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Initial sequence of the chimpanzee genome and comparison with the human genome
Open accessAbstract
Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differences that have accumulated since the human and chimpanzee species diverged from our common ancestor, constituting approximately thirty-five million single-nucleotide changes, five million insertion/deletion events, and various chromosomal rearrangements. We use this catalogue to explore the magnitude and regional variation of mutational forces shaping these two genomes, and the strength of positive and negative selection acting on their genes. In particular, we find that the patterns of evolution in human and chimpanzee protein-coding genes are highly correlated and dominated by the fixation of neutral and slightly deleterious alleles. We also use the chimpanzee genome as an outgroup to investigate human population genetics and identify signatures of selective sweeps in recent human evolution.
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“It has been estimated that 3.5% of the sequence differences between chimpanzees and humans is due to INDELs [34,35] and that this INDEL variation may be of particular evolutionary significance [9].”
From Identification, characterization and comparative genomics of chimpanzee endogenous retroviruses (2006) · cites this paper as [34]
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“Frequent turnover of gene copy and/or protein domain number has been proposed as a major mechanism underlying the adaptive divergence of closely related species 9,[17][18][19] .”
From The yak genome and adaptation to life at high altitude (2012) · cites this paper as [9]
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“Genomic comparisons between closely related species provide insights into the genetic basis of mammalian divergence and adaptation 8,9 .”
From The yak genome and adaptation to life at high altitude (2012) · cites this paper as [9]
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“Yak and cattle were estimated to have diverged approximately 4.9 million years ago, which is comparable to the time at which humans and chimpanzees diverged 9 (Supplementary Fig. 12).”
From The yak genome and adaptation to life at high altitude (2012) · cites this paper as [9]
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“results presented here and elsewhere [34] suggest that the number of endogenous retroviruses in chimpanzees may be higher than in humans.”
From Identification, characterization and comparative genomics of chimpanzee endogenous retroviruses (2006) · cites this paper as [34]
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Cites
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
<tt>BLAT</tt> —The <tt>BLAST</tt> -Like Alignment Tool
Kent, W. J. (2002) · Genome Research · doi:10.1101/gr.229202 · Cited by 8,480
Ohno, S. (1970) · doi:10.1007/978-3-642-86659-3 · Cited by 7,833
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
Base-Calling of Automated Sequencer Traces Using Phred. I. Accuracy AssessmentPreprint
Ewing, B., Hillier, L., Wendl, M. C., & Green, P. (1998) · Genome Research · doi:10.1101/gr.8.3.175 · Cited by 6,993
The International HapMap Project
†The International HapMap Consortium, Genotyping centres: Baylor College of Medicine and ParAllele BioScience, Gibbs, R. A., Belmont, J. W., Hardenbol, P., Willis, T. D., Yu, F., Chinese HapMap Consortium, Yang, H., Ch'ang, L.-Y., et al. (2003) · Nature · doi:10.1038/nature02168 · Cited by 6,057
Self-citationFinishing the euchromatic sequence of the human genome
International Human Genome Sequencing Consortium (2004) · Nature · doi:10.1038/nature03001 · Cited by 4,971
The hitch-hiking effect of a favourable gene
Smith, J. M., & Haigh, J. (1974) · Genetical Research · doi:10.1017/s0016672300014634 · Cited by 3,415
Adaptive protein evolution at the Adh locus in Drosophila
McDonald, J. H., & Kreitman, M. (1991) · Nature · doi:10.1038/351652a0 · Cited by 3,313
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Casillas, S., Mulet, R., Villegas-Mirón, P., Hervas, S., Sanz, E., Velasco, D., Bertranpetit, J., Laayouni, H., & Barbadilla, A. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx943 · Cited by 29
Schneider, E., Hajj, N. E., Richter, S., Roche-Santiago, J., Nanda, I., Schempp, W., Riederer, P., Navarro, B., Bontrop, R. E., Kondova, I. I., et al. (2014) · Epigenetics · doi:10.4161/epi.27689 · Cited by 34
