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Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome
Abstract
Familial advanced sleep phase syndrome (FASPS) is a human behavioural phenotype characterized by early sleep times and early-morning awakening. It was the first human, mendelian circadian rhythm variant to be well-characterized, and was shown to result from a mutation in a phosphorylation site within the casein kinase I (CKI)-binding domain of the human PER2 gene. To gain a deeper understanding of the mechanisms of circadian rhythm regulation in humans, we set out to identify mutations in human subjects leading to FASPS. We report here the identification of a missense mutation (T44A) in the human CKIdelta gene, which results in FASPS. This mutant kinase has decreased enzymatic activity in vitro. Transgenic Drosophila carrying the human CKIdelta-T44A gene showed a phenotype with lengthened circadian period. In contrast, transgenic mice carrying the same mutation have a shorter circadian period, a phenotype mimicking human FASPS. These results show that CKIdelta is a central component in the mammalian clock, and suggest that mammalian and fly clocks might have different regulatory mechanisms despite the highly conserved nature of their individual components.
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“Herein, specific mutations in circadian clock regulators that affect human circadian behavior and the period of the underlying clock have been identified (38, 39).”
From Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health (2019) · cites this paper as [39]
Citations
Cites
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900
Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior
Vitaterna, M. H., King, D. P., Chang, A.-M., Kornhauser, J. M., Lowrey, P. L., McDonald, J. D., Dove, W. F., Pinto, L. H., Turek, F. W., & Takahashi, J. S. (1994) · Science · doi:10.1126/science.8171325 · Cited by 1,632
An h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome
Toh, K. L., Jones, C. R., He, Y., Eide, E. J., Hinz, W. A., Virshup, D. M., Ptáček, L. J., & Fu, Y.-H. (2001) · Science · doi:10.1126/science.1057499 · Cited by 1,460
Self-citationInteracting molecular loops in the mammalian circadian clock
Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der, G. T. J., Horst, et al. (2000) · Science · doi:10.1126/science.288.5468.1013 · Cited by 1,367
Posttranslational Mechanisms Regulate the Mammalian Circadian Clock
Lee, C., Etchegaray, J., Cagampang, F. R. A., Loudon, A. S. I., & Reppert, S. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00610-9 · Cited by 1,174
Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau
Lowrey, P. L., Shimomura, K., Antoch, M. P., Yamazaki, S., Zemenides, P. D., Ralph, M. R., Menaker, M., & Takahashi, J. S. (2000) · Science · doi:10.1126/science.288.5465.483 · Cited by 860
double-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation
Price, J. L., Blau, J., Rothenfluh, A., Abodeely, M., Kloss, B., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81224-6 · Cited by 839
Beck, A. T., Ward, C. H., Mendelson, M., Mock, J., & Erbauch, J. (1961) · PsycTESTS Dataset · doi:10.1037/t00741-000 · Cited by 816
A Mutation of the Circadian System in Golden Hamsters
Ralph, M. R., & Menaker, M. (1988) · Science · doi:10.1126/science.3413487 · Cited by 697
The Drosophila Clock Gene double-time Encodes a Protein Closely Related to Human Casein Kinase Iε
Kloss, B., Price, J. L., Sáez, L., Blau, J., Rothenfluh, A., Wesley, C. S., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81225-8 · Cited by 682
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Rainero, I., Vacca, A., Govone, F., Gai, A., Pinessi, L., & Rubino, E. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180719120215 · Cited by 15
