The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Replication and protection of telomeres
Abstract
During the evolution of linear genomes, it became essential to protect the natural chromosome ends to prevent triggering of the DNA-damage repair machinery and enzymatic attack. Telomeres - tightly regulated complexes consisting of repetitive G-rich DNA and specialized proteins - accomplish this task. Telomeres not only conceal linear chromosome ends from detection and inappropriate repair but also provide a buffer to counteract replication-associated shortening. Lessons from many model organisms have taught us about the complications of maintaining these specialized structures. Here, we discuss how telomeres interact and cooperate with the DNA replication and DNA-damage repair machineries.
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“Telomeres that can no longer exert end-protective functions are said to be dysfunctional, and these telomeres could arise either from progressive telomere attrition, or when components of the shelterin complex are perturbed, resulting in inappropriate chromosomal end-to-end fusions through the non-homologous end joining (NHEJ) or homologous recombination (HR) DNA repair pathways 17.”
From Telomere dysfunction and tumour suppression: the senescence connection (2008) · cites this paper as [17]
Citations
Cites
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Telomeres shorten during ageing of human fibroblasts
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Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056
A DNA damage checkpoint response in telomere-initiated senescence
Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,917
Mammalian Telomeres End in a Large Duplex Loop
Griffith, J. D., Comeau, L., Rosenfield, S., Stansel, R. M., Bianchi, A., Moss, H., & de Lange, T. (1999) · Cell · doi:10.1016/s0092-8674(00)80760-6 · Cited by 2,447
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
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TRF2 Protects Human Telomeres from End-to-End Fusions
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Cited by
Sorted by citations
The DNA-damage response in human biology and disease
Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
Michishita, E., McCord, R. A., Berber, E., Kioi, M., Padilla-Nash, H., Damian, M., Cheung, P., Kusumoto, R., Kawahara, T. L. A., Barrett, J. C., et al. (2008) · Nature · doi:10.1038/nature06736 · Cited by 1,111
Telomeres: protecting chromosomes against genome instability
O’Sullivan, R. J., & Karlseder, J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2848 · Cited by 1,043
Self-citationPatel, D. J., Phan, A. T., & Kuryavyi, V. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm711 · Cited by 892
The MRE11 complex: starting from the ends
Stracker, T. H., & Petrini, J. H. J. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3047 · Cited by 734
Metadata
- Authors
- Verdun, R. E., & Karlseder, J.
- Affiliations
- Salk Institute for Biological Studies (US)
- ORCID
- Karlseder, Jan
- Venue
- Nature
- Published
- 2007-06-20
- Volume
- 447
- Issue
- 7147
- Pages
- 924-931
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2086095857
- Cited by
- 463
- References
- 102
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 16 · 2023: 9 · 2022: 17 · 2021: 15 · 2020: 14 · 2019: 14 · 2018: 19 · 2017: 29 · 2016: 28 · 2015: 30 · 2014: 28 · 2013: 31 · 2012: 32
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Leukemia and Lymphoma Society
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- telomeres, telomere replication, telomere protection, DNA repair, chromosome ends, DNA replication, telomere shortening, telomere proteins
- MeSH terms
- Animals, DNA Damage, DNA Repair, DNA Replication, Humans, Neoplasms, Telomere, Cellular Senescence
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