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Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
Open accessAbstract
Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the neoplastic transformation process. Here we engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mouse models in cancer gene discovery and the extent of cross-species overlap in cancer-associated copy number aberrations. Along with targeted re-sequencing, our comparative oncogenomic studies identified FBXW7 and PTEN to be commonly deleted both in murine lymphomas and in human T-cell acute lymphoblastic leukaemia/lymphoma (T-ALL). The murine cancers acquire widespread recurrent amplifications and deletions targeting loci syntenic to those not only in human T-ALL but also in diverse human haematopoietic, mesenchymal and epithelial tumours. These results indicate that murine and human tumours experience common biological processes driven by orthologous genetic events in their malignant evolution. The highly concordant nature of genomic events encourages the use of genomically unstable murine cancer models in the discovery of biological driver events in the human oncogenome.
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“Unlike classical balanced translocations, non-reciprocal translocations lead to copy number changes of the genes residing near the translocation breakage-rearrangement point (105).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [105]
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Mutations of the BRAF gene in human cancer
Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674
Self-citationA census of human cancer genes
Futreal, P. A., Coin, L., Marshall, M., Down, T., Hubbard, T., Wooster, R., Rahman, N., & Stratton, M. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1299 · Cited by 3,184
Self-citationActivating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Weng, A. P., Ferrando, A. A., Lee, W., Morris, J. P., Silverman, L. B., Sanchez-Irizarry, C., Blacklow, S. C., Look, A. T., & Aster, J. C. (2004) · Science · doi:10.1126/science.1102160 · Cited by 2,706
Self-citationHingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609
Circular binary segmentation for the analysis of array-based DNA copy number data
Olshen, A. B., Venkatraman, E. S., Lucito, R., & Wigler, M. H. (2004) · Biostatistics · doi:10.1093/biostatistics/kxh008 · Cited by 2,304
Ellisen, L. W., Bird, J., West, D. C., Soreng, A. L., Reynolds, T. C., Smith, S. D., & Sklar, J. (1991) · Cell · doi:10.1016/0092-8674(91)90111-b · Cited by 1,691
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
Schroeter, E. H., Kisslinger, J. A., & Kopan, R. (1998) · Nature · doi:10.1038/30756 · Cited by 1,624
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
Olive, K. P., Tuveson, D. A., Ruhe, Z. C., Yin, B., Willis, N. A., Bronson, R. T., Crowley, D., & Jacks, T. (2004) · Cell · doi:10.1016/j.cell.2004.11.004 · Cited by 1,308
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
Artandi, S. E., Chang, S., Lee, S.-L., Alson, S., Gottlieb, G. J., Chin, L., & DePinho, R. A. (2000) · Nature · doi:10.1038/35020592 · Cited by 1,085
Self-citationGain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
Lang, G. A., Iwakuma, T., Suh, Y.-A., Liu, G., Rao, V. A., Parant, J. M., Valentin-Vega, Y. A., Terzian, T., Caldwell, L. C., Strong, L. C., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.006 · Cited by 1,069
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Alu elements mediate MYB gene tandem duplication in human T-ALL
O’Neil, J., Tchinda, J., Gutiérrez, A., Moreau, L. A., Maser, R. S., Wong, K., Li, W., McKenna, K., Liu, X. S., Feng, B., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071637 · Cited by 97
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Cruz, L. L., Soares, P., & Correia, M. (2021) · Pharmaceuticals · doi:10.3390/ph14090848 · Cited by 98
The mouse prostate: a basic anatomical and histological guideline
