Cited by 861Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and Work-Related Fatigue

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Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome

Xu, Ying, Padiath, Quasar S., Shapiro, Robert E., Jones, Christopher R., Wu, Susan C., Saigoh, Noriko, Saigoh, Kazumasa, Ptáček, Louis J., Fu, Ying-Hui·2005·Nature

DOI 10.1038/nature03453

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Abstract

Familial advanced sleep phase syndrome (FASPS) is a human behavioural phenotype characterized by early sleep times and early-morning awakening. It was the first human, mendelian circadian rhythm variant to be well-characterized, and was shown to result from a mutation in a phosphorylation site within the casein kinase I (CKI)-binding domain of the human PER2 gene. To gain a deeper understanding of the mechanisms of circadian rhythm regulation in humans, we set out to identify mutations in human subjects leading to FASPS. We report here the identification of a missense mutation (T44A) in the human CKIdelta gene, which results in FASPS. This mutant kinase has decreased enzymatic activity in vitro. Transgenic Drosophila carrying the human CKIdelta-T44A gene showed a phenotype with lengthened circadian period. In contrast, transgenic mice carrying the same mutation have a shorter circadian period, a phenotype mimicking human FASPS. These results show that CKIdelta is a central component in the mammalian clock, and suggest that mammalian and fly clocks might have different regulatory mechanisms despite the highly conserved nature of their individual components.

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Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900
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An h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome
Toh, K. L., Jones, C. R., He, Y., Eide, E. J., Hinz, W. A., Virshup, D. M., Ptáček, L. J., & Fu, Y.-H. (2001) · Science · doi:10.1126/science.1057499 · Cited by 1,460
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Interacting molecular loops in the mammalian circadian clock
Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der, G. T. J., Horst, et al. (2000) · Science · doi:10.1126/science.288.5468.1013 · Cited by 1,367
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Lee, C., Etchegaray, J., Cagampang, F. R. A., Loudon, A. S. I., & Reppert, S. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00610-9 · Cited by 1,174
Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau
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Price, J. L., Blau, J., Rothenfluh, A., Abodeely, M., Kloss, B., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81224-6 · Cited by 839
Beck Depression Inventory
Beck, A. T., Ward, C. H., Mendelson, M., Mock, J., & Erbauch, J. (1961) · PsycTESTS Dataset · doi:10.1037/t00741-000 · Cited by 816
A Mutation of the Circadian System in Golden Hamsters
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Kloss, B., Price, J. L., Sáez, L., Blau, J., Rothenfluh, A., Wesley, C. S., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81225-8 · Cited by 682

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Approach to the patient who cannot sleep
Silber, M. H., Krahn, L. E., & Morgenthaler, T. I. (2013) · CRC Press eBooks · doi:10.3109/9781616310059-14
Faculty Opinions recommendation of Circadian Rhythms and Sleep in Drosophila melanogaster.
Ueda, H. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727464625.793558640
Genetics of Circadian Disorders in Humans☆
Abbott, S. M., Chang, A.-M., & Zee, P. C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.04603-1
Familial and genetic factors
Cuddapah, V. A., & Gehrman, P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00011-6
Genetics of Circadian Disorders in Humans
Chang, A.-M., & Zee, P. C. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-375073-0.50029-4
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Pien, G. W., & Pack, A. I. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-4710-0.00079-1
Adjunctive and alternative treatments of circadian rhythm sleep disorders
Mistlberger, R. E., & Juda, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00367-4
Molecular mechanisms of the mammalian circadian system
Tominaga, K., & Okamura, H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00368-6
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(2008) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195332834.002.0004
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[Molecular mechanisms of circadian clock: how digestive organs tick?].
Okamura, H. (2005) · PubMed
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Emerging genetics of sleep and circadian disorders
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Modified frequency-based sensitivity analysis for oscillatory system models
Ma, X., & Mager, D. E. (2026) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-026-10067-2
BindingDB Entry 50009762: Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ.
BindingDB (2021) · UC San Diego · doi:10.7270/q2833whr
BindingDB Entry 50040761: Structural basis for the potent and selective inhibition of casein kinase 1 epsilon.
BindingDB (2013) · UC San Diego · doi:10.7270/q2ff3tgg
BindingDB Entry 50034557: Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor.
BindingDB (2012) · UC San Diego · doi:10.7270/q2x63nfw
Genetische Diagnostik von Schlafstörungen
Young, P. (2014) · Somnologie - Schlafforschung und Schlafmedizin · doi:10.1007/s11818-014-0687-4
The Molecular Mechanism of Migraine
Watson, K. D. (2011) · ScholarsArchive (Brigham Young University)

Authors: Xu, Y., Padiath, Q. S., Shapiro, R. E., Jones, C. R., Wu, S. C., Saigoh, N., Saigoh, K., Ptáček, L. J., & Fu, Y.-H.
Affiliations: University of California, San Francisco (US)
University of Vermont (US)
University of Utah (US)
Howard Hughes Medical Institute (US)
Corresponding author: Fu, Ying-Hui
ORCID: Xu, Ying
Padiath, Quasar S.
Shapiro, Robert E.
Jones, Christopher R.
Saigoh, Kazumasa
Ptáček, Louis J.
Fu, Ying-Hui
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2005-03
Volume: 434
Issue: 7033
Pages: 640-644
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature03453
OpenAlex: W1974495707
Cited by: 861
References: 30
Citations by year: 2026: 14 · 2025: 19 · 2024: 33 · 2023: 27 · 2022: 40 · 2021: 33 · 2020: 48 · 2019: 40 · 2018: 37 · 2017: 38 · 2016: 33 · 2015: 32 · 2014: 43 · 2013: 53 · 2012: 42
FWCI: 20.52
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Howard Hughes Medical Institute
Deutsches Krebsforschungszentrum
Stryker
National Institutes of Health
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: CK1δ, circadian rhythm, melatonin rhythm, transgenic Drosophila, transgenic mice, circadian period, clock gene regulation, sleep disorders
MeSH terms: Amino Acid Sequence, Animals, Caseins, Circadian Rhythm, Darkness, Drosophila melanogaster, Female, Humans, Light, Male, Mice, Transgenic, Molecular Sequence Data, Motor Activity, Pedigree, Phenotype, Phosvitin, Sleep Wake Disorders, Syndrome, Time Factors, Mutation, Missense, Animals, Genetically Modified, Casein Kinase Idelta, Mice

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Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome

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