Cited by 2,779Ion Channels and ReceptorsCalcium signaling and nucleotide metabolismBiochemical Analysis and Sensing Techniques

The DOI matches its Crossref record; 99 of the 100 references it cites were found in a registry or an index.

TRP channels as cellular sensors

Clapham, David E.·2003·Nature

DOI 10.1038/nature02196

Open this paper in CoChat — free account

Abstract

TRP channels are the vanguard of our sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than classical sensory transduction. They are an ancient sensory apparatus for the cell, not just the multicellular organism, and they have been adapted to respond to all manner of stimuli, from both within and outside the cell.

Integrity signals

Registry

Crossref · 10.1038/nature02196

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132
Ion Channels/Excitable Membranes
(2011) · Springer eBooks · doi:10.1007/springerreference_33998 · Cited by 4,066
Impaired nociception and pain sensation in mice lacking the capsaicin receptor
Caterina, M. J., Leffler, A., Malmberg, A. B., Martin, W. J., Trafton, J., Petersen-Zeitz, K. R., Koltzenburg, M., Basbaum, A. I., & Julius, D. (2000) · Science · doi:10.1126/science.288.5464.306 · Cited by 3,544
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
McKemy, D. D., Neuhausser, W., & Julius, D. J. (2002) · Nature · doi:10.1038/nature719 · Cited by 2,716
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00158-2 · Cited by 2,494
A TRP Channel that Senses Cold Stimuli and Menthol
Peier, A. M., Moqrich, A., Hergarden, A. C., Reeve, A. J., Andersson, D. A., Story, G. M., Earley, T. J., Dragoni, I., McIntyre, P., Bevan, S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00652-9 · Cited by 2,361
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057
A capsaicin-receptor homologue with a high threshold for noxious heat
Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J., & Julius, D. J. (1999) · Nature · doi:10.1038/18906 · Cited by 1,599
Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor
Liedtke, W., Choe, Y., Martı́-Renom, M. A., Bell, A. M., Denis, C. S., AndrejŠali, Hudspeth, A. J., Friedman, J. M., & Heller, S. (2000) · Cell · doi:10.1016/s0092-8674(00)00143-4 · Cited by 1,391
Coding of Sweet, Bitter, and Umami Tastes
Zhang, Y., Hoon, M. A., Chandrashekar, J., Mueller, K. L., Cook, B., Wu, D., Zuker, C. S., & Ryba, N. J. P. (2003) · Cell · doi:10.1016/s0092-8674(03)00071-0 · Cited by 1,312

Flagged first, then by citations

Show all 100 references

1 of the 100 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Nilius, B. TRP Channels: facts, fiction, challenges. Cell Calcium 14, 33–34 (2003)