Oliveira, D. S. M., Dzinic, S. H., Bonfil, A. I., Saliganan, A. D., Sheng, S., & Bonfil, R. D. (2015) · Bosnian Journal of Basic Medical Sciences · doi:10.17305/bjbms.2016.917 · Cited by 107
Carbon nanotube exploration in cancer cell lines
Kesharwani, P., Ghanghoria, R., & Jain, N. K. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.05.003 · Cited by 98
Ashworth, T. D., Pear, W. S., Chiang, M. Y., Blacklow, S. C., Mastio, J., Xu, L., Kelliher, M. A., Kastner, P., Chan, S. H., & Aster, J. C. (2010) · Blood · doi:10.1182/blood-2010-05-286328 · Cited by 89
Self-citationAcute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss
Medyouf, H., Gao, X., Armstrong, F., Gusscott, S., Liu, Q., Gedman, A. L., Matherly, L. H., Schultz, K. R., Pflumio, F., You, M. J., et al. (2009) · Blood · doi:10.1182/blood-2009-04-214718 · Cited by 89
SCFFbw7 Modulates the NFκB Signaling Pathway by Targeting NFκB2 for Ubiquitination and Destruction
Fukushima, H., Matsumoto, A., Inuzuka, H., Zhai, B., Lau, A. W., Wan, L., Gao, D., Shaik, S., Yuan, M., Gygi, S. P., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.04.002 · Cited by 90
Molecular Genetics of Acute Lymphoblastic Leukemia
Teitell, M. A., & Pandolfi, P. P. (2008) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092227 · Cited by 93
Targeting Nonclassical Oncogenes for Therapy in T-ALL
Subramaniam, P. S., Whye, D., Efimenko, E., Chen, J., Tosello, V., Keersmaecker, K. D., Kashishian, A., Thompson, M. A., Castillo-Martín, M., Cordon‐Cardo, C., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.029 · Cited by 89
Kim, W. J., Okimoto, R. A., Purton, L. E., Goodwin, M., Haserlat, S. M., Dayyani, F., Sweetser, D. A., McClatchey, A. I., Bernard, O., Look, A. T., et al. (2008) · Blood · doi:10.1182/blood-2007-10-113068 · Cited by 91
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Eifert, C., & Powers, S. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3299 · Cited by 90
Potts, R. C., Zhang, P., Wurster, A. L., Precht, P., Mughal, M. R., Wood, W. H., Zhang, Y., Becker, K. G., Mattson, M. P., & Pazin, M. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024515 · Cited by 90
Xu, Y., Sengupta, T., Kukreja, L., & Minella, A. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152306 · Cited by 86
de Bock, C. E., Ardjmand, A., Molloy, T. J., Bone, S., Johnstone, D. M., Campbell, D. M., Shipman, K. L., Yeadon, T. M., Holst, J., Spanevello, M., et al. (2011) · Leukemia · doi:10.1038/leu.2011.319 · Cited by 87
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Baldus, C. D., Thibaut, J., Goekbuget, N., Stroux, A., Schlee, C., Mossner, M., Burmeister, T., Schwartz, S., Bloomfield, C. D., Hoelzer, D. T., et al. (2009) · Haematologica · doi:10.3324/haematol.2008.005272 · Cited by 85
Jenkinson, S., Koo, K., Mansour, M. R., Goulden, N., Vora, A. J., Mitchell, C., Wade, R. L., Richards, S. M., Hancock, J. P., Moorman, A. V., et al. (2012) · Leukemia · doi:10.1038/leu.2012.176 · Cited by 84
Self-citationValidating the anticancer potential of carbon nanotube-based therapeutics through cell line testing
Kesharwani, P., Mishra, V. K., & Jain, N. K. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.05.004 · Cited by 84
Mendes, R. D., Sarmento, L. M., Canté-Barrett, K., Zuurbier, L. C., Buijs-Gladdines, J. G. C. A. M., Póvoa, V., Smits, W. K., Abecasis, M., Yunes, J. A., Sonneveld, E., et al. (2014) · Blood · doi:10.1182/blood-2014-03-562751 · Cited by 84
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Liu, X., Karnell, J. L., Yin, B., Zhang, R., Zhang, J., Li, P., Choi, Y., Maltzman, J. S., Pear, W. S., Bassing, C. H., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42382 · Cited by 84
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Mullighan, C. G., & Downing, J. R. (2008) · Seminars in Hematology · doi:10.1053/j.seminhematol.2008.09.005 · Cited by 84
Bonnet, M., Loosveld, M., Montpellier, B., Navarro, J., Quilichini, B., Picard, C., Cristofaro, J. D., Bagnis, C., Fossat, C., Hernandez, L., et al. (2011) · Blood · doi:10.1182/blood-2011-02-336842 · Cited by 86
Life in the Fast Lane: Mammalian Disease Models in the Genomics Era
