Global changes to the ubiquitin system in Huntington's disease

Cited by (497)

Items 101–200 of 497

  1. Proteasomal dysfunction in aging and Huntington disease
    Xiao‐Jiang Li, Shihua Li · 2010 · Neurobiology of Disease
  2. Huntingtonʼs disease
    Ainhi D. Ha, Victor S.C. Fung · 2012 · Current Opinion in Neurology
  3. Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1–PP2A protein complex
    Sybille Krauß, Nadine Griesche, Ewa Jastrzebska, Changwei Chen, Désirée Rutschow, Clemens Achmüller, Stephanie Dorn, Sylvia Boesch, Maciej M. Lalowski, Erich E. Wanker et al. · 2013 · Nature Communications
  4. Targeted protein degradation directly engaging lysosomes or proteasomes
    Jiseong Kim, Insuk Byun, Do Young Kim, Hyunhi Joh, Hak Joong Kim, Min Jae Lee · 2024 · Chemical Society Reviews
  5. Single Neuron Ubiquitin-Proteasome Dynamics Accompanying Inclusion Body Formation in Huntington Disease
    Siddhartha S. Mitra, Andrey S. Tsvetkov, Steven M. Finkbeiner · 2008 · Journal of Biological Chemistry
  6. Protein aggregation as a paradigm of aging
    Ariel B. Lindner, Alice Démarez · 2009 · Biochimica et Biophysica Acta (BBA) - General Subjects
  7. Therapeutic approaches against common structural features of toxic oligomers shared by multiple amyloidogenic proteins
    Marcos Jair Guerrero‐Munoz, Diana Laura Castillo‐Carranza, Rakez Kayed · 2014 · Biochemical Pharmacology
  8. Deubiquitinating enzymes (DUBs): decipher underlying basis of neurodegenerative diseases
    Baohua Liu, Jing Ruan, Meng Chen, Zhongding Li, Gloria M. Manjengwa, Dirk Schlüter, Weihong Song, Xu Wang · 2021 · Molecular Psychiatry
  9. Proteomics in human Parkinson's disease research
    Virginie Licker, Enikò Kövari, Denis F. Hochstrasser, Pierre R. Burkhard · 2009 · Journal of Proteomics
  10. Intranuclear Degradation of Polyglutamine Aggregates by the Ubiquitin-Proteasome System
    Atsushi Iwata, Yu Nagashima, Lumine Matsumoto, Takahiro Suzuki, Tomoyuki Yamanaka, Hidetoshi Date, Ken Deoka, Nobuyuki Nukina, Shoji Tsuji · 2009 · Journal of Biological Chemistry
  11. Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma
    Ming‐Chang Chiang, Chiung‐Mei Chen, Maw-Rong Lee, Hsiao-Wen Chen, Huimei Chen, Yu-Shuo Wu, Cheng-Han Hung, Jheng-Jie Kang, Ching‐Pang Chang, Chen Chang et al. · 2010 · Human Molecular Genetics
  12. Protein aggregation and ER stress
    Navit Ogen‐Shtern, Tamuz Ben David, Gerardo Zelmar Lederkremer · 2016 · Brain Research
  13. Partners in crime: bidirectional transcription in unstable microsatellite disease
    Ranjan Batra, Konstantinos Charizanis, Maurice S. Swanson · 2010 · Human Molecular Genetics
  14. TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease
    Xiaobei Zhao, Xu‐Qiao Chen, Eugene Kiwo Han, Yue Hu, Paul K. Paik, Zhiyong Ding, Julia Overman, Alice Lau, Sarah H. Shahmoradian, Wah Chiu et al. · 2016 · Proceedings of the National Academy of Sciences
  15. Role of ubiquitin–proteasome-mediated proteolysis in nervous system disease
    Ashok N. Hegde, Sudarshan C. Upadhya · 2010 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  16. ER Stress-Induced eIF2-alpha Phosphorylation Underlies Sensitivity of Striatal Neurons to Pathogenic Huntingtin
    Julia Leitman, Boaz Barak, Ron Benyair, Marina Shenkman, Uri Ashery, F. Ulrich Hartl, Gerardo Zelmar Lederkremer · 2014 · PLoS ONE
  17. Acute Polyglutamine Expression in Inducible Mouse Model Unravels Ubiquitin/Proteasome System Impairment and Permanent Recovery Attributable to Aggregate Formation
    Zaira Ortega, Miguel Dı́az-Hernández, Christa J. Maynard, Félix Hernández, Nico P. Dantuma, José J. Lucas · 2010 · Journal of Neuroscience
  18. Extraproteasomal Rpn10 Restricts Access of the Polyubiquitin-Binding Protein Dsk2 to Proteasome
    Yulia Matiuhin, Donald S. Kirkpatrick, Inbal Ziv, Woong Kim, Arun Dakshinamurthy, Oded Kleifeld, Steven P. Gygi, Noa Reis, Michael H. Glickman · 2008 · Molecular Cell
  19. Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment
    Christa J. Maynard, Claudia Böttcher, Zaira Ortega, Ruben A Smith, Bogdan I. Florea, Miguel Dı́az-Hernández, Patrik Brundin, Herman S. Overkleeft, Jiayi Li, José J. Lucas et al. · 2009 · Proceedings of the National Academy of Sciences
  20. Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene
    Kwon‐Yul Ryu, Jacob C. Garza, Xin‐Yun Lu, Gregory S. Barsh, Ron R. Kopito · 2008 · Proceedings of the National Academy of Sciences
  21. Emerging roles for Lys11-linked polyubiquitin in cellular regulation
    Anja Bremm, David Komander · 2011 · Trends in Biochemical Sciences
  22. A Data Set of Human Endogenous Protein Ubiquitination Sites
    Yi Shi, Doug W. Chan, Sung Yun Jung, Anna Malovannaya, Yi Wang, Jun Qin · 2010 · Molecular & Cellular Proteomics
  23. A Screen for Enhancers of Clearance Identifies Huntingtin as a Heat Shock Protein 90 (Hsp90) Client Protein
    Barbara Baldo, Andreas Weiss, Christian N. Parker, Miriam Bibel, Paolo Paganetti, Klemens Kaupmann · 2011 · Journal of Biological Chemistry
  24. Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation
    Kirandeep K. Deol, Sean O. Crowe, Jiale Du, Heather A. Bisbee, Robert G. Guenette, Eric R. Strieter · 2020 · Molecular Cell
  25. Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments
    Janine Kirstein, Daisuke Morito, Taichi Kakihana, Munechika Sugihara, Anita Minnen, Mark S. Hipp, Carmen I. Nussbaum-Krammer, Prasad Kasturi, F. Ulrich Hartl, Kazuhiro Nagata et al. · 2015 · The EMBO Journal
  26. Transglutaminases and neurodegeneration
    Thomas M. Jeitner, John Thomas Pinto, Boris F. Krasnikov, Mark A. Horswill, Arthur J.L. Cooper · 2009 · Journal of Neurochemistry
  27. Blood–Brain Barrier and Neurodegenerative Diseases—Modeling with iPSC-Derived Brain Cells
    Ying‐Chieh Wu, Tuuli-Maria Sonninen, Sanni Peltonen, Jari Koıstınaho, Šárka Lehtonen · 2021 · International Journal of Molecular Sciences
  28. K63-linked ubiquitination and neurodegeneration
    Kah‐Leong Lim, Grace G.Y. Lim · 2010 · Neurobiology of Disease
  29. Intracellular protein degradation in mammalian cells: recent developments
    Erwin Knecht, Carmen Aguado, Jaime Cárcel‐Trullols, Inmaculada Esteban, Juan M. Esteve, Ghita Ghislat, Jose F. Moruno-Manchon, José Manuel Vidal, Rosana Sáez · 2009 · Cellular and Molecular Life Sciences
  30. Does Impairment of the Ubiquitin-Proteasome System or the Autophagy-Lysosome Pathway Predispose Individuals to Neurodegenerative Disorders such as Parkinson's Disease?
    Noriyuki Matsuda, Keiji Tanaka · 2010 · Journal of Alzheimer s Disease
  31. Comparison of CID versus ETD based MS/MS fragmentation for the analysis of protein ubiquitination
    Frank Sobott, STEPHEN J. WATT, Julia R. Smith, Mariola J. Edelmann, Holger Kramer, Benedikt Mathias Kessler · 2009 · Journal of the American Society for Mass Spectrometry
  32. Uncovering Ubiquitin and Ubiquitin-like Signaling Networks
    Alfred C.O. Vertegaal · 2011 · Chemical Reviews
  33. A protein quality control pathway regulated by linear ubiquitination
    Eva M. van Well, Verian Bader, Maria Patra, Ana Sánchez‐Vicente, Jens Meschede, Nikolas Furthmann, Cathrin Schnack, Alina Blusch, Joseph Longworth, Elisabeth Petrasch‐Parwez et al. · 2019 · The EMBO Journal
  34. What does make an amyloid toxic: Morphology, structure or interaction with membrane?
    Karine Berthelot, Christophe Cullin, Sophie Lecomte · 2012 · Biochimie
  35. Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease
    Brett A. Barbaro, Tamás Lukácsovich, Namita Agrawal, John Burke, Douglas J. Bornemann, Judith M. Purcell, Shane A. Worthge, Andrea Caricasole, Andreas Weiss, Wan Song et al. · 2014 · Human Molecular Genetics
  36. The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin–proteasome system
    Ming‐Chang Chiang, Huimei Chen, Hsing‐Lin Lai, Hsiao-Wen Chen, Szu‐Yi Chou, Chiung‐Mei Chen, Fuu‐Jen Tsai, Yijuang Chern · 2009 · Human Molecular Genetics
  37. c-Cbl-Dependent Monoubiquitination and Lysosomal Degradation of gp130
    Yoshinori Tanaka, Nobuyuki Tanaka, Yasushi Saeki, Keiji Tanaka, Masaaki Murakami, Toshio Hirano, Naoto Ishii, Kazuo Sugamura · 2008 · Molecular and Cellular Biology
  38. Hsp70 and Hsp40 Functionally Interact with Soluble Mutant Huntingtin Oligomers in a Classic ATP-dependent Reaction Cycle
    Gregor P. Lotz, Justin A. Legleiter, Rebecca Aron, Emily Mitchell Sontag, Shaoyi Huang, Che-Ping Ng, Charles G. Glabe, Leslie Michels Thompson, Paul J. Muchowski · 2010 · Journal of Biological Chemistry
  39. Impacts of Methylxanthines and Adenosine Receptors on Neurodegeneration: Human and Experimental Studies
    Jiang‐Fan Chen, Yijuang Chern · 2010 · Handbook of experimental pharmacology
  40. Bifunctional Anti-Huntingtin Proteasome-Directed Intrabodies Mediate Efficient Degradation of Mutant Huntingtin Exon 1 Protein Fragments
    David C. Butler, Anne C. Messer · 2011 · PLoS ONE
  41. Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease
    Dagmar E. Ehrnhoefer, Dale D. O. Martin, Mandi E. Schmidt, Xiaofan Qiu, Safia Ladha, Nicholas S. Caron, Niels Henning Skotte, Yen T.N. Nguyen, Kuljeet Vaid, Amber L. Southwell et al. · 2018 · Acta Neuropathologica Communications
  42. Dual Function of USP14 Deubiquitinase in Cellular Proteasomal Activity and Autophagic Flux
    Eun‐Kyoung Kim, Seoyoung Park, Jung Hoon Lee, Ji Young Mun, Won Hoon Choi, Yejin Yun, Jee‐Young Lee, Ji Hyeon Kim, Min-Ji Kang, Min Jae Lee · 2018 · Cell Reports
  43. Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT
    Naoki Hayashida, Mitsuaki Fujimoto, Ke Tan, Ramachandran Prakasam, Toyohide Shinkawa, Liangping Li, Hitoshi Ichikawa, Ryosuke Takii, Akira Nakai · 2010 · The EMBO Journal
  44. A Large Number of Protein Expression Changes Occur Early in Life and Precede Phenotype Onset in a Mouse Model for Huntington Disease
    Claus Zabel, Lei Mao, Ben Woodman, Michael Rohe, Maik A. Wacker, Yvonne Kläre, Andrea Koppelstaetter, Grit Nebrich, Oliver Klein, S. Grams et al. · 2008 · Molecular & Cellular Proteomics
  45. Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Associates with Huntingtin Protein and Promotes Its Atypical Ubiquitination to Enhance Aggregate Formation
    Silvia Zucchelli, Federica Marcuzzi, Marta Codrich, Elena Agostoni, Sandra Vilotti, Marta Biagioli, Milena Pinto, Alisia Carnemolla, Claudio Santoro, Stefano Gustincich et al. · 2011 · Journal of Biological Chemistry
  46. Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation
    Toyohide Shinkawa, Ke Tan, Mitsuaki Fujimoto, Naoki Hayashida, Kaoru Yamamoto, Eiichi Takaki, Ryosuke Takii, Ramachandran Prakasam, Sachiye Inouye, Valérie Mezger et al. · 2011 · Molecular Biology of the Cell
  47. Composition of the Intranuclear Inclusions of Fragile X-associated Tremor/Ataxia Syndrome
    Lisa Ma, Anthony W. Herren, Glenda M. Espinal, Jamie Leah Randol, Bridget E. McLaughlin, Verónica Martínez‐Cerdeño, Isaac N. Pessah, Randi Jenssen Hagerman, Paul J. Hagerman · 2019 · Acta Neuropathologica Communications
  48. The Ubiquitin-Proteasome Pathway in Huntington's Disease
    Siddhartha S. Mitra, Steven M. Finkbeiner · 2008 · The Scientific World JOURNAL
  49. Dendritic spinopathy in transgenic mice expressing ALS/dementia-linked mutant UBQLN2
    George Gorrie, Faisal Fecto, Daniel Radzicki, Craig Weiss, Yong Shi, Hongxin Dong, Hong Zhai, R. Fu, Erdong Liu, Sisi Li et al. · 2014 · Proceedings of the National Academy of Sciences
  50. Osteoblast function in myeloma
    G. David Roodman · 2010 · Bone
  51. The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases
    Mei Ding, Kang Shen · 2008 · BioEssays
  52. Pulsed Azidohomoalanine Labeling in Mammals (PALM) Detects Changes in Liver-Specific LKB1 Knockout Mice
    Daniel B. McClatchy, Yuanhui Ma, Chao Liu, Benjamin D. Stein, Salvador Martínez‐Bartolomé, Debbie S. Vasquez, Kristina Hellberg, Reuben J. Shaw, John R. Yates · 2015 · Journal of Proteome Research
  53. Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity
    Judy C. Triplett, Antonella Tramutola, Aaron M. Swomley, Jessime M. Kirk, Kelly M. Grimes, Kaitlyn N. Lewis Hardell, Miranda E. Orr, Karl A. Rodriguez, Jian Cai, Jon B. Klein et al. · 2015 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  54. Heat shock proteins in neurodegenerative diseases: Pathogenic roles and therapeutic implications
    Hiroaki Adachi, Masahisa Katsuno, Masahiro Waza, Makoto Minamiyama, Fumiaki Tanaka, Gen Sobue · 2009 · International Journal of Hyperthermia
  55. Fatty acid synthase is preferentially degraded by autophagy upon nitrogen starvation in yeast
    Tomer Shpilka, Evelyn Welter, Noam Borovsky, Nira Amar, Frida Shimron, Yoav Peleg, Zvulun Elazar · 2015 · Proceedings of the National Academy of Sciences
  56. The parallel reaction monitoring method contributes to a highly sensitive polyubiquitin chain quantification
    Hikaru Tsuchiya, Keiji Tanaka, Yasushi Saeki · 2013 · Biochemical and Biophysical Research Communications
  57. RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage
    Atanu Paul, Bin Wang · 2017 · Molecular Cell
  58. Oxidative protein damage and the proteasome
    Stefanie Grimm, Annika Höhn, Tilman Grune · 2010 · Amino Acids
  59. Regulation of Feedback between Protein Kinase A and the Proteasome System Worsens Huntington's Disease
    Lin, Jiun-Tsai, Chang, Wei-Cheng, Chen, Hui-Mei, Lai, Hsing-Lin, Chen, Chih-Yeh, Tao, Mi-Hua, Chern, Yijuang · 2013 · Molecular and Cellular Biology
  60. Protein misfolding inside cells: The case of huntingtin and Huntington's disease
    Danny M. Hatters · 2008 · IUBMB Life
  61. Protective Effect of Natural Products against Huntington’s Disease: An Overview of Scientific Evidence and Understanding Their Mechanism of Action
    Pei Teng Lum, Mahendran Sekar, Siew Hua Gan, Srinivasa Reddy Bonam, Mohd. Farooq Shaikh · 2021 · ACS Chemical Neuroscience
  62. Protein homeostasis and aging: Role of ubiquitin protein ligases
    Jana, Nihar Ranjan · 2012 · Neurochemistry International
  63. Roles of autophagy in HIV infection
    Christina Dinkins, Manohar Pilli, John H. Kehrl · 2014 · Immunology and Cell Biology
  64. Insulin/IGF-1 Signaling Regulates Proteasome Activity through the Deubiquitinating Enzyme UBH-4
    Olli Matilainen, Leena Arpalahti, Ville Rantanen, Sampsa Hautaniemi, Carina I. Holmberg · 2013 · Cell Reports
  65. Early and Late Events Induced by PolyQ-expanded Proteins
    Alessandra Bertoni, Paola Giuliano, Mario Galgani, Deborah Rotoli, Luca Ulianich, Annagrazia Adornetto, Maria Rosaria Santillo, Antonio Porcellini, Vittorio Enrico Avvedimento · 2010 · Journal of Biological Chemistry
  66. Understanding the Role of the Josephin Domain in the PolyUb Binding and Cleavage Properties of Ataxin-3
    Giuseppe Nicastro, Sokol V. Todi, Ezgi Karaca, Alexandre M. J. J. Bonvin, Henry Lauris Paulson, Annalisa Pastore · 2010 · PLoS ONE
  67. Recent developments in quantitative proteomics
    Christopher H. Becker, Marshall W. Bern · 2010 · Mutation Research/Genetic Toxicology and Environmental Mutagenesis
  68. The Ubiquitin-Proteasome Reporter GFPu Does Not Accumulate in Neurons of the R6/2 Transgenic Mouse Model of Huntington's Disease
    John S. Bett, Casey N. Cook, Leonard Petrucelli, Gillian P. Bates · 2009 · PLoS ONE
  69. The De-Ubiquitinylating Enzyme, USP2, Is Associated with the Circadian Clockwork and Regulates Its Sensitivity to Light
    H. Scoma, Monica S. Humby, Geetha Yadav, Qingjiong Zhang, Joseph Fogerty, Joseph C. Besharse · 2011 · PLoS ONE
  70. Correction of Huntington’s Disease Phenotype by Genistein-Induced Autophagy in the Cellular Model
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  71. Cross‐functional E3 ligases Parkin and C‐terminus Hsp70‐interacting protein in neurodegenerative disorders
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  72. Apelin/APJ system: A novel promising target for neurodegenerative diseases
    Huaiqing Luo, Li Han, Jin Xu · 2019 · Journal of Cellular Physiology
  73. Increased Prothrombin, Apolipoprotein A-IV, and Haptoglobin in the Cerebrospinal Fluid of Patients with Huntington's Disease
    Yen-Chu Huang, Yih‐Ru Wu, Mu‐Yun Tseng, Yi‐Chun Chen, Sen‐Yung Hsieh, Chiung‐Mei Chen · 2011 · PLoS ONE
  74. Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin
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  75. Endoplasmic reticulum stress: The cause and solution to Huntington's disease?
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  76. Protein Quality Control During Erythropoiesis and Hemoglobin Synthesis
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  77. Role of Medicinal Plants against Neurodegenerative Diseases
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  78. Ligand-switchable Substrates for a Ubiquitin-Proteasome System
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  79. Proteasome inhibitors and cardiac cell growth
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  80. The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias
    J. Eric Davies, Sovan Sarkar, David Chaim Rubinsztein · 2007 · BMC Biochemistry
  81. SCAMP5 Links Endoplasmic Reticulum Stress to the Accumulation of Expanded Polyglutamine Protein Aggregates via Endocytosis Inhibition
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  82. Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome‐blocking complexes
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  83. Mammalian plasma membrane proteins as potential biomarkers and drug targets
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  84. Targeting the 26S Proteasome To Protect Against Proteotoxic Diseases
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  85. Atypical Ubiquitination and Parkinson’s Disease
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  86. Sigma-1 receptor is involved in degradation of intranuclear inclusions in a cellular model of Huntington's disease
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  87. N‐methyl‐ d ‐aspartate receptor‐ and metabotropic glutamate receptor‐dependent long‐term depression are differentially regulated by the ubiquitin‐proteasome system
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  89. Posttranslational Modification of Ataxin-7 at Lysine 257 Prevents Autophagy-Mediated Turnover of an N-Terminal Caspase-7 Cleavage Fragment
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  95. Modeling Huntington disease in yeast: Perspectives and future directions
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