Sorted by citations

Items 601–700 of 1,001

Regulation of TRP channels by PIP2
Rohács, T. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0153-7 · Cited by 84
Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I
Valente, P., García‐Sanz, N., Gomis, A., Fernández-Carvajal, A. M., Fernandez-Ballester, G. J., Viana, F., Belmonte, C., & Ferrer-Montiel, A. V. (2008) · The FASEB Journal · doi:10.1096/fj.08-107425 · Cited by 83
Neuroprotective Effect of Resveratrol on Ischemia/Reperfusion Injury in Rats Through TRPC6/CREB Pathways
Lin, Y., Chen, F., Zhang, J., Wang, T., Wei, X., Wu, J., Feng, Y., Dai, Z., & Wu, Q. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-9977-8 · Cited by 82
Inhibition of transient receptor potential canonical channels impairs cytokinesis in human malignant gliomas
Bomben, V. C., & Sontheimer, H. W. (2008) · Cell Proliferation · doi:10.1111/j.1365-2184.2007.00504.x · Cited by 85
Inhibition of TRPV1 for the treatment of sensitive skin
Kueper, T., Krohn, M., Haustedt, L. O., Hatt, H. H., Schmaus, G., & Vielhaber, G. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01122.x · Cited by 82
TRP channels interaction with lipids and its implications in disease
Taberner, F. J., Fernandez-Ballester, G. J., Fernández-Carvajal, A. M., & Ferrer-Montiel, A. V. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.03.022 · Cited by 82
OS-9 Regulates the Transit and Polyubiquitination of TRPV4 in the Endoplasmic Reticulum
Wang, Y., Fu, X., Gaiser, S., Köttgen, M., Kramer-Zucker, A. G., Walz, G., & Węgierski, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703903200 · Cited by 81
TNF-α/TNFR1 Signaling Is Required for the Development and Function of Primary Nociceptors
Wheeler, M. A., Heffner, D. L., Kim, S., Espy, S. M., Spano, A., Cleland, C. L., & Deppmann, C. D. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.009 · Cited by 84
The odontoblast as a sensory receptor cell? The expression of TRPV1 (VR-1) channels
Okumura, R., Shima, K., Muramatsu, T., Nakagawa, K.-I., Shimono, M., SUZUKI, T. A., Magloire, H., & Shibukawa, Y. (2005) · Archivum histologicum japonicum · doi:10.1679/aohc.68.251 · Cited by 81
Isoform-Selective Physical Coupling of TRPC3 Channels to IP 3 Receptors in Smooth Muscle Cells Regulates Arterial Contractility
Adebiyi, A., Zhao, G., Narayanan, D., Thomas, C., Bannister, J. P., & Jaggar, J. H. (2010) · Circulation Research · doi:10.1161/circresaha.110.216804 · Cited by 81
A TRPC1-mediated increase in store-operated Ca2+ entry is required for the proliferation of adult hippocampal neural progenitor cells
Li, M., Chen, C., Zhou, Z., Xu, S., & Yu, Z. (2012) · Cell Calcium · doi:10.1016/j.ceca.2012.04.014 · Cited by 81
A Finite Element Framework for Studying the Mechanical Response of Macromolecules: Application to the Gating of the Mechanosensitive Channel MscL
Tang, Y., Cao, G., Chen, X., Yoo, J., Yethiraj, A., & Cui, Q. (2006) · Biophysical Journal · doi:10.1529/biophysj.106.085985 · Cited by 81
Increased Expression of Three Types of Transient Receptor Potential Channels (TRPA1, TRPV4 and TRPV3) in Burn Scars with Post-burn Pruritus
Yang, Y., Cho, S. I., Choi, M., Choi, Y. W., Kwak, I., Park, C., & Kim, H. O. (2015) · Acta Dermato Venereologica · doi:10.2340/00015555-1858 · Cited by 81
Modulation of sensory neuron mechanotransduction by PKC- and nerve growth factor-dependent pathways
Castro, M. A. D., Drew, L., Wood, J. N., & Cesare, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508005103 · Cited by 81
Temperature Modulates Taste Responsiveness and Stimulates Gustatory Neurons in the Rat Geniculate Ganglion
Breza, J. M., Curtis, K. S., & Contreras, R. J. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00793.2005 · Cited by 81
Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits
Badheka, D., Yudin, Y. K., Borbíró, I., Hartle, C. M., Yazici, A. T., Mirshahi, T., & Rohács, T. (2017) · eLife · doi:10.7554/elife.26147 · Cited by 82