Ono, Y., Shindo, M., Doi, N., Kitamura, F., Gregorio, C. C., & Sorimachi, H. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411959111 · Cited by 33
Ancient humans and the origin of modern humans
Kelso, J. F., & Prüfer, K. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.09.004 · Cited by 35
An unusual haplotype structure on human chromosome 8p23 derived from the inversion polymorphism
Deng, L., Zhang, Y., Kang, J., Liu, T., Zhao, H., Gao, Y., Li, C., Pan, H., Tang, X., Wang, D.-M., et al. (2008) · Human Mutation · doi:10.1002/humu.20775 · Cited by 32
Liao, Z., Wan, Q., Xiao, X., Ji, J., & Su, J. (2018) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2018.01.002 · Cited by 33
Developing a theoretical evolutionary framework to solve the mystery of parturition initiation
Rokas, A., Mesiano, S. A., Tamam, O., LaBella, A. L., Zhang, G., & Muglia, L. J. (2020) · eLife · doi:10.7554/elife.58343 · Cited by 33
Human Genetic Diversity and the Epidemiology of Parasitic and Other Transmissible Diseases
Tibayrenc, M. (2007) · Advances in Parasitology/Advances in parasitology · doi:10.1016/s0065-308x(06)64004-9 · Cited by 33
Evolution of C2H2-zinc finger genes revisited
Thomas, J. H., & Emerson, R. (2009) · BMC Evolutionary Biology · doi:10.1186/1471-2148-9-51 · Cited by 33
The evolutionary significance of copy number variation in the human genome
Perry, G. H. (2008) · Cytogenetic and Genome Research · doi:10.1159/000184719 · Cited by 35
Ghika, J.-A. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2008.05.034 · Cited by 34
Disotell, T. R., & Tosi, A. J. (2007) · Genome biology · doi:10.1186/gb-2007-8-9-226 · Cited by 33
Recurring genomic breaks in independent lineages support genomic fragility.
Hinsch, H., & Hannenhalli, S. S. (2006) · BMC Evolutionary Biology · doi:10.1186/1471-2148-6-90 · Cited by 33
What is the future of electrophoresis in large‐scale genomic sequencing?
Fredlake, C. P., Hert, D. G., Mardis, E. R., & Barron, A. E. (2006) · Electrophoresis · doi:10.1002/elps.200600408 · Cited by 33
Mittleman, B. E., Pott, S., Warland, S., Barr, K., Cuevas, C., & Gilad, Y. (2021) · eLife · doi:10.7554/elife.62548 · Cited by 30
The precision of the hominid timescale estimated by relaxed clock methods
Schrago, C. G., & Voloch, C. M. (2013) · Journal of Evolutionary Biology · doi:10.1111/jeb.12076 · Cited by 33
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Drillon, G., & Fischer, G. (2011) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2011.05.011 · Cited by 31
Improving the in silico assessment of pathogenicity for compensated variants
Azevedo, L., Mort, M. E., Costa, A. C., Silva, R. M., Quelhas, D., Amorim, A., & Cooper, D. N. (2016) · European Journal of Human Genetics · doi:10.1038/ejhg.2016.129 · Cited by 34
Almeida‐Warren, K., Sommer, V., Stewart, A. P. F. S. A. P. F., & Pascual‐Garrido, A. (2017) · American Journal of Physical Anthropology · doi:10.1002/ajpa.23269 · Cited by 32
Probabilistic Estimation of Identity by Descent Segment Endpoints and Detection of Recent Selection
Browning, S. R., & Browning, B. L. (2020) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2020.09.010 · Cited by 34
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Sang, J., Zhuang, D., Zhang, T., Wu, Q., Yu, J., & Zhang, Z. (2022) · mSystems · doi:10.1128/msystems.01512-21 · Cited by 35
Neaux, D., Guy, F., Gilissen, E., Coudyzer, W., & Ducrocq, S. (2013) · The Anatomical Record · doi:10.1002/ar.22654 · Cited by 32
Montoya‐Burgos, J. I. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024800 · Cited by 32
Paar, V., Glunčić, M., Rosandić, M., Basar, I., & Vlahović, I. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr009 · Cited by 31
Phylogenomic evidence of adaptive evolution in the ancestry of humans
Goodman, M., & Sterner, K. N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914626107 · Cited by 32
Hayakawa, T., Sugawara, T., Go, Y., Udono, T., Hirai, H., & Imai, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043277 · Cited by 32
Analysis of Nuclear Receptor Pseudogenes in Vertebrates: How the Silent Tell Their Stories
Zhang, Z. D., Cayting, P. D., Weinstock, G. M., & Gerstein, M. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm251 · Cited by 32
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Shibata, D. K. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq239 · Cited by 32