Dow, L. E., & Lowe, S. W. (2012) · Cell · doi:10.1016/j.cell.2012.02.023 · Cited by 83
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Mansour, M. R., Duke, V. M., Foroni, L., Patel, B., Allen, C. G., Ancliff, P. J., Gale, R. E., & Linch, D. C. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1474 · Cited by 79
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Jenkinson, S., Kirkwood, A. A., Goulden, N., Vora, A. J., Linch, D. C., & Gale, R. E. (2015) · Leukemia · doi:10.1038/leu.2015.206 · Cited by 78
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Dudgeon, C., Chan, C. H., Kang, W., Sun, Y., Emerson, R., Robins, H. S., & Levine, A. J. (2014) · Genes & Development · doi:10.1101/gad.252148.114 · Cited by 77
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Graham, N. A., Minasyan, A., Lomova, A., Cass, A. A., Balanis, N. G., Friedman, M., Chan, S. T., Zhao, S. R., Delgado, A., Go, J. L., et al. (2017) · Molecular Systems Biology · doi:10.15252/msb.20167159 · Cited by 78
Silva, A., Jotta, P. Y., Silveira, A. B., Ribeiro, D., Brandalise, S. R., Yunes, J. A., & Barata, J. T. (2009) · Haematologica · doi:10.3324/haematol.2009.011999 · Cited by 76
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Huang, L.-Y., Zhao, J., Chen, H., Wan, L., Inuzuka, H., Guo, J., Fu, X., Zhai, Y., Lu, Z., Wang, X., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06038-y · Cited by 78
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Bongiovanni, D., Saccomani, V., & Piovan, E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091904 · Cited by 78
Collier, L. S., Adams, D. J., Hackett, C. S., Bendzick, L. E., Akagi, K., Davies, M. N., Diers, M. D., Rodríguez, F. J., Bender, A. M., Tieu, C., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1760 · Cited by 71
Kusy, S., Gerby, B., Goardon, N., Gault, N., Ferri, F., Gérard, D., Armstrong, F., Ballerini, P. F., Cayuela, J., Baruchel, A., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100745 · Cited by 72
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Guo, W., Schubbert, S., Chen, J. Y., Valamehr, B. B., Mosessian, S., Shi, H., Dang, N. H., Garcia, C., Theodoro, M. F., Varella‐Garcia, M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006937108 · Cited by 73
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Spunt, S. L., Skapek, S. X., & Coffin, C. M. (2008) · The Oncologist · doi:10.1634/theoncologist.2007-0182 · Cited by 68
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Lobbardi, R., Pinder, J. B., Martínez-Pastor, B., Theodorou, M., Blackburn, J. S., Abraham, B. J., Namiki, Y., Mansour, M. R., Abdelfattah, N. S., Molodtsov, A. K., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0267 · Cited by 67
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Dail, M., Li, Q., McDaniel, A., Wong, J. W. H., Akagi, K., Huang, B. J., Kang, H. C., Kogan, S. C., Shokat, K. M., Wolff, L., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001064107 · Cited by 63
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Pan, Q., Lou, X., Zhang, J., Zhu, Y., Li, F., Shan, Q., Chen, X., Xie, Y., Su, S., Wei, H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00057-3 · Cited by 63
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Goriki, A., Seiler, R., Wyatt, A. W., Contreras‐Sanz, A., Bhat, A. V., Matsubara, A., Hayashi, T., & Black, P. C. (2018) · Nature Reviews Urology · doi:10.1038/s41585-018-0005-1 · Cited by 63
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Hu, Q., Akatsuka, S., Yamashita, Y., Ohara, H., Nagai, H., Okazaki, Y., Takahashi, T., & Toyokuni, S. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2009.140 · Cited by 62
Dettman, E. J., Simko, S. J., Ayanga, B. A., Carofino, B. L., Margolin, J., Morse, H. C., & Justice, M. J. (2011) · Oncogene · doi:10.1038/onc.2011.12 · Cited by 62
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Luo, Z., Mu, L., Zheng, Y., Shen, W., Li, J., Xu, L., Zhong, B., Liu, Y., & Zhou, Y. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz088 · Cited by 61
