Cited by 309Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene RegulationMuscle Physiology and Disorders

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins

Chen, Alice E., Ginty, David D., Fan, Chen-Ming·2005·Nature

DOI 10.1038/nature03126

Open this paper in CoChat — free account

Abstract

Select members of the Wnt family of secreted glycoproteins have been implicated in inducing the myogenic determinant genes Pax3, MyoD and Myf5 during mammalian embryogenesis, but the mechanism of induction has not been defined. We describe an unexpected role for protein kinase A (PKA) signalling via CREB in this induction. Using a combination of in vitro explant assays, mutant analysis and gene delivery into mouse embryos cultured ex vivo, we demonstrate that adenylyl cyclase signalling via PKA and its target transcription factor CREB are required for Wnt-directed myogenic gene expression. Wnt proteins can also stimulate CREB-mediated transcription, providing evidence for a Wnt signalling pathway involving PKA and CREB. Our findings raise the possibility that PKA/CREB signalling may also contribute to other Wnt-regulated processes in embryonic patterning, stem cell renewal and cancer.

Integrity signals

Registry

Crossref · 10.1038/nature03126

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals
Shaywitz, A. J., & Greenberg, M. E. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.821 · Cited by 2,133
Function and regulation of CREB family transcription factors in the nervous system
Lonze, B. E., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00828-0 · Cited by 2,127
Self-citation
MyoD or Myf-5 is required for the formation of skeletal muscle
Rudnicki, M. A., Schnegelsberg, P. N. J., Stead, R. H., Braun, T. W., Arnold, H.-H., & Jaenisch, R. (1993) · Cell · doi:10.1016/0092-8674(93)90621-v · Cited by 1,731
Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.
Weintraub, H. M., Tapscott, S. J., Davis, R. L., Thayer, M. J., Adam, M. A., Lassar, A. B., & Miller, A. D. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.14.5434 · Cited by 985
The Promise and Perils of Wnt Signaling Through β-Catenin
Moon, R. T., Bowerman, B. A., Boutros, M., & Perrimon, N. (2002) · Science · doi:10.1126/science.1071549 · Cited by 970
The Wnt/Ca2+ pathway
Kühl, M., Sheldahl, L. C., Park, M., Miller, J. R., & Moon, R. T. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(00)02028-x · Cited by 862
Redefining the Genetic Hierarchies Controlling Skeletal Myogenesis: Pax-3 and Myf-5 Act Upstream of MyoD
Tajbakhsh, S., Rocancourt, D., Cossu, G., & BUCKINGHAM, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80189-0 · Cited by 842
Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds
Parr, B. A., Shea, M. J., Vassileva, G., & McMahon, A. P. (1993) · Development · doi:10.1242/dev.119.1.247 · Cited by 800
Early expression of the myogenic regulatory gene, myf-5 , in precursor cells of skeletal muscle in the mouse embryo
Ott, M., Bober, E., Lyons, G. E., Arnold, H., & BUCKINGHAM, M. E. (1991) · Development · doi:10.1242/dev.111.4.1097 · Cited by 561
The Wnt signalling pathway
Huelsken, J., & Behrens, J. (2002) · Journal of Cell Science · doi:10.1242/jcs.00089 · Cited by 537

Show all 27 references

Research works printed but not linked: 3

Ordahl, C. (ed.) Somitogenesis Part 2 129–268 (Academic, Toronto, 2000)
Manning, D. G proteins: Techniques of Analysis (Florida, CRC, 1999)
Iyengar, R. Methods in Enzymology: Heterotrimeric G Proteins Vol. 237 26–37 (Academic, San Diego, 1994)

