Apolipoprotein-mediated pathways of lipid antigen presentation

A Receptor-Mediated Pathway for Cholesterol Homeostasis

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Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

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Apolipoprotein E: Far More Than a Lipid Transport Protein

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CD1: Antigen Presentation and T Cell Function

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CD91 Is a Common Receptor for Heat Shock Proteins gp96, hsp90, hsp70, and Calreticulin

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The LDL–receptor–related protein, LRP, is an apolipoprotein E-binding protein

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Mechanism of CD1d-restricted natural killer T cell activation during microbial infection

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Receptor-Mediated Antigen Uptake and its Effect on Antigen Presentation to Class II-Restricted T Lymphocytes

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CDlb restricts the response of human CD4−8−T lymphocytes to a microbial antigen

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Trafficking and Release of Mycobacterial Lipids from Infected Macrophages

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Correction: Chylomicrons Promote Intestinal Absorption and Systemic Dissemination of Dietary Antigen (Ovalbumin) in Mice

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CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids

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Endolysosomal phospholipidosis and cytosolic lipid droplet storage and release in macrophages

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A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d

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Photoaffinity Antigens for Human γδ T Cells

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Apolipoprotein E Plays a Key Role against Cryptosporidial Infection in Transgenic Undernourished Mice

de Azevedo, O. G. R., Bolick, D. T., Roche, J. K., Pinkerton, R., Lima, A. Â. M., Vitek, M. P., Warren, C. A., Oriá, R. B., & Guerrant, R. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089562 · Cited by 51

Role of lipid trimming and CD1 groove size in cellular antigen presentation

Cheng, T., Relloso, M., Rhijn, I. V., Young, D. C., Besra, G. S., Briken, V., Zajonc, D. M., Wilson, I. A., Porcelli, S. A., & Moody, D. B. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601185 · Cited by 51

TLR gateways to CD1 function

Moody, D. B. (2006) · Nature Immunology · doi:10.1038/ni1368 · Cited by 50

The processing and presentation of lipids and glycolipids to the immune system

Vartabedian, V. F., Savage, P. B., & Teyton, L. (2016) · Immunological Reviews · doi:10.1111/imr.12431 · Cited by 49

Associations of apolipoprotein E gene with ischemic stroke and intracranial atherosclerosis

Abboud, S., Viiri, L. E., Lütjohann, D., Goebeler, S., Luoto, T. M., Friedrichs, S., Desfontaines, P., Gazagnes, M., Laloux, P., Peeters, A. P., et al. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.27 · Cited by 48

pH-Dependent Interdomain Tethers of CD1b Regulate Its Antigen Capture

Relloso, M., Cheng, T., Im, J. S., Parisini, E., Roura‐Mir, C., Debono, C. A., Zajonc, D. M., Murga, L. F., Ondrechen, M. J., Wilson, I. A., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.04.017 · Cited by 48

Antigen presentation by CD1 molecules and the generation of lipid-specific T cell immunity

Bricard, G., & Porcelli, S. A. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7007-0 · Cited by 47

Sulfatide in health and disease. The evaluation of sulfatide in cerebrospinal fluid as a possible biomarker for neurodegeneration

Blomqvist, M., Zetterberg, H., Blennow, K., & Månsson, J. (2021) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2021.103670 · Cited by 47

CD1a, CD1b, and CD1c in Immunity Against Mycobacteria

Rhijn, I. V., Ly, D., & Moody, D. B. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6111-1_10 · Cited by 45

Immunomodulation of the inflammatory response in atherosclerosis

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ApoE ε2/ε3/ε4 polymorphism, ApoC-III/ApoE ratio and metabolic syndrome

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LilrB3 is a putative cell surface receptor of APOE4

Zhou, J., Wang, Y., Huang, G., Yang, M., Zhu, Y., Jin, C., Jing, D., Ji, K., & Shi, Y. (2023) · Cell Research · doi:10.1038/s41422-022-00759-y · Cited by 44

Lipid-driven immunometabolic responses in atherosclerosis

Gisterå, A., & Ketelhuth, D. F. J. (2018) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000540 · Cited by 43