Mahony, S., Corcoran, D. L., Feingold, E., & Benos, P. V. (2007) · Genome biology · doi:10.1186/gb-2007-8-5-r84 · Cited by 31
Global Patterns of Diversity and Selection in Human Tyrosinase Gene
Hudjashov, G., Villems, R., & Kivisild, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074307 · Cited by 32
The Minimal Active Human SVA Retrotransposon Requires Only the 5′-Hexamer and Alu-Like Domains
Hancks, D. C., Mandal, P. K., Cheung, L. E., & Kazazian, H. H. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00860-12 · Cited by 34
Brandies, P. A., Tang, S. S. K., Johnson, R., Hogg, C. J., & Belov, K. (2020) · Gigabyte · doi:10.46471/gigabyte.7 · Cited by 29
Triplet repeat length bias and variation in the human transcriptome
Molla, M. N., Delcher, A. L., Sunyaev, S. R., Cantor, C. R., & Kasif, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907112106 · Cited by 31
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Tang, H. (2007) · Chemical Reviews · doi:10.1021/cr0683008 · Cited by 33
XSAnno: a framework for building ortholog models in cross-species transcriptome comparisons
Zhu, Y., Li, M., Sousa, A. M. M., & Šestan, N. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-343 · Cited by 31
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Bhutkar, A. J., Gelbart, W. M., & Smith, T. F. (2007) · Genome biology · doi:10.1186/gb-2007-8-11-r236 · Cited by 31
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Jin, X., He, M., Ferguson, B. M., Meng, Y., Ouyang, L., Ren, J., Mailund, T., Sun, F., Sun, L., Shen, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040637 · Cited by 30
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Buzdin, A. A. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.270 · Cited by 30
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Harris, R. A., Rogers, J., & Milosavljevic, A. (2007) · Science · doi:10.1126/science.1139477 · Cited by 31
Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogaster
Rollmann, S. M., Magwire, M. M., Morgan, T. J., Özsoy, E. D., Ah, Y., Mackay, T. F. C., & Anholt, R. R. H. (2006) · Nature Genetics · doi:10.1038/ng1823 · Cited by 31
Glinsky, G. V. (2015) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/022913 · Cited by 31
Climate change and population genetic structure of marine species
Brutto, S. L., Arculeo, M., & Grant, W. S. (2011) · Chemistry and Ecology · doi:10.1080/02757540.2010.547486 · Cited by 30
The First Sequenced Carnivore Genome Shows Complex Host-Endogenous Retrovirus Relationships
Barrio, Á. M., Ekerljung, M., Jern, P., Benachenhou, F., Sperber, G., Bongcam‐Rudloff, E., Blomberg, J., & Andersson, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019832 · Cited by 31
Genomic approaches to studying human-specific developmental traits
Franchini, L. F., & Pollard, K. S. (2015) · Development · doi:10.1242/dev.120048 · Cited by 29
Germline de novo mutation rates on exons versus introns in humans
Rodriguez-Galindo, M., Casillas, S., Weghorn, D., & Barbadilla, A. (2020) · Nature Communications · doi:10.1038/s41467-020-17162-z · Cited by 32
Hopkins, W. D., Mareno, M. C., Webb, S. J. N., Schapiro, S. J., Raghanti, M. A., & Sherwood, C. C. (2020) · American Journal of Primatology · doi:10.1002/ajp.23214 · Cited by 30
Rutjens, E., Mazza, S., Biassoni, R., Koopman, G., Radic, L., Fogli, M., Costa, P., Mingari, M. C., Moretta, L., Heeney, J. L., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1702 · Cited by 30
Grass Genomic Synteny Illuminates Plant Genome Function and Evolution
Bennetzen, J. L., & Chen, M. (2008) · Rice · doi:10.1007/s12284-008-9015-6 · Cited by 31
Calafell, F., Almasy, L. A., Sabater‐Lleal, M., Buil, A., Mordillo, C., Ramírez-Soriano, A., Sikora, M., Souto, J. C., Blangero, J., Fontcuberta, J., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp517 · Cited by 30
Scanning the human genome for signals of selection
McVean, G., & Spencer, C. C. A. (2006) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.09.004 · Cited by 30
Tempo and mode of ERV-K evolution in human and chimpanzee genomes
Romano, C., Ramalho, R., & Zanotto, P. M. D. A. (2006) · Archives of Virology · doi:10.1007/s00705-006-0792-1 · Cited by 34
Subramanian, S., & Kumar, S. (2006) · Molecular Biology and Evolution · doi:10.1093/molbev/msl123 · Cited by 28
Kirsch, S., Münch, C., Jiang, Z., Cheng, Z., Chen, L., Batz, C., Eichler, E. E., & Schempp, W. (2008) · Genome Research · doi:10.1101/gr.076711.108 · Cited by 30
Cell resilience in species life spans: a link to inflammation?