Sorted by citations

Wnt signal transduction pathways
Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528
Proximal events in Wnt signal transduction
Angers, S., & Moon, R. T. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2717 · Cited by 1,135
Osteocytes, mechanosensing and Wnt signaling
Bonewald, L. F., & Johnson, M. L. (2008) · Bone · doi:10.1016/j.bone.2007.12.224 · Cited by 1,076
CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer
Wang, J., Liu, X., Wu, H., Ni, P., Gu, Z., Qiao, Y., Chen, N., Sun, F., & Fan, Q. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq285 · Cited by 1,008
Wnt9b Plays a Central Role in the Regulation of Mesenchymal to Epithelial Transitions Underlying Organogenesis of the Mammalian Urogenital System
Carroll, T. J., Park, J., Hayashi, S., Majumdar, Å., & McMahon, A. P. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.05.016 · Cited by 903
Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis
Braun, T., & Gautel, M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3118 · Cited by 713
Suppression of canonical Wnt/ -catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy
Garcia-Gras, E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27751 · Cited by 623
Wnt–β-catenin signalling in liver development, health and disease
Perugorria, M. J., Olaizola, P., Labiano, I., Esparza-Baquer, A., Marzioni, M., Marín, J. J. G., Bujanda, L., & Bañales, J. M. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0075-9 · Cited by 622
Wnt7a Activates the Planar Cell Polarity Pathway to Drive the Symmetric Expansion of Satellite Stem Cells
Grand, F. L., Jones, A., Seale, V., Scimè, A., & Rudnicki, M. A. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.03.013 · Cited by 565
Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?
Takahashi‐Yanaga, F., & Kahn, M. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2943 · Cited by 503
Myogenic progenitor cells and skeletal myogenesis in vertebrates
BUCKINGHAM, M. E. (2006) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.08.008 · Cited by 452
Phosphorylation of β-Catenin by Cyclic AMP-Dependent Protein Kinase Stabilizes β-Catenin through Inhibition of Its Ubiquitination
Hino, S., Tanji, C., Nakayama, K. I., & Kikuchi, A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.20.9063-9072.2005 · Cited by 428
Role of β-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease
Lynch, G. S., & Ryall, J. G. (2008) · Physiological Reviews · doi:10.1152/physrev.00028.2007 · Cited by 410
Alternative Wnt Signaling Is Initiated by Distinct Receptors
van Amerongen, R., Mikels, A. J., & Nusse, R. (2008) · Science Signaling · doi:10.1126/scisignal.135re9 · Cited by 408
Wnt signaling in myogenesis
von Maltzahn, J., Chang, N. C., Bentzinger, C. F., & Rudnicki, M. A. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.07.008 · Cited by 408
The differentiation and morphogenesis of craniofacial muscles
Noden, D. M., & Francis‐West, P. H. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20697 · Cited by 400
Wnt/β-catenin signaling regulates nephron induction during mouse kidney development
Park, J., Valerius, M. T., & McMahon, A. P. (2007) · Development · doi:10.1242/dev.006155 · Cited by 371
Wnt signaling pathway: A comprehensive review
Hayat, R., Manzoor, M., & Hussain, A. (2022) · Cell Biology International · doi:10.1002/cbin.11797 · Cited by 379
The emerging biology of satellite cells and their therapeutic potential
Kuang, S., & Rudnicki, M. A. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.004 · Cited by 351
Osteoblast physiology in normal and pathological conditions
Neve, A., Corrado, A., & Cantatore, F. P. (2010) · Cell and Tissue Research · doi:10.1007/s00441-010-1086-1 · Cited by 354
Glucagon-like Peptide-1 Activation of TCF7L2-dependent Wnt Signaling Enhances Pancreatic Beta Cell Proliferation
Liu, Z., & Habener, J. F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706105200 · Cited by 327
Noncanonical Wnt Signaling through G Protein-Linked PKCδ Activation Promotes Bone Formation
Tu, X., Joeng, K. S., Nakayama, K., Nakayama, K., Rajagopal, J., Carroll, T. J., McMahon, A. P., & Long, F. (2007) · Developmental Cell · doi:10.1016/j.devcel.2006.11.003 · Cited by 321
Embryonic and fetal limb myogenic cells are derived from developmentally distinct progenitors and have different requirements for β-cateninPreprint
Hutcheson, D. A., Zhao, J., Merrell, A. J., Haldar, M., & Kardon, G. (2009) · Genes & Development · doi:10.1101/gad.1769009 · Cited by 301
Wnt signaling and cellular metabolism in osteoblasts
Karner, C. M., & Long, F. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2425-5 · Cited by 295
The genetics of vertebrate myogenesis
Bryson‐Richardson, R. J., & Currie, P. D. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2369 · Cited by 303
Wnt signaling and osteoblastogenesis
Bodine, P. V. N., & Komm, B. S. (2006) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-006-9002-4 · Cited by 295
A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis
Ortega‐Martínez, S. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00046 · Cited by 285
Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity
Maekawa, Y., Minato, Y., Ishifune, C., Kurihara, T., Kitamura, A., Kojima, H., Yagita∥, H., Sakata‐Yanagimoto, M., Saito, T., Taniuchi, I., et al. (2008) · Nature Immunology · doi:10.1038/ni.1649 · Cited by 269
SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes
Berdeaux, R., Goebel, N., Banaszynski, L. A., Takemori, H., Wandless, T. J., Shelton, G. D., & Montminy, M. (2007) · Nature Medicine · doi:10.1038/nm1573 · Cited by 270
GSK-3β regulates cyclin D1 expression: A new target for chemotherapy
Takahashi‐Yanaga, F., & Sasaguri, T. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.10.018 · Cited by 262
New Insights into the Mechanism of Wnt Signaling Pathway Activation
Kikuchi, A., Yamamoto, H., Sato, A., & Matsumoto, S. (2011) · International review of cytology · doi:10.1016/b978-0-12-386035-4.00002-1 · Cited by 275
Wnt signalling and the control of cellular metabolism
Sethi, J. K., & Vidal‐Puig, A. (2010) · Biochemical Journal · doi:10.1042/bj20091866 · Cited by 254
Wnt7a–Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle
von Maltzahn, J., Bentzinger, C. F., & Rudnicki, M. A. (2011) · Nature Cell Biology · doi:10.1038/ncb2404 · Cited by 245
Key Genes Regulating Skeletal Muscle Development and Growth in Farm Animals
Mohammadabadi, M., Bordbar, F., Jensen, J., Du, ‬., & Guo, W. (2021) · Animals · doi:10.3390/ani11030835 · Cited by 258
Myoblast fusion: When it takes more to make one
Rochlin, K. M., Yu, S. F., Roy, S., & Baylies, M. K. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.024 · Cited by 242
Notch 1 Overexpression Inhibits Osteoblastogenesis by Suppressing Wnt/β-Catenin but Not Bone Morphogenetic Protein Signaling
Deregowski, V., Gazzerro, E., Priest, L., Rydziel, S., & CANALIS, E. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508370200 · Cited by 231
International Union of Basic and Clinical Pharmacology. LXXX. The Class Frizzled Receptors
Schulte, G. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002931 · Cited by 237
Effects of parathyroid hormone on Wnt signaling pathway in bone
Kulkarni, N. H., Halladay, D. L., Miles, R. R., Gilbert, L. C., Frolik, C. A., Galvin, R. J. S., Martin, T. J., Gillespie, M. T., & Onyia, J. E. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20506 · Cited by 227
Targeting cAMP/PKA pathway for glycemic control and type 2 diabetes therapy
Yang, H., & Yang, L. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0316 · Cited by 198
Hedgehog Signaling in Mature Osteoblasts Regulates Bone Formation and Resorption by Controlling PTHrP and RANKL Expression
Mak, K. K., Bi, Y., Wan, C., Chuang, P.-T., Clemens, T., Young, M., & Yang, Y. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.02.003 · Cited by 202
Notch Inhibits Osteoblast Differentiation and Causes Osteopenia
Zanotti, S., Smerdel‐Ramoya, A., Stadmeyer, L., Durant, D., Radtke, F., & CANALIS, E. M. (2008) · Endocrinology · doi:10.1210/en.2008-0140 · Cited by 200
Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development
Sakai, D., SUZUKI, T. A., Osumi, N., & Wakamatsu, Y. (2006) · Development · doi:10.1242/dev.02297 · Cited by 201
Regulation of Lrp6 phosphorylation
Niehrs, C., & Shen, J. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0329-3 · Cited by 195
Exercise Can Prevent and Reverse the Severity of Hypertrophic Cardiomyopathy
Konhilas, J. P., Watson, P. A., Maass, A. H., Boucek, D., Horn, T. R., Stauffer, B. L., Luckey, S. W., Rosenberg, P. B., & Leinwand, L. A. (2006) · Circulation Research · doi:10.1161/01.res.0000205766.97556.00 · Cited by 193
Drug screening in a zebrafish model of Duchenne muscular dystrophy
Kawahara, G., Karpf, J. A., Myers, J. A., Alexander, M. S., Guyon, J. R., & Kunkel, L. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102116108 · Cited by 194
Wnt pathway, an essential role in bone regeneration
Chen, Y., & Alman, B. A. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22020 · Cited by 191
cAMP signaling in skeletal muscle adaptation: hypertrophy, metabolism, and regeneration
Berdeaux, R., & Stewart, R. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00555.2011 · Cited by 190
From individual Wnt pathways towards a Wnt signalling network
Kestler, H. A., & Kühl, M. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2007.2251 · Cited by 195
G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the β-catenin pathway
Yang, M., Zhong, W., Srivastava, N., Slavin, A., Yang, J., Hoey, T., & An, S. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501535102 · Cited by 188
Comparative Analyses by Sequencing of Transcriptomes during Skeletal Muscle Development between Pig Breeds Differing in Muscle Growth Rate and Fatness
Zhao, X. L., Mo, D., Li, A., Gong, W., Xiao, S., Zhang, Y., Qin, L., Niu, Y., Guo, Y., Liu, X., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019774 · Cited by 189
The Wnt/β-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis
Borello, U., Berarducci, B., Murphy, P., Bajard, L., Buffa, V., Piccolo, S., BUCKINGHAM, M. E., & Cossu, G. (2006) · Development · doi:10.1242/dev.02517 · Cited by 191
WNT / F rizzled signalling: receptor–ligand selectivity with focus on FZD ‐ G protein signalling and its physiological relevance: IUPHAR Review 3
Dijksterhuis, J. P., Petersen, J., & Schulte, G. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12364 · Cited by 187