Guillen, R. X., Beckley, J. R., Chen, J., & Gould, K. L. (2020) · Scientific Reports · doi:10.1038/s41598-020-63669-2 · Cited by 15
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Segal, G. (2008) · Oxford University Press eBooks · doi:10.1093/oso/9780195332827.003.0006 · Cited by 16
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Lamont, E. W., & Amir, S. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-045396-5.00223-2 · Cited by 19
Network switches and their role in circadian clocks
del Olmo, M., Legewie, S., Brunner, M., Höfer, T., Kramer, A., Blüthgen, N., & Herzel, H. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107220 · Cited by 15
Jiang, P., Franklin, K. M., Duncan, M. J., O’Hara, B. F., & Wisor, J. P. (2012) · SLEEP · doi:10.5665/sleep.2120 · Cited by 14
Pharmacodynamic study on insomnia-curing effects of Shuangxia Decoction in Drosophila melanogaster
Zhang, Z., Degejin, Di, G. E. N. G., ZHANG, Q., Tian, Y., Yuan, X. I., Wen-Qi, W. A. N. G., Tang, H., Xu, B., Lin, H., et al. (2016) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(16)30077-2 · Cited by 14
Sheardown, E., Mech, A. M., Petrazzini, M. E. M., Leggieri, A., Gidziela, A., Hosseinian, S., Sealy, I. M., Torres-Pérez, J. V., Busch‐Nentwich, E. M., Malanchini, M., et al. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104559 · Cited by 13
Wisor, J. P., Striz, M., DeVoss, J., Murphy, G. M., Edgar, D. M., & O’Hara, B. F. (2007) · SLEEP · doi:10.1093/sleep/30.10.1255 · Cited by 14
Loss of the clock protein PER2 shortens the erythrocyte life span in mice
Sun, Q., Zhao, Y., Yang, Y., Yang, X., Li, M., Xu, X., Wen, D., Wang, J., & Zhang, J. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.783985 · Cited by 14
Integration of genome-scale data identifies candidate sleep regulators
Lee, Y. Y., Endale, M., Wu, G., Ruben, M. D., Francey, L. J., Morris, A. R., Choo, N. Y., Anafi, R. C., Smith, D. F., Liu, A. C., et al. (2022) · SLEEP · doi:10.1093/sleep/zsac279 · Cited by 13
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Gršković, P., & Korać, P. (2023) · Genes · doi:10.3390/genes14091703 · Cited by 15
Increased presynaptic excitability in a migraine with aura mutation
Suryavanshi, P. S., Sawant-Pokam, P., Clair, S., & Brennan, K. C. (2023) · Brain · doi:10.1093/brain/awad326 · Cited by 14
Ebisawa, T. (2013) · Molecular Genetics and Genomics · doi:10.1007/s00438-013-0745-9 · Cited by 13
Circadian clocks and phosphorylation: Insights from computational modeling
Leloup, J. (2009) · Open Life Sciences · doi:10.2478/s11535-009-0025-1 · Cited by 14
Clinical neurophysiology of circadian rhythm sleep–wake disorders
Saeed, Y., Zee, P. C., & Abbott, S. M. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64142-7.00061-8 · Cited by 13
Advance-Related Sleep Complaints and Advanced Sleep Phase Disorder
Auger, R. R. (2009) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2009.01.012 · Cited by 13
Ca2+-dependent hyperpolarization hypothesis for mammalian sleep
Tatsuki, F., Ode, K. L., & Ueda, H. R. (2017) · Neuroscience Research · doi:10.1016/j.neures.2017.03.012 · Cited by 13
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Shankara, J. V., Horsley, K. G., Cheng, N., Rho, J. M., & Antle, M. C. (2022) · Journal of Biological Rhythms · doi:10.1177/07487304221102279 · Cited by 14
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Vanselow, J. T., & Kramer, A. (2009) · Springer eBooks · doi:10.1007/978-1-4419-1262-6_3 · Cited by 12
Circadian rhythms and mood: Opportunities for multi‐level analyses in genomics and neuroscience
Li, J. Z. (2013) · BioEssays · doi:10.1002/bies.201300141 · Cited by 13
Genetics of narcolepsy and other major sleep disorders
Maret, S., & Tafti, M. (2005) · Swiss Medical Weekly · doi:10.4414/smw.2005.11162 · Cited by 13
Gillette, M. U., & Abbott, S. M. (2009) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2009.01.005 · Cited by 12
Tau reduction attenuates autism-like features in Fmr1 knockout mice
Zhao, S., Jiang, X., Han, L., Jiang, Y., Wang, Y., Meng, J., Zhu, X., Zhang, X., Luo, H., & Zhang, Y.-W. (2023) · Molecular Autism · doi:10.1186/s13229-023-00574-1 · Cited by 12
Jiang, Y., Shi, J., Tai, J., & Yan, L. (2024) · Biology · doi:10.3390/biology13120958 · Cited by 12
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Zaki, N. F. W., Spence, D. W., Subramanian, P., Bharti, V. K., Ramanujam, K., BaHammam, A. S., & Pandi-Perumal, S. R. (2020) · Europe PMC (PubMed Central) · doi:10.5935/1984-0063.20200026 · Cited by 12
Eachus, H., Oberski, L., Paveley, J., Bacila, I. A., Ashton, J., Esposito, U., Seifuddin, F., Pirooznia, M., Elhaik, E., Placzek, M., et al. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.050141 · Cited by 12
Albrecht, U. (2007) · Nature Chemical Biology · doi:10.1038/nchembio0307-139 · Cited by 12
Episodic and Electrical Nervous System Disorders Caused by Nonchannel Genes
Lee, H.-Y., Fu, Y., & Ptáček, L. J. (2014) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071814 · Cited by 12
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Landolt, H., & Dijk, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00030-1 · Cited by 11
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Weaver, D. R., & Emery, P. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-385870-2.00039-1 · Cited by 13
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Kingsbury, N. J., Taylor, S. R., & Henson, M. A. (2016) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2016.02.039 · Cited by 12
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Wang, J., Fan, J.-Y., Zhao, Z., Dissel, S., & Price, J. L. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010035 · Cited by 11
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Dall’Ara, I., Ghirotto, S., Ingusci, S., Bagarolo, G., Bertolucci, C., & Barbujani, G. (2016) · Heredity · doi:10.1038/hdy.2016.39 · Cited by 13
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Brookheart, R. T., Lee, C.-Y. S., & Espenshade, P. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.511899 · Cited by 11
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Self-citationde Boer, I., Harder, A. V. E., Ferrari, M. D., van den Maagdenberg, A. M. J. M., & Terwindt, G. M. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-12-823356-6.00012-3 · Cited by 9
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Metadata
- Authors
- Xu, Y., Padiath, Q. S., Shapiro, R. E., Jones, C. R., Wu, S. C., Saigoh, N., Saigoh, K., Ptáček, L. J., & Fu, Y.-H.
- Affiliations
- University of California, San Francisco (US)
- University of Vermont (US)
- University of Utah (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Fu, Ying-Hui
- ORCID
- Venue
- Nature
- Published
- 2005-03
- Volume
- 434
- Issue
- 7033
- Pages
- 640-644
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1974495707
- Cited by
- 861
- References
- 30
- Citations by year
- 2026: 14 · 2025: 19 · 2024: 33 · 2023: 27 · 2022: 40 · 2021: 33 · 2020: 48 · 2019: 40 · 2018: 37 · 2017: 38 · 2016: 33 · 2015: 32 · 2014: 43 · 2013: 53 · 2012: 42
- FWCI
- 20.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Deutsches Krebsforschungszentrum
- Stryker
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- CK1δ, circadian rhythm, melatonin rhythm, transgenic Drosophila, transgenic mice, circadian period, clock gene regulation, sleep disorders
- MeSH terms
- Amino Acid Sequence, Animals, Caseins, Circadian Rhythm, Darkness, Drosophila melanogaster, Female, Humans, Light, Male, Mice, Transgenic, Molecular Sequence Data, Motor Activity, Pedigree, Phenotype, Phosvitin, Sleep Wake Disorders, Syndrome, Time Factors, Mutation, Missense, Animals, Genetically Modified, Casein Kinase Idelta, Mice
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