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Sanda, T., Li, X., Gutiérrez, A., Ahn, Y., Neuberg, D. S., O’Neil, J., Strack, P. R., Winter, C. G., Winter, S. S., Larson, R. A., et al. (2009) · Blood · doi:10.1182/blood-2009-07-235143 · Cited by 60
Self-citationAbdelali, R. B., Asnafi, V., Leguay, T., Boissel, N., Buzyn, A., Chevallier, P., Thomas, X., Leprêtre, S., Huguet, F., Vey, N., et al. (2011) · Blood · doi:10.1182/blood-2011-02-334219 · Cited by 59
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Heo, J., Eki, R., & Abbas, T. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.09.015 · Cited by 60
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Satija, Y. K., Bhardwaj, A., & Das, S. (2013) · International Journal of Cancer · doi:10.1002/ijc.28129 · Cited by 58
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Ghosh, P., & Chin, L. (2009) · Expert Review of Dermatology · doi:10.1586/edm.09.2 · Cited by 60
Self-citationPerera, S. A., Maser, R. S., Xia, H., McNamara, K. L., Protopopov, A. I., Chen, L., Hezel, A. F., Kim, C. F., Bronson, R. T., Castrillón, D. H., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn050 · Cited by 59
Self-citationLefebure, M., Tothill, R. W., Kruse, E., Hawkins, E. D., Shortt, J., Matthews, G. M., Gregory, G. P., Martin, B. P., Kelly, M. J., Todorovski, I., et al. (2017) · Nature Communications · doi:10.1038/ncomms14581 · Cited by 55
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Iacobucci, I., Papayannidis, C., Lonetti, A., Ferrari, A., Baccarani, M., & Martinelli, G. (2012) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-012-0122-5 · Cited by 56
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Kastner, P. (2011) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v2.i6.108 · Cited by 53
Gusscott, S., Jenkins, C. E., Lam, S. H. L., Giambra, V., Pollak, M., & Weng, A. P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161158 · Cited by 53
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Ksionda, O., Limnander, A., & Roose, J. P. (2013) · Frontiers in Biology · doi:10.1007/s11515-013-1276-9 · Cited by 52
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Chen, X. F., Cai, S., Chen, Q. G., Ni, Z., Tang, J. H., Xu, D., & Wang, X. B. (2012) · Genetics and Molecular Research · doi:10.4238/2012.february.16.2 · Cited by 52
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Nalapareddy, K., Jiang, H., Gutierrez, L. M. G., & Rudolph, K. L. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.09.002 · Cited by 50
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MacPherson, D. P. (2008) · Cell Division · doi:10.1186/1747-1028-3-9 · Cited by 50
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Yang, M., Govern, C. C., Chakraborty, A. K., Hartzell, C., Ksionda, O., Lemmens, E., Coakley, K. M., Dail, M., Harvey, R. C., Bakker, J., et al. (2012) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 49
Akahane, K., Sanda, T., Mansour, M. R., Radimerski, T., DeAngelo, D. J., Weinstock, D. M., & Look, A. T. (2015) · Leukemia · doi:10.1038/leu.2015.222 · Cited by 49
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Martens, J. H. A. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.05.014 · Cited by 51
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Carroll, S. L. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.10.023 · Cited by 51
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Tang, J., Le, S., Sun, L. T., Yan, X., Zhang, M., MacLeod, J., LeRoy, B. E., Northrup, N. C., Ellis, A. E., Yeatman, T. J., et al. (2010) · Genome Research · doi:10.1101/gr.092726.109 · Cited by 49
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Stakaitytė, G., Wood, J. J., Knight, L., Abdul-Sada, H., Adzahar, N., Nwogu, N., Macdonald, A., & Whitehouse, A. (2014) · Cancers · doi:10.3390/cancers6031267 · Cited by 52
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Stegh, A. H. (2012) · Integrative Biology · doi:10.1039/c2ib20104f · Cited by 51
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Burrell, R. A., Birkbak, N. J., Johnston, S. R. D., Reis-Filho, J. S., Szállási, Z., & Swanton, C. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22781 · Cited by 48