Re-employment of developmental transcription factors in adult heart disease
Oka, T., Xu, J., & Molkentin, J. D. (2006) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2006.11.012 · Cited by 181
A Zebrafish Embryo Culture System Defines Factors that Promote Vertebrate Myogenesis across Species
Xu, C., Tabebordbar, M., Iovino, S., Ciarlo, C., Liu, J., Castiglioni, A., Price, E., Liu, M., Barton, E. R., Kahn, C. R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.023 · Cited by 172
Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo
Grifone, R., Demignon, J., Giordani, J., Niro, C., Souil, E., Bertin, F., Laclef, C., Xu, P., & Maire, P. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.059 · Cited by 172
The Wnt signaling pathway: Aging gracefully as a protectionist?
Maiese, K., Li, F., Chong, Z. Z., & Shang, Y. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.01.004 · Cited by 171
Wnt Signaling in Skeletal Muscle Development and Regeneration
Girardi, F., & Grand, F. L. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.11.026 · Cited by 170
Multiple upstream modules regulate zebrafish myf5expression
Chen, Y., Wang, Y., Chang, M.-Y., Lin, C., Weng, C.-W., Westerfield, M., & Tsai, H. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-1 · Cited by 160
Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways
Weivoda, M. M., Ruan, M. M., Hachfeld, C. M., Pederson, L. G., Howe, A. K., Davey, R. A., Zajac, J. D., Kobayashi, Y., Williams, B. O., Westendorf, J. J., et al. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2599 · Cited by 157
The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis
Knight, J. D. R., & Kothary, R. (2011) · Skeletal Muscle · doi:10.1186/2044-5040-1-29 · Cited by 164
Transgenic Wnt/TCF pathway reporters: all you need is Lef?
Barolo, S. (2006) · Oncogene · doi:10.1038/sj.onc.1210057 · Cited by 157
Mechanisms underlying the transcriptional regulation of skeletal myogenesis
Sartorelli, V., & Caretti, G. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.04.015 · Cited by 162
Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses
Stewart, E., McEvoy, J., Wang, H., Chen, X., Honnell, V., Ocarz, M., Gordon, B., Dapper, J., Blankenship, K., Yang, Y., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.07.012 · Cited by 153
N-terminal α-methylation of RCC1 is necessary for stable chromatin association and normal mitosis
Chen, T., Muratore‐Schroeder, T. L., Tooley, C. E. S., Shabanowitz, J., Hunt, D. F., & Macara, I. G. (2007) · Nature Cell Biology · doi:10.1038/ncb1572 · Cited by 148
The Wnt signaling pathway and bone metabolism
Johnson, M. L., & Kamel, M. A. (2007) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32816e06f9 · Cited by 140
The Wnt/β-Catenin Signaling Pathway as a Target in Drug Discovery
Takahashi‐Yanaga, F., & Sasaguri, T. (2007) · Journal of Pharmacological Sciences · doi:10.1254/jphs.cr0070024 · Cited by 137
Common critical pathways in embryogenesis and cancer
Kelleher, F. C., Fennelly, D. W., & Rafferty, M. (2006) · Acta Oncologica · doi:10.1080/02841860600602946 · Cited by 131
Wnt signaling in bone and muscle
Rudnicki, M. A., & Williams, B. O. (2015) · Bone · doi:10.1016/j.bone.2015.02.009 · Cited by 132
Bioassays for Anticancer Activities
McCauley, J. I., Zivanovic, A., & Skropeta, D. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-577-4_14 · Cited by 131
Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin
Henríquez, J. P., Webb, A., Bence, M., Bildsoe, H., Sahores, M., Hughes, S. M., & Salinas, P. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806300105 · Cited by 136
Diseases of Wnt signaling
Johnson, M. L., & Rajamannan, N. M. (2006) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-006-9003-3 · Cited by 134
Transcriptional profiling of myostatin‐knockout mice implicates Wnt signaling in postnatal skeletal muscle growth and hypertrophy
Steelman, C. A., Recknor, J. C., Nettleton, D. S., & Reecy, J. M. (2006) · The FASEB Journal · doi:10.1096/fj.05-5125fje · Cited by 133
Induction of the neural crest state: Control of stem cell attributes by gene regulatory, post-transcriptional and epigenetic interactions
Prasad, M. S., Sauka‐Spengler, T., & LaBonne, C. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.03.014 · Cited by 133
The epigenetic network regulating muscle development and regeneration
Palacios, D., & Puri, P. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20489 · Cited by 128
Carney complex and McCune Albright syndrome: An overview of clinical manifestations and human molecular genetics
Salpea, P., & Stratakis, C. A. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.08.022 · Cited by 121
Tissue-specific splicing of a ubiquitously expressed transcription factor is essential for muscle differentiationPreprint
Sebastian, S., Faralli, H., Yao, Z., Rakopoulos, P., Palii, C. G., Cao, Y., Singh, K., Liu, Q.-C., Chu, A., Aziz, A., et al. (2013) · Genes & Development · doi:10.1101/gad.215400.113 · Cited by 124
Molecular mechanisms of skeletal muscle development, regeneration, and osteogenic conversion
Endo, T. (2015) · Bone · doi:10.1016/j.bone.2015.02.028 · Cited by 117
Wnt signalling and cancer stem cells
Espada, J., Blanco, M., Díaz‐Prado, S., & Médina, V. (2009) · Clinical & Translational Oncology · doi:10.1007/s12094-009-0380-4 · Cited by 116