SRC family kinases in cell volume regulation
Cohen, D. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00452.2004 · Cited by 81
Targeting TRP channels for chronic cough: from bench to bedside
Bonvini, S. J., Birrell, M. A., Smith, J. A., & Belvisi, M. G. (2015) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-014-1082-1 · Cited by 80
Electrophysiological and pharmacological validation of vagal afferent fiber type of neurons enzymatically isolated from rat nodose ganglia
Li, B., & Schild, J. H. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.04.003 · Cited by 80
Membrane-Delimited Coupling of TRPV1 and mGluR5 on Presynaptic Terminals of Nociceptive Neurons
Kim, Y. H., Park, C., Back, S. K., Lee, C. J., Hwang, S. J., Bae, Y. C., Na, H. S., Kim, J. S., Jung, S. J., & Oh, S. B. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5030-08.2009 · Cited by 80
Thermal sensitivity of isolated vagal pulmonary sensory neurons: role of transient receptor potential vanilloid receptors
Ni, D., Gu, Q., Hu, H., Gao, N., Zhu, M. X., & Lee, L. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00016.2006 · Cited by 80
TRP channels in prostate cancer: the good, the bad and the ugly?
Gkika, D., & Prevarskaya, N. B. (2011) · Asian Journal of Andrology · doi:10.1038/aja.2011.18 · Cited by 80
TRP channels: new targets for visceral pain
Blackshaw, L. A., Brierley, S. M., & Hughes, P. A. (2009) · Gut · doi:10.1136/gut.2009.179523 · Cited by 82
Magnetogenetics: remote activation of cellular functions triggered by magnetic switches
Sol‐Fernández, S. D., Martínez‐Vicente, P., Gomollón-Zueco, P., Castro-Hinojosa, C., Gutiérrez, L., Fratila, R. M., & Moros, M. (2021) · Nanoscale · doi:10.1039/d1nr06303k · Cited by 81
C‐type natriuretic peptide activates a non‐selective cation current in acutely isolated rat cardiac fibroblasts via natriuretic peptide C receptor‐mediated signalling
Rose, R. A., Hatano, N., Ohya, S., Imaizumi, Y., & Giles, W. R. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.120832 · Cited by 79
Non-Random Distribution and Sensory Functions of Primary Cilia in Vascular Smooth Muscle Cells
Lu, C. J., Du, H., Wu, J., Jansen, D. A., Jordan, K. L., Xu, N., Sieck, G. C., & Qian, Q. (2008) · Kidney & Blood Pressure Research · doi:10.1159/000132462 · Cited by 82
TRPC Channels and Their Splice Variants are Essential for Promoting Human Ovarian Cancer Cell Proliferation and Tumorigenesis
Zeng, B., Yuan, C., Yang, X., Atkin, S. L., & Xu, S. (2012) · Current Cancer Drug Targets · doi:10.2174/156800913804486629 · Cited by 79
Cell biology of polycystin-2
Tsiokas, L., Kim, S., & Ong, E. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.09.005 · Cited by 81
Local Regulation of Microvascular Perfusion
Davis, M. J., Hill, M. A., & Kuo, L. (2008) · Microcirculation · doi:10.1016/b978-0-12-374530-9.00006-1 · Cited by 78
Sensory TRP Channels in Three Dimensions
Diver, M. M., King, J. V. L., Julius, D. J., & Cheng, Y. (2022) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-032620-105738 · Cited by 79
Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels.
Ma, S., Gisselmann, G., Ak, V.-E., Doerner, J. F., & Hatt, H. H. (2008) · PubMed · Cited by 78
Calcium Regulates Podocyte Actin Dynamics
Greka, A., & Mundel, P. H. (2012) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2012.06.003 · Cited by 78
Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli
Liedtke, W. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.07000 · Cited by 78
State-of-the-art automated patch clamp devices: heat activation, action potentials, and high throughput in ion channel screening
Stoelzle, S. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00076 · Cited by 78
Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate Mediates Calcium-induced Inactivation of TRPV6 Channels
Thyagarajan, B., Lukacs, V., & Rohács, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m704224200 · Cited by 78
Lipids as central modulators of sensory TRP channels