Finch, C. E., Morgan, T. E., Longo, V. D., & De Magalhaes, J. P. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00578.x · Cited by 29
Miga, K. H. (2017) · Journal of Heredity · doi:10.1093/jhered/esw039 · Cited by 32
Gordon, A. D., Marcus, E., & Wood, B. A. (2013) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22391 · Cited by 29
Emergence of mammals by emergency: exaptation
Okada, N., Sasaki, T., Shimogori, T., & Nishihara, H. (2010) · Genes to Cells · doi:10.1111/j.1365-2443.2010.01429.x · Cited by 33
Fukuda, K., Ichiyanagi, K., Yamada, Y. M. A., Go, Y., Udono, T., Wada, S., Maeda, T., Soejima, H., Saitou, N., Ito, T., et al. (2013) · Journal of Human Genetics · doi:10.1038/jhg.2013.55 · Cited by 34
Holmes, R. S., Cox, L. A., & VandeBerg, J. L. (2010) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2010.05.004 · Cited by 29
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Lee, Y. C. G., Ventura, I. M., Rice, G. R., Chen, D.-Y., Colmenares, S. U., & Long, M. (2019) · Molecular Biology and Evolution · doi:10.1093/molbev/msz137 · Cited by 28
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Teffer, K., Buxhoeveden, D. P., Stimpson, C. D., Fobbs, A. J., Schapiro, S. J., Baze, W. B., McArthur, M. J., Hopkins, W. D., Hof, P. R., Sherwood, C. C., et al. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23412 · Cited by 29
An experimental test on the probability of extinction of new genetic variants
Chelo, I. M., Nédli, J., Gordo, I., & Teotónio, H. (2013) · Nature Communications · doi:10.1038/ncomms3417 · Cited by 29
Atlantic cod (Gadus morhua) CC chemokines: Diversity and expression analysis
Borza, T., Stone, C., Rise, M. L., Bowman, S., & Johnson, S. C. (2010) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2010.03.011 · Cited by 29
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Garcia, S. P., Pinho, A. J., Rodrigues, J. M. O. S., Bastos, C. A. C., & Ferreira, P. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016065 · Cited by 32
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Arsenault, R. J., Trost, B., & Kogut, M. H. (2014) · Frontiers in Veterinary Science · doi:10.3389/fvets.2014.00022 · Cited by 30
Trombetta, B., Sellitto, D., Scozzari, R., & Cruciani, F. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu155 · Cited by 29
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Sharbrough, J., Havird, J. C., Noe, G. R., Warren, J. M., & Sloan, D. B. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evx114 · Cited by 27
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Zhang, J., Jia, K. X., Jia, J., & Qian, Y. (2018) · BMC Bioinformatics · doi:10.1186/s12859-018-2152-z · Cited by 29
Recombination-suppression: how many mechanisms for chromosomal speciation?
Jackson, B. (2011) · Genetica · doi:10.1007/s10709-011-9558-0 · Cited by 29
Lu, Z., Peng, J., & Su, B. (2007) · Human Mutation · doi:10.1002/humu.20547 · Cited by 29
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Perry, G. H., Tito, R. Y., & Verrelli, B. C. (2006) · Molecular Biology and Evolution · doi:10.1093/molbev/msm002 · Cited by 29
Human polymorphism around recombination hotspots
Spencer, C. C. A. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340535 · Cited by 29
Ruan, Y., Wang, H., Chen, B., Wen, H., & Wu, C. (2019) · Molecular Biology and Evolution · doi:10.1093/molbev/msz283 · Cited by 28
The uniqueness of human vulnerability to brain aging in great ape evolution
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Gleimer, M., Wahl, A. R., Hickman, H. D., Abi‐Rached, L., Norman, P. J., Guethlein, L. A., Hammond, J. A., Draghi, M., Adams, E. J., Juo, Z. S., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002990 · Cited by 28
Progress of non-human primate animal models of cancers.