Apolipoprotein E-Mediated Immune Regulation in Sepsis

Kattan, O. M., Kasravi, F. B., Elford, E. L., Schell, M. T., & Harris, H. W. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.2.1399 · Cited by 44

Carbohydrate specificity of the recognition of diverse glycolipids by natural killer T cells

Zajonc, D. M., & Kronenberg, M. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00802.x · Cited by 43

Natural Killer T Cells and Atherosclerosis: Form and Function Meet Pathogenesis

Braun, N. A., Covarrubias, R., & Major, A. S. (2010) · Journal of Innate Immunity · doi:10.1159/000296915 · Cited by 42

Effects of different isoforms of apoE on aggregation of the α‐synuclein protein implicated in Parkinson’s disease

Emamzadeh, F. N., Aojula, H., McHugh, P. C., & Allsop, D. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.02.042 · Cited by 42

Novel insights into lipid antigen presentation

Libero, G. D., & Mori, L. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.01.005 · Cited by 41

Effect of interleukin-6 receptor blockage on renal injury in apolipoprotein E-deficient mice

Tomiyama-Hanayama, M., Rakugi, H., Kohara, M., Mima, T., Adachi, Y., Ohishi, M., Katsuya, T., Hoshida, Y., Aozasa, K., Ogihara, T., et al. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90680.2008 · Cited by 41

Architecture of CD1 Proteins

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Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation

Lam, S. M., Wang, Z., Song, J., Shi, Y., Liu, W., Wan, L., Duan, K., Chua, G. H., Zhou, Y., Wang, G., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.09.009 · Cited by 45

CD1d-mediated Presentation of Endogenous Lipid Antigens by Adipocytes Requires Microsomal Triglyceride Transfer Protein

Rakhshandehroo, M., Gijzel, S. M. W., Siersbæk, R., Broekema, M. F., de Haar, C. G., Schipper, H. S., Boes, M. L., Mandrup, S., & Kalkhoven, E. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.551242 · Cited by 39

Structure, Biosynthesis, and Activities of the Phosphatidyl-myo-Inositol-Based Lipoglycans

Gilleron, M., Jackson, M., Nigou, J., & Puzo, G. (2014) · ASM Press eBooks · doi:10.1128/9781555815783.ch6 · Cited by 42

Natural killer T cells in lipoprotein metabolism and atherosclerosis

Getz, G. S., VanderLaan, P. A., & Reardon, C. A. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-05-0336 · Cited by 38

Plasma disturbance of phospholipid metabolism in major depressive disorder by integration of proteomics and metabolomics

Gui, S., Liu, Y., Zhong, X., Liu, X., Zheng, P., Pu, J., Zhou, J., Chen, J., Zhao, L., Liu, L., et al. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s164134 · Cited by 39

Hepatoprotective effect of apolipoprotein A4 against carbon tetrachloride induced acute liver injury through mediating hepatic antioxidant and inflammation response in mice

Li, X., Liu, X., Zhang, Y., Cheng, C., Fan, J., Zhou, J., Garstka, M. A., & Li, Z. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.11.024 · Cited by 38

Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helper-dependent adenovirus vector

Oka, K., Belalcazar, L. M., Dieker, C., Nour, E. A., Nuno-Gonzalez, P., Paul, A., Cormier, S., Shin, J.-K., Finegold, M. J., & Chan, L. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302819 · Cited by 38

Lipid metabolism, atherogenesis and CD1-restricted antigen presentation

Major, A. S., Joyce, S., & Kaer, L. V. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.04.004 · Cited by 38

A review of the immunologic findings observed in retinitis pigmentosa

McMurtrey, J. J., & Tso, M. O. M. (2018) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2018.03.002 · Cited by 36

The CD1 family: serving lipid antigens to T cells since the Mesozoic era

Zajonc, D. M. (2016) · Immunogenetics · doi:10.1007/s00251-016-0931-0 · Cited by 36

Transcriptomic Approaches in the Zebrafish Model for Tuberculosis—Insights Into Host- and Pathogen-specific Determinants of the Innate Immune Response

Benard, E. L., Rougeot, J., Racz, P. I., Spaink, H. P., & Meijer, A. H. (2016) · Advances in genetics · doi:10.1016/bs.adgen.2016.04.004 · Cited by 35

Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease

Lathe, R., Schultek, N. M., Balin, B. J., Ehrlich, G. D., Alberi, L. A., Perry, G. L., Breitschwerdt, E. B., Corry, D. B., Doty, R. L., Rissman, R. A., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13076 · Cited by 39

The role of full-length apoE in clearance of Gram-negative bacteria and their endotoxins

Petruk, G., Elvén, M., Hartman, E., Davoudi, M., Schmidtchen, A., Puthia, M., & Petrlová, J. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100086 · Cited by 33

Widespread natural variation in murine natural killer T‐cell number and function

Rymarchyk, S., Lowenstein, H., Mayette, J., Foster, S. R., Damby, D. E., Howe, I. W., Aktan, I., Meyer, R. E., Poynter, M. E., & Boyson, J. E. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.02846.x · Cited by 35

Apolipoprotein CI enhances the biological response to LPS via the CD14/TLR4 pathway by LPS-binding elements in both its N- and C-terminal helix

Berbée, J. F. P., Coomans, C. P., Westerterp, M., Romijn, J. A., Havekes, L. M., & Rensen, P. C. N. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m006809 · Cited by 35

Regulation of the Actin Cytoskeleton by Rho Kinase Controls Antigen Presentation by CD1d

Gallo, R. M., Khan, M. A., Shi, J., Kapur, R., Wei, L., Bailey, J. C., Liu, J., & Brutkiewicz, R. R. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101484 · Cited by 34

Increased levels of invariant natural killer T lymphocytes worsen metabolic abnormalities and atherosclerosis in obese mice

Subramanian, S., Turner, M. S., Ding, Y., Goodspeed, L., Wang, S., Buckner, J. H., O’Brien, K. D., Getz, G. S., Reardon, C. A., & Chait, A. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m041020 · Cited by 34

The autophagy machinery restrains iNKT cell activation through CD1D1 internalization

Keller, C. W., Loi, M., Ewert, S., Quast, I., Theiler, R., Gannagé, M., Münz, C., Libero, G. D., Freigang, S., & Lünemann, J. D. (2017) · Autophagy · doi:10.1080/15548627.2017.1297907 · Cited by 34

Shotgun proteomics of coelomic fluid from the purple sea urchin, Strongylocentrotus purpuratus

Dheilly, N. M., Raftos, D. A., Haynes, P. A., Smith, L. C., & Nair, S. V. (2013) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2013.01.007 · Cited by 34

Elevated serum uric acid in nondiabetic people mark pro-inflammatory state and HDL dysfunction and independently predicts coronary disease

Onat, A., Can, G., Örnek, E., Altay, S., Yüksel, M., & Ademoğlu, E. (2013) · Clinical Rheumatology · doi:10.1007/s10067-013-2339-7 · Cited by 34

NKT cells in cardiovascular diseases

van Puijvelde, G. H. M., & Kuiper, J. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.03.052 · Cited by 33

Apolipoprotein E in Cardiovascular Diseases: Novel Aspects of an Old-fashioned Enigma

Liehn, E. A., Ponomariov, V., Diaconu, R., Streață, I., Ioana, M. I., Crespo-Avilan, G. E., Hernández‐Reséndiz, S., & Cabrera-Fuentes, H. A. (2018) · Archives of Medical Research · doi:10.1016/j.arcmed.2018.08.008 · Cited by 30

Immune landscape and the key role of APOE+ monocytes of lupus nephritis under the single‐cell and spatial transcriptional vista

Tang, Y., Zhang, Y., Li, X., Xu, R., Ji, Y., Liu, J., Liu, J., Zhuang, Q., & Zhang, H. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1237 · Cited by 35

Apolipoprotein Mimetic Peptides: A New Approach for the Treatment of Asthma

Yao, X., Vitek, M. P., Remaley, A. T., & Levine, S. J. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00037 · Cited by 32

How do natural killer T cells help B cells?

Lang, M. L. (2009) · Expert Review of Vaccines · doi:10.1586/erv.09.56 · Cited by 33

Glycolipid-peptide conjugate vaccines enhance CD8+ T cell responses against human viral proteins

Speir, M., Authier-Hall, A., Brooks, C., Farrand, K. J., Compton, B. J., Anderson, R. J., Heiser, A., Osmond, T. L., Tang, C., Berzofsky, J. A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-14690-5 · Cited by 33

Apolipoprotein E mediation of neuro-inflammation in a murine model of multiple sclerosis

Shin, S., Walz, K. A., Archambault, A. S., Sim, J., Bollman, B. P., Koenigsknecht-Talboo, J., Cross, A. H., Holtzman, D. M., & Wu, G. F. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.03.010 · Cited by 32

Invariant natural killer T cells in adipose tissue: novel regulators of immune-mediated metabolic disease

Rakhshandehroo, M., Kalkhoven, E., & Boes, M. L. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1414-1 · Cited by 32

ApoE-Dependent Modulation of HDL and Atherosclerosis by G2A in LDL Receptor–Deficient Mice Independent of Bone Marrow–Derived Cells

Parks, B. W., Srivastava, R., Yu, S., & Kabarowski, J. H. S. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179937 · Cited by 31

Peroxisome Proliferator-Activated Receptor γ-Regulated Cathepsin D Is Required for Lipid Antigen Presentation by Dendritic Cells

Nakken, B., Varga, T., Szatmári, I., Széles, L., Gyöngyösi, A., Illarionov, P. A., Dezsö, B., Gogolák, P., Rajnavölgyi, É., & Nagy, L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002421 · Cited by 30

Apolipoprotein E is an HIV-1-inducible inhibitor of viral production and infectivity in macrophages

Siddiqui, R., Suzu, S., Ueno, M., Nasser, H., Koba, R., Bhuyan, F., Noyori, O., Hamidi, S., Sheng, G., Yasuda-Inoue, M., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007372 · Cited by 31

CD1d and Natural Killer T Cells in Immunity to Mycobacterium tuberculosis

Arora, P., Foster, E. L., & Porcelli, S. A. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6111-1_11 · Cited by 30

Apo E4 and lipoprotein-associated phospholipase A2 synergistically increase cardiovascular risk

Gungor, Z., Anuurad, E., Enkhmaa, B., Zhang, W., Kim, K., & Berglund, L. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.04.021 · Cited by 27

High-density lipoprotein phospholipids interfere with dendritic cell Th1 functional maturation

Perrin‐Cocon, L., Diaz, O., Carreras, M., Dollet, S., Guironnet‐Paquet, A., André, P., & Lotteau, V. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.07.030 · Cited by 32

Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis

Harthi, F. A., Huraib, G. B., Zouman, A., Arfin, M., Tariq, M., & Al-Asmari, A. (2014) · Disease Markers · doi:10.1155/2014/239645 · Cited by 30

An N-Linked Glycan Modulates the Interaction between the CD1d Heavy Chain and β2-Microglobulin

Paduraru, C., Spiridon, L. N., Yuan, W., Bricard, G., Valencia, X., Porcelli, S. A., Illarionov, P. A., Besra, G. S., Petrescu, S. M., Petrescu, A., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608518200 · Cited by 30

Plasma Levels of Apolipoprotein E and Risk of Stroke in Old Age

VLIET, P. V., Mooijaart, S. P., de Craen, A. J. M., Rensen, P. C. N., van Heemst, D., & Westendorp, R. G. J. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1395.012 · Cited by 30

Antigen targeting to dendritic cells: Still a place in future immunotherapy?

Stoitzner, P., Romani, N., Rademacher, C., Probst, H. C., & Mahnke, K. (2022) · European Journal of Immunology · doi:10.1002/eji.202149515 · Cited by 29

The Framingham Study on Cardiovascular Disease Risk and Stress-Defenses: A Historical Review

Abohelwa, M., Kopel, J. J., Shurmur, S. W., Ansari, M. M., Awasthi, S., & Awasthi, S. (2023) · Journal of Vascular Diseases · doi:10.3390/jvd2010010 · Cited by 43

Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice

Freigang, S., Zadorozhny, V., McKinney, M. K., Krebs, P., Herro, R., Pawlak, J. B., Kain, L., Schrantz, N., Masuda, K. R., Liu, Y., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40451 · Cited by 29

How the immune system detects lipid antigens

Libero, G. D., & Mori, L. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.10.002 · Cited by 29

Mechanisms of lipid-antigen generation and presentation to T cells

Libero, G. D., & Mori, L. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.08.001 · Cited by 29

Cholesterol accumulation inhibits ER to Golgi transport and protein secretion: studies of apolipoprotein E and VSVGt

Kockx, M., Dinnes, D. L. M., Huang, K.-Y., Sharpe, L. J., Jessup, W., Brown, A. J., & Kritharides, L. (2012) · Biochemical Journal · doi:10.1042/bj20111891 · Cited by 32

Analysis of apolipoprotein genes and their involvement in disease response of channel catfish after bacterial infection

Yang, Y., Fu, Q., Zhou, T., Li, Y., Liu, S., Zeng, Q., Wang, X., Jin, Y., Tian, C., Qin, Z., et al. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.09.007 · Cited by 28

Liver X Receptor Alpha Associates With Human Life Span

Mooijaart, S. P., Kuningas, M., Westendorp, R. G. J., Houwing‐Duistermaat, J. J., Slagboom, P. E., Rensen, P. C. N., & van Heemst, D. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.4.343 · Cited by 28

Glycolipid activators of invariant NKT cells as vaccine adjuvants

Kharkwal, S. S., Arora, P., & Porcelli, S. A. (2016) · Immunogenetics · doi:10.1007/s00251-016-0925-y · Cited by 27

Cyclosporin A Decreases Apolipoprotein E Secretion from Human Macrophages via a Protein Phosphatase 2B-dependent and ATP-binding Cassette Transporter A1 (ABCA1)-independent Pathway

Kockx, M., Guo, D. L., Traini, M. D., Gaus, K., Kay, J. G., Wimmer-Kleikamp, S. H., Rentero, C., Burnett, J. R., Goff, W. L., Eck, M. V., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.032615 · Cited by 29

Apolipoprotein E negatively regulates murine allergic airway inflammation via suppressing the activation of NLRP3 inflammasome and oxidative stress

Zhao, C.-C., Xu, J., Xie, Q., Fan, X.-Y., Fei, G., & Wu, H. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106301 · Cited by 27

Apolipoproteins AI and E are associated with neuroaxonal injury to gray matter in multiple sclerosis

McComb, M., Parambi, R., Browne, R. W., Bodziak, M. L., Jakimovski, D., Bergsland, N., Maceski, A. M., Weinstock‐Guttman, B., Kühle, J., Zivadinov, R., et al. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102389 · Cited by 27

Presentation of lipid antigens to T cells

Mori, L., & Libero, G. D. (2008) · Immunology Letters · doi:10.1016/j.imlet.2007.11.027 · Cited by 27

Parental history of Alzheimer disease associated with lower plasma apolipoprotein E levels

van Vliet, P., Westendorp, R. G. J., Eikelenboom, P., Comijs, H. C., Frölich, M. A., Bakker, E., van der Flier, W. M., & van Exel, E. R. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b59c2e · Cited by 26

CD36 family members are TCR-independent ligands for CD1 antigen–presenting molecules

Gherardin, N. A., Redmond, S. J., McWilliam, H. E. G., Almeida, C. F., Gourley, K. H. A., Seneviratna, R., Li, S., Rose, R. D., Ross, F. J., Nguyen-Robertson, C. V., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abg4176 · Cited by 32

New Kids on the Block

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Autoreactivity to Sulfatide by Human Invariant NKT Cells

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