Ciardo, M. G., & Ferrer-Montiel, A. V. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.04.012 · Cited by 81
The vanilloid receptor and hypertension1
Wang, D. H. (2005) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2005.00057.x · Cited by 79
Role of phosphoinositol 4,5-bisphosphate and diacylglycerol in regulating native TRPC channel proteins in vascular smooth muscle
Large, W. A., Saleh, S. N., & Albert, A. P. (2009) · Cell Calcium · doi:10.1016/j.ceca.2009.02.007 · Cited by 77
TRPP2 and autosomal dominant polycystic kidney disease
Köttgen, M. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.01.003 · Cited by 80
Novel aspects of signaling and ion-homeostasis regulation in immunocytesThe TRPM ion channels and their potential role in modulating the immune response
Perraud, A. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.04.013 · Cited by 77
A Cytosolic Residue Mediates Mg2+Block and Regulates Inward Current Amplitude of a Transient Receptor Potential Channel
Obukhov, A. G., & Nowycky, M. C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4451-04.2005 · Cited by 77
The human corneal endothelium: New insights into electrophysiology and ion channels
Mergler, S., & Pleyer, U. (2007) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2007.02.001 · Cited by 77
INSIGHTS ON TRP CHANNELS FROM IN VIVO STUDIES IN DROSOPHILA
Minke, B., & Parnas, M. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040204.100939 · Cited by 77
TRPM2 Channel in Microglia as a New Player in Neuroinflammation Associated With a Spectrum of Central Nervous System Pathologies
Malko, P., Mortadza, S. A. S., McWilliam, J., & Jiang, L. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00239 · Cited by 79
Regulation of TRP Channels by Phosphorylation
Yao, X., Kwan, H. Y., & Huang, Y. (2005) · Neurosignals · doi:10.1159/000093042 · Cited by 76
Plasma membrane insertion of TRPC5 channels contributes to the cholinergic plateau potential in hippocampal CA1 pyramidal neurons
Tai, C., Hines, D. J., Choi, H. B., & MacVicar, B. A. (2010) · Hippocampus · doi:10.1002/hipo.20807 · Cited by 76
Transient receptor potential (TRP) gene superfamily encoding cation channels
Pan, Z., Yang, H., & Reinach, P. S. (2011) · Human Genomics · doi:10.1186/1479-7364-5-2-108 · Cited by 76
The Role of the N Terminus and Transmembrane Domain of TRPM8 in Channel Localization and Tetramerization
Phelps, C. B., & Gaudet, R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707205200 · Cited by 76
TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production
Wang, J., Lu, R., Yang, J., Li, H., He, Z., Jing, N., Wang, X., & Wang, Y. (2015) · Nature Communications · doi:10.1038/ncomms9876 · Cited by 78
Desensitization of canonical transient receptor potential channel 5 by protein kinase C
Zhu, M. H., Chae, M. R., Kim, H. J., Lee, Y., Kim, M. J., Jin, N., Yang, D. K., So, I., & Kim, K. W. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00440.2004 · Cited by 76
A TRPC5-regulated calcium signaling pathway controls dendrite patterning in the mammalian brainPreprint
Puram, S. V., Riccio, A., Koirala, S., Ikeuchi, Y., Kim, A. H., Corfas, G., & Bonni, A. (2011) · Genes & Development · doi:10.1101/gad.174060.111 · Cited by 76
Function and regulation of the channel-kinase TRPM7 in health and disease
Visser, D., Middelbeek, J., van Leeuwen, F. N., & Jalink, K. (2014) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2014.07.001 · Cited by 82
Organellar TRP channels
Zhang, X., Hu, M., Yang, Y., & Xu, H. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0148-z · Cited by 77
Ca2+ Signaling in Cardiac Fibroblasts and Fibrosis-Associated Heart Diseases
Feng, J., Armillei, M. K., Yu, A. S., Liang, B. T., Runnels, L. W., & Yue, L. (2019) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd6040034 · Cited by 75
Calcium Ions in the Physiology and Pathology of the Central Nervous System
