Apolipoprotein-mediated pathways of lipid antigen presentation

A Receptor-Mediated Pathway for Cholesterol Homeostasis

Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028

Apolipoprotein E: Far More Than a Lipid Transport Protein

Mahley, R. W., & Rall, S. C. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.507 · Cited by 1,836

CD1: Antigen Presentation and T Cell Function

Brigl, M., & Brenner, M. B. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104608 · Cited by 1,033

CD91 Is a Common Receptor for Heat Shock Proteins gp96, hsp90, hsp70, and Calreticulin

Basu, S., Binder, R. J., Ramalingam, T., & Srivastava, P. K. (2001) · Immunity · doi:10.1016/s1074-7613(01)00111-x · Cited by 900

The LDL–receptor–related protein, LRP, is an apolipoprotein E-binding protein

Beisiegel†, U., Weber, W. T., Ihrke, G., Herz, J., & Stanley, K. K. (1989) · Nature · doi:10.1038/341162a0 · Cited by 680

Mechanism of CD1d-restricted natural killer T cell activation during microbial infection

Brigl, M., Bry, L., Kent, S. C., Gumperz, J. E., & Brenner, M. B. (2003) · Nature Immunology · doi:10.1038/ni1002 · Cited by 672

Receptor-Mediated Antigen Uptake and its Effect on Antigen Presentation to Class II-Restricted T Lymphocytes

Lanzavecchia, A. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.004013 · Cited by 595

CDlb restricts the response of human CD4−8−T lymphocytes to a microbial antigen

Porcelli, S. A., Morita, C. T., & Brenner, M. B. (1992) · Nature · doi:10.1038/360593a0 · Cited by 572

Trafficking and Release of Mycobacterial Lipids from Infected Macrophages

Beatty, W. L., Rhoades, E. R., Ullrich, H., Chatterjee, D., Heuser, J. E., & Russell, D. G. (2000) · Traffic · doi:10.1034/j.1600-0854.2000.010306.x · Cited by 362

PCSK6 ablation in blood circulating cells increases atherosclerotic burden, but improves plaque stability by activating Th17-smooth muscle cell modulatory axis

Suur, B. E., Karadimou, G., Willems, C., Bergman, O., Lengquist, M., Kronqvist, M., Baumgartner, R., Malin, S., Gisterå, A., Hansson, G. K., et al. (2025) · Vascular Pharmacology · doi:10.1016/j.vph.2025.107490 · Cited by 4

The Impact of Apolipoprotein E Allelic Variants on Alzheimer’s Disease

Serrano, E., Sanz, P. G., & Barrantes, F. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-61721-9_29 · Cited by 4

Nasal immune gene expression in response to azelastine and fluticasone propionate combination or monotherapy

Watts, A. M., West, N. P., Smith, P. K., Zhang, P., Cripps, A. W., & Cox, A. J. (2021) · Immunity Inflammation and Disease · doi:10.1002/iid3.571 · Cited by 4

Genetics and molecular biology: single nucleotide polymorphism associations and their functional significance

Baralle, M., & Baralle, F. E. (2006) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000226127.40500.0c · Cited by 4

Kinetic Assessment and Therapeutic Modulation of Metabolic and Inflammatory Profiles in Mice on a High-Fat and Cholesterol Diet

Engstrom, L., Bober, L. A., Chen, S., Fine, J. S., Li, Y., Stanton, M. C., Kinsley, D., Cui, L., Jackson, J. V., Rojas-Triana, A., et al. (2010) · PPAR Research · doi:10.1155/2010/970164 · Cited by 4

Apolipoprotein E Gene Polymorphism, Serum Lipids, and Risk of Superficial Fungal Infections in Egyptian Patients – A Preliminary Case-Controlled Study

Mustafa, A. I., Shams, G. M., Fawzy, E. M., Alhusseini, N. F., Khashaba, R. A., & El-Shimi, O. S. (2023) · Indian Journal of Dermatology · doi:10.4103/ijd.ijd_1001_22 · Cited by 3

The Role of Invariant Natural Killer T Cells in Autoimmune Diseases

Wingender, G., & Kronenberg, M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-384929-8.00008-3 · Cited by 3

Invariant natural killer T cells and incidence of first-time coronary events: a nested case-control study

Tomas, L., Katra, P., Badn, W., Andersson, L. I. M., Nilsson, J. Å., Șchiopu, A., Engelbertsen, D., Gonçalves, I., Bengtsson, E., & Björkbacka, H. (2023) · European Heart Journal Open · doi:10.1093/ehjopen/oead094 · Cited by 3

Arsenic-induced mutagenesis and carcinogenesis: A possible mechanism

Maiti, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89847-8.00016-x · Cited by 3

IMPACT OF CARDIOVASCULAR RISK GENES POLYMORPHISM IN THE DEVELOPMENT OF METABOLIC DISORDERS IN PERSONS EXPOSED TO VINYL CHLORIDE

Валерьевна, К. И., Dyakovich, O. A., Katamanova, E. V., & Ещина, И. М. (2019) · Hygiene and Sanitation · doi:10.18821/0016-9900-2019-98-10-1113-1118 · Cited by 3

Mycobacterium tuberculosis: Life and Death in the Phagosome

Russell, D. G. (2008) · doi:10.1002/9783527611614.ch14 · Cited by 3

CD1-restricted T cells: are unconventional allies the key to future TB vaccines?

Milton, M., & Mansour, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1629466 · Cited by 2

Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity

Ostendorf, B. N., Goldstein, J. G., Liu, S., Gonsalves, F. C., Bilanovic, J., Yuan, M., Kim, J.-Y., Rouya, C., Tavazoie, M. F., & Tavazoie, S. F. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20252290 · Cited by 2

Proteomic analyses of smear-positive/negative tuberculosis patients uncover differential antigen-presenting cell activation and lipid metabolism

Ju, Y., Jin, C., Chen, S., Wang, J., Li, C., Wang, X., Wang, P., Yue, L., Jiang, X., Tuohetaerbaike, B., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1240516 · Cited by 3

Common hereditary variants of the APOE gene and posttransplant outcome in acute myeloid leukemia

Ronnacker, J., Grau, M., Klasmeier, M., Klesse, C., Baldauf, H., Abert, S., Berdel, A. F., Füsser, F. T., Sandmann, S., Albring, J. C., et al. (2025) · Blood · doi:10.1182/blood.2024026886 · Cited by 3

Aminobisphosphonates inhibit dendritic cell-mediated antigen-specific activation of CD1d-restricted iNKT cells

Schneiders, F. L., Huijts, C. M., Mantici, A., Menks, M. A. C., Scotet, E., Veerhuis, R., Verheul, H. M. W., de Gruijl, T. D., & van der Vliet, H. J. (2015) · Clinical Immunology · doi:10.1016/j.clim.2015.03.007 · Cited by 2

Mecanismos de activación de las células T asesinas naturales invariantes (iNKT)

de Antioquia, U., Baena, A., Gómez-Giraldo, L., de Antioquia, U., Carreño, L., & de Chile, U. (2015) · IATREIA · doi:10.17533/udea.iatreia.v29n1a05 · Cited by 2

Immune System Links Psoriasis-Mediated Inflammation to Cardiovascular Diseases via Traditional and Non-Traditional Cardiovascular Risk Factors

Frers, R. A. K., Losada, M. E. O., Kersberg, E., Cosentino, V. L., & Capani, F. (2017) · InTech eBooks · doi:10.5772/intechopen.68559 · Cited by 2

Cellular endocytic compartment localization of expressed canine CD1 molecules

Schjærff, M., Keller, S. M., Affolter, V. K., Kristensen, A. T., & Moore, P. F. (2016) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2016.08.012 · Cited by 2

Glycolipid Presentation by CD1

Layre, E., Mazurek, J., & Gilleron, M. (2015) · Wiley eBooks · doi:10.1002/9780470015902.a0020182.pub2 · Cited by 2

Mycobacterial surface shedding drives bystander cells response during early intracellular infectionPreprint

D’Amico, D., Raykov, L., Soldati, T., & Foulon, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.13.687818 · Cited by 2

mRNA vaccines for COVID-19

Sengupta, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91814-5.00007-6 · Cited by 1

APOE and Cancer Immunology

Montenegro, R. C., Souza, P. F. N., & Mesquita, F. P. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_34-1 · Cited by 1

Single-cell transcriptomic atlas-guided NRG3-ERBB4 axis enhances the efficacy of chemo-immunotherapy during induction phase in high-risk neuroblastoma

Miao, L., Wang, H., Man-na, Z., Zhang, W., Zeng, H.-J., Li, D., Xu, Y., Luo, S.-X., Zhuo, Z., Tang, J., et al. (2026) · Molecular Therapy · doi:10.1016/j.ymthe.2026.04.031 · Cited by 1

Oxidized lipoprotein autoimmunity: an emerging drug target in cardiovascular disease

Nilsson, J. Å., Fredrikson, G. N., Chyu, K., Shah, P. K., & Björkbacka, H. (2006) · Future Lipidology · doi:10.2217/17460875.1.3.321 · Cited by 1

The expression of the human apolipoprotein genes and their regulation by PPARs

Juuso, U. (2008) · Cited by 1

GENOTYPES AND SERUM LEVELS OF APOLIPOPROTEIN E AND PARAOXONASE 1 IN CALCIFIC AORTIC VALVE STENOSIS

Витальевна, Щ. Е., Laipanova, A., Baikulova, M. K. H., Chotchaeva, Z. K. H., Rogova, S. S., Kolesnikov, V. N., & Боева, О. И. (2017) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2017-10-107-112 · Cited by 1

T-Cell recognition of microbial lipoglycans and glycolipids

Libero, G. D. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374546-0.00036-5 · Cited by 1

How T cells recognize lipids as antigens

Libero, G. D. (2009) · Clinical Lipidology · doi:10.2217/clp.09.10 · Cited by 1

The association between (8390G>A) single nucleotide polymorphism in APOE gene with Alzheimer’s and Parkinson disease

Lashkari, F. M., Meybodi, A. M., Mansouri, Z., Kalantari, H., Farahmand, K., & Vaziri, H. (2015) · Egyptian Journal of Medical Human Genetics · doi:10.1016/j.ejmhg.2015.11.003 · Cited by 1

The Role of Invariant Natural Killer T Cells in Autoimmune Diseases

Wingender, G., & Kronenberg, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812102-3.00007-5 · Cited by 1

Natural Killer T Cells

Bezbradica, J. S., Kaer, L. V., & Joyce, S. (2007) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0020180 · Cited by 1

Glycolipid Presentation by CD1

Libero, G. D. (2007) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0020182 · Cited by 1

EVALUATION OF HIGH-THROUGHPUT METHODOLOGY FOR MULTI-GENE SCREENING IN PATIENTS WITH NON- ALCOHOLIC FATTY LIVER DISEASE (NAFLD)

Fisher, L. R. (2011) · SUNScholar (Stellenbosch University) · Cited by 1

[Immune recognition of mycobacteria-derived lipid components].

Sugita, M. (2006) · Nippon Saikingaku Zasshi · doi:10.3412/jsb.61.405 · Cited by 1

Functional characterization of the PPAR targets ANGPTL4 and HILPDA in lipid metabolism

Mattijssen, F. (2014) · doi:10.18174/302873 · Cited by 1

Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages

Grandl, M. (2006) · University of Regensburg Publication Server (University of Regensburg) · doi:10.5283/epub.10433 · Cited by 1

Characterisation of anti-glycan monoclonal antibodies

Noble, P. W. (2011) · Nottingham ePrints (University of Nottingham)

A study into genes encoding longevity in humans

Kuningas, M. (2007) · Leiden Repository (Leiden University)

The Immune Response to Intracellular Pathogens

Korbel, D. S., & Schaible, U. E. (2009) · Wiley eBooks · doi:10.1002/9783527629176.ch12

Activation and immunoregulatory function of type II natural killer T lymphocytes

Rhost, S. (2013) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Adaptive immune responses in atherosclerosis - or how to prolong the use of your yellow socks

Kolbus, D. (2011) · Lund University Publications (Lund University)

The role of dysfunctional High Density Lipoprotein in immune activation and atherosclerosis associated with Human Immunodeficiency Virus Type 1 infection

Kelesidis, T. (2013) · eScholarship (California Digital Library)

Genetic and metabolic studies of APOE, PCSK9, TM6SF2 and PNPLA3

Mahdessian, H. (2014) · Figshare

CD1d ANTIGEN PRESENTATION - LIPIDS ARE THE KEY

Paduraru, C., & Cresswell, P. (2010)

Presenting lipid antigens

LeBrasseur, N. D. (2005) · The Journal of Cell Biology · doi:10.1083/jcb1712rr4

The high- and low-activity forms of human plasma phospholipid transfer protein (PLTP)

Jänis, M. T. (2006) · STM:n Hallinnonalan avoin julkaisuarkisto (Julkari)

Projeto Bambuí: Um Estudo Epidemiológico de Base Populacional do Polimorfismo da Apolipoproteína E e sua Associação com Variáveis Demográficas, Biológicas e com a Hipertensão Arterial Prevalente em Idosos.

Fuzikawa, A. K. (2007) · Americanae (AECID Library)

Association and functional studies on promoter polymorphisms within the apolipoprotein E gene, regarding lipid metabolism and atherosclerosis

Viiri, L. E. (2008) · Tampere University Institutional Repository (Tampere University)

Host Genomics and Response to Infectious Agents

Moraru, M., & Vilches, C. (2015) · Springer eBooks · doi:10.1007/978-3-319-17942-1_4

RNAi screens of lysosomal trafficking

Garg, S., & Brenner, M. B. (2015) · Methods in cell biology · doi:10.1016/bs.mcb.2014.10.030

Characterisation of innate T cells in response to oral bacterial infection

Fong, S. B. (2015) · Minerva Access (University of Melbourne)

POLIMORFISMO DA APOLIPOPROTEÍNA E E SUA ASSOCIAÇÃO COM INCAPACIDADE FUNCIONAL EM IDOSOS: PROJETO BAMBUÍ

da Saúde, M. (2014)

Ingestão alimentar, homocisteína e proteoma plasmático no lúpus eritematoso sistêmico juvenil

Salomão, R. G. (2017) · doi:10.11606/t.17.2017.tde-06012017-104132

The role of invariant Natural Killer T cells in SLE patients with atherosclerosis

Smith, E. C. (2016) · UCL Discovery (University College London)

The Role of Macrophage Low Density Lipoprotein Receptor-Related Protein in the Activation of Invariant Natural Killer T cells

Covarrubias, R. (2015)

Faculty Opinions recommendation of B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo.

Snow, E. C. (2008) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1119327.575508

Lipid antigens in adipose tissue

van Eijkeren, R. J. (2022) · doi:10.33540/1201

BIBLIOGRAPHY

(2007) · Elsevier eBooks · doi:10.1016/b978-012373657-4/50008-8

载脂蛋白C1调控斑马鱼原肠胚形成中的外包运动

周, 莉., 汪, 洋., 桂, 建., 李, 文., & 李, 志. (2014) · Scientia Sinica Vitae · doi:10.1360/zc2014-44-1-29

Emerging insights into early atherosclerosis in adolescents with chronic disease

Ververs, F. A. (2022) · doi:10.33540/1389

Identifying immune cell infiltration and constructing a ceRNA network to explore novel diagnostic biomarkers and therapeutic targets in atopic dermatitisPreprint

Chen, C., Lu, J., Yan, S., Peng, F., Zhong, X., Gao, L., Wang, D., Zeng, J., & Tan, L. (2023) · Research Square · doi:10.21203/rs.3.rs-2589492/v1

Whole-genome analyses reveal selective signals in four Xinjiang cattle breeds

Wen, Y., Huang, J., Zhang, Y., Li, J., Xu, L., Chen, Q., Guo, Y., & Geng, J. (2024) · Gene Reports · doi:10.1016/j.genrep.2024.102000

ApoE and Intestinal Mucosal Immunity

de Azevedo, O. G. R., Brito, G. A. D. C., Warren, C. A., & Oriá, R. B. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_17-1

Apolipoprotein E reduces the number and activation of non-invariant Natural Killer T cellsPreprint

Chakrabarti, R., Duddu, S., & Shukla, P. C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.04.663139

Nasal Vaccination: Breaking New Ground in Immune Response

Sharma, A., Sharma, S., Sharma, A., Mishra, A., & Agrawal, P. (2025) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815324570125010005

ApoE, Obesity, and Metabolic Syndrome

Carvalho-Rassbach, M., & ALVAREZ-LEITE, J. I. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_27-1

Optimisation de l’activité de l’alpha-galactosylcéramide, ligand des lymphocytes T Natural Killer invariants

Fernandez, É. M. (2012) · theses.fr (ABES) · doi:10.70675/57ccc5b2ze8faz494cz9447z61d356e2eb29

Facteurs métaboliques de risque cardio-vasculaire : interaction entre les régimes alimentaires et les polymorphismes de gènes impliqués dans le métabolisme des lipides

Hammoud, A. (2010) · theses.fr (ABES) · doi:10.70675/c282a641z49c3z45c9za640z109f3de2a616

Lymphomes Natural-Killer T cells (NKT) : impact des stimulations antigéniques chroniques et mécanismes de la lymphomagénèse

Robinot, R. (2017) · theses.fr (ABES) · doi:10.70675/aad64642z420cz4594zaf5fzf1f38142568c

Leishmania infantum extracellular material and human invariant natural killer T cells : a functional study

Belo, R. (2017) · theses.fr (ABES) · doi:10.70675/e0088998ze080z4d35zbfe5z385f1b3b82d0

Etude des mécanismes de présentation des lipides mycobactériens par les protéines CD1

Carrat, C. (2019) · theses.fr (ABES) · doi:10.70675/76f8b00ez6f78z4269z801bzbc4e01fff600

Optimization of a bivalent HBV-HCV vaccine by its association with apolipoprotein E and sequential immunizations with particles bearing HCV envelope proteins of various genotypes

Gomez‐Escobar, E. (2021) · theses.fr (ABES) · doi:10.70675/99acb662zf232z409cz86c7z1e47d175d22b

Influence of bile acids metabolism on hepatic immunity in mice

Guinot, V. (2022) · theses.fr (ABES) · doi:10.70675/b69bb11eza30fz4874z9af2za6e31b2d5ad8

ApoE, Obesity, and Metabolic Syndrome

Carvalho-Rassbach, M., & ALVAREZ-LEITE, J. I. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_27

Roles of cholesteryl α-glucosides produced by Helicobacter pylori in the interactions with the host immune system

Shimamura, M. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168325

Apolipoprotein E and autoimmune disorders: Therapeutic frontier

Pandey, S., Nayak, R., Pai, K. S. R., & Kumar, D. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40563-1.00013-2

Analysis of the Role of N‐Linked Glycans on Human CD1d Molecules

Bandyopadhyay, S., & Pradhan, S. (2026) · Cell Biochemistry and Function · doi:10.1002/cbf.70306

The Proteome of Plasma Extracellular Vesicles in Latent and Active Tuberculosis Reveals Phase‐Specific Composition and Immunometabolic Insights

S.‐Peregrino, E., Castañeda‐Casimiro, J., Vallejo‐Castillo, L., Soria‐Fragoso, M., Ortega-Díaz, G. M., Mondragón‐Lara, K. I., Méndez-Tenorio, A., Chacón‐Salinas, R., García‐Pérez, B. E., Serafín‐López, J., et al. (2026) · FASEB BioAdvances · doi:10.1096/fba.2026-00238

Macrophages: Microbial Recognition and Response

Plüddemann, A., & Gordon, S. (2014) · ASM Press eBooks · doi:10.1128/9781555816650.ch2

Serum lipoproteins: Trojan horses of the immune response?

Schümann, J., & Libero, G. D. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.12.005 · Cited by 7

Lipid metabolism, atherogenesis and CD1-restricted antigen presentation

Major, A. S., Joyce, S., & Kaer, L. V. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.04.004 · Cited by 38

Lipids in T Cell Presentation

(2004) · Science s STKE · doi:10.1126/stke.2172004tw35

Mechanisms of Lipid Antigen Presentation by CD1

Porcelli, S. A., & Jackman, R. M. (1999) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v19.i1.20 · Cited by 29

THE CD1 SYSTEM: Antigen-Presenting Molecules for T Cell Recognition of Lipids and Glycolipids

Porcelli, S. A., & Modlin, R. L. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.297 · Cited by 697