016/j.ceca.2024.102870 · Cited by 93
TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane
Brauchi, S., Krapivinsky, G. B., Krapivinsky, L., & Clapham, D. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800881105 · Cited by 94
Self-citation
Capsaicin Interaction with TRPV1 Channels in a Lipid Bilayer: Molecular Dynamics Simulation
Hanson, S. M., Newstead, S. L., Swartz, K. J., & Sansom, M. S. P. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.02.013 · Cited by 92
Taste Receptors in the Gastrointestinal Tract. V. Acid sensing in the gastrointestinal tract
Holzer, P. D. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00517.2006 · Cited by 92
E3-targeted anti-TRPC5 antibody inhibits store-operated calcium entry in freshly isolated pial arterioles
Xu, S., Boulay, G., Flemming, R., & Beech, D. J. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00495.2006 · Cited by 92
The dual role of TRPV1 in peripheral neuropathic pain: pain switches caused by its sensitization or desensitization
Gao, N., Li, M., Wang, W., Liu, Z., & Guo, Y. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1400118 · Cited by 91
The Role of Transient Receptor Potential Melastatin 7 (TRPM7) in Cell Viability: A Potential Target to Suppress Breast Cancer Cell Cycle
Liu, H., Dilger, J. P., & Lin, J. (2020) · Cancers · doi:10.3390/cancers12010131 · Cited by 90
Functional Coupling between TRPC3 and RyR1 Regulates the Expressions of Key Triadic Proteins
Lee, E. H., Cherednichenko, G., Pessah, I. N., & Allen, P. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600981200 · Cited by 90
Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation
Dai, W., Bai, Y., Hebda, L., Zhong, X. Y., Liu, J., Kao, J. Y., & Duan, C. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.177 · Cited by 90
Crystal structure of the human TRPV2 channel ankyrin repeat domain
McCleverty, C. J., Koesema, E., Patapoutian, A., Lesley, S. A., & Kreusch, A. (2006) · Protein Science · doi:10.1110/ps.062357206 · Cited by 90
Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations
Kim, S., Barry, D. M., Liu, X., Yin, S., Munanairi, A., Meng, Q.-T., Cheng, W., Ping, M., Wan, L., Liu, S.-B., et al. (2016) · Science Signaling · doi:10.1126/scisignal.aaf1047 · Cited by 90
Emerging evidence indicates that physiologically relevant thermal stress regulates dendritic cell function
Ostberg, J. R., & Repasky, E. A. (2005) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-005-0689-y · Cited by 91
Transient Receptor Potential Channels as Targets for Phytochemicals
Premkumar, L. S. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500094a · Cited by 89
The mouthfeel of white wine
Gawel, R., Smith, P. A., Cicerale, S., & Keast, R. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1346584 · Cited by 88
TRPV1 Blocking Alleviates Airway Inflammation and Remodeling in a Chronic Asthma Murine Model
Choi, J. Y., Lee, H. Y., Hur, J., Kim, K.-H., Kang, J. Y., Rhee, C. K., & Lee, S. Y. (2018) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2018.10.3.216 · Cited by 88
Improved superfusion technique for rapid cooling or heating of cultured cells under patch-clamp conditions
Dittert, I., Benedikt, J., Vyklický, L., Zimmermann, K., Reeh, P. W., & Vlachová, V. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.07.005 · Cited by 88
Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity
Du, J., Xie, J., & Yue, L. (2009) · The Journal of General Physiology · doi:10.1085/jgp.200910254 · Cited by 88
Phototransduction in Microvillar Photoreceptors of Drosophila and Other Invertebrates
Hardie, R., & Postma, M. (2008) · Elsevier eBooks · doi:10.1016/b978-012370880-9.00402-3 · Cited by 88
Phospholipase C-dependent control of cardiac calcium homeostasis involves a TRPC3-NCX1 signaling complex
Eder, P., PROBST, D., Rosker, C., Poteser, M., Wolinski, H., Kohlwein, S. D., Romanin, C., & Groschner, K. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.10.016 · Cited by 88
Glycosylation of the osmoresponsive transient receptor potential channel TRPV4 on Asn-651 influences membrane trafficking
Xu, H., Fu, Y., Tian, W., & Cohen, D. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00245.2005 · Cited by 88
Evolution of Thermal Response Properties in a Cold-Activated TRP Channel
Myers, B. R., Sigal, Y. M., & Julius, D. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005741 · Cited by 88
Calcium signalling and cancer cell growth
Capiod, T., Шуба, Я. М., Skryma, R. N., & Prevarskaya, N. B. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4020-6191-2_15 · Cited by 88
