Cited by 309Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene RegulationMuscle Physiology and Disorders

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Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins

Chen, Alice E., Ginty, David D., Fan, Chen-Ming·2005·Nature

DOI 10.1038/nature03126

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Abstract

Select members of the Wnt family of secreted glycoproteins have been implicated in inducing the myogenic determinant genes Pax3, MyoD and Myf5 during mammalian embryogenesis, but the mechanism of induction has not been defined. We describe an unexpected role for protein kinase A (PKA) signalling via CREB in this induction. Using a combination of in vitro explant assays, mutant analysis and gene delivery into mouse embryos cultured ex vivo, we demonstrate that adenylyl cyclase signalling via PKA and its target transcription factor CREB are required for Wnt-directed myogenic gene expression. Wnt proteins can also stimulate CREB-mediated transcription, providing evidence for a Wnt signalling pathway involving PKA and CREB. Our findings raise the possibility that PKA/CREB signalling may also contribute to other Wnt-regulated processes in embryonic patterning, stem cell renewal and cancer.

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Authors: Chen, A. E., Ginty, D. D., & Fan, C.-M.
Affiliations: Carnegie Institution for Science (US)
Howard Hughes Medical Institute (US)
Corresponding author: Fan, Chen-Ming
ORCID: Ginty, David D.
Fan, Chen-Ming
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2004-11-28
Volume: 433
Issue: 7023
Pages: 317-322
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature03126
OpenAlex: W2073269248
Cited by: 309
References: 27
Citations by year: 2026: 3 · 2025: 6 · 2024: 10 · 2023: 8 · 2022: 9 · 2021: 8 · 2020: 12 · 2019: 13 · 2018: 7 · 2017: 15 · 2016: 6 · 2015: 14 · 2014: 12 · 2013: 15 · 2012: 17
FWCI: 8.19
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Howard Hughes Medical Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: Wnt signaling, protein kinase A, CREB, myogenesis, Pax3, MyoD, Myf5, adenylate cyclase, transcriptional regulation, embryonic patterning
MeSH terms: PAX3 Transcription Factor, Adenylyl Cyclases, Animals, Cell Line, DNA-Binding Proteins, Muscle Proteins, Muscles, Mutation, RNA, Messenger, Transcription Factors, Signal Transduction, Trans-Activators, Cyclic AMP Response Element-Binding Protein, MyoD Protein, Cyclic AMP-Dependent Protein Kinases, Mice, Knockout, Gene Expression Regulation, Developmental, Coculture Techniques, Somites, Muscle Development, Intercellular Signaling Peptides and Proteins, Embryo Culture Techniques, Wnt Proteins, Mice, Paired Box Transcription Factors, Myogenic Regulatory Factor 5

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Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins

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