Xia, H., & Chen, C.-S. (2011) · PubMed · doi:10.3724/sp.j.1141.2011.01070 · Cited by 28
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Goodwin, Z. A., & Strong, C. D. G. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2016.00227 · Cited by 27
Ge, Q., Guo, Y., Zheng, W., Cai, Y., Qi, X., & Zhao, S. (2021) · BMC Genomics · doi:10.1186/s12864-021-08044-9 · Cited by 29
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Ronald, J., Tang, H., & Brem, R. B. (2006) · Genetics · doi:10.1534/genetics.106.060863 · Cited by 29
Kobayashi, D., & Takeda, H. (2008) · Briefings in Functional Genomics and Proteomics · doi:10.1093/bfgp/eln044 · Cited by 27
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Cole, C. G., McCann, O. T., Collins, J. E., Oliver, K. L., Willey, D. L., Gribble, S. M., Yang, F., McLaren, K., Rogers, J., Ning, Z., et al. (2008) · Genome biology · doi:10.1186/gb-2008-9-5-r78 · Cited by 28
Small proline rich protein 2a in benign and malignant liver disease
Mizuguchi, Y., Isse, K., Specht, S. M., Lunz, J. G., Corbitt, N., Takizawa, T., & Demetris, A. J. (2013) · Hepatology · doi:10.1002/hep.26889 · Cited by 27
Regulatory DNAs and the evolution of human development
Noonan, J. P. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.10.002 · Cited by 27
Wilson, G. A., Butcher, L. M., Foster, H. R., Feber, A., Roos, C., Walter, L., Woszczek, G., Beck, S., & Bell, C. G. (2014) · Genome Medicine · doi:10.1186/gm536 · Cited by 27
Maximizing the acquisition of unique reads in noninvasive capture sequencing experiments
Fontsere, C., Álvarez-Estapé, M., Lester, J. D., Arandjelovic, M., Kuhlwilm, M., Dieguez, P., Agbor, A., Angedakin, S., Ayimisin, E. A., Bessone, M., et al. (2020) · Molecular Ecology Resources · doi:10.1111/1755-0998.13300 · Cited by 26
Robust inference of positive selection on regulatory sequences in the human brain
Liu, J., & Robinson‐Rechavi, M. (2020) · Science Advances · doi:10.1126/sciadv.abc9863 · Cited by 30
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Hanson, H. E., & Liebl, A. L. (2022) · Epigenomes · doi:10.3390/epigenomes6040033 · Cited by 28
Quantifying harmful mutations in human populations
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Metadata
- Authors
- The Chimpanzee Sequencing and Analysis Consortium
- Corresponding author
- The Chimpanzee Sequencing and Analysis Consortium
- Venue
- Nature
- Published
- 2005-09
- Volume
- 437
- Issue
- 7055
- Pages
- 69-87
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1689369637
- Semantic Scholar
- 21067a3992473f2ba32eeca5d5db5722a696e35d
- Cited by
- 2,459
- References
- 180
- Citations by year
- 2026: 39 · 2025: 69 · 2024: 60 · 2023: 76 · 2022: 60 · 2021: 88 · 2020: 109 · 2019: 60 · 2018: 91 · 2017: 81 · 2016: 89 · 2015: 103 · 2014: 121 · 2013: 129 · 2012: 139
- FWCI
- 84.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Funders
- National Science Foundation
- European Molecular Biology Laboratory
- Broad Institute
- National Institutes of Health
- National Human Genome Research Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
- Keywords
- chimpanzee genome, chimpanzees, human-chimpanzee divergence, single nucleotide polymorphisms, insertion/deletion polymorphism, chromosomal rearrangements, positive selection, negative selection, deleterious alleles, protein-coding genes, human population genetics, selective sweeps, comparative genomics
- MeSH terms
- Alleles, Animals, Base Composition, Pan troglodytes, Disease, DNA Transposable Elements, Humans, Phylogeny, Polymorphism, Genetic, Recombination, Genetic, Time Factors, Genome, Human, Mutagenesis, Telomere, Sequence Analysis, DNA, Evolution, Molecular, Computational Biology, Alu Elements, Genomics
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