Deletion of vanilloid receptor (TRPV1) in mice alters behavioral effects of ethanol
Blednov, Y. A., & Harris, R. A. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.01.007 · Cited by 87
Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel
Inada, H., Procko, E., Sotomayor, M. M., & Gaudet, R. (2012) · Biochemistry · doi:10.1021/bi300279b · Cited by 87
A TR(i)P to Cell Migration: New Roles of TRP Channels in Mechanotransduction and Cancer
Canales, J., Morales, D., Blanco, C., Rivas, J., Díaz, N., Angelopoulos, I., & Cerda, O. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00757 · Cited by 90
A pan-cancer-bioinformatic-based literature review of TRPM7 in cancers
Liu, H., Dilger, J. P., & Lin, J. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108302 · Cited by 91
TRPM7 channel regulates PDGF-BB-induced proliferation of hepatic stellate cells via PI3K and ERK pathways
Fang, L., Zhan, S., Huang, C. Z., Cheng, X., Lv, X., Si, H., & Li, J. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.08.009 · Cited by 89
A Role of the Transient Receptor Potential Domain of Vanilloid Receptor I in Channel Gating
García‐Sanz, N., Valente, P., Gomis, A., Fernández-Carvajal, A. M., Fernandez-Ballester, G. J., Viana, F., Belmonte, C., & Ferrer-Montiel, A. V. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2457-07.2007 · Cited by 87
Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion
Elg, S., Marmigère, F., Mattsson, J. P., & Ernfors, P. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21351 · Cited by 87
An essential role for stromal interaction molecule 1 in neointima formation following arterial injury
Guo, R., Wang, H., Gao, P., Li, M., Zeng, C., Yu, Y., Chen, J., Song, M., Shi, Y.-K., & Huang, L. J. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn338 · Cited by 87
Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor
Xue, Q., Jong, B. E., Chen, T., & Schumacher, M. A. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04363.x · Cited by 87
Ca2+ signaling in the regulation of dendritic cell functions
Shumilina, E. V., Huber, S. M., & Lang, F. J. W. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00039.2011 · Cited by 88
Regulation of TRPM8 channel activity
Yudin, Y. K., & Rohács, T. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.10.023 · Cited by 88
TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium–calcium exchangers in rat odontoblasts
Tsumura, M., Sobhan, U., Muramatsu, T., Sato, M., Ichikawa, H., Sahara, Y., Tazaki, M., & Shibukawa, Y. (2012) · Cell Calcium · doi:10.1016/j.ceca.2012.05.002 · Cited by 86
Close Functional Coupling between Ca2+ Release-activated Ca2+ Channels, Arachidonic Acid Release, and Leukotriene C4 Secretion
Chang, W., & Parekh, A. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403969200 · Cited by 86
TRPC6 and FSGS: The latest TRP channelopathy
Mukerji, N., Damodaran, T. V., & Winn, M. P. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.03.005 · Cited by 86
Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis
de Jong, P. R., Takahashi, N., Harris, A. R., Lee, J., Bertin, S., Jeffries, J., Jung, M., Duong, J., Triano, A. I., Lee, J., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72340 · Cited by 86
TRP channels: potential drug target for neuropathic pain
Marwaha, L., Bansal, Y., Singh, R., Saroj, P., Bhandari, R., & Kuhad, A. (2016) · Inflammopharmacology · doi:10.1007/s10787-016-0288-x · Cited by 86
TRP channels in calcium homeostasis: from hormonal control to structure-function relationship of TRPV5 and TRPV6
van Goor, M. K. C., Hoenderop, J. G. J., & van der Wijst, J. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.11.027 · Cited by 86
Molecular Determinants in TRPV5 Channel Assembly
Chang, Q., Gyftogianni, E., van de Graaf, S. F. J., Hoefs, S., Weidema, F., Bindels, R. J. M., & Hoenderop, J. G. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406222200 · Cited by 86
Deep Sequencing of the Murine Olfactory Receptor Neuron Transcriptome
Kanageswaran, N., Demond, M., Nagel, M., Schreiner, B. S. P., Baumgart, S., Scholz, P., Altmüller, J., Becker, C., Doerner, J. F., Conrad, H., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0113170 · Cited by 85
Induced TRPC1 expression sensitizes intestinal epithelial cells to apoptosis by inhibiting NF-κB activation through Ca2+ influx
Marasa, B. S., Rao, J. N., Zou, T., Liu, L., Keledjian, K. M., Zhang, A., Xiao, L., Chen, J., Turner, D. J., & Wang, J. (2006) · Biochemical Journal · doi:10.1042/bj20060124 · Cited by 85
Cannabidiol induces autophagy via ERK1/2 activation in neural cells
Vrechi, T. A. D. M., Leão, A. H. F. F., Morais, I. B. M., Abílio, V. C., Zuardi, A. W., Hallak, J. E. C., Crippa, J. A. S., Bincoletto, C., Ureshino, R. P., Smaili, S. S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-84879-2 · Cited by 87
Heteromerization of TRP channel subunits: extending functional diversity
Cheng, W., Sun, C., & Zheng, J. (2010) · Protein & Cell · doi:10.1007/s13238-010-0108-9 · Cited by 85
Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity
Yin, S., Luo, J., Qian, A., Du, J., Yang, Q. K., Zhou, S., Yu, W., Du, G., Clark, R. B., Walters, E. T., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66413 · Cited by 84
Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels
Cuypers, E., Yanagihara, A. A., Karlsson, E., & Tytgat, J. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.09.030 · Cited by 84
Upregulation of Na+/Ca2+ exchanger contributes to the enhanced Ca2+ entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension
Zhang, S., Dong, H., Rubin, L. J., & Yuan, J. X. ‐. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00383.2006 · Cited by 84
Transient Receptor Potential A1 Channels
Belvisi, M. G., Dubuis, E. D., & Birrell, M. A. (2011) · CHEST Journal · doi:10.1378/chest.10-3327 · Cited by 84
TRPA1-Mediated Accumulation of Aminoglycosides in Mouse Cochlear Outer Hair Cells
Stepanyan, R., Indzhykulian, A. A., Vélez-Ortega, A. C., Boger, E. T., Steyger, P. S., Friedman, T. B., & Frolenkov, G. I. (2011) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-011-0288-x · Cited by 84
TRP channels in kidney disease
Hsu, Y., Hoenderop, J. G. J., & Bindels, R. J. M. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.02.001 · Cited by 84
TRPV6 Is a Ca2+ Entry Channel Essential for Ca2+-induced Differentiation of Human Keratinocytes
Lehen’kyi, V., Beck, B., Polakowska, R. R., Charveron, M., Bordat, P., Skryma, R. N., & Prevarskaya, N. B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611398200 · Cited by 84
Introduction to TRP Channels: Structure, Function, and Regulation
Song, M., & Yuan, J. X. ‐. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-60761-500-2_6 · Cited by 83
TRPV1 stimulation triggers apoptotic cell death of rat cortical neurons
Shirakawa, H., Yamaoka, T., Sanpei, K., Sasaoka, H., Nakagawa, T., & Kaneko, S. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.152 · Cited by 83
Transient Receptor Potential (TRP) Channels and Cardiac Fibrosis
Yue, Z., Zhang, Y., Xie, J., Jiang, J., & Yue, L. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026611313030005 · Cited by 86
Prolactin receptor in regulation of neuronal excitability and channels
Patil, M. J., Henry, M. A., & Akopian, A. N. (2014) · Channels · doi:10.4161/chan.28946 · Cited by 83
A 3.5-nm Structure of Rat TRPV4 Cation Channel Revealed by Zernike Phase-contrast Cryoelectron Microscopy
Shigematsu, H., Sokabe, T., Danev, R., Tominaga, M., & Nagayama, K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.090712 · Cited by 83
Orexin-A-induced Ca2+ Entry
Larsson, K., Peltonen, H. M., Bart, G., Louhivuori, L. M., Penttonen, A., Antikainen, M. S. H., Kukkonen, J. P., & Åkerman, K. E. O. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406073200 · Cited by 83
Molecular Mechanisms of TRPV4‐Mediated Neural Signaling
Liedtke, W. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1418.012 · Cited by 83

Authors: Clapham, D. E.
Affiliations: Boston Children's Hospital (US)
Corresponding author: Clapham, David E.
ORCID: Clapham, David E.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2003-12
Volume: 426
Issue: 6966
Pages: 517-524
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature02196
OpenAlex: W2040664792
Cited by: 2,779
References: 100
Citations by year: 2026: 82 · 2025: 85 · 2024: 113 · 2023: 84 · 2022: 129 · 2021: 115 · 2020: 128 · 2019: 120 · 2018: 96 · 2017: 94 · 2016: 120 · 2015: 112 · 2014: 124 · 2013: 117 · 2012: 137
FWCI: 12.80
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords: TRP channels, sensory transduction, temperature sensing, mechanosensing, pain, osmolarity, pheromones, taste, intracellular signaling, ion channels
MeSH terms: Animals, Calcium, Cells, Humans, Models, Biological, Calcium Channels, Signal Transduction, Ion Channel Gating, TRPC Cation Channels

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

TRP channels as cellular sensors

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks