Cited by 463Telomeres, Telomerase, and SenescenceDNA Repair MechanismsDNA and Nucleic Acid Chemistry

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Replication and protection of telomeres

Verdun, Ramiro E., Karlseder, Jan·2007·Nature

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Abstract

During the evolution of linear genomes, it became essential to protect the natural chromosome ends to prevent triggering of the DNA-damage repair machinery and enzymatic attack. Telomeres - tightly regulated complexes consisting of repetitive G-rich DNA and specialized proteins - accomplish this task. Telomeres not only conceal linear chromosome ends from detection and inappropriate repair but also provide a buffer to counteract replication-associated shortening. Lessons from many model organisms have taught us about the complications of maintaining these specialized structures. Here, we discuss how telomeres interact and cooperate with the DNA replication and DNA-damage repair machineries.

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See all 463

Authors: Verdun, R. E., & Karlseder, J.
Affiliations: Salk Institute for Biological Studies (US)
ORCID: Karlseder, Jan
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2007-06-20
Volume: 447
Issue: 7147
Pages: 924-931
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature05976
OpenAlex: W2086095857
Cited by: 463
References: 102
Citations by year: 2026: 4 · 2025: 5 · 2024: 16 · 2023: 9 · 2022: 17 · 2021: 15 · 2020: 14 · 2019: 14 · 2018: 19 · 2017: 29 · 2016: 28 · 2015: 30 · 2014: 28 · 2013: 31 · 2012: 32
FWCI: 4.84
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Leukemia and Lymphoma Society
National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords: telomeres, telomere replication, telomere protection, DNA repair, chromosome ends, DNA replication, telomere shortening, telomere proteins
MeSH terms: Animals, DNA Damage, DNA Repair, DNA Replication, Humans, Neoplasms, Telomere, Cellular Senescence

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Replication and protection of telomeres

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