Dynamic gene expression in fish muscle during recovery growth induced by a fasting-refeeding schedule
Rescan, P., Montfort, J., Rallière, C., Cam, A. L., Esquerré, D., & Hugot, K. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-438 · Cited by 110
Detection of somatic β-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD)
Tadjine, M., Lampron, A., Ouadi, L., Horvath, A., Stratakis, C. A., & Bourdeau, I. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03273.x · Cited by 108
RETRACTED: Follistatin induction by nitric oxide through cyclic GMP: a tightly regulated signaling pathway that controls myoblast fusion
Pisconti, A., Brunelli, S., Padova, M. D., Palma, C. D., Deponti, D., Baesso, S., Sartorelli, V., Cossu, G., & Clementi, E. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200507083 · Cited by 107
Retracted
Regulation of αA‐crystallin via Pax6, c‐Maf, CREB and a broad domain of lens‐specific chromatin
Yang, Y., Stopka, T., Golestaneh, N., Wang, Y., Wu, K., Li, A., Chauhan, B. K., Gao, C., Cveklová, K., Duncan, M. K., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601114 · Cited by 107
Dishevelled: A Mobile Scaffold Catalyzing Development
Malbon, C. C., & Wang, H. (2005) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)72002-0 · Cited by 107
Noncanonical Wnt‐4 signaling and EAF2 are required for eye development in Xenopus laevis
Maurus, D., Héligon, C., Bürger-Schwärzler, A., Brändli, A. W., & Kühl, M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600603 · Cited by 104
On mechanically driven biological stimulus for bone remodeling as a diffusive phenomenon
Giorgio, I., dell’Isola, F., Andreaus, U., Alzahrani, F. S., Hayat, T., & Lekszycki, T. (2019) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-019-01166-w · Cited by 103
Biomechanical forces promote blood development through prostaglandin E2 and the cAMP–PKA signaling axis
Diaz, M. F., Li, N., Lee, H. J., Adamo, L., Evans, S. M., Willey, H. E., Arora, N., Torisawa, Y., Vickers, D. A. L., Morris, S. A., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20142235 · Cited by 101
Wnt Signaling, Stem Cells, and the Cellular Origin of Breast Cancer
Lindvall, C. J., Bu, W., Williams, B. O., & Li, Y. (2007) · Stem Cell Reviews and Reports · doi:10.1007/s12015-007-0025-3 · Cited by 103
Current Progress and Challenges for Skeletal Muscle Differentiation from Human Pluripotent Stem Cells Using Transgene-Free Approaches
Jiwlawat, N., Lynch, E., Jeffrey, J., van Dyke, J. V., & Suzuki, M. (2018) · Stem Cells International · doi:10.1155/2018/6241681 · Cited by 73
Wnt signaling control of bone cell apoptosis
Bodine, P. V. N. (2008) · Cell Research · doi:10.1038/cr.2008.13 · Cited by 106
Targeting CREB signalling in neurogenesis
Dworkin, S., & Mantamadiotis, T. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.501332 · Cited by 96
Beta catenin-independent activation of MyoD in presomitic mesoderm requires PKC and depends on Pax3 transcriptional activity
Brunelli, S., Relaix, F., Baesso, S., BUCKINGHAM, M. E., & Cossu, G. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.01.006 · Cited by 91
TSH signalling and cancer
García‐Jiménez, C., & Santisteban, P. (2007) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302007000500003 · Cited by 88
Protein Kinase A Represses Skeletal Myogenesis by Targeting Myocyte Enhancer Factor 2D
Du, ‬., Perry, R. L., Nowacki, N., Gordon, J. W., Salma, J., Zhao, J., Aziz, A., Chan, J., Siu, K. W. M., & McDermott, J. C. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00248-08 · Cited by 84
Multiple pathological events in exercised dystrophic mdx mice are targeted by pentoxifylline: outcome of a large array of in vivo and ex vivo tests
Burdi, R., Rolland, J., Fraysse, B., Litvinova, K. S., Cozzoli, A., Giannuzzi, V., Liantonio, A., Camerino, G. M., Sblendorio, V. T., Capogrosso, R. F., et al. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90985.2008 · Cited by 83
How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?
Almeida, M. Q., & Stratakis, C. A. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.018 · Cited by 85
β2-Adrenergic agonists and the treatment of skeletal muscle wasting disorders
Joassard, O. R., Durieux, A., & Freyssenet, D. G. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.025 · Cited by 85
CREB Is Activated by Muscle Injury and Promotes Muscle Regeneration
Stewart, R., Flechner, L., Montminy, M., & Berdeaux, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024714 · Cited by 81
Contractile activity-specific transcriptome response to acute endurance exercise and training in human skeletal muscle
Popov, D. V., Makhnovskii, P. A., Shagimardanova, E. I., Gazizova, G. R., Lysenko, E. A., Gusev, O., & Виноградова, О. Л. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00449.2018 · Cited by 82
Wnt11 in 2011 – the regulation and function of a non‐canonical Wnt
Onganer, P. U., & Kypta, R. M. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02297.x · Cited by 81
Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: Inhibitors of the Wnt/β-Catenin Signaling Pathway as Novel Anticancer Drugs
Takahashi‐Yanaga, F., & Sasaguri, T. (2009) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08r28fm · Cited by 79