Pikor, D., Hurła, M., Słowikowski, B. K., Szymanowicz, O., Poszwa, J., Banaszek, N., Drelichowska, A., Jagodziński, P. P., Kozubski, W. P., & Dorszewska, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313133 · Cited by 80
Brief Reports: TRPM7 Senses Mechanical Stimulation Inducing Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells
Xiao, E., Yang, H.-Q., Gan, Y., Duan, D., He, L., Guo, Y., Wang, S., & Zhang, Y. (2014) · Stem Cells · doi:10.1002/stem.1858 · Cited by 76
Overexpression of wild‐type and mutant mucolipin proteins in mammalian cells: effects on the late endocytic compartment organization
Manzoni, M., Monti, E., Bresciani, R., Bozzato, A., Barlati, S., Bassi, M. T., & Borsani, G. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.04.080 · Cited by 75
Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1
Fusi, C., Materazzi, S., Benemei, S., Coppi, E., Trevisan, G., Marone, I. M., Minocci, D., Logu, F. D., Tuccinardi, T., Tommaso, M. R. D., et al. (2014) · Nature Communications · doi:10.1038/ncomms6736 · Cited by 77
RANKL-induced TRPV2 expression regulates osteoclastogenesis via calcium oscillations
Kajiya, H., Okamoto, F., Nemoto, T., 来海, 慶., Goto-T, K., Nakayana, S., & Okabe, K. (2010) · Cell Calcium · doi:10.1016/j.ceca.2010.09.010 · Cited by 75
Function and regulation of TRP family channels in C. elegans
Xiao, R., & Xu, X. Z. S. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0678-7 · Cited by 75
Peptidyl-Prolyl Isomerase FKBP52 Controls Chemotropic Guidance of Neuronal Growth Cones via Regulation of TRPC1 Channel Opening
Shim, S., Yuan, J. P., Kim, J. Y., Zeng, W., Huang, G. N., Milshteyn, A., Kern, D., Muallem, S., Ming, G., & Worley, P. F. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.025 · Cited by 75
Activation of TRPA1 Channels by the Fatty Acid Amide Hydrolase Inhibitor 3′-Carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597)
Niforatos, W., Zhang, X., Lake, M. R., Walter, K. A., Neelands, T. R., Holzman, T. F., Scott, V., Faltynek, C. R., Moreland, R. B., & Chen, J. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.033621 · Cited by 75
Gating of human TRPV3 in a lipid bilayer
Deng, Z., Maksaev, G. I., Rau, M., Xie, Z., Hu, H., Fitzpatrick, J. A. J., & Yuan, P. (2020) · Nature Structural & Molecular Biology · doi:10.1038/s41594-020-0428-2 · Cited by 75
Hearing in Drosophila: Development of Johnston's organ and emerging parallels to vertebrate ear development
Boekhoff‐Falk, G. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20207 · Cited by 75
Structural mechanisms of TRPM7 activation and inhibition
Nadezhdin, K. D., Correia, L., Narangoda, C., Patel, D. S., Neuberger, A., Gudermann, T. W., Kurnikova, M. G., Chubanov, V., & Sobolevsky, A. I. (2023) · Nature Communications · doi:10.1038/s41467-023-38362-3 · Cited by 74
TRPM7 regulates gastrulation during vertebrate embryogenesis
Liu, W., Su, L.-T., Khadka, D., Mezzacappa, C., Komiya, Y., Sato, A., Habas, R., & Runnels, L. W. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.11.034 · Cited by 75
Sensing pressure in the cardiovascular system: Gq-coupled mechanoreceptors and TRP channels
Sharif‐Naeini, R., Folgering, J. H. A., Bichet, D., Duprat, F., Delmas, P., Patel, A. J., & Honoré, É. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.03.020 · Cited by 74
Domain Mapping of the Polycystin-2 C-terminal Tail Using de Novo Molecular Modeling and Biophysical Analysis
Ćelić, A. S., Petri, E. T., Demeler, B., Ehrlich, B. E., & Boggon, T. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802743200 · Cited by 74
TRP-channels as key integrators of lipid pathways in nociceptive neurons
Sisignano, M., Bennett, D., Geißlinger, G., & Scholich, K. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.11.002 · Cited by 76
Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators
Beck, B., Bidaux, G., Bavencoffe, A. G., Lemonnier, L., Thébault, S. C., Шуба, Я. М., Barritt, G. J., Skryma, R. N., & Prevarskaya, N. B. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.07.002 · Cited by 74
“Immuno-Transient Receptor Potential Ion Channels”: The Role in Monocyte- and Macrophage-Mediated Inflammatory Responses
Santoni, G., Morelli, M. B., Amantini, C., Santoni, M., Nabissi, M., Marinelli, O., & Santoni, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01273 · Cited by 74
Immunohistochemical localization of vanilloid receptor subtype 1 (TRPV1) in the guinea pig respiratory system
Watanabe, N., Horie, S., Michael, G. J., Spina, D., Page, C. P., & Priestley, J. V. (2005) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2004.12.002 · Cited by 74
Effects of antioxidants on calcium influx through TRPM2 channels in transfected cells activated by hydrogen peroxide
Nazıroğlu, M., & Lückhoff, A. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.03.003 · Cited by 74
The ER and ageing II: Calcium homeostasis
Puzianowska-Kuznicka, M., & Kuznicki, J. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.05.002 · Cited by 73
The role of TRPV1 channel in aged human skin
Lee, Y. M., Kang, S. M., & Chung, J. H. (2012) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2011.11.003 · Cited by 73
Expression of ion channels of the TRP family in articular chondrocytes from osteoarthritic patients: changes between native and in vitro propagated chondrocytes
Gavénis, K., Schumacher, C., Schneider, U., Eisfeld, J., Mollenhauer, J., & Schmidt-Rohlfing, B. (2008) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-9927-x · Cited by 73
Targeting ion channels for the treatment of gastrointestinal motility disorders
Beyder, A., & Farrugia, G. (2011) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x11415892 · Cited by 73
Physiology of epithelial Ca2+ and Mg2+ transport
van de Graaf, S. F. J., Bindels, R. J. M., & Hoenderop, J. G. J. (2007) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2006_0607 · Cited by 73
Novel Vanilloid Receptor-1 Antagonists: 3. The Identification of a Second-Generation Clinical Candidate with Improved Physicochemical and Pharmacokinetic Properties
Wang, H.-L., Katon, J. G., Chenera, B., Bannon, A. W., Bernard, C., Doherty, E. M., Dominguez, C., Gavva, N. R., Gore, V., Ma, V., et al. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm070191h · Cited by 73
Casein Kinase II and Calcineurin Modulate TRPP Function and Ciliary Localization
Hu, J., Bae, Y. K., Knobel, K. M., & Barr, M. M. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-10-0935 · Cited by 73
Nav1.7-A1632G Mutation from a Family with Inherited Erythromelalgia: Enhanced Firing of Dorsal Root Ganglia Neurons Evoked by Thermal Stimuli
Yang, Y., Huang, J., Mis, M. A., Estación, M., Macala, L. J., Shah, P., Schulman, B. R. M., Horton, D. B., Dib‐Hajj, S. D., & Waxman, S. G. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0462-16.2016 · Cited by 72
Involvement of TRPC Channels in CCL2-Mediated Neuroprotection against Tat Toxicity
Yao, H., Peng, F., Dhillon, N. K., Callen, S. E., Bokhari, S. M., Stehno‐Bittel, L., Ahmad, S. O., Wang, J. Q., & Buch, S. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2781-08.2009 · Cited by 72
Hyperforin activates nonselective cation channels (NSCCs)
Treiber, K., Singer, A., Henke, B., & Müller, W. E. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706155 · Cited by 72
Transient Receptor Potential Canonical 3 Inhibitor Pyr3 Improves Outcomes and Attenuates Astrogliosis After Intracerebral Hemorrhage in Mice
Munakata, M., Shirakawa, H., Nagayasu, K., Miyanohara, J., Miyake, T., Nakagawa, T., Katsuki, H., & Kaneko, S. (2013) · Stroke · doi:10.1161/strokeaha.113.679332 · Cited by 72
Optical Control of TRPV1 Channels
Stein, M., Breit, A., Fehrentz, T., Gudermann, T. W., & Trauner, D. H. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201302530 · Cited by 72
Renal Medullary Circulation
Pallone, T. L., Edwards, A., & Mattson, D. L. (2012) · Comprehensive physiology · doi:10.1002/cphy.c100036 · Cited by 72
Psychiatric Disorders and TRP Channels: Focus on Psychotropic Drugs
Nazıroğlu, M., & Demirdaş, A. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150304001606 · Cited by 71
Structure and function of polycystins: insights into polycystic kidney disease
Douguet, D., Patel, A. J., & Honoré, É. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0143-6 · Cited by 72
Structural basis of TRPC4 regulation by calmodulin and pharmacological agents
Vinayagam, D., Quentin, D., Yu-Strzelczyk, J., Sitsel, O., Merino, F., Stabrin, M., Hofnagel, O., Yu, M., Ledeboer, M. W., Nagel, G., et al. (2020) · eLife · doi:10.7554/elife.60603 · Cited by 71
TRPV4: physiological role and therapeutic potential in respiratory diseases
Goldenberg, N. M., Ravindran, K., & Kuebler, W. M. (2014) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-014-1058-1 · Cited by 76
TRPC channels determine human keratinocyte differentiation: New insight into basal cell carcinoma
Beck, B., Lehen’kyi, V., Roudbaraki, M. M., Flourakis, M., Charvéron, M., Bordat, P., Polakowska, R. R., Prevarskaya, N. B., & Skryma, R. N. (2007) · Cell Calcium · doi:10.1016/j.ceca.2007.08.005 · Cited by 71
Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats
Kondo, T., Obata, K., Miyoshi, K., Sakùrai, J., Tanaka, J., Miwa, H., & Noguchi, K. (2009) · Gut · doi:10.1136/gut.2008.175901 · Cited by 71
Transient Receptor Potential (TRP) Channels and Taste Sensation
Ishimaru, Y., & Matsunami, H. (2009) · Journal of Dental Research · doi:10.1177/0022034508330212 · Cited by 75
A Potent and Site-Selective Agonist of TRPA1
Takaya, J., Mio, K., Shiraishi, T., Kurokawa, T., Otsuka, S., Mori, Y., & Uesugi, M. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b10162 · Cited by 71
Versatile Roles of Intracellularly Located TRPV1 Channel
Zhao, S. R., & Tsang, S. Y. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25704 · Cited by 74
TRPpathies
Kiselyov, K. I., Soyombo, A. A., & Muallem, S. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.119024 · Cited by 72
TRPV4 Is Required for Hypoxic Pulmonary Vasoconstriction
Goldenberg, N. M., Wang, L., Ranke, H., Liedtke, W., Tabuchi, A., & Kuebler, W. M. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000647 · Cited by 70
Cell membrane mechanics and mechanosensory transduction
Martinac, B., Nikolaev, Y. A., Silvani, G., Bavi, N., Romanov, V., Nakayama, Y., Martinac, A. D., Rohde, P. R., Bavi, O., & Cox, C. D. (2020) · Current topics in membranes · doi:10.1016/bs.ctm.2020.08.002 · Cited by 71
Participation of interleukin 17A in neuroimmune interactions
Moynes, D. M., Vanner, S. J., & Lomax, A. E. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.03.004 · Cited by 70
Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells
Oike, H., Wakamori, M., Mori, Y., Nakanishi, H., Taguchi, R., Misaka, T., Matsumoto, I., & Abe, K. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.07.005 · Cited by 70

Authors: Clapham, D. E.
Affiliations: Boston Children's Hospital (US)
Corresponding author: Clapham, David E.
ORCID: Clapham, David E.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2003-12
Volume: 426
Issue: 6966
Pages: 517-524
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature02196
OpenAlex: W2040664792
Cited by: 2,779
References: 100
Citations by year: 2026: 82 · 2025: 85 · 2024: 113 · 2023: 84 · 2022: 129 · 2021: 115 · 2020: 128 · 2019: 120 · 2018: 96 · 2017: 94 · 2016: 120 · 2015: 112 · 2014: 124 · 2013: 117 · 2012: 137
FWCI: 12.80
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords: TRP channels, sensory transduction, temperature sensing, mechanosensing, pain, osmolarity, pheromones, taste, intracellular signaling, ion channels
MeSH terms: Animals, Calcium, Cells, Humans, Models, Biological, Calcium Channels, Signal Transduction, Ion Channel Gating, TRPC Cation Channels

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

TRP channels as cellular sensors

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks