Protein homeostasis and aging: Role of ubiquitin protein ligases

The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction

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The genetics of ageing

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

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Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

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The roles of intracellular protein-degradation pathways in neurodegeneration

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The ubiquitin pathway in Parkinson's disease

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Modification of Proteins by Ubiquitin and Ubiquitin-Like Proteins

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Gene expression profile of aging and its retardation by caloric restriction

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UBE3A/E6-AP mutations cause Angelman syndrome

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Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

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Proteolysis: from the lysosome to ubiquitin and the proteasome

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Gene-expression profile of the ageing brain in mice

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The Ubiquitin Proteasome System in Neurodegenerative Diseases

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Mutation of the Angelman Ubiquitin Ligase in Mice Causes Increased Cytoplasmic p53 and Deficits of Contextual Learning and Long-Term Potentiation

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Toxin-induced models of Parkinson’s disease

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A century-old debate on protein aggregation and neurodegeneration enters the clinic

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Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

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A systematic RNAi screen for longevity genes in C. elegansPreprint

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Global changes to the ubiquitin system in Huntington's disease

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Substrate Targeting in the Ubiquitin System

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A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal

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The role of the ubiquitin-proteasome pathway in apoptosis

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Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

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Targeting of substrates to the 26S proteasome

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Protein quality control: U-box-containing E3 ubiquitin ligases join the fold

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Mutations in NHLRC1 cause progressive myoclonus epilepsy

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Co-chaperone CHIP Associates with Expanded Polyglutamine Protein and Promotes Their Degradation by Proteasomes

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p62/SQSTM1: A Missing Link between Protein Aggregates and the Autophagy Machinery

Bjørkøy, G., Lamark, T., & Johansen, T. (2006) · Autophagy · doi:10.4161/auto.2.2.2405 · Cited by 322 · see citing works

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

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Impairment of proteasome structure and function in aging

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Impaired ERAD and ER stress are early and specific events in polyglutamine toxicityPreprint

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Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

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Parkin Facilitates the Elimination of Expanded Polyglutamine Proteins and Leads to Preservation of Proteasome Function

Tsai, Y. C., Fishman, P. S., Thakor, N. V., & Oyler, G. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212235200 · Cited by 282 · see citing works

Protein Degradation or Regulation: Ub the Judge

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Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain

Keller, J. N., Dimayuga, E. R., Chen, Q., Thorpe, J. A., Gee, J. R., & Ding, Q. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.05.003 · Cited by 271 · see citing works

Antioxidant defense and aging in C. elegans : Is the oxidative damage theory of aging wrong?

Gems, D., & Doonan, R. (2009) · Cell Cycle · doi:10.4161/cc.8.11.8595 · Cited by 264 · see citing works

Possible involvement of proteasome inhibition in aging: implications for oxidative stress

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CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control

Min, J.-N., Whaley, R. A., Sharpless, N. E., Lockyer, P., Portbury, A. L., & Patterson, C. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00296-08 · Cited by 256 · see citing works

HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans

Chen, D., Thomas, E. L., & Kapahi, P. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000486 · Cited by 250 · see citing works

The proteasome in brain aging

Keller, J. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(01)00006-x · Cited by 247 · see citing works

Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans

Mehta, R., Steinkraus, K. A., Sutphin, G. L., Ramos, F. J., Shamieh, L. S., Huh, A., Davis, C., Chandler-Brown, D. B., & Kaeberlein, M. R. (2009) · Science · doi:10.1126/science.1173507 · Cited by 243 · see citing works

CHIP Suppresses Polyglutamine Aggregation and ToxicityIn VitroandIn Vivo

Miller, V. M., Nelson, R. F., Gouvion, C. M., Williams, A. J., Rodríguez-Lebrón, E., Harper, S. Q., Davidson, B. L., Rebagliati, M. R., & Paulson, H. L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3001-05.2005 · Cited by 236 · see citing works

Inhibition of Proteasomal Function by Curcumin Induces Apoptosis through Mitochondrial Pathway

Jana, N. R., Dikshit, P., Goswami, A., & Nukina, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310369200 · Cited by 232 · see citing works

Insulin/IGF-like signalling, the central nervous system and aging

Broughton, S., & Partridge, L. (2009) · Biochemical Journal · doi:10.1042/bj20082102 · Cited by 228 · see citing works

Age-Related Decline of Rat Liver Multicatalytic Proteinase Activity and Protection from Oxidative Inactivation by Heat-Shock Protein 90

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Cellular environment facilitates protein accumulation in aged rat hippocampus

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The WD40 Repeat Protein WDR-23 Functions with the CUL4/DDB1 Ubiquitin Ligase To Regulate Nuclear Abundance and Activity of SKN-1 in Caenorhabditis elegans

Choe, K. P., Przybysz, A. J., & Strange, K. B. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01811-08 · Cited by 186 · see citing works

Role of Proteasomes in Cellular Regulation

Konstantinova, I. M., Сергеевна, Ц. А., & Mittenberg, A. G. (2008) · International review of cytology · doi:10.1016/s1937-6448(08)00602-3 · Cited by 175 · see citing works

Aging perturbs 26S proteasome assembly in Drosophila melanogaster

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CHIP Overexpression Reduces Mutant Androgen Receptor Protein and Ameliorates Phenotypes of the Spinal and Bulbar Muscular Atrophy Transgenic Mouse Model

Adachi, H., Waza, M., Tokui, K., Katsuno, M., Minamiyama, M., Tanaka, F., Doyu, M., & Sobue, G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1242-07.2007 · Cited by 156 · see citing works

The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy

Janiesch, P. C., Kim, J., Mouysset, J., Barikbin, R., Lochmüller, H., Cassata, G., Krause, S., & Hoppe, T. (2007) · Nature Cell Biology · doi:10.1038/ncb1554 · Cited by 143 · see citing works

Regulation of <i>Caenorhabditis elegans</i> lifespan by a proteasomal E3 ligase complex

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A conserved ubiquitination pathway determines longevity in response to diet restriction

Carrano, A. C., Liu, Z., Dillin, A. G., & Hunter, T. R. (2009) · Nature · doi:10.1038/nature08130 · Cited by 131 · see citing works

Immune and non-immune functions of the immunoproteasome

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RLE-1, an E3 Ubiquitin Ligase, Regulates C. elegans Aging by Catalyzing DAF-16 Polyubiquitination

Li, W., Gao, B., Lee, S., Bennett, K. L., & Fang, D. (2007) · Developmental Cell · doi:10.1016/j.devcel.2006.12.002 · Cited by 130 · see citing works

Proteasome Regulation of Oxidative Stress in Aging and Age-Related Diseases of the CNS

Ding, Q., Dimayuga, E. R., & Keller, J. N. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.163 · Cited by 127 · see citing works

Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction

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Lipofuscin inhibits the proteasome by binding to surface motifs

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Proteasome Function in Aging and Oxidative Stress: Implications in Protein Maintenance Failure

Farout, L., & Friguet, B. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.205 · Cited by 112 · see citing works

EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan

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Aging and regulated protein degradation: who has the UPPer hand?

Vernace, V. A., Schmidt‐Glenewinkel, T., & Figueiredo‐Pereira, M. E. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00329.x · Cited by 110 · see citing works

The malin–laforin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin–proteasome system

Garyali, P., Siwach, P., Singh, P. K., Puri, R., Mittal, S., Sengupta, S., Parihar, R., & Ganesh, S. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn398 · Cited by 108 · see citing works

A photoconvertible reporter of the ubiquitin-proteasome system in vivo

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Ubiquitin, Proteasomes, and the Aging Brain

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In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis

Williams, A. J., Knutson, T. M., Gould, V. F. C., & Paulson, H. L. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.10.016 · Cited by 103 · see citing works

The Ubiquitin Ligase E6-AP Is Induced and Recruited to Aggresomes in Response to Proteasome Inhibition and May Be Involved in the Ubiquitination of Hsp70-bound Misfolded Proteins

Mishra, A., Godavarthi, S. K., Maheshwari, M., Goswami, A., & Jana, N. R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806804200 · Cited by 99 · see citing works

Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in <i>Caenorhabditis elegans</i>

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E6-AP Promotes Misfolded Polyglutamine Proteins for Proteasomal Degradation and Suppresses Polyglutamine Protein Aggregation and Toxicity

Mishra, A., Dikshit, P., Purkayastha, S., Sharma, J., Nukina, N., & Jana, N. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706620200 · Cited by 94 · see citing works

Immunoproteasomes and immunosenescence

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Caretaker or undertaker? The role of the proteasome in aging

Gaczynska, M. E., Osmulski, P. A., & Ward, W. F. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00246-3 · Cited by 83 · see citing works

The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis

Kuhlbrodt, K., Janiesch, P. C., Kevei, É., Segref, A., Barikbin, R., & Hoppe, T. (2011) · Nature Cell Biology · doi:10.1038/ncb2200 · Cited by 81 · see citing works

Proteasomal dysfunction in sporadic Parkinson's disease

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Loss of dopaminergic neurons and resulting behavioural deficits in mouse model of Angelman syndrome

Mulherkar, S. A., & Jana, N. R. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.08.002 · Cited by 71 · see citing works

Aging and dietary restriction alter proteasome biogenesis and composition in the brain and liver

Dasuri, K., Zhang, L., Ebenezer, P. J., Liu, Y., Fernandez‐Kim, S. O., & Keller, J. N. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.10.003 · Cited by 69 · see citing works

Age‐related increase in the immunoproteasome content in rat hippocampus: molecular and functional aspects

Gavilán, M. P., Castaño, A., Torres, M., Portavella, M., Caballero, C., Jiménez, S., García‐Martínez, A., Parrado, J., Vitórica, J., & Ruano, D. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05762.x · Cited by 67 · see citing works

Sequestration of chaperones and proteasome into Lafora bodies and proteasomal dysfunction induced by Lafora disease-associated mutations of malin

Rao, S. N. R., Maity, R., Sharma, J., Dey, P. N., Shankar, S. K., Satishchandra, P., & Jana, N. R. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq407 · Cited by 67 · see citing works

A Screenable in vivo Assay to Study Proteostasis Networks in Caenorhabditis elegans

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Recent advances in understanding the pathogenesis of polyglutamine diseases: involvement of molecular chaperones and ubiquitin-proteasome pathway

Jana, N. R., & Nukina, N. (2003) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(03)00029-2 · Cited by 59 · see citing works

The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias

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Aging and dietary restriction effects on ubiquitination, sumoylation, and the proteasome in the heart

Li, F., Zhang, L., Craddock, J., Bruce‐Keller, A. J., Dasuri, K., Nguyen, A., & Keller, J. N. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.04.007 · Cited by 48 · see citing works

Dramatic loss of Ube3A expression during aging of the mammalian cortex

Williams, K. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00018 · Cited by 34 · see citing works

p97 homologs from Caenorhabditis elegans, CDC‐48.1 and CDC‐48.2, suppress the aggregate formation of huntingtin exon1 containing expanded polyQ repeat

Nishikori, S., Yamanaka, K., Sakurai, T., Esaki, M., & Ogura, T. (2008) · Genes to Cells · doi:10.1111/j.1365-2443.2008.01214.x · Cited by 34 · see citing works

Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress

Dasuri, K., Zhang, L., Ebenezer, P. J., Fernandez‐Kim, S. O., Bruce‐Keller, A. J., Szweda, L. I., & Keller, J. N. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.08.001 · Cited by 33 · see citing works

The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc

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Absence of Ataxin-3 Leads to Enhanced Stress Response in C. elegans

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Age-Related Accumulation of High-Molecular-Weight Ubiquitin Protein Conjugates in Mouse Brains

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CHIP E3 ligase regulates mammalian senescence by modulating the levels of oxidized proteins

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Role of Ubiquitin Protein Ligases in the Pathogenesis of Polyglutamine Diseases

Dikshit, P., & Jana, N. R. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9459-x · Cited by 4 · see citing works

Autophagy as a Potential Target for Sarcopenia: AUTOPHAGY REGULATION IN SARCOPENIA

Fan, J., Kou, X., Jia, S., Yang, X., Yang, Y., & Chen, N. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25260 · Cited by 101 · see citing works

Proteasome activation delays aging in vitro and in vivo

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Impact of Reactive Species on Amino Acids—Biological Relevance in Proteins and Induced Pathologies

Andrés, C. M. C., Pérez de la Lastra, J. M., Andrés Juan, C., Plou, F. J., & Pérez-Lebeña, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214049 · Cited by 71 · see citing works

GHK and DNA: Resetting the human genome to health

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Autoregulation of the 26S proteasome by in situ ubiquitination

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HECT ubiquitin ligases as accessory proteins of the plant proteasome

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P53: Stability from the Ubiquitin–Proteasome System and Specific 26S Proteasome Inhibitors

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