Schubbert, S., Cardenas, A. M., Chen, H., Garcia, C., Guo, W., Bradner, J. E., & Wu, H. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1470 · Cited by 47
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Zhang, Z., Hou, S.-Q., He, J., Gu, T., Yin, Y., & Shen, W. H. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1203493 · Cited by 46
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Djaafri, I., Khayati, F., Ménashi, S., Tost, J., Podgorniak, M.-P., Sadoux, A., Daunay, A., Teixeira, L., Soulier, J., Idbaïh, A., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2125 · Cited by 45
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Wang, Z. P., Fukushima, H., Gao, D., Inuzuka, H., Wan, L., Lau, A. W., Liu, P., & Wei, W. (2011) · BioEssays · doi:10.1002/bies.201100101 · Cited by 45
Nucleolar Targeting of the Fbw7 Ubiquitin Ligase by a Pseudosubstrate and Glycogen Synthase Kinase 3
Welcker, M., Larimore, E. A., Frappier, L., & Clurman, B. E. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01347-10 · Cited by 42
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Schmidt, E., & Burkhardt, B. (2013) · Pediatric Hematology and Oncology · doi:10.3109/08880018.2013.789574 · Cited by 43
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Choorapoikayil, S., Kers, R., Herbomel, P., Kissa, K., & den Hertog, J. (2013) · Blood · doi:10.1182/blood-2013-05-501544 · Cited by 43
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Telomeres and Cancer: From Crisis to Stability to Crisis to Stability
Campbell, P. J. (2012) · Cell · doi:10.1016/j.cell.2012.01.043 · Cited by 36
Self-citation
Metadata
- Authors
- Maser, R. S., Choudhury, B., Campbell, P. J., Feng, B., Wong, K.-K., Protopopov, A., O’Neil, J., Gutierrez, A., Ivanova, E., Perna, I., Lin, E., Mani, V., Jiang, S., McNamara, K., Zaghlul, S., Edkins, S., Stevens, C., Brennan, C., Martin, E. S., Wiedemeyer, R., Kabbarah, O., Nogueira, C., Histen, G., Aster, J., Mansour, M., Duke, V., Foroni, L., Fielding, A. K., Goldstone, A. H., Rowe, J. M., Wang, Y. A., Look, A. T., Stratton, M. R., Chin, L., Futreal, P. A., & DePinho, R. A.
- Affiliations
- Dana-Farber Cancer Institute (US)
- Wellcome Sanger Institute (GB)
- Agilent Technologies (United States) (US)
- Memorial Sloan Kettering Cancer Center (US)
- The Royal Free Hospital (GB)
- University College London (GB)
- Technion – Israel Institute of Technology (IL)
- Harvard University (US)
- Corresponding author
- DePinho, Ronald A.
- ORCID
- Choudhury, Bhudipa
- Campbell, Peter J.
- Feng, Bin
- Wong, Kwok-Kin
- Protopopov, Alexei
- O’Neil, Jennifer
- Ivanova, Elena
- Lin, Eric
- Jiang, Shan
- Edkins, Sarah
- Brennan, Cameron
- Martin, Eric S.
- Kabbarah, Omar
- Nogueira, Cristina
- Aster, Jon
- Mansour, Marc
- Fielding, Adele K.
- Goldstone, Anthony H.
- Rowe, Jacob M.
- Look, A. Thomas
- Stratton, Michael R.
- Futreal, P. Andrew
- DePinho, Ronald A.
- Venue
- Nature
- Published
- 2007-05-21
- Volume
- 447
- Issue
- 7147
- Pages
- 966-971
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2714968
- OpenAlex
- W1982767015
- Cited by
- 377
- References
- 50
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 8 · 2023: 8 · 2022: 8 · 2021: 5 · 2020: 11 · 2019: 6 · 2018: 12 · 2017: 16 · 2016: 17 · 2015: 21 · 2014: 25 · 2013: 34 · 2012: 32
- FWCI
- 15.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- Damon Runyon Cancer Research Foundation
- Wellcome Trust (077012, 088340)
- Kay Kendall Leukaemia Fund
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- chromosomal instability, mouse lymphoma model, T-cell acute lymphoblastic lymphoma, FBXW7, PTEN, notches, copy number alterations, genomic instability, driver mutations, tumor evolution, syntenic loci
- MeSH terms
- Animals, Chromosome Aberrations, Humans, Leukemia-Lymphoma, Adult T-Cell, Lymphoma, T-Cell, Genome, Conserved Sequence, Synteny, Chromosomal Instability, PTEN Phosphohydrolase, Mice
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