Authors: Chen, A. E., Ginty, D. D., & Fan, C.-M.
Affiliations: Carnegie Institution for Science (US)
Howard Hughes Medical Institute (US)
Corresponding author: Fan, Chen-Ming
ORCID: Ginty, David D.
Fan, Chen-Ming
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2004-11-28
Volume: 433
Issue: 7023
Pages: 317-322
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature03126
OpenAlex: W2073269248
Cited by: 309
References: 27
Citations by year: 2026: 3 · 2025: 6 · 2024: 10 · 2023: 8 · 2022: 9 · 2021: 8 · 2020: 12 · 2019: 13 · 2018: 7 · 2017: 15 · 2016: 6 · 2015: 14 · 2014: 12 · 2013: 15 · 2012: 17
FWCI: 8.19
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Howard Hughes Medical Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: Wnt signaling, protein kinase A, CREB, myogenesis, Pax3, MyoD, Myf5, adenylate cyclase, transcriptional regulation, embryonic patterning
MeSH terms: PAX3 Transcription Factor, Adenylyl Cyclases, Animals, Cell Line, DNA-Binding Proteins, Muscle Proteins, Muscles, Mutation, RNA, Messenger, Transcription Factors, Signal Transduction, Trans-Activators, Cyclic AMP Response Element-Binding Protein, MyoD Protein, Cyclic AMP-Dependent Protein Kinases, Mice, Knockout, Gene Expression Regulation, Developmental, Coculture Techniques, Somites, Muscle Development, Intercellular Signaling Peptides and Proteins, Embryo Culture Techniques, Wnt Proteins, Mice, Paired Box Transcription Factors, Myogenic Regulatory